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Olfactory Receptor family 10 subfamily G member 4.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MSNASLVTAF ILTGLPHAPG LDALLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL 

       110        120        130        140        150        160        170        180        190        200 
YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTSMMSGSRC ALLATGTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA PPILKLACAD TSANVMVIFV 

       210        220        230        240        250        260        270        280        290        300 
DIGIVASGCF VLIVLSYVSI VCSILRIRTS DGRRRAFQTC ASHCIVVLCF FVPCVVIYLR PGSMDAMDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK 

       310        320 
LRDKVAHPQR K

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

L G P A        L  S H F S       L   A S T D  L Y I V  M A D M  
 L A D    T M L    A V C   I T Q V   M V N    V C P    V G D   
I G F L  M K P V  F Y L Q   A S H   V F I V  V F F C  F I A V  
 V L F    T V T    F H F   L S G S   G I D    L V V    V T Y   
L V Y V  S F W M  T S G L   L W T   S A V I  I C H S  L P T L  
 L V T    D I F    F C E   G T A L   F C G    A C T    P N L   
L L N G  S L N T  V T Y L   L A C   V I L V  Q F A R  T Y V V  
 L L I    L F Y    Y S M   R S G S   Y S L    R R G        L   
  R I V  Y M P T  L Y R D           V I S V  D S T R           
                   S I A             I S C                     
                        Y               R L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
guaiacol -7.7 1 10 1  phenolic, smoky, spicy, vanilla, woody
ethyl vanillin -4.9 1 9.5 1  caramellic, creamy, sweet, vanilla
vanillin -5 2 9 1  chocolate, creamy, sweet, vanilla
isoeugenol -2.71 3 7.9167 3  carnation, clove, floral, spicy, sweet, woody
4-vinylguaiacol -4.52 4 2.2667 4  spicy, clove, carnation, phenolic, peppery, smoky, woody, powdery
anisaldehyde -3.3 5 1.7647 5  anisic, balsamic, floral, hawthorn, mimosa, powdery, sweet
muscone - 0 6  animal, fatty, musk, natural, powdery, sweet
3-octen-2-one - 0 7  earthy, spicy, herbal, sweet, mushroom, hay, blueberry

1.) J.D. Mainland, A. Keller, Y.R. Li, T. Zhou, C. Trimmer, L.L. Snyder, A.H. Moberly, K.A. Adipietro, W.L.L. Liu, H. Zhuang et al, The missense of smell: functional variability in the human odorant receptor repertoire, Nat. Neurosci. 17 (2014) 114-120

2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

3.) C. Trimmer, A. Keller, N. R. Murphy, L. L. Snyder, J. R. Willer, M. H. Nagai, N. Katsanis, L. B. Vosshall, H. Matsunami, and J. D. Mainland Genetic variation across the human olfactory receptor repertoire alters odor perception PNAS | May 7, 2019 | vol. 116 | no. 19 | 9475–9480

4.) Aya Namba, Naoko Saito, Keiichi Yoshikawa, Ichiro Mori (2015) Search method of urine odor suppressor JP2015211667A

5.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.

6.) Keiichi Yoshikawa, Naoko Saito (2016) Method for selecting odor-controlling substance EP3305898B1

7.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147