SMILES:
COC1=C(C=CC(=C1)CC=C)O
Aroma Description:
clove, spicy, sweet, woody1
| Receptor | Expression | log10 EC50 | Adj. Top | Antagonist? | Correlated Perceptual Qualities |
|---|---|---|---|---|---|
| OR10G7 | 80 | -8 2, -3.83 3, -9 7, -6.29 10 | 5.654 2, 3.8333 3, (agonist) 7 | vanilla, clove, carnation, spicy, smoky | |
| OR4Q3 | 92 | -6 2 | - | clove, alliaceous, chemical, sweet, garlic, onion, metallic, animal | |
| OR2W3 | 100 | - | 7.2093 6 | sweet, lemon, citrus, clove | |
| OR4K2 | 100 | -5.71 2 | 0.8147 2 | clove, animal, cortex, sweet, foliage | |
| OR10H5 | 96 | -5 2 | 0.2518 2 | watery, marine, clove, ozone, clean, sweet | |
| OR1D5 | ? | -5 2 | 0.2205 2 | rose, fresh, sweet, floral, honey, bready | |
| OR4K5 | 61 | -4.08 2 | 0.4813 2 | vetiver, clove, dry | |
| OR4F6 | ? | -3.97 2 | 0.578 2 | (insufficient data) | |
| OR56A3 | 96 | -3.97 2 | 0.3351 2 | cheesy, dairy, buttery, clove, creamy, sharp | |
| OR11G2 | 80 | -3.63 2 | 0.4208 2 | honey, sweet, strawberry, clove | |
| OR4F17 | 92 | -3.48 2 | 0.3917 2 | clove, animal | |
| OR13D1 | 100 | -3.29 2 | 0.2761 2 | (insufficient data) | |
| OR4K3 | ? | -3.3 2 | 0.207 2 | (insufficient data) | |
| OR2A12 | ? | -2.89 2 | 0.5624 2 | clove, mentholic | |
| OR5D16 | 42 | -2.74 2 | 0.18 2 | (insufficient data) | |
| OR14A2 | ? | -1.88 2 | 0.3269 2 | cilantro, chicken_fat | |
| TAAR5 | ? | - | 1 5 | corn_chip, seafood, fishy, sharp, cyclamen, tart, sweet, fresh, hay, watery | |
| OR5K1 | 100 | - | 0.2667 3 | hazelnut, nutty, peanut, roasted, carnation, cocoa, almond | |
| OR7D4 | 96 | - | 0.2 4 | animal, citrus, orange, peely, tart, aldehydic, blueberry | |
| OR10G3 | 96 | - | 0.1 3 | vanilla, carnation | |
| OR10J5 | 84 | - | 0 3 | ||
| OR11A1 | 100 | - | 0 3 | ||
| OR1A1 | 73 | - | 0 3 | ||
| OR1C1 | 100 | - | 0 3 | ||
| OR2A25 | 100 | - | 0 3 | ||
| OR2B11 | 100 | - | 0 3 | ||
| OR2J2 | 92 | - | 0 3 | ||
| OR2J3 | 100 | - | 0 3 | ||
| OR2W1 | 53 | - | 0 3 | ||
| OR51E1 | 100 | - | 0 3 | ||
| OR51L1 | 88 | - | 0 3 | ||
| OR56A4 | 100 | - | 0 3 | ||
| OR8D1 | 96 | - | 0 3 | ||
| OR8K3 | 92 | - | 0 3 | ||
| OR7A17 | 100 | - | 0 9 | ||
| OR10D3 | ? | - | 0 10 | ||
| OR2L13 | 88 | - | -1 8 | ||
| OR5P3 | 100 | - | -2.1667 3 |
SMILES:
COC1=C(C=CC(=C1)CC=C)O
Aroma Description:
clove, spicy, sweet, woody
| Receptor | Expr.% | Agonist? | Dock Score | Known agonist | Correlated Perceptual Qualities |
|---|
Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.
1.) The Good Scents Company
2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
3.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821
4.) Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468-72. doi: 10.1038/nature06162. Epub 2007 Sep 16. PMID: 17873857.
5.) Wallrabenstein I, Singer M, Panten J, Hatt H, Gisselmann G. Timberol® Inhibits TAAR5-Mediated Responses to Trimethylamine and Influences the Olfactory Threshold in Humans. PLoS One. 2015;10(12):e0144704. Published 2015 Dec 18. doi:10.1371/journal.pone.0144704
6.) Huang, J., Lam, H., Koziol-White, C., Limjunyawong, N., Kim, D., Kim, N., ... & An, S. S. (2020). The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. Proceedings of the National Academy of Sciences, 117(45), 28485-28495.
7.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.
8.) Morrell CN, Mix D, Aggarwal A, Bhandari R, Godwin M, Owens P 3rd, Lyden SP, Doyle A, Krauel K, Rondina MT, Mohan A, Lowenstein CJ, Shim S, Stauffer S, Josyula VP, Ture SK, Yule DI, Wagner LE 3rd, Ashton JM, Elbadawi A, Cameron SJ. Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms. J Clin Invest. 2022 May 2;132(9):e152373. doi: 10.1172/JCI152373. PMID: 35324479; PMCID: PMC9057618.
9.) Dan Takase, Tomohiro Shirai, Kensuke Misawa, Hiroaki Matsunami, Keiichi Yoshikawa, An odorant receptor for a key odor constituent of ambergris. Communications Biology | (2025)8:792. doi: 10.1038/s42003-025-08229-y
10.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025