Olfactory Receptor family 2 subfamily C member 1.
Sequence:
10 20 30 40 50 60 70 80 90 100 MDGVNDSSLQ GFVLMGISDH PQLEMIFFIA ILFSYLLTLL GNSTIILLSR LEARLHTPMY FFLSNLSSLD LAFATSSVPQ MLINLWGPGK TISYGGCITQ 110 120 130 140 150 160 170 180 190 200 LYVFLWLGAT ECILLVVMAF DRYVAVCRPL RYTAIMNPQL CWLLAVIACL GGLGNSVIQS TFTLQLPLCG HRRVEGFLCE VPAMIKLACG DTSLNQAVLN 210 220 230 240 250 260 270 280 290 300 GVCTFFTAVP LSIIVISYCL IAQAVLKIRS AEGRRKAFNT CLSHLLVVFL FYGSASYGYL LPAKNSKQDQ GKFISLFYSL VTPMVNPLIY TLRNMEVKGA 310 320 LRRLLGKGRE VG
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 L Q P H N I L G G Y S T F L S T D P L Q D Q K I M E M Q P V T I C T S Q I A Q N L Y G Y F K G A I F F S S T V Y L Q V S N G N L V S A S F L S I F L I A F A L W L F G L G G T C V G Y F L L S Y L L Y S D L S T A G L L C A A T F F F V V M P T V L L T S L N S I C E I V A L L P V L L H S P N V T S N G L F F V V L L L W C V I I S L C T T Y I L L I I Y M P T F A M L Q P N Y S I N F A K L R S L V Y R D A I L C R R G C V A V A Q E A S R R K L UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| octanethiol | -8.36 1 | 9.5 2 | sulfurous | |
| nonanethiol | -5.3 3 | 9.8 2 | ||
| pentanethiol | -4.7 4 | 10 4 | sulfurous, fatty, roasted, meaty, vegetable | |
| heptanethiol | -4.9 4 | 9.5 4 | onion, skunk, sulfurous | |
| hexanethiol | -4.8 4 | 6.5 4 | alliaceous, burnt, fatty, garlic, meaty, nutty, roasted, rubbery, sulfurous | |
| cinnamaldehyde | -4 1 | 1.4653 1 | sweet, spicy, candy, cinnamon, warm | |
| acetophenone | - | 0 2 | sweet, pungent, hawthorn, mimosa, almond, acacia, chemical | |
| aldehyde C-10 | - | 0 2 | aldehydic, citrus, floral, orange, peel, sweet, waxy | |
| aldehyde C-8 | - | 0 2 | aldehydic, citrus, fatty, green, orange, peel, waxy | |
| aldehyde C-9 | - | 0 2 | aldehydic, fatty, fresh, orange, orris, peel, peely, rose, waxy | |
| allyl heptanoate | - | 0 2 | banana, cognac, fruity, fusel, pineapple, sweet, waxy | |
| allyl phenylacetate | - | 0 2 | fruity, honey, rummy | |
| allylbenzene | - | 0 2 | ||
| amyl hexanoate | - | 0 2 | apple, estery, fatty, fruity, green, pear, pineapple, sweet | |
| benzene | - | 0 2 | ||
| benzophenone | - | 0 2 | balsamic, geranium, herbal, metallic, powdery, rose | |
| benzyl acetate | - | 0 2 | floral, fresh, fruity, jasmine, sweet | |
| butyl butyryl lactate | - | 0 2 | buttermilk, buttery, cheesy, creamy, dairy | |
| butyl formate | - | 0 2 | brandy, fruity, plum, rummy | |
| (-)-camphor | - | 0 2 | ||
| camphor | - | 0 2 | camphoraceous | |
| capric acid | - | 0 2 | citrus, fatty, rancid, sour | |
| caproic acid | - | 0 2 | cheesy, fatty, sour, sweaty | |
| gamma-caprolactone | - | 0 2 | coconut, coumarinic, herbal, sweet, tobacco | |
| caprylic acid | - | 0 2 | cheesy, fatty, oily, rancid, vegetable, waxy | |
| (R)-(-)-carvone | - | 0 2 | herbal, minty, spearmint, sweet | |
| (S)-(+)-carvone | - | 0 2 | bready, caraway, minty, spicy | |
| 4-chromanone | - | 0 2 | ||
| (S)-(-)-citronellol | - | 0 2 | citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy | |
| 2-coumaranone | - | 0 2 | ||
| coumarin | - | 0 2 | coumarinic, hay, sweet, tonka | |
| cyclohexanone | - | 0 2 | acetone, minty | |
| 1-decanol | - | 0 2 | aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy | |
| (+)-dihydrocarvone | - | 0 2 | herbal, mentholic, minty | |
| dihydrojasmone | - | 0 2 | floral, fresh, herbal, jasmine, myrrh, outdoors, spicy, woody | |
| ethyl isobutyrate | - | 0 2 | alcoholic, ethereal, fruity, fusel, rummy, sweet | |
| fenchone | - | 0 2 | camphoraceous, earthy, herbal, woody | |
| geraniol | - | 0 2 | citrus, floral, fruity, rose, sweet, waxy | |
| heptanal | - | 0 2 | aldehydic, cognac, fatty, fresh, green, herbal, ozone | |
| 1-heptanol | - | 0 2 | apple, banana, fruity, green, herbal, leafy, musty, peony, pungent, sweet, vegetable, violet, woody | |
| 2-heptanone | - | 0 2 | banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody | |
| 3-heptanone | - | 0 2 | fatty, fruity, green | |
| hexanal | - | 0 2 | aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty | |
| 2,3-hexanedione | - | 0 2 | buttery, sweet | |
| 3,4-hexanedione | - | 0 2 | almond, buttery, caramellic, nutty, toasted | |
| 1-hexanol | - | 0 2 | alcoholic, ethereal, fruity, fusel, green, herbal, oily, pungent, sweet | |
| 2-hexanone | - | 0 2 | ethereal | |
| hexyl acetate | - | 0 2 | apple, banana, fruity, green, sweet | |
| 4-hydroxycoumarin | - | 0 2 | ||
| lyral | - | 0 2 | aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody | |
| 1-nonanol | - | 0 2 | aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet | |
| 2-nonanone | - | 0 2 | earthy, fresh, fruity, green, herbal, sweet, weedy | |
| 1-octanol | - | 0 2 | aldehydic, green, mushroom, orange, rose, waxy | |
| 2-octanone | - | 0 2 | earthy, herbal, natural, weedy, woody | |
| 3-octanone | - | 0 2 | fresh, herbal, lavender, mushroom, sweet | |
| oenanthic acid | - | 0 2 | rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity | |
| pelargonic acid | - | 0 2 | cheesy, dairy, dirty, waxy | |
| pentanol | - | 0 2 | balsamic, fermented, fusel, oily, sweet | |
| 2-pentanone | - | 0 2 | banana, ethereal, fruity, sweet, winey, woody | |
| phenyl acetate | - | 0 2 | animal, burnt, castoreum, medicinal, phenolic, resinous, smoky, woody | |
| (+)-2-phenylbutyric acid | - | 0 2 | ||
| prenyl acetate | - | 0 2 | balsamic, banana, fresh, fruity, heliotrope, jasmine, ripe, sweet | |
| propionic acid | - | 0 2 | acidic, cheesy, pungent, vinegar | |
| valeric acid | - | 0 2 | acidic, cheesy, fruity, milky, sharp, sour, tobacco | |
| vanillic acid | - | 0 2 | beany, brown, creamy, dairy, milky, phenolic, powdery, sweet, vanilla |
1.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
2.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.
3.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.
4.) Block, Batista, Matsunami, Zhuang, Ahmed The role of metals in mammalian olfaction of low molecular weight organosulfur compound Nat. Prod. Rep., 2017,34, 529-557