Olfactory Receptor family 8 subfamily B member 4.
Estimated Expression: 61% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MTLRNSSSVT EFILVGLSEQ PELQLPLFLL FLGIYVFTVV GNLGLITLIG INPSLHTPMY FFLFNLSFID LCYSCVFTPK MLNDFVSESI ISYVGCMTQL 110 120 130 140 150 160 170 180 190 200 FFFCFFVNSE CYVLVSMAYD RYVAICNPLL YMVTMSPRVC FLLMFGSYVV GFAGAMAHTG SMLRLTFCDS NVIDHYLCDV LPLLQLSCTS THVSELVFFI 210 220 230 240 250 260 270 280 290 300 VVGVITMLSS ISIVISYALI LSNILCIPSA EGRSKAFSTW GSHIIAVALF FGSGTFTYLT TSFPGSMNHG RFASVFYTNV VPMLNPSIYS LRNKDDKLAL 310 GKTLKRVLF
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 G H N M L Y T V H T S M S S I I S V F L E P Q A F R F T G L E S G T H A G V Y D N L P L Q Y F V S S G F F I F F V M A G Q T M C M K P T L L F L V N T L A V G V V A F G V F F L F V C G L F L M P V A I I H M T I V V Y S F F C F S Y C L F V Y I S P N S G W S S L G F M L S N V D I F V V T L S Y I T S F A V I S I L F C V Y C E S L N F G L N G R K S R Y S I V R P S S V L L F F T I L G E A S L I L A D Y A M Y M P T I G I L I N S V Y R N I C L N C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
1.) Ashti Baghaei, K. (2015). Large scale analysis of olfactory receptors with highly genetically variations in relation with specific anosmia (Doctoral dissertation, Bochum, Ruhr-Universität Bochum, Diss., 2013).
2.) Ojiro I, Katsuyama H, Kaneko R, Ogasawara S, Murata T, Terada Y, et al. (2024) Enhancement of transcription efficiency by TAR-Tat system increases the functional expression of human olfactory receptors. PLoS ONE 19(6): e0306029. https://doi.org/10.1371/journal.pone.0306029
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR8B4 | 100 | 61% | Y | L | F | C | V | N | C | Y | G | G | A | H | L | D | V | L | F | V | V | I | T | F | G | Y | T | S | V | Y | T |
| OR5T2 | 89 | 61% | Y | V | A | C | G | T | C | F | G | H | A | H | F | D | I | P | L | F | V | I | E | Y | I | Y | S | S | I | Y | T |
| OR5T3 | 87 | 50% | Y | M | F | V | G | T | C | F | G | H | A | H | F | D | M | P | L | F | V | I | E | H | I | Y | S | S | I | Y | T |
| OR5AR1 | 87 | 53% | Y | F | F | V | V | D | C | Y | G | S | L | H | F | E | I | P | L | L | C | I | E | Y | V | Y | T | S | V | Y | T |
| OR5C1 | 86 | 100% | Y | M | F | A | A | D | C | C | G | S | A | H | F | D | I | P | L | I | C | I | Q | Y | L | Y | S | S | V | Y | T |
| OR5W2 | 85 | 46% | Y | F | F | C | A | D | C | L | G | D | A | H | F | D | I | P | L | V | F | I | E | Q | L | Y | S | S | L | Y | T |
| OR5T1 | 85 | 88% | Y | M | A | C | G | T | C | F | S | H | A | H | F | N | M | P | F | F | V | I | E | H | I | Y | S | S | I | Y | T |
| OR5H14 | 84 | 92% | L | L | F | A | V | T | C | F | G | H | A | H | Y | D | I | I | V | F | A | I | Q | Y | L | Y | A | S | L | Y | T |
| OR8B2 | 84 | 88% | Y | L | F | L | V | I | C | Y | G | G | A | H | L | D | I | L | V | V | V | N | I | F | A | Y | Y | S | V | Y | T |
| OR8B3 | 84 | 88% | Y | L | F | L | V | I | C | Y | G | G | A | H | L | D | I | L | V | V | V | N | I | F | A | Y | Y | S | V | Y | T |
| OR5B21 | 82 | 100% | Y | F | F | V | A | T | C | Y | G | N | A | H | F | D | I | P | V | V | A | N | V | Y | I | Y | N | S | V | Y | T |
| OR5H6 | 82 | 57% | L | F | L | V | V | T | C | F | G | H | A | H | Y | D | I | I | V | F | A | V | Q | Y | L | Y | A | S | L | Y | T |
| OR5AC2 | 82 | 76% | T | F | F | A | A | T | C | F | G | H | P | H | Y | E | I | L | I | F | G | I | Q | Y | L | Y | A | S | L | Y | T |
| OR2AG2 | 82 | 100% | F | M | A | L | G | S | D | L | A | I | A | H | L | E | I | P | I | T | G | F | L | Y | A | Y | S | S | V | Y | T |
| OR8B12 | 82 | 92% | F | L | F | C | V | V | S | F | G | G | A | H | M | D | I | L | V | V | V | D | V | F | G | Y | L | S | L | Y | T |
| OR9I1 | 82 | 96% | Y | F | F | T | A | G | C | F | G | G | A | R | F | D | L | P | I | F | G | V | I | F | L | Y | S | S | V | Y | T |
| OR9Q1 | 81 | 96% | Y | F | F | T | G | S | C | Y | G | S | A | R | F | D | L | P | I | F | A | V | I | F | L | Y | N | S | V | Y | T |
| OR9Q2 | 81 | 100% | Y | F | F | T | A | S | C | Y | G | S | A | R | F | D | L | P | I | F | A | V | M | F | L | Y | N | S | V | Y | T |
| OR10K2 | 81 | 96% | Y | M | F | L | G | C | S | F | G | V | A | I | F | D | I | A | I | L | C | V | L | Y | A | Y | Q | S | V | Y | T |
| OR5H2 | 81 | 65% | I | F | F | A | G | T | C | F | G | H | A | H | Y | D | I | I | V | L | S | I | Q | Y | L | Y | A | S | V | Y | T |
| OR10W1 | 81 | 100% | Y | M | F | I | G | S | C | F | G | L | S | L | F | D | V | P | V | A | A | A | I | Y | C | Y | S | S | L | Y | T |
| OR8U9 | 81 | 80% | Y | L | F | L | M | T | C | L | S | V | A | H | Y | D | D | M | I | C | A | M | F | Y | L | Y | S | S | V | Y | T |
| OR14A16 | 81 | 100% | L | V | L | L | A | S | L | L | G | I | A | H | F | D | I | P | L | I | N | L | D | L | G | Y | A | S | V | Y | T |
| OR8B8 | 80 | 100% | Y | L | F | L | V | V | S | F | G | G | A | H | M | D | I | L | V | V | V | D | I | F | G | Y | F | S | L | Y | T |
| OR5I1 | 80 | 46% | Y | F | F | C | A | D | S | F | G | S | S | H | F | D | L | P | L | Y | G | V | E | Q | L | Y | S | S | V | Y | T |
| OR14L1 | 80 | Y | A | F | M | A | T | V | A | G | C | G | H | F | N | I | P | V | F | G | L | V | M | G | Y | I | S | A | Y | T | |
| OR8G1 | 80 | 88% | H | L | F | L | A | I | C | H | G | C | A | H | F | D | L | L | I | V | G | N | I | F | A | Y | S | S | V | Y | T |
| OR5B12 | 80 | 100% | Y | F | F | V | I | T | S | F | G | N | A | H | F | D | A | P | I | V | V | N | D | Y | G | Y | N | S | V | Y | A |
| OR2D3 | 80 | 100% | F | I | F | L | G | C | C | A | G | V | S | D | F | E | P | P | I | M | G | I | L | Y | G | Y | N | S | V | Y | T |
| OR8D1 | 80 | 96% | Y | L | F | V | V | V | G | Y | G | S | A | H | F | D | V | L | L | I | A | N | T | F | I | Y | P | S | V | Y | T |