Olfactory Receptor family 51 subfamily B member 5.
Estimated Expression: Unknown.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MSSSGSSHPF LLTGFPGLEE AHHWISVFFL FMYISILFGN GTLLLLIKED HNLHEPMYFF LAMLAATDLG LALTTMPTVL GVLWLDHREI GSAACFSQAY 110 120 130 140 150 160 170 180 190 200 FIHSLSFLES GILLAMAYDR FIAICNPLRY TSVLTNTRVV KIGLGVLMRG FVSVVPPIRP LYFFLYCHSH VLSHAFCLHQ DVIKLACADT TFNRLYPAVL 210 220 230 240 250 260 270 280 290 300 VVFIFVLDYL IIFISYVLIL KTVLSIASRE ERAKALITCV SHICCVLVFY VTVIGLSLIH RFGKQVPHIV HLIMSYAYFL FPPLMNPITY SVKTKQIQNA 310 320 ILHLFTTHRI GT
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 V I H P G F T T D L P G I E R L W A E E L I L H F R H I L R N R I P P A A S L V G W H H A Y S M L S L V A P Y V V S Q S F C L V T P F V S I L F Y G I V T V V L V F G R F Y A M T T F L F L P P F V Y F V F I F M L V L S H I L A L G S I Y M P N M V L V C Y D L G L G I L F S L D T F L I S Y T I C I H F I I L K V V I G S E A A L M T G N G V S V C T Y S I R T N T A L L A L F L L L I L A L I L V D Y A M F Y M P E K I L K A R E V T K I F R D I S L C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| farnesol | -4.74 1 | 5.2143 1 | fresh, sweet, linden_flower, floral, angelica, dry | |
| isononyl alcohol | -3.89 2 | 10 2 | aldehydic, berry, camphorous, cooling, earthy, floral, grassy, green, hay, herbal, leafy, melon, weedy, woody | |
| lauric acid | -5.12 1 | 3.5714 1 | bay, coconut, fatty | |
| phenylacetic acid | - | 5 3 | sweet, honey, floral, honeysuckle, sour, waxy, civet | |
| diacetyl | - | 3.3333 4 | buttery, caramellic, creamy, pungent, sweet | |
| 4-methyl-3-hexenoic acid | - | (agonist) 3 | ||
| butyric acid | - | 0 4 | sharp, acetic, cheesy, buttery, fruity, dairy, creamy | |
| delta-decalactone | - | 0 4 | coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet |
1.) Emily A. Yasi, Sara L. Eisen, Hanfei Wang, Widianti Sugianto, Anita R. Minniefield, Kaitlyn A. Hoover, Paul J. Branham, and Pamela Peralta-Yahya Rapid Deorphanization of Human Olfactory Receptors in Yeast Biochemistry 2019, 58, 2160-2166
2.) Tsai T, Veitinger S, Peek I, Busse D, Eckardt J, Vladimirova D, Jovancevic N, Wojcik S, Gisselmann G, Altmüller J, Ständer S, Luger T, Paus R, Cheret J, Hatt H. Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation. Exp Dermatol 26: 58 - 65, 2017. doi:10.1111/exd.13132
3.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1
4.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR51B5 | 100 | L | A | I | H | S | F | S | G | G | S | V | P | F | L | H | Q | P | L | V | I | F | Y | V | S | R | S | Y | Y | F | |
| OR51B6 | 95 | V | A | I | H | S | V | S | G | A | S | I | I | F | L | H | Q | P | V | L | M | V | Y | V | T | R | S | Y | H | F | |
| OR51B2 | 93 | 100% | V | A | I | H | S | V | S | G | G | S | I | V | F | L | H | Q | P | L | I | T | I | Y | V | T | R | S | Y | Y | F |
| OR51D1 | 85 | 65% | L | M | I | H | S | A | S | A | G | F | F | L | F | L | H | Q | G | I | I | V | M | Y | L | S | R | A | N | Y | L |
| OR51I2 | 83 | 100% | I | M | I | H | S | M | S | G | S | T | L | L | Y | L | H | P | G | V | L | T | F | Y | M | S | R | S | N | Y | L |
| OR51I1 | 83 | 100% | V | M | I | H | S | F | S | G | S | T | L | F | Y | L | H | P | G | V | I | T | Y | Y | I | S | R | S | N | Y | L |
| OR51E1 | 81 | 100% | I | M | I | H | S | G | S | T | G | L | M | L | Y | L | H | Q | G | V | I | A | I | Y | F | S | R | A | N | Y | L |
| OR51E2 | 81 | 96% | L | M | I | H | S | A | S | T | G | F | F | L | Y | V | H | Q | G | A | I | V | M | Y | L | S | R | G | D | Y | L |