Olfactory Receptor family 11 subfamily G member 2.
Estimated Expression: 80% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MHFLSQNDLN INLIPHLCLH RHSVIAGAFT IHRHMKIFNS PSNSSTFTGF ILLGFPCPRE GQILLFVLFT VVYLLTLMGN GSIICAVHWD QRLHAPMYIL 110 120 130 140 150 160 170 180 190 200 LANFSFLEIC YVTSTVPSML ANFLSDTKII SFSGCFLQFY FFFSLGSTEC FFLAVMAFDR YLAICRPLRY PTIMTRRLCT NLVVNCWVLG FIWFLIPIVN 210 220 230 240 250 260 270 280 290 300 ISQMSFCGSR IIDHFLCDPA PLLTLTCKKG PVIELVFSVL SPLPVFMLFL FIVGSYALVV RAVLRVPSAA GRRKAFSTCG SHLAVVSLFY GSVLVMYGSP 310 320 330 340 350 PSKNEAGKQK TVTLFYSVVT PLLNPVIYSL RNKDMRKALK KFWGT
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 Q K G A P V P G K I N S I I K L F G E R P V T K S G Y M L E I V I P I G S F N A L L I Q Y F L T V L V V S F V L F W Q L F C M S P V L V F L V V S S G Y F P S L I F G L F Y F T S T V T F L L P T L S V F V P L V W C L S F F V Y C I L L Y V V P N V A L H F L M N V V L T S G E L F M L T S Y I S G C V I F L N T C F F C E S F N A S G N G T S F A Y S G L R R T V A L L L I C I I K R R V V L A D F A M Y M P A W H V A G A A S V A R L Y R D V R L R C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| strawberry glycidate 2 | -4.80 1 | (agonist) 1 | sweet, strawberry, berry, floral, tropical, honey, rose | |
| eugenol | -3.63 2 | 0.4208 2 | clove, spicy, sweet, woody | |
| ethyl cyclohexanecarboxylate | - | 1 3 | cheesy, fruity, winey | |
| heptanal | - | 0 4 | aldehydic, cognac, fatty, fresh, green, herbal, ozone |
1.) Ichie Ojiro, Ryusei Kaneko, Takahiro Kashiwagi, Ikuo Terada, Kunihide Hoshino, Yuko Terada, Keisuke Ito, Odorants have the potential to enhance the heterologous expression of human olfactory receptors: evidence from ethyl 3-phenylglycidate and its effects on OR1A1, OR11G2, and OR2W1, Biochemical and Biophysical Research Communications, 2025, 151459, ISSN 0006-291X,
2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
3.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025
4.) Lim J. H., J. Park, E. H. Oh, H. J. Ko, S. Hong, and Park, T. H. (2014) Nanovesicle-based bioelectronic nose for the diagnosis of lung cancer from human blood. Adv. Healthcare Mater., 3: 360–366.
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR11G2 | 100 | 80% | Y | F | F | F | G | S | C | F | G | W | F | P | L | D | P | A | F | L | S | P | V | Y | V | Y | P | T | L | Y | S |
| OR11H1 | 90 | 92% | Y | F | F | F | G | T | C | L | G | W | F | P | V | D | P | G | C | L | S | V | I | Y | L | Y | G | T | L | Y | A |
| OR11H2 | 90 | 92% | Y | F | F | F | G | T | C | L | G | W | F | P | V | D | P | G | C | L | S | V | I | Y | L | Y | G | T | L | Y | A |
| OR11H12 | 90 | 92% | Y | F | F | F | G | T | C | L | G | W | F | P | V | D | P | G | C | L | S | V | I | Y | L | Y | G | T | L | Y | A |
| OR11H6 | 86 | 96% | Y | F | F | F | G | T | C | F | G | C | Y | P | V | D | P | G | C | F | N | I | I | Y | L | Y | T | T | L | Y | T |
| OR11H4 | 86 | 100% | Y | F | F | F | G | T | C | L | G | G | Y | P | L | D | M | D | F | Q | S | V | L | Y | V | Y | T | T | L | Y | S |
| OR11H7 | 85 | Y | F | F | F | G | T | C | F | G | G | H | S | L | D | V | D | F | V | S | F | I | Y | I | Y | T | T | L | Y | S | |
| OR5H2 | 84 | 65% | I | F | F | A | G | T | C | F | G | H | A | H | Y | D | I | I | V | L | S | I | Q | Y | L | Y | A | S | V | Y | T |
| OR10K2 | 83 | 96% | Y | M | F | L | G | C | S | F | G | V | A | I | F | D | I | A | I | L | C | V | L | Y | A | Y | Q | S | V | Y | T |
| OR11L1 | 82 | 100% | Y | L | F | V | G | A | C | F | G | T | G | P | F | D | L | P | I | L | S | V | L | Y | M | Y | S | S | V | Y | T |
| OR10T2 | 82 | 65% | Y | L | F | L | A | C | C | L | G | I | A | A | F | D | M | A | L | L | S | V | I | Y | A | Y | K | A | V | Y | T |
| OR10Q1 | 81 | 100% | Y | M | F | V | G | S | C | F | A | P | S | L | L | D | V | P | L | V | S | V | L | Y | C | Y | R | A | L | Y | T |
| OR5P2 | 81 | 100% | Y | L | A | A | A | T | C | V | G | I | A | Y | F | D | F | A | L | S | S | I | I | Y | I | Y | N | S | V | Y | T |
| OR2M4 | 80 | 96% | L | I | Y | V | L | G | C | F | G | D | G | V | F | D | V | A | L | C | C | M | L | Y | A | Y | A | S | A | Y | T |
| OR10W1 | 80 | 100% | Y | M | F | I | G | S | C | F | G | L | S | L | F | D | V | P | V | A | A | A | I | Y | C | Y | S | S | L | Y | T |
| OR14J1 | 80 | 88% | F | V | F | I | A | S | V | A | G | S | G | H | F | D | V | P | L | F | T | A | A | L | A | F | P | S | V | Y | T |