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Olfactory Receptor family 2 subfamily J member 2.

Estimated Expression: 92% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MMIKKNASSE DFFILLGFSN WPQLEVVLFV VILIFYLMTL TGNLFIIILS YVDSHLHTPM YFFLSNLSFL DLCHTTSSIP QLLVNLRGPE KTISYAGCMV 

       110        120        130        140        150        160        170        180        190        200 
QLYFVLALGI TECVLLVVMS YDRYVAVCRP LHYTVLMHPR FCHLLVAASW VIGFTISALH SSFTFWVPLC GHRLVDHFFC EVPALLRLSC VDTHANELTL 

       210        220        230        240        250        260        270        280        290        300 
MVMSSIFVLI PLILILTTYG AIARAVLSMQ STTGLQKVFR TCGAHLMVVS LFFIPVMCMY LQPPSENSPD QGKFIALFYT VVTPSLNPLI YTLRNKHVKG 

       310        320 
AAKRLLGWEW GK

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

Q D P S       S   A H T D     T F   I T K E      R L  L Q P W  
 F K G   P P Q L   L E N   S S H L   A Y S    N V L    V V E   
F L A I   Y M C   V M L T   A S I   V M C G  L Q P I  V V F L  
 V T Y   M V P I   S S M   T F G I   Y L Q    S S T    I L I   
S P T V   F F L   L V F I   V W S   A L V F  T H C L  M L Y F  
 P N L   S V V M   L P I   A A V L   I G L    D L F    T L T   
    I L   L H A   L I L I   L H C   V C E T  S L N S  F L N G  
         G C T R   Y T T   F R P H   V L L    L F F    I I I   
          F V K   A I A G           Y S M V  Y M P T  V Y S L  
         Q L G T   V A R             Y R D                 D   
                    M S L           C V A V                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB 2 3 4
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
methyl eugenol -7 1 9.3333 1  carnation, cinnamon, clove, fresh, spicy, sweet, warm
1-octanol -7 2 8.3 2  aldehydic, green, mushroom, orange, rose, waxy
(Z)-3-hexen-1-ol -5.7 2 10 2  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
coumarin -5 2 9.7 2  coumarinic, hay, sweet, tonka
cyclohexanone -5 2 0 3  acetone, minty
1-heptanol -3.27 3 10 3  musty, leafy, violet, herbal, green, sweet, woody, peony, pungent, vegetable, fruity, apple, banana
1-nonanol -4.16 3 8.4 3  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
1-decanol -3.42 3 9 3  aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
3-octen-2-one - 7 4  earthy, spicy, herbal, sweet, mushroom, hay, blueberry
butyl anthranilate -5.75 5 3.7443 5  petitgrain, plum, sweet, grape, fruity, winey, floral, berry, powdery, chemical
isoeugenol -5 6 3 6  carnation, clove, floral, spicy, sweet, woody
oranger crystals -4.3 7 3.7647 7  sweet, neroli, orangeflower, powdery, honey, floral, orange, naphthyl, citrus
phenylacetaldehyde -6 5 (agonist) 5  clover, cocoa, floral, green, honey, hyacinth, sweet
cinnamaldehyde - 5 8  sweet, spicy, candy, cinnamon, warm
ethyl vanillin -4 1 3.3333 1  sweet, creamy, vanilla, caramellic
androstenone -5 1 0.2033 1  animal, musky
para-anisaldehyde -3.5 7 2.2353 7  sweet, powdery, mimosa, floral, hawthorn, balsamic, vanilla, anise, woody, coumarinic, creamy, spicy
2,4-DNT - 3.6667 1  
eugenyl acetate - 3.6667 1  carnation, clove, floral, fresh, malty, spicy, sweet, woody
citral - 2.6667 1  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
quinoline - 2.1667 1  earthy, medicinal, musty, rubbery, tobacco
benzyl salicylate - 2 6  balsamic, clean, herbal, oily, sweet
vanillin - 2 6  chocolate, creamy, sweet, vanilla
(1S,2R,5S)-(+)-menthol - 1.1667 1  cooling, mentholic, minty
methyl tuberate - (agonist) 9  waxy, lactonic, metallic, tuberose, plum
helional - 0.6 1  cyclamen, fresh, green, hay, ozone, watery
octanethiol - 0.3333 1  sulfurous
nonanal - 0.1667 3  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
acetophenone - 0 3  sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
allyl heptanoate - 0 3  sweet, pineapple, fruity, waxy, banana, fusel, cognac, ripe, fermented
allyl phenylacetate - 0 1  honey, fruity, rummy
allylbenzene - 0 3  
n-amyl alcohol - 0 1  fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
amyl hexanoate - 0 1  sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
l-arabinose - 0 1  
benzene - 0 1  gasoline, phenolic, solvent, cinnamon
benzophenone - 0 3  balsamic, rose, metallic, powdery, geranium, herbal, plastic, phenolic
benzyl acetate - 0 3  sweet, floral, fruity, jasmine, fresh
butyl butyryl lactate - 0 3  creamy, buttery, buttermilk, dairy, cheesy, fatty, waxy, sweaty, green
butyl formate - 0 1  fruity, plum, rummy, brandy
butyric acid - 0 1  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
(-)-camphor - 0 3  
camphor - 0 3  camphorous
capric acid - 0 3  citrus, fatty, rancid, sour
caproic acid - 0 3  cheesy, fatty, sour, sweaty
gamma-caprolactone - 0 3  herbal, coconut, sweet, coumarinic, tobacco, creamy, lactonic, green
caprylic acid - 0 3  cheesy, fatty, oily, rancid, vegetable, waxy
(R)-(-)-carvone - 0 3  herbal, minty, spearmint, sweet
(S)-(+)-carvone - 0 1  bready, caraway, minty, spicy
4-chromanone - 0 3  
(S)-(-)-citronellol - 0 3  citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
coffee difuran - 0 1  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
2-coumaranone - 0 3  
beta-damascone - 0 1  berry, currant, floral, fruity, honey, plum, rose, tobacco
delta-decalactone - -  coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet
gamma-decalactone - -  fresh, oily, waxy, peach, coconut, buttery, sweet
decanal - 0 1  sweet, aldehydic, waxy, orange_peel, citrus, floral
(+)-dihydrocarvone - 0 3  herbal, minty, mentholic
dihydrojasmone - 0 3  floral, fresh, herbal, jasmine, myrrh, outdoors, spicy, woody
dimethyl disulfide - 0 1  sulfurous, vegetable, cabbage, onion, malty, creamy
delta-dodecalactone - -  fresh, sweet, metallic, peach, oily, coconut, buttery, fatty, creamy, dairy, fruity, apricot, milky
gamma-dodecalactone - -  fatty, fruity, metallic, peach, sweet
2-ethyl fenchol - 0 1  camphorous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl isobutyrate - 0 3  alcoholic, ethereal, fruity, fusel, rummy, sweet
eugenol - 0 1  clove, spicy, sweet, woody
fenchone - 0 3  camphorous, earthy, herbal, woody
geraniol - 0 3  citrus, floral, fruity, rose, sweet, waxy
geranyl acetate - 0 1  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
gamma-heptalactone - 0 9  
heptanal - 0 3  aldehydic, cognac, fatty, fresh, green, herbal, ozone
2-heptanone - 0 1  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
3-heptanone - 0 3  fatty, fruity, green
hexanal - 0 3  aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
2,3-hexanedione - 0 3  buttery, sweet
3,4-hexanedione - 0 3  almond, buttery, caramellic, nutty, toasted
hexanol - 0 3  ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
2-hexanone - 0 3  ethereal
hexyl acetate - 0 3  apple, banana, fruity, green, sweet
4-hydroxycoumarin - 0 3  
isobutylamine - 0 1  cheesy, fishy
d-limonene - 0 1  citrus, orange, fresh, sweet
linalool - 0 1  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
lyral - 0 1  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
methyl furfuryl disulfide - 0 1  sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
methyl salicylate - 0 1  minty, wintergreen
nectaryl - 0 9  fruity, tropical, lactonic, peach, apricot, oily, waxy, custard, coconut
gamma-nonalactone - -  buttery, coconut, creamy, oily, sweet, waxy
nonanethiol - 0 3  
2-nonanone - 0 3  fresh, sweet, green, weedy, earthy, herbal, fruity, waxy, soapy, cheesy, coconut, dairy, dirty, buttery
gamma-octalactone - -  sweet, coconut, waxy, creamy, tonka, dairy, fatty
octanal - 0 3  aldehydic, citrus, fatty, green, orange, peel, waxy
2-octanone - 0 3  earthy, herbal, natural, weedy, woody
3-octanone - 0 3  fresh, herbal, lavender, mushroom, sweet
octyl octanoate - 0 1  coconut, oily, fruity
oenanthic acid - 0 3  rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
pelargonic acid - 0 1  cheesy, dairy, dirty, waxy
2-pentanone - 0 3  sweet, fruity, ethereal, winey, banana, woody, fermented
phenyl acetate - 0 3  phenolic, medicinal, animal, resinous, castoreum, woody, smoky, burnt
(+)-2-phenylbutyric acid - 0 3  
prenyl acetate - 0 3  sweet, fresh, banana, fruity, jasmine, ripe, heliotrope, balsamic
propanal - 0 1  alcoholic, cocoa, earthy, nutty, whisky, winey
propionic acid - 0 1  acidic, cheesy, pungent, vinegar
pyrazine - 0 1  pungent, sweet, corn, roasted, hazelnut, barley
terpinyl acetate - 0 1  bergamot, citrus, herbal, lavender, lime
gamma-undecalactone - -  fruity, peach, creamy, fatty, lactonic, apricot, ketonic, coconut
valeric acid - 0 3  acidic, cheesy, fruity, milky, sharp, sour, tobacco
vanillic acid - 0 3  beany, brown, creamy, dairy, milky, phenolic, powdery, sweet, vanilla

1.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

2.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

3.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

4.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147

5.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

6.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

7.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.

8.) Fukutani, Y., Koshizawa, T., & Yohda, M. (2021). Application of Vapor Phase Stimulation Method for Screening of Human Odorant Receptors Responding to Cinnamaldehyde. Sensors and Materials, 33(12), 4203-4210.

9.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1
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