☰

Olfactory Receptor family 2 subfamily AG member 2.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MELRNSTLGS GFILVGILND SGSPELLYAT FTILYMLALT SNGLLLLAIT IEARLHMPMY LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ 

       110        120        130        140        150        160        170        180        190        200 
MFLALTMGSA EDLLLAFMAY DRYVAICHPL KYMTLMSPRV CWIMVATSWI LASLIAIGHT MYTMHLPFCV SWEIRHLLCE IPPLLKLACA DTSRYELIIY 

       210        220        230        240        250        260        270        280        290        300 
VTGVTFLLLP ISAIVASYTL VLFTVLRMPS NEGRKKALVT CSSHLIVVGM FYGAATFMYV LPSSFHSPKQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA 

       310        320 
LRRVLGKYIL LAHSTL

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


D Q K P       F   R S T D     T Y   S I T N      L F  S G S D  
 I I N   S S P L   L E Y   M T H G   G G F    D A L    L E P   
Y F V S   V Y M   V Y I I   I A I   Q L A C  A K P T  T A Y L  
 V I T   F T A A   V G T   L S A L   L F M    V V S    I T F   
L A P T   G Y F   L L F T   I W S   M T L A  T F L L  L M Y L  
 L P N   M G V V   I P L   T A V M   A S G    D M L    T L A   
    Y I   I L H   V I A S   I W C   L L D E  S L Q G  L G N S  
         S S C T   Y S A   V R P S   F A L    L L L    L L L   
          V L A   L V L T           D Y A M  Y M P M  I T I A  
         K K R G   V T F             V Y R                 E   
                    M R L           H C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
benzyl acetone -6.24 1 (agonist) 1  floral, balsamic, strawberry
cinnamyl alcohol -6.07 1 (agonist) 1  balsamic, cinnamon, cinnamyl, fermented, floral, green, hyacinth, powdery, spicy, sweet
(S)-(-)-citronellol -5.87 1 (agonist) 1  citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
geraniol -5.74 1 (agonist) 1  citrus, floral, fruity, rose, sweet, waxy
benzyl salicylate -5.35 2 (agonist) 2  balsamic, clean, herbal, oily, sweet
nerol -5.29 1 (agonist) 1  citrus, floral, fresh, green, lemon, lime, magnolia, natural, neroli, spicy, sweet, waxy
linalool -5.25 1 (agonist) 1  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
(Z)-3-hexen-1-ol -5.01 1 (agonist) 1  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
phenylpropyl alcohol -4.99 1 (agonist) 1  sweet, spicy, cinnamyl, floral, hyacinth, balsamic, cinnamon, fruity, honey, winey
phenethyl alcohol -4.82 1 (agonist) 1  floral, rose, dried_rose, sweet, fresh, bready, honey
benzyl alcohol - 0 1  floral, rose, phenolic, balsamic
cyclamal - 0 1  cyclamen, floral, fresh, green, musty, rhubarb
alpha-damascone - 0 1  floral, rose, apple, fruity, black_currant, sweet, green, berry
alpha-ionone - 0 1  sweet, woody, floral, violet, orris, tropical, fruity
beta-ionone - 0 1  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
lavandulol - 0 1  floral, waxy, mimosa, herbal
lyral - 0 1  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
melafleur - 0 1  floral, clean, muguet, ozone, marine, sandy, balsamic
nonadecane - 0 1  bland

1.) Duroux R, Mandeau A, Guiraudie-Capraz G, Quesnel Y, Loing E. A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors. Molecules. 2020 Oct 16;25(20):4743. doi: 10.3390/molecules25204743. PMID: 33081083; PMCID: PMC7587601.

2.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1
Prot.Sim.Expr.2.53 3.29 3.32 3.33 3.36 3.37 3.40 3.41 4.53 4.56 4.57 4.60 45.49 45.51 45.52 45.53 5.39 5.42 5.43 5.46 5.47 6.48 6.51 6.55 6.59 7.38 7.39 7.41 7.42
OR2AG2100 100%F M A L G S D L A I A H L E I P I T G F L Y A Y S S V Y T
OR2AG188 100%F M A L G G D L A S A Y L E I P V M G F L Y A Y S S V Y T
OR5P287 100%Y L A A A T C V G I A Y F D F A L S S I I Y I Y N S V Y T
OR8U983 80%Y L F L M T C L S V A H Y D D M I C A M F Y L Y S S V Y T
OR10K283 96%Y M F L G C S F G V A I F D I A I L C V L Y A Y Q S V Y T
OR14C3683 84%Y V V V V Y L L G Y A H F D I P I S A V G L C Y P S G Y S
OR8B482 61%Y L F C V N C Y G G A H L D V L F V V I T F G Y T S V Y T
OR10K182 100%Y M F L G S S F G V S T F D I S I L G A L Y A Y K S V Y T
OR1F182 30%F M V F V D N F A N V H F D V T I E G V M Y I Y L T V Y T
OR8B281 88%Y L F L V I C Y G G A H L D I L V V V N I F A Y Y S V Y T
OR8B381 88%Y L F L V I C Y G G A H L D I L V V V N I F A Y Y S V Y T
OR2D381 100%F I F L G C C A G V S D F E P P I M G I L Y G Y N S V Y T
OR5B2181 100%Y F F V A T C Y G N A H F D I P V V A N V Y I Y N S V Y T
OR8U181 80%Y L F L M I S L S M A H Y D D M I C A M F Y L Y S S V Y T
OR5T281 61%Y V A C G T C F G H A H F D I P L F V I E Y I Y S S I Y T
OR10A781 15%F M F F G S C F G V S Q F D G P A S T F I Y A Y K S L Y T
OR1J180 100%F T F I A D S F A C A H F D L G I A A A I Y I Y P S V Y T
OR14L180Y A F M A T V A G C G H F N I P V F G L V M G Y I S A Y T
OR5B380 88%Y M F V A T N Y G N A H F D I P L V V N I Y I Y S P V Y T
OR1C180 100%F L F V V N S L T H A H F D L N I V G L A Y A Y S T I Y S
OR5T380 50%Y M F V G T C F G H A H F D M P L F V I E H I Y S S I Y T
OR8B880 100%Y L F L V V S F G G A H M D I L V V V D I F G Y F S L Y T
OR10W180 100%Y M F I G S C F G L S L F D V P V A A A I Y C Y S S L Y T
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