Olfactory Receptor family 10 subfamily G member 7.
Sequence:
10 20 30 40 50 60 70 80 90 100 MSNATLLTAF ILTGLPHAPG LDAPLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRT ISFHSCVAQL 110 120 130 140 150 160 170 180 190 200 YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTNMMTGRSC ALLATGTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA PPILKLACAD TSANEMVIFV 210 220 230 240 250 260 270 280 290 300 NIGLVASGCF VLIVLSYVSI VCSILRIRTS EGRHRAFQTC ASHCIVVLCF FGPGLFIYLR PGSRDALHGV VAVFYTTLTP LFNPVVYTLR NKEVKKALLK 310 320 LKNGSVFAQG E
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 L G P A L S H F S L A S T D L Y I F L A D R P A D T M L A V C I T Q V M E N L G P V G H I G F L M K P V F Y L Q A S H V F I V G F F C F V A V V L F T V T F H F L S G S G I N L V V T T Y L V Y V S F W M T S G L L W T S A V L I C H S L P T L L V T D I F F C E G T A L F C G A C T P N F L L N G S L N T V T Y L L A C V I L V Q F A R T Y V V L L I L F Y Y S M S R G T Y S L H R G L R I V Y M P T L Y R D V I S V E S T R S I A I S C Y R L UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| eugenol | -9 1 | 5.654 2 | clove, spicy, sweet, woody | |
| creosol | -6 2 | 10 2 | burnt, clove, leathery, medicinal, phenolic, smoky, spicy, vanilla, woody | |
| guaiacol | -6 2 | 8.1972 2 | phenolic, smoky, spicy, vanilla, woody | |
| methyl eugenol | -6 2 | 2.3333 3 | carnation, cinnamon, clove, fresh, spicy, sweet, warm | |
| isoeugenol | -3.23 4 | 5.4167 4 | carnation, clove, floral, spicy, sweet, woody | |
| 4-vinylguaiacol | -4.7 5 | 1.3333 5 | spicy, clove, carnation, phenolic, peppery, smoky, woody, powdery | |
| eugenyl acetate | - | 3 3 | carnation, clove, floral, fresh, malty, spicy, sweet, woody | |
| ethyl vanillin | - | 0.2333 3 | caramellic, creamy, sweet, vanilla | |
| coumarin | - | 0.1667 3 | coumarinic, hay, sweet, tonka | |
| octyl octanoate | - | 0.1667 3 | coconut, fruity, oily | |
| methyl furfuryl disulfide | - | 0.1333 3 | alliaceous, coffee, meaty, roasted, sulfurous | |
| 1-octanol | - | 0.1333 3 | aldehydic, green, mushroom, orange, rose, waxy | |
| quinoline | - | 0.0667 3 | earthy, medicinal, musty, rubbery, tobacco | |
| aldehyde C-9 | - | 0 3 | aldehydic, fatty, fresh, orange, orris, peel, peely, rose, waxy | |
| allyl phenylacetate | - | 0 3 | fruity, honey, rummy | |
| androstenone | - | 0 3 | animal, musky | |
| l-arabinose | - | 0 3 | ||
| butyric acid | - | 0 3 | acetic, buttery, cheesy, fruity, sharp | |
| caramel furanone | - | 0 3 | burnt, caramellic, coffee, maple, sugar, sweet | |
| (S)-(+)-carvone | - | 0 3 | bready, caraway, minty, spicy | |
| citral | - | 0 3 | citrus, lemon, sharp, sweet | |
| coffee difuran | - | 0 3 | cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty | |
| dimethyl disulfide | - | 0 3 | cabbage, onion, sulfurous, vegetable | |
| 2,4-DNT | - | 0 3 | ||
| 2-ethyl fenchol | - | 0 3 | camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea | |
| geranyl acetate | - | 0 3 | floral, green, lavender, rose, waxy | |
| helional | - | 0 3 | cyclamen, fresh, green, hay, ozone, watery | |
| heptanal | - | 0 6 | aldehydic, cognac, fatty, fresh, green, herbal, ozone | |
| 2-heptanone | - | 0 3 | banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody | |
| cis-3-hexen-1-ol | - | 0 3 | foliage, fresh, grassy, green, herbal, oily, vegetable | |
| isobutylamine | - | 0 3 | cheesy, fishy | |
| d-limonene | - | 0 3 | citrus, fresh, orange, sweet | |
| linalool | - | 0 3 | blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody | |
| lyral | - | 0 3 | aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody | |
| methyl salicylate | - | 0 3 | minty, wintergreen | |
| 1-nonanol | - | 0 3 | aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet | |
| octanethiol | - | 0 3 | sulfurous | |
| 3-octen-2-one | - | 0 7 | earthy, spicy, herbal, sweet, mushroom, hay, blueberry | |
| pelargonic acid | - | 0 3 | cheesy, dairy, dirty, waxy | |
| propionic acid | - | 0 3 | acidic, cheesy, pungent, vinegar | |
| pyrazine | - | 0 3 | pungent, sweet, corn, roasted, hazelnut, barley | |
| terpinyl acetate | - | 0 3 | bergamot, citrus, herbal, lavender, lime | |
| aldehyde C-10 | - | -0.0667 3 | aldehydic, citrus, floral, orange, peel, sweet, waxy | |
| amyl hexanoate | - | -0.0667 3 | apple, estery, fatty, fruity, green, pear, pineapple, sweet | |
| benzene | - | -0.0667 3 | ||
| butyl formate | - | -0.0667 3 | brandy, fruity, plum, rummy | |
| beta-damascone | - | -0.0667 3 | berry, currant, floral, fruity, honey, plum, rose, tobacco | |
| (+)-menthol | - | -0.0667 3 | cooling, mentholic, minty | |
| pentanol | - | -0.0667 3 | balsamic, fermented, fusel, oily, sweet | |
| propanal | - | -0.0667 3 | alcoholic, cocoa, earthy, nutty, whiskey, winey |
1.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.
2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
3.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821
4.) C. Trimmer, A. Keller, N. R. Murphy, L. L. Snyder, J. R. Willer, M. H. Nagai, N. Katsanis, L. B. Vosshall, H. Matsunami, and J. D. Mainland Genetic variation across the human olfactory receptor repertoire alters odor perception PNAS | May 7, 2019 | vol. 116 | no. 19 | 9475–9480
5.) Aya Namba, Naoko Saito, Keiichi Yoshikawa, Ichiro Mori (2015) Search method of urine odor suppressor JP2015211667A
6.) Lim J. H., J. Park, E. H. Oh, H. J. Ko, S. Hong, and Park, T. H. (2014) Nanovesicle-based bioelectronic nose for the diagnosis of lung cancer from human blood. Adv. Healthcare Mater., 3: 360–366.
7.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147