Olfactory Receptor family 1 subfamily G member 1.
Sequence:
10 20 30 40 50 60 70 80 90 100 MEGKNLTSIS ECFLLGFSEQ LEEQKPLFGS FLFMYLVTVA GNLLIILVII TDTQLHTPMY FFLANLSLAD ACFVSTTVPK MLANIQIQSQ AISYSGCLLQ 110 120 130 140 150 160 170 180 190 200 LYFFMLFVML EAFLLAVMAY DCYVAICHPL HYILIMSPGL CIFLVSASWI MNALHSLLHT LLMNSLSFCA NHEIPHFFCD INPLLSLSCT DPFTNELVIF 210 220 230 240 250 260 270 280 290 300 ITGGLTGLIC VLCLIISYTN VFSTILKIPS AQGKRKAFST CSSHLSVVSL FFGTSFCVDF SSPSTHSAQK DTVASVMYTV VTPMLNPFIY SLRNQEIKSS 310 320 LRKLIWVRKI HSP
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 E E L Q N A L G S Y S M L T F P D S K Q A S P K Q M K P V L L C L T H L L E N F D V C V T D S G F L T T S F Y L Q L S H I F I V F S T M V S A F L F V F C A L M F L A N M G G T G F F L V T Y V L Y M D A L L M V F I W S L G T L S V V M P T V A V T S L N A F A E A S V L V C I S L H S P N L L L N G L F F V A L L F I C I L C L S C T S Y I F L I I Y M P T Y A M L G P S Y S I S F A K L T I I V V Y C D F V N T R K G C I A I T S Q A S P H K L UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| vanillin | -6.3 1 | 10 1 | chocolate, creamy, sweet, vanilla | |
| 2-undecanone | - | 10 2 | creamy, fatty, floral, fruity, orris, waxy | |
| (S)-methylthiobutanoate | - | 10 3 | cabbage, cheesy, eggy, fruit, garlic, metallic, musty, sulfurous, tomato | |
| 1-nonanol | - | 9.8985 3 | aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet | |
| ethyl isobutyrate | - | 9.5431 3 | alcoholic, ethereal, fruity, fusel, rummy, sweet | |
| gamma-decalactone | - | 9.4924 3 | buttery, coconut, fresh, oily, peach, sweet, waxy | |
| 2-ethyl-1-hexanol | - | 9.1371 3 | citrus, fatty, floral, fresh, fruity, oily, sweet | |
| benzothiazole | - | 7.6142 3 | coffee, cooked, meaty, nutty, rubbery, sulfurous, vegetable | |
| thiazole | - | 7.6142 3 | fishy, meaty, nutty | |
| safrole | - | 7.3604 3 | anise, floral, sassafrass, spicy, sweet, warm, woody | |
| 9-decen-1-ol | - | 7.3529 4 | aldehydic, clean, dewy, floral, fresh, rose, waxy | |
| hedione | - | 7.3096 3 | floral, green, jasmine, lactonic, natural, oily, tropical | |
| acetophenone | - | 7.1066 3 | sweet, pungent, hawthorn, mimosa, almond, acacia, chemical | |
| thymol | - | 7.1066 3 | camphoraceous, herbal, medicinal, phenolic, thyme | |
| manzanate | -4.5 5 | 7 5 | apple, fresh, fruity, green, melon, natural, pineapple, waxy | |
| 3-nonanone | - | 6.802 3 | floral, fresh, fruity, herbal, jasmine, leafy, spicy, sweet | |
| camphor | - | 6.7647 4 | camphoraceous | |
| geraniol | - | 6.599 3 | citrus, floral, fruity, rose, sweet, waxy | |
| quinoline | - | 6.4467 3 | earthy, medicinal, musty, rubbery, tobacco | |
| eugenyl acetate | -4 5 | - | carnation, clove, floral, fresh, malty, spicy, sweet, woody | |
| jasmonyl | -4 5 | - | floral, green, herbal, jasmine, mushroom, oily | |
| piperonyl acetone | - | 6.3959 3 | berry, candy, cotton, floral, fruity, heliotrope, jammy, powdery, raspberry, sweet | |
| maltyl isobutyrate | -5.7 5 | 3.5 5 | berry, caramellic, cotton_candy, fruity, strawberry, sweet, tropical | |
| 2-nonanone | - | 6.2944 3 | earthy, fresh, fruity, green, herbal, sweet, weedy | |
| trans-anethole | - | 6.0914 3 | anise, licorice, medicinal, sweet | |
| aldehyde C-9 | -2.49 6 | 7.9412 4 | aldehydic, fatty, fresh, orange, orris, peel, peely, rose, waxy | |
| capric acid | - | 5.8376 3 | citrus, fatty, rancid, sour | |
| benzaldehyde | - | 5.5838 3 | sharp, sweet, bitter, almond, cherry | |
| (+)-menthol | - | 5.5838 3 | cooling, mentholic, minty | |
| guaiacol | - | 5.3299 3 | phenolic, smoky, spicy, vanilla, woody | |
| aldehyde C-8 | - | 5.2284 3 | aldehydic, citrus, fatty, green, orange, peel, waxy | |
| lyral | - | 5.0761 3 | aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody | |
| citral | - | 5.0254 3 | citrus, lemon, sharp, sweet | |
| isoamyl acetate | - | 5 7 | banana, fruity, solvent, sweet | |
| 1-heptanol | - | 4.8223 3 | apple, banana, fruity, green, herbal, leafy, musty, peony, pungent, sweet, vegetable, violet, woody | |
| 2-methyl pyrazine | - | 4.8223 3 | chocolate, cocoa, earthy, green, musty, nutty, peanut, roasted | |
| ethyl butyrate | - | 4.7716 3 | cognac, fruit, fruity, juicy, pineapple | |
| 1-dodecanol | - | 4.5685 3 | aldehydic, coconut, earthy, fatty, honey, soapy, waxy | |
| d-limonene | - | 4.5685 3 | citrus, fresh, orange, sweet | |
| maltol | - | 4.5685 3 | baked, bread, caramellic, cotton_candy, fruity, jammy, sweet | |
| pyridine | - | 4.5685 3 | ammoniacal, fishy, sour | |
| floralozone | -3.7 5 | 3 5 | clean, fresh, green, marine, ozone | |
| 2-octanol | - | 4.4162 3 | earthy, fresh, green, herbal, spicy, woody | |
| 4-octanol | - | 4.4162 3 | ||
| 2-nonanol | - | 4.3147 3 | cheesy, citrus, creamy, fruity, green, orange, waxy | |
| ethyl decanoate | - | 4.0609 3 | apple, brandy, fruity, grape, oily, sweet, waxy | |
| pyrazine | - | 4.0609 3 | pungent, sweet, corn, roasted, hazelnut, barley | |
| 1-decanol | - | 3.8071 3 | aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy | |
| 1-octanol | - | 3.8071 3 | aldehydic, green, mushroom, orange, rose, waxy | |
| methyl decanoate | - | 3.7563 3 | fermented, floral, fruity, oily, winey | |
| benzyl alcohol | - | 3.5533 3 | floral, rose, phenolic, balsamic | |
| 1-hexanol | - | 3.5533 3 | Y | alcoholic, ethereal, fruity, fusel, green, herbal, oily, pungent, sweet |
| 3-hydroxybutan-2-one | - | 3.5533 3 | buttery, creamy, dairy, fatty, milky, sweet | |
| methyl caprylate | - | 3.5533 3 | aldehydic, green, herbal, orange, sweet, vegetable, waxy | |
| 3-octanol | - | 3.5533 3 | earthy, mushroom, herbal, melon, citrus, woody, spicy, minty, dairy, musty, creamy, waxy, fermented, green | |
| cinnamaldehyde | -4 5 | 0.2538 3 | sweet, spicy, candy, cinnamon, warm | |
| ethyl vanillin | - | 3.2995 3 | caramellic, creamy, sweet, vanilla | |
| undecanal | - | 3.2995 3 | aldehydic, citrus, cloth, fatty, floral, green, laundered, soapy, waxy | |
| coumarin | - | 3.2487 3 | coumarinic, hay, sweet, tonka | |
| ethyl caprylate | - | 3.198 3 | apricot, banana, brandy, fruity, pear, sweet, waxy, winey | |
| aldehyde C-10 | - | 3.1472 3 | aldehydic, citrus, floral, orange, peel, sweet, waxy | |
| (R)-(+)-citronellal | - | 3.1472 3 | citrus, fresh, herbal | |
| (S)-(-)-citronellal | - | 3.1472 3 | citrus, clean, herbal | |
| heptanal | - | 3.0457 3 | aldehydic, cognac, fatty, fresh, green, herbal, ozone | |
| hexanal | - | 3.0457 3 | Y | aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty |
| ethyl pelargonate | - | 2.7919 3 | fruity, natural, rose, rummy, tropical, waxy, winey | |
| methyl pelargonate | - | 2.7919 3 | fruity, pear, sweet, tropical, waxy, winey | |
| pelargonic acid | - | 2.7919 3 | cheesy, dairy, dirty, waxy | |
| tridecanal | - | 2.6582 2 | aldehydic, citrus, clean, fresh, grapefruit, peel, petal, soapy, waxy | |
| galbanum pyrazine | - | 2.4365 3 | green, pea, pepper | |
| 6-methyl-5-hepten-2-one | - | 2.132 3 | apple, citrus, green, lemongrass, musty | |
| indole | - | 1.7766 3 | animal, fecal, floral, naphthyl | |
| 2-decanone | - | 1.6244 3 | cheesy, fatty, fermented, floral, orange, peach | |
| 3-octanone | - | 1.6244 3 | fresh, herbal, lavender, mushroom, sweet | |
| beta-ionone | - | 1.5228 3 | beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent | |
| estragole | - | 1.4721 3 | anise, anisic, fennel, green, herbal, sassafrass, spicy, sweet | |
| menthone | - | 1.3706 3 | minty | |
| lauric acid | - | 1.269 3 | bay, coconut, fatty | |
| oenanthic acid | - | 1.269 3 | rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity | |
| anisole | - | 1.2183 3 | phenolic, gasoline, ethereal, anise | |
| eucalyptol | - | 1.1675 3 | camphoraceous, eucalyptus, herbal | |
| 2-heptanone | - | 1.0152 3 | banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody | |
| lauric aldehyde | - | 1.0152 3 | aldehydic, citrus, floral, green, soapy, waxy | |
| citralva | - | 0.9645 3 | aldehydic, citrus, lemon, metallic | |
| geranyl acetate | - | 0.7107 3 | floral, green, lavender, rose, waxy | |
| butyric acid | - | 0.6091 3 | acetic, buttery, cheesy, fruity, sharp | |
| cyclohexanone | - | 0.6091 3 | Y | acetone, minty |
| butyl butyrate | - | 0.5076 3 | banana, fruity, pineapple, sweet | |
| methyl oenanthate | - | 0.5076 3 | berry, floral, fruity, green, orris, sweet, waxy | |
| propionic acid | - | 0.5076 3 | acidic, cheesy, pungent, vinegar | |
| ethyl oenanthate | - | 0.4569 3 | cognac, fruity, pineapple, rummy, winey | |
| dimethyl disulfide | - | 0.4061 3 | cabbage, onion, sulfurous, vegetable | |
| methyl caproate | - | 0.4061 3 | apricot, bacon, banana, ethereal, fruit, fruity, pineapple, strawberry, tropical | |
| helional | - | 0.3046 3 | cyclamen, fresh, green, hay, ozone, watery | |
| methyl salicylate | - | 0.3046 3 | minty, wintergreen | |
| 2-octanone | - | 0.3046 3 | earthy, herbal, natural, weedy, woody | |
| ethyl caproate | - | 0.2538 3 | banana, fruity, green, pineapple, sweet, waxy | |
| isobutyric acid | - | 0.2538 3 | acidic, buttery, cheesy, dairy, rancid, sour | |
| para-anisaldehyde | - | 0.1523 3 | anisic, balsamic, floral, hawthorn, mimosa, powdery, sweet | |
| trans-cinnamic acid | - | 0.1269 3 | balsamic, cinnamyl, storax, sweet | |
| caproic acid | - | 0.0508 3 | cheesy, fatty, sour, sweaty | |
| caprylic acid | - | 0.0508 3 | cheesy, fatty, oily, rancid, vegetable, waxy | |
| isovaleric acid | - | 0.0508 3 | cheesy, sour, sweaty, tropical | |
| cis-4-hexen-1-ol | - | 0 2 | brothy, gassy, green, tomato, turnip, vegetable |
1.) Sanz G, Thomas-Danguin T, Hamdani el H, Le Poupon C, Briand L, Pernollet JC, Guichard E, Tromelin A. Relationships between molecular structure and perceived odor quality of ligands for a human olfactory receptor. Chem Senses. 2008 Sep;33(7):639-53. doi: 10.1093/chemse/bjn032. Epub 2008 Jul 5. PMID: 18603653.
2.) J. Topin, C.A. de March, L. Charlier, C. Ronin, S. Antonczak, J. Golebiowski, Discrimination between Olfactory Receptor Agonists and Non-agonists, Chem. Eur. J. 20 (2014) 10227-10230.
3.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002
4.) L. Charlier, J. Topin, C. Ronin, S.K. Kim, W.A. Goddard, 3rd, R. Efremov, J. Golebiowski, How broadly tuned olfactory receptors equally recognize their agonists. Human OR1G1 as a test case, Cell. Mol. Life Sci. 69 (2012) 4205-4213.
5.) D. Gonzalez-Kristeller, J.B.P. do Nascimento, P.A.F. Galante, B. Malnic, Identification of agonists for a group of human odorant receptors, Front. Pharmacol. 6 (2015)
6.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
7.) V. Matarazzo, O. Clot-Faybesse, B. Marcet, G. Guiraudie-Capraz, B. Atanasova, G. Devauchelle, M. Cerutti, P. Etiévant, C. Ronin, Functional Characterization of Two Human Olfactory Receptors Expressed in the Baculovirus Sf9 Insect Cell System, Chem. Sens. 30 (2005) 195-207.