Olfactory Receptor family 5 subfamily R member 1.
Estimated Expression: 34% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MAEVNIIYVT VFILKGITNR PELQAPCFGV FLVIYLVTVL GNLGLITLIK IDTRLHTPMY YFLSHLAFVD LCYSSAITPK MMVNFVVERN TIPFHACATQ 110 120 130 140 150 160 170 180 190 200 LGCFLTFMIT ECFLLASMAY DCYVAICSPL HYSTLMSRRV CIQLVAVPYI YSFLVALFHT VITFRLTYCG PNLINHFYCD DLPFLALSCS DTHMKEILIF 210 220 230 240 250 260 270 280 290 300 AFAGFDMISS SSIVLTSYIF IIAAILRIRS TQGQHKAIST CGSHMVTVTI FYGTLIFMYL QPKSNHSLDT DKMASVFYTV VIPMLNPLIY SLRNKEVKDA 310 320 330 SKKALDKGCE NLQILTFLKI RKLY
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 D T D L K P M H T D T I P I T N V F L E P R A M K Q L Y M I E K V T H F A H F N V M P A Q Y F V S F I L A F I L L A V Q T A C M K P T V G F C V V T T G Y F G A F L F S Y C G L I A S V L F L M P I I T V I M D F I Y P F T L F S Y C L V L Y I L P N T V M H S S S V A V L T I M D V F L V T Y I S G C L V I S Q I C L F C E A L H S G L N G T S I A Y S T V R R S S A L L F Y T I L K H Q I I F I D Y A M Y M P T I K I L G Q T S I A A V Y C D I R L S C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| (R)-(-)-carvone | -4.9 1 | 9.4737 1 | herbal, minty, spearmint, sweet | |
| acetophenone | -5.6 1 | 7.8947 1 | sweet, pungent, hawthorn, mimosa, almond, acacia, chemical | |
| coumarin | -5 1 | 7.7895 1 | coumarinic, hay, sweet, tonka | |
| 4-chromanone | -3.8 1 | 7.6842 1 | ||
| androstenone | -4.15 2 | 0.1662 2 | animal, musky |
1.) Xiaojing Cong, Wenwen Ren, Jody Pacalon, Claire A. de March, Lun Xu, Hiroaki Matsunami, Yiqun Yu, Jérôme Golebiowski Functions of olfactory receptors are decoded from their sequence https://doi.org/10.1101/2020.01.06.895540
2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR5R1 | 100 | 34% | Y | L | F | L | M | I | C | F | S | V | A | H | Y | D | D | L | I | F | A | D | M | Y | L | Y | K | S | V | Y | T |
| OR8U8 | 90 | Y | L | F | L | M | V | S | L | S | M | A | H | Y | D | D | M | I | C | A | T | F | Y | L | Y | S | S | V | Y | T | |
| OR8U1 | 88 | 80% | Y | L | F | L | M | I | S | L | S | M | A | H | Y | D | D | M | I | C | A | M | F | Y | L | Y | S | S | V | Y | T |
| OR8K3 | 88 | 92% | Y | L | F | L | I | G | L | F | C | I | S | V | Y | D | S | L | I | F | A | D | L | Y | L | Y | K | S | I | Y | T |
| OR8U9 | 86 | 80% | Y | L | F | L | M | T | C | L | S | V | A | H | Y | D | D | M | I | C | A | M | F | Y | L | Y | S | S | V | Y | T |
| OR8B2 | 85 | 88% | Y | L | F | L | V | I | C | Y | G | G | A | H | L | D | I | L | V | V | V | N | I | F | A | Y | Y | S | V | Y | T |
| OR8B3 | 85 | 88% | Y | L | F | L | V | I | C | Y | G | G | A | H | L | D | I | L | V | V | V | N | I | F | A | Y | Y | S | V | Y | T |
| OR10AG1 | 84 | 65% | Y | M | F | L | G | G | C | L | T | V | V | E | F | D | I | P | V | V | A | F | I | F | G | Y | K | S | L | Y | T |
| OR8G1 | 84 | 88% | H | L | F | L | A | I | C | H | G | C | A | H | F | D | L | L | I | V | G | N | I | F | A | Y | S | S | V | Y | T |
| OR8B8 | 84 | 100% | Y | L | F | L | V | V | S | F | G | G | A | H | M | D | I | L | V | V | V | D | I | F | G | Y | F | S | L | Y | T |
| OR8G5 | 82 | 100% | H | L | F | L | A | I | C | H | G | C | A | H | F | D | L | I | I | F | S | N | I | F | A | Y | S | S | V | Y | T |
| OR5AP2 | 82 | 61% | Y | F | F | G | L | G | C | F | G | N | A | H | Y | D | T | P | I | F | S | I | V | F | I | Y | T | S | V | Y | T |
| OR8H1 | 82 | 88% | Y | M | F | V | G | A | C | F | S | N | S | N | F | D | T | S | I | L | A | T | L | Y | M | Y | R | S | V | Y | T |
| OR8B12 | 82 | 92% | F | L | F | C | V | V | S | F | G | G | A | H | M | D | I | L | V | V | V | D | V | F | G | Y | L | S | L | Y | T |
| OR8D4 | 81 | 96% | Y | L | F | C | V | I | C | Y | G | D | A | H | F | D | I | V | I | I | G | N | M | Y | L | Y | A | S | V | Y | T |
| OR8K1 | 81 | 42% | Y | L | F | E | I | I | L | F | S | V | S | L | Y | D | C | I | I | F | S | N | L | Y | L | Y | K | S | V | Y | T |
| OR10A2 | 81 | F | M | F | F | G | V | C | F | G | V | A | Q | F | D | S | P | A | G | T | V | V | Y | L | Y | K | S | L | Y | T | |
| OR2A12 | 81 | Y | T | Y | L | A | I | C | L | S | L | A | H | F | Q | I | M | L | G | S | I | L | F | A | Y | K | S | L | Y | S | |
| OR10A3 | 81 | 100% | F | M | I | L | G | G | C | F | G | V | A | Q | F | E | T | P | A | G | T | I | V | Y | A | Y | K | S | L | Y | T |
| OR8K5 | 80 | 61% | N | L | F | L | I | I | F | F | S | Q | A | F | Y | D | D | V | S | F | S | N | L | Y | L | Y | N | S | V | Y | T |
| OR5B21 | 80 | 100% | Y | F | F | V | A | T | C | Y | G | N | A | H | F | D | I | P | V | V | A | N | V | Y | I | Y | N | S | V | Y | T |