Olfactory Receptor family 2 subfamily W member 1.

Estimated Expression: 53% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MDQSNYSSLH GFILLGFSNH PKMEMILSGV VAIFYLITLV GNTAIILASL LDSQLHTPMY FFLRNLSFLD LCFTTSIIPQ MLVNLWGPDK TISYVGCIIQ 

       110        120        130        140        150        160        170        180        190        200 
LYVYMWLGSV ECLLLAVMSY DRFTAICKPL HYFVVMNPHL CLKMIIMIWS ISLANSVVLC TLTLNLPTCG NNILDHFLCE LPALVKIACV DTTTVEMSVF 

       210        220        230        240        250        260        270        280        290        300 
ALGIIIVLTP LILILISYGY IAKAVLRTKS KASQRKAMNT CGSHLTVVSM FYGTIIYMYL QPGNRASKDQ GKFLTLFYTV ITPSLNPLIY TLRNKDMKDA 

       310        320 
LKKLMRFHHK STKIKRNCKS 

    

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

Q D K S       N   T T T D     T L   I T K D      W L  M K P H  
 F K G   G P Q L   M E V   T C L V   V Y S    N V L    I M E   
F L T L   Y M Y   A F V S   V S N   I I C G  M Q P I  V G S L  
 V T Y   I I T G   I G L   A L S I   Y L Q    I S T    I A V   
S P T I   Y F M   L V I I   S W I   W M Y V  T F C L  I L Y F  
 P N L   S V V T   L P T   M I I M   S G L    D L F    V L T   
    I L   L H S   L I L I   K L C   L C E V  S L N R  A T N G  
         G C T N   Y S I   L H P N   A L L    L F F    L I I   
          M A K   A I Y G           Y S M V  Y M P T  L L S A  
         R Q S A   V A K             F R D                 D   
                    T R L           C I A T                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Docks Aroma Notes
allyl phenylacetate -8.3 1 9.8 2   honey, fruity, rummy
geraniol -8.46 3 9.5 2   citrus, floral, fruity, rose, sweet, waxy
2-heptanone -7.52 1 9 2   banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
hexanal -6.52 1 10 2   aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
cinnamaldehyde - 10 4   sweet, spicy, candy, cinnamon, warm
1-octanol -6.52 1 9.5 2   aldehydic, green, mushroom, orange, rose, waxy
benzophenone -5.9 5 10 5   balsamic, rose, metallic, powdery, geranium, herbal, plastic, phenolic
benzyl acetate -5.47 6 10 6   sweet, floral, fruity, jasmine, fresh
(Z)-3-hexen-1-ol -5.7 1 9 7   fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
coumarin -5.3 1 9.5 2   coumarinic, hay, sweet, tonka
(S)-(-)-citronellol -5.11 2 9.5 2   citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
2-pentylpyridine -5.52 8 -   fatty, tallow, green, bell_pepper, mushroom, herbal
phenethyl mercaptan -5.45 8 -   rubbery, sulfurous
furfuryl sulfide -5.406 9 -   
methyl cinnamate -5.38 8 -   balsamic, cherry, strawberry, sweet
(R)-(-)-carvone -4.66 2 9.7 2   herbal, minty, spearmint, sweet
1-nonanol -5.05 8 9 2   aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
(S)-(+)-carvone -4.65 2 9.5 2   bready, caraway, minty, spicy
(+)-dihydrocarvone -4.76 2 9.3 2   herbal, minty, mentholic
nonanal -5.21 8 8.5 2   waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
hexyl acetate -4.86 2 9 2   apple, banana, fruity, green, sweet
hexanol -4.85 2 9 2   ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
1-heptanol -4.83 2 9 2   musty, leafy, violet, herbal, green, sweet, woody, peony, pungent, vegetable, fruity, apple, banana
octanal -5.45 8 8 2   aldehydic, citrus, fatty, green, orange, peel, waxy
3,4-hexanedione -4.78 2 9 2   almond, buttery, caramellic, nutty, toasted
cinnamyl acetate -5.2 8 -   sweet, floral, spicy, balsamic, cinnamon
anisyl acetate -5.72 10 7.3529 10   sweet, powdery, balsamic, vanilla, fruity, plum, cherry, tonka, creamy, spicy, coumarinic, licorice
benzyl methyl disulfide -5.141 9 -   
3-mercaptohexyl acetate -5.14 8 -   floral, fruity, pear, tropical, passionfruit, blackberry, raspberry, blackcurrant_bud
(Z)-2-octenal -5.058 9 -   fatty, nutty
2-hexanone -4.13 2 9.5 2   ethereal
ethyl cinnamate -5.013 9 -   sweet, balsamic, fruity, spicy, powdery, berry, plum, cinnamyl, green
3-octanone -5.02 2 8 2   fresh, herbal, lavender, mushroom, sweet
2-nonanone -4.7 2 8.5 2   fresh, sweet, green, weedy, earthy, herbal, fruity, waxy, soapy, cheesy, coconut, dairy, dirty, buttery
l-limonene -5 8 -   terpenic, pine, herbal, peppery
3-octen-2-one - 8 11   earthy, spicy, herbal, sweet, mushroom, hay, blueberry
4-chromanone -4.04 2 9.5 2   
caprylic acid -4.85 2 8.2 2   cheesy, fatty, oily, rancid, vegetable, waxy
capric acid -3.76 2 9.8 2   citrus, fatty, rancid, sour
methyl furfuryl disulfide -4.941 9 -   sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
dihydrojasmone -4.25 2 9 2   floral, fresh, herbal, jasmine, myrrh, outdoors, spicy, woody
1-octen-3-one -4.902 9 -   earthy, metallic, mushroom
1-decanol -4.37 2 8.5 2   aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
pelargonic acid -3.72 2 9.5 2   cheesy, dairy, dirty, waxy
octanethiol -4.03 2 9 13   sulfurous
4-methyl acetophenone -4.82 8 -   hawthorn, sweet, mimosa, coumarinic, cherry, acacia
methyl propyl trisulfide -4.800 9 -   sulfurous, onion, garlic, green, metallic
estragole -4.79 8 -   sweet, sassafrass, anise, spicy, green, herbal, fennel, phenolic, minty
diallyl disulfide -4.766 9 -   alliaceous, garlic, metallic, onion
nonanethiol -4.06 2 8.7 2   
(E,Z)-2,6-nonadienal -4.718 9 -   cucumber
butyl formate -4.43 2 8 2   fruity, plum, rummy, brandy
caproic acid -4.22 14 8.3333 15   cheesy, fatty, sour, sweaty
(E)-anethole -4.7 8 -   sweet, anise, licorice, mimosa, medicinal, spicy
2-octanone -4.4 2 8 2   earthy, herbal, natural, weedy, woody
prenyl acetate -4.07 2 8.5 2   sweet, fresh, banana, fruity, jasmine, ripe, heliotrope, balsamic
p,alpha-dimethylstyrene -4.69 8 -   clove, guaiacol, phenolic, spicy, styrene, terpenic
hexanethiol -5 13 7 13   burnt, fatty, sulfurous, meaty, garlic, roasted, alliaceous, nutty, rubbery, vegetable
beta-naphthyl ethyl ether -5.7 5 5.8333 5   naphthyl, floral, orangeflower, powdery, grape
1-octen-3-ol -4.65 8 -   mushroom
(E)-2-heptenal -4.57 8 -   pungent, green, vegetable, fresh, fatty
cuminaldehyde -4.509 9 -   spicy, cumin, green, herbal
(E)-2-nonenal -4.482 9 -   fatty, green, cucumber, aldehydic, citrus, soapy, melon
3-heptanone -4.48 2 -   fatty, fruity, green
heptanal -4.06 2 7.8 2   aldehydic, cognac, fatty, fresh, green, herbal, ozone
ethyl cyclohexanecarboxylate -4.44 8 -   cheesy, fruity, winey
coffee difuran -5.365 9 5.5 12   cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
benzyl methyl sulfide -4.385 9 -   
acetophenone -4.37 2 -   sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
2-heptanol -4.36 8 -   floral, fresh, fruity, green, herbal, lemongrass, sweet, coconut, dill
(E,E)-2,4-nonadienal -4.355 9 -   chicken, cucumber, fat, fatty, fruit, green, leaf, melon, tropical, violet, waxy
gamma-octalactone -4.32 8 -   sweet, coconut, waxy, creamy, tonka, dairy, fatty
isoamyl acetate -4.21 8 -   banana, fruity, solvent, sweet
1-phenylethanethiol -4.197 9 -   
ethyl benzoate -4.191 9 -   starfruit
benzyl ethyl ketone -5.2 10 4.9412 10   earthy, green
(Z)-4-decenal -4.124 9 -   green, musty
ethyl phenylacetate -4.122 9 -   beeswax
(E),(E)-2,4-decadienal -4.111 9 -   oily, cucumber, melon, citrus, pumpkin, nutty, fatty, chicken, fried, chicken_fat, coriander, brothy
gamma-decalactone -4.103 9 -   fresh, oily, waxy, peach, coconut, buttery, sweet
ethyl decanoate -4.096 9 -   apple, brandy, fruity, grape, oily, sweet, waxy
grapefruit mercaptan -4.091 9 -   sulfurous, aromatic, grapefruit, naphthyl, resinous, woody, alliaceous, onion, garlic, tropical
benzyl mercaptan -4.089 9 -   
2-thiophenemethanethiol -4.010 9 -   coffee, sulfurous
(Z)-3-hexen-1-yl acetate -3.977 9 -   
(E,Z)-2,6-nonadienol -3.972 9 -   metallic, cucumber
dipropyl trisulfide -3.942 9 -   sulfurous, alliaceous, onion, green, garlic, tropical
2,3-hexanedione -3.36 2 7 2   buttery, sweet
gamma-nonalactone -3.856 9 -   buttery, coconut, creamy, oily, sweet, waxy
furfuryl methyl sulfide -3.845 9 -   
d-limonene -4.95 8 4.3333 12   citrus, orange, fresh, sweet
2-furfurylthiol -3.743 9 -   coffee, sulfurous, burnt
1-cyclohexylethanol -5.23 10 3.5294 10   clean, fresh
alpha-phellandrene -3.708 9 -   citrus, herbal, terpenic, green, woody, black_pepper
raspberry ketone -4.8 10 4.1765 10   berry, floral, jammy, raspberry, ripe, seedy, sweet, woody
para-anisaldehyde -3.628 9 -   sweet, powdery, mimosa, floral, hawthorn, balsamic, vanilla, anise, woody, coumarinic, creamy, spicy
phenethyl alcohol -4.01 10 5.1765 10   floral, rose, dried_rose, sweet, fresh, bready, honey
methyl benzoate -3.584 9 -   starfruit, sweet
2-acetylpyrazine -3.582 9 -   popcorn, roasty
phenethyl acetate -5.82 16 1.9444 16   floral, fruity, honey, rose, sweet, tropical
ethyl caproate -3.511 9 -   banana, fruity, green, pineapple, sweet, waxy
cinnamyl alcohol -3.500 9 -   balsamic, cinnamon, cinnamyl, fermented, floral, green, hyacinth, powdery, spicy, sweet
phenylpropyl alcohol -3.469 9 -   sweet, spicy, cinnamyl, floral, hyacinth, balsamic, cinnamon, fruity, honey, winey
styralyl alcohol -3.8 10 5 10   almond, fresh, gardenia, hyacinth, sweet
alpha-terpineol -3.450 9 -   pine, terpenic, lilac, citrus, woody, floral, resinous, cooling, lemon, lime
eucalyptol -3.443 9 -   camphorous, eucalyptus, herbal
(+)-sabinene -3.427 9 -   
piperonal -3.394 9 -   maraschino_cherry, bitter_almond, cherry, tropical, custard, vanilla, spicy, sweet, creamy, cinnamyl
(Z)-4-heptenal -3.364 9 -   fishy
3-mercapto-3-methylbutyl formate -3.358 9 -   catty, blackcurrant
delta-octalactone -3.325 9 -   coconut
3-methyl-2,4-nonanedione -3.317 9 -   burnt, caramellic, fruity, hay
2-cyclohexyl ethanol -5.08 10 2.4706 10   cooling, dewy, floral, green, lily, peony, rose, waxy
cis-whisky lactone -3.293 9 -   coconut
myrcene -3.290 9 -   peppery, terpenic, spicy, balsamic, plastic, herbal, woody, rose, celery, carrot
3-ethyl phenol -3.289 9 -   phenolic, leathery
5-methyl guaiacol -3.289 9 -   smoky, clove
(S)-3-mercapto-3-methylhexan-1-ol -5.7 17 1.4 17   passionfruit, currant, blackcurrant, green, fruity
ethyl isobutyrate -3.268 9 -   alcoholic, ethereal, fruity, fusel, rummy, sweet
2-methylbutyl acetate -3.243 9 -   sweet, fruity
4-vinylguaiacol -4.4 18 3.3333 18   spicy, clove, carnation, phenolic, peppery, smoky, woody, powdery
(R)-3-mercapto-3-methylhexan-1-ol -5.7 17 1.2 17   passionfruit, currant, blackcurrant, green, fruity
dipropyl disulfide -3.213 9 -   sulfurous, earthy, burnt, onion, green_onion
heptanethiol -4.5 13 3 13   onion, skunk, sulfurous
4-vinyl phenol -3.049 9 -   chemical, phenolic, medicinal, sweet, musty, meaty
3-methyl-3-mercapto butyl methyl ether -2.971 9 -   catty, blackcurrant
strawberry glycidate 2 -5.2 19 -   sweet, strawberry, berry, floral, tropical, honey, rose
helional - 4.6 12   cyclamen, fresh, green, hay, ozone, watery
citral -4.89 6 1.3065 6   sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
p-cresol -4.52 18 1.8667 18   phenolic, narcissus, animal, mimosa
oranger crystals -4.4 20 2 20   sweet, neroli, orangeflower, powdery, honey, floral, orange, naphthyl, citrus
ethyl 3-methylthiopropionate -2.817 9 -   sulfurous, fruity
(S)-(-)-citronellal -4.68 6 1.2419 6   citrus, clean, herbal
ethyl butyrate -2.530 9 -   cognac, fruit, fruity, juicy, pineapple
skatole -4.82 21 0.2846 21   animal, civet, fecal, naphthyl
indole -4.7 21 0.3252 21   animal, fecal, floral, naphthyl
3-methyl-2-hexenoic acid -4.22 17 0.8 17   cheesy, fruity
3,4-dimethoxyphenylacetone -4.23 10 0.5882 10   floral, sweet, woody
pentanethiol - 3.5 13   sulfurous, fatty, roasted, meaty, vegetable
methanethiol -3 13 1.5 13   alliaceous, cabbage, cheesy, creamy, eggy, garlic, meaty, oily, vegetable
eugenyl acetate - 2.5 12   carnation, clove, floral, fresh, malty, spicy, sweet, woody
butanethiol - 2.5 13   sulfurous, garlic, onion, eggnog, coffee, fatty, beefy, roasted, cooked
p-cresyl acetate - 2.2 22   narcissus, phenolic, animal
ethanethiol - 1.5 13   cabbage, onion, sulfurous
isopropanethiol - 1.5 13   brothy, chicken, gassy, meaty, onion, ripe, sulfurous
propanethiol - 1.5 13   cabbage, gassy, sweet, onion
tert-butyl mercaptan - 1.3 13   skunk, sulfurous
thietane - 1 13   sulfurous
methyl salicylate - 0.3333 12   minty, wintergreen
allyl heptanoate - 0 2   sweet, pineapple, fruity, waxy, banana, fusel, cognac, ripe, fermented
allylbenzene - 0 2   
amyl hexanoate - 0 12   sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
l-arabinose - 0 12   
benzene - 0 12   gasoline, phenolic, solvent, cinnamon
1,4-bis(4-vinylphenoxy)butane - 0 5   
butyl butyryl lactate - 0 2   creamy, buttery, buttermilk, dairy, cheesy, fatty, waxy, sweaty, green
(-)-camphor - 0 2   
camphor - 0 2   camphorous
gamma-caprolactone - 0 2   herbal, coconut, sweet, coumarinic, tobacco, creamy, lactonic, green
2-coumaranone - 0 2   
cyclohexanone - 0 2   acetone, minty
beta-damascone - 0 12   berry, currant, floral, fruity, honey, plum, rose, tobacco
decanal - 0 12   sweet, aldehydic, waxy, orange_peel, citrus, floral
dimethyl disulfide - 0 12   sulfurous, vegetable, cabbage, onion, malty, creamy
2,4-DNT - 0 12   
ethyl vanillin - 0 12   sweet, creamy, vanilla, caramellic
ethylphenyl acetate - 0 8   anisic, balsamic, black, chocolate, cocoa, dark, floral, honey, licorice, rose, sweet
eugenol - 0 12   clove, spicy, sweet, woody
fenchone - 0 2   camphorous, earthy, herbal, woody
geranyl acetate - 0 12   floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
4-hydroxycoumarin - 0 2   
linalool - 0 12   blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
lyral - 0 12   aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
(1S,2R,5S)-(+)-menthol - 0 12   cooling, mentholic, minty
methyl eugenol - 0 12   carnation, cinnamon, clove, fresh, spicy, sweet, warm
oenanthic acid - 0 2   rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
2-pentanone - 0 2   sweet, fruity, ethereal, winey, banana, woody, fermented
phenyl acetate - 0 2   phenolic, medicinal, animal, resinous, castoreum, woody, smoky, burnt
(+)-2-phenylbutyric acid - 0 2   
propionic acid - 0 12   acidic, cheesy, pungent, vinegar
quinoline - 0 12   earthy, medicinal, musty, rubbery, tobacco
sotolone - 0 12   sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
terpinyl acetate - 0 12   bergamot, citrus, herbal, lavender, lime
valeric acid - 0 2   acidic, cheesy, fruity, milky, sharp, sour, tobacco
vanillic acid - 0 2   beany, brown, creamy, dairy, milky, phenolic, powdery, sweet, vanilla
allyl cyclohexylpropionate - -0.1626 21   sweet, pineapple, tropical, fruity, candy, waxy, apple, green
citronellal - -0.1626 21   sweet, dry, floral, herbal, waxy, aldehydic, citrus
citronellyl acetate - -0.1626 21   floral, green, rose, fruity, citrus, woody, fruit, tropical_fruit
cyclamen homoaldehyde - -0.1626 21   floral, muguet, lily, green, tropical, oily, greasy, marine, balsamic
2-cyclohexylpropanal - -0.1626 21   natural, fresh, green, dusty, fruity
delta-damascone - -0.1626 21   fruity, sweet, rose, natural, petal, currant_bud, black_currant_bud, tobacco
(-)-alpha-fenchol - -0.1626 21   camphorous, clean, cooling, eucalyptus, green, herbal, minty, piney, woody
hydroxycitronellal - -0.1626 21   floral, green, lily, melon, sweet, tropical, waxy
beta-ionone - -0.1626 21   beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
lilial - -0.1626 21   floral, muguet, watery, green, powdery, cumin
7-methoxycitronellal - -0.1626 21   fresh, melon, floral, lily, sweet
muscenone - -0.1626 21   animal, musk, soapy
myraldyl acetate - -0.1626 21   fresh, lily, magnolia, sweet, citrus, freesia, green
tetrahydrogeraniol - -0.1626 21   leathery, musty, plastic, rose, sweet
thymol - -0.1626 21   camphorous, herbal, medicinal, phenolic, thyme
triplal - -0.1626 21   green, aldehydic, leafy, cortex, tart, floral, peely
1-(4-hydroxy-3-methoxyphenyl)butan-2-one - -0.2941 10   ginger, phenolic, spicy, sweet, vanilla, woody
ebanol - -0.4065 21   sandalwood, woody, musk
ethyl linalyl ether - -0.4065 21   floral
exaltolide - -0.4065 21   animal, fruity, musk, natural, powdery
galaxolide - -0.4065 21   floral, musk, sweet
(Z)-3-hexenyl salicylate - -0.4065 21   floral, green, metallic, herbal, balsamic
hexyl salicylate - -0.4065 21   fresh, herbal, orchid, green
(Z)-jasmone - -0.4065 21   woody, herbal, floral, spicy, jasmine, celery
labienoxime - -0.4065 21   currant_bud, blackcurrant_bud, green, grapefruit, herbal, rose, sage
melafleur - -0.4065 21   floral, clean, muguet, ozone, marine, sandy, balsamic
methyl ionone gamma - -0.4065 21   violet, sweet, orris, powdery, floral, woody
methyl jasmonate - -0.4065 21   jasmin, floral, oily, green, petal, greasy, soft
3-(3-propen-2-yl phenyl) butanal - -0.4065 21   ozone, cortex, green, floral, melon
gamma-undecalactone -3.642 9 -0.4065 21   fruity, peach, creamy, fatty, lactonic, apricot, ketonic, coconut
amber butanol - -0.6504 21   woody, amber, ambrette
(-)-ambroxide - -0.6504 21   dry, amber, ambergris, paper, musk, woody, cedar, pine, green, seedy
bourgeonal - -0.6504 21   fresh, watery, floral, cyclamen, sweet
civetone - -0.6504 21   clean, musk, dry, animal, sweet
galbascone - -0.6504 21   fresh, green, galbanum, earthy, weedy, pineapple, narcissus, hyacinth, fruity
globanone - -0.6504 21   animal, balsamic, cloth, dry, floral, laundered, musk, tobacco, waxy
(R,S)-methyl cedryl ketone - -0.6504 21   woody, vetiver, amber, leathery, musk, cedar
myrac aldehyde - -0.6504 21   aldehydic, citrus, floral, greasy, marine
nerolidol - -0.6504 21   floral, green, waxy, citrus, woody, fruity, melon
spicy carbonate - -0.6504 21   spicy, woody, floral, green, herbal
octyl octanoate - -0.6667 12   coconut, oily, fruity
n-amyl alcohol - -0.8333 12   fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
butyric acid - -0.9333 12   sharp, acetic, cheesy, buttery, fruity, dairy, creamy
2-ethyl fenchol - -1 12   camphorous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
isobutylamine - -1 12   cheesy, fishy
pyrazine - -1.3333 12   pungent, sweet, corn, roasted, hazelnut, barley
propanal - -1.6667 12   alcoholic, cocoa, earthy, nutty, whisky, winey
florhydral - -1.8182 14   floral, green, muguet, linden_flower, lily_of_the_valley, fresh
androstenone - -2.3333 12   animal, musky

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4.) Fukutani, Y., Koshizawa, T., & Yohda, M. (2021). Application of Vapor Phase Stimulation Method for Screening of Human Odorant Receptors Responding to Cinnamaldehyde. Sensors and Materials, 33(12), 4203-4210.

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