SMILES:
C1=CC=C2C(=C1)C=CC(=O)O2

Aroma Description:
coumarinic, hay, sweet, tonka1

Receptor Expression log10 EC50 Adj. Top Antagonist? Correlated Perceptual Qualities
OR5P3 100 -5.44 2, -2.85 5, -5.25 6 6.357 2, 2.8333 5, 9.7 6  mimosa, hawthorn, spearmint, coumarinic, hay, sweet, acacia, orangeflower, powdery, naphthyl
OR1C1 100 -6 2 -  blueberry, bois_de_rose, sweet, rose, citrus
OR2J2 92 -3.68 6, -5 9 5.8333 5, 9.7 6, (agonist) 9  tart, sweet, carnation, hay, orange, warm, cinnamon, clove, coumarinic
OR2W1 53 -4.06 6, -5.3 9 2.3333 5, 9.5 6, (agonist) 9  sweet, tart, hay, fatty, coumarinic, orange, peony, cinnamon, herbal, tonka
OR2B11 100 -3.45 2, -2.14 5, -3.5 7 1.8005 2, 9.3333 5, 9 7  hay, coumarinic, tonka, sweet, candy, cinnamon, rubbery, warm, orange, medicinal
OR5R1 34 -5 3 7.7895 3  spearmint, acacia, hawthorn, mimosa, chemical, coumarinic, sweet, hay, tonka, almond
OR11H12 92 -4.1 3 7.8947 3  spearmint, acacia, hawthorn, chemical, mimosa, sweet, coumarinic
OR2J1 ? -7.85 2 0.0647 2  hay, coumarinic, tonka, sweet
OR1G1 61 - 3.2487 4  sweet, waxy, citrus, fresh, tart, orange, aldehydic, floral, rose, fatty
OR4N2 73 -2.29 2 0.4578 2  tonka, hay, coumarinic, sweet, animal
OR2J3 100 - 1.8333 5  tart, hay, sweet, foliage, passionfruit, cinnamon, warm, blackcurrant, coumarinic, candy
OR52D1 100 - 0.9645 4  dairy, cheesy, anise, milky, creamy, sour, sharp, peach, lactonic, rancid
OR10G7 80 - 0.1667 5  vanilla, clove, carnation, spicy, smoky
OR10G3 96 - 0 5   
OR10J5 84 - 0 5, 0 6   
OR11A1 100 - 0 5   
OR1A1 73 - 0 5, 0 6   
OR2A25 100 - 0 5   
OR51E1 100 - 0 5, 0 6   
OR51L1 88 - 0 5, 0 6   
OR56A4 100 - 0 5   
OR5K1 100 - 0 5   
OR8D1 96 - 0 5   
OR8K3 92 - 0 5   
OR2C1 100 - 0 6   
OR7A17 100 - 0 10   
TAAR5 ? - -1 8   
 

SMILES:
C1=CC=C2C(=C1)C=CC(=O)O2

Aroma Description:
coumarinic, hay, sweet, tonka

Receptor Expr.% Agonist? Dock Score Known agonist Correlated Perceptual Qualities

Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.

1.) The Good Scents Company

2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

3.) Xiaojing Cong, Wenwen Ren, Jody Pacalon, Claire A. de March, Lun Xu, Hiroaki Matsunami, Yiqun Yu, Jérôme Golebiowski Functions of olfactory receptors are decoded from their sequence https://doi.org/10.1101/2020.01.06.895540

4.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

5.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

6.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

7.) J.D. Mainland, A. Keller, Y.R. Li, T. Zhou, C. Trimmer, L.L. Snyder, A.H. Moberly, K.A. Adipietro, W.L.L. Liu, H. Zhuang et al, The missense of smell: functional variability in the human odorant receptor repertoire, Nat. Neurosci. 17 (2014) 114-120

8.) Wallrabenstein I, Singer M, Panten J, Hatt H, Gisselmann G. Timberol® Inhibits TAAR5-Mediated Responses to Trimethylamine and Influences the Olfactory Threshold in Humans. PLoS One. 2015;10(12):e0144704. Published 2015 Dec 18. doi:10.1371/journal.pone.0144704

9.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

10.) Dan Takase, Tomohiro Shirai, Kensuke Misawa, Hiroaki Matsunami, Keiichi Yoshikawa, An odorant receptor for a key odor constituent of ambergris. Communications Biology | (2025)8:792. doi: 10.1038/s42003-025-08229-y

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