Olfactory Receptor family 51 subfamily B member 5.
Sequence:
10 20 30 40 50 60 70 80 90 100 MSSSGSSHPF LLTGFPGLEE AHHWISVFFL FMYISILFGN GTLLLLIKED HNLHEPMYFF LAMLAATDLG LALTTMPTVL GVLWLDHREI GSAACFSQAY 110 120 130 140 150 160 170 180 190 200 FIHSLSFLES GILLAMAYDR FIAICNPLRY TSVLTNTRVV KIGLGVLMRG FVSVVPPIRP LYFFLYCHSH VLSHAFCLHQ DVIKLACADT TFNRLYPAVL 210 220 230 240 250 260 270 280 290 300 VVFIFVLDYL IIFISYVLIL KTVLSIASRE ERAKALITCV SHICCVLVFY VTVIGLSLIH RFGKQVPHIV HLIMSYAYFL FPPLMNPITY SVKTKQIQNA 310 320 ILHLFTTHRI GT
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 E E L G V G L A A S G P F T T D I V I H P H H A V T P M S F C R I P P L R N L S L G I L H V S I W T T L F Y A Q V V S V A P Y I V T A Y S M L F F A L G L S H I V F G R V V L V Y F V L F Y I Y M F D T A L F S L M L V V F I F L V C L P P F L I S A L M A G S E G L G I Y D L C I H S P N M G N G F L F F A L L I K V V F I I L V C T S Y T I L L T Y M P E Y A M R T N T Y S I I L A K K V K I L L I F R D L I L V A R E C I A V T K E R S A N S L UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| isononyl alcohol | -3.89 1 | 10 2 | aldehydic, berry, camphoraceous, cooling, earthy, floral, grassy, green, hay, herbal, leafy, melon, weedy, woody | |
| farnesol | -4.74 3 | 5.2143 3 | fresh, sweet, linden_flower, floral, angelica, dry | |
| lauric acid | -5.12 3 | 3.5714 3 | bay, coconut, fatty | |
| diacetyl | - | 3.3333 4 | buttery, caramellic, creamy, pungent, sweet | |
| butyric acid | - | 0 4 | sharp, acetic, cheesy, buttery, fruity, dairy, creamy | |
| delta-decalactone | - | 0 4 | coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet |
1.) Tsai T, Veitinger S, Peek I, Busse D, Eckardt J, Vladimirova D, Jovancevic N, Wojcik S, Gisselmann G, Altmüller J, Ständer S, Luger T, Paus R, Cheret J, Hatt H. Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation. Exp Dermatol 26: 58 - 65, 2017. doi:10.1111/exd.13132
2.) Manteniotis, S., Wojcik, S., Göthert, J. et al. Deorphanization and characterization of the ectopically expressed olfactory receptor OR51B5 in myelogenous leukemia cells. Cell Death Discovery 2, 16010 (2016). https://doi.org/10.1038/cddiscovery.2016.10
3.) Emily A. Yasi, Sara L. Eisen, Hanfei Wang, Widianti Sugianto, Anita R. Minniefield, Kaitlyn A. Hoover, Paul J. Branham, and Pamela Peralta-Yahya Rapid Deorphanization of Human Olfactory Receptors in Yeast Biochemistry 2019, 58, 2160-2166
4.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.