☰

Olfactory Receptor family 8 subfamily K member 3.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MEQHNLTTVN EFILTGITDI AELQAPLFAL FLMIYVISVM GNLGMIVLTK LDSRLQTPMY FFLRHLAFMD LGYSTTVGPK MLVNFVVDKN IISYYFCATQ 

       110        120        130        140        150        160        170        180        190        200 
LAFFLVFIGS ELFILSAMSY DLYVAICNPL LYTVIMSRRV CQVLVAIPYL YCTFISLLVT IKIFTLSFCG YNVISHFYCD SLPLLPLLCS NTHEIELIIL 

       210        220        230        240        250        260        270        280        290        300 
IFAAIDLISS LLIVLLSYLL ILVAILRMNS AGRQKAFSTC GAHLTVVIVF YGTLLFMYVQ PKSSHSFDTD KVASIFYTLV IPMLNPLIYS LRNKDVKYAL 

       310        320 
RRTWNNLCNI FV

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

L E A I      V F  F Y Y S       K   E H T N    Y M F  T D F S  
 P A Q    N V L    T A C   I T V L   L E I    L L T    V K D   
L A F L  M K P G  F A L Q   L S I   I L I I  G Y F V  F I S A  
 M L F    V T T    V L F   F T C Y   A A F    I V V    L T Y   
I V Y I  S Y G L  S G I F   L Y P   I L D I  T L H A  M P I V  
 M V S    D M F    F L E   I A V L   L S S    G C T    P N L   
G L N G  A L H R  A S L I   V Q C   L V I L  S F A K  S Y I L  
 V I M    L F F    Y S M   V R R S   Y S L    Q R G        L   
  K T L  Y M P T  V Y L D           L I L L  A S N M           
                   C I A             I A V                     
                        N               R L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
(1S,2R,5S)-(+)-menthol -5.32 1 0.1 2  cooling, mentholic, minty
beta-damascone - 2.3333 2  berry, currant, floral, fruity, honey, plum, rose, tobacco
quinoline - 0.0667 2  earthy, medicinal, musty, rubbery, tobacco
allyl phenylacetate - 0 2  honey, fruity, rummy
amyl hexanoate - 0 2  sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
androstenone - 0 2  animal, musky
l-arabinose - 0 2  
benzene - 0 2  
butyl formate - 0 2  fruity, plum, rummy, brandy
butyric acid - 0 2  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
(S)-(+)-carvone - 0 2  bready, caraway, minty, spicy
citral - 0 2  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
coffee difuran - 0 2  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
coumarin - 0 2  coumarinic, hay, sweet, tonka
decanal - 0 2  sweet, aldehydic, waxy, orange_peel, citrus, floral
dimethyl disulfide - 0 2  sulfurous, vegetable, cabbage, onion, malty, creamy
2,4-DNT - 0 2  
2-ethyl fenchol - 0 2  camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl vanillin - 0 2  sweet, creamy, vanilla, caramellic
eugenol - 0 2  clove, spicy, sweet, woody
eugenyl acetate - 0 2  carnation, clove, floral, fresh, malty, spicy, sweet, woody
geranyl acetate - 0 2  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
helional - 0 2  cyclamen, fresh, green, hay, ozone, watery
2-heptanone - 0 2  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
(Z)-3-hexen-1-ol - 0 2  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
isobutylamine - 0 2  cheesy, fishy
d-limonene - 0 2  citrus, orange, fresh, sweet
linalool - 0 2  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
lyral - 0 2  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
methyl eugenol - 0 2  carnation, cinnamon, clove, fresh, spicy, sweet, warm
methyl furfuryl disulfide - 0 2  sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
methyl salicylate - 0 2  minty, wintergreen
nonanal - 0 2  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
1-nonanol - 0 2  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
octanethiol - 0 2  sulfurous
1-octanol - 0 2  aldehydic, green, mushroom, orange, rose, waxy
octyl octanoate - 0 2  coconut, oily, fruity
pelargonic acid - 0 2  cheesy, dairy, dirty, waxy
pentanol - 0 2  fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
propanal - 0 2  alcoholic, cocoa, earthy, nutty, whiskey, winey
propionic acid - 0 2  acidic, cheesy, pungent, vinegar
pyrazine - 0 2  pungent, sweet, corn, roasted, hazelnut, barley
sotolone - 0 2  sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
terpinyl acetate - 0 2  bergamot, citrus, herbal, lavender, lime

1.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

2.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821
×
 
 

Code version:
 

Docker used:
 

Files:
Active model: text 3D download
Inactive model: text 3D download
Active dock: text 3D download
Inactive dock: text 3D download
JSON entry: text   download