OR51E1

Olfactory Receptor family 51 subfamily E member 1.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MVDPNGNESS ATYFILIGLP GLEEAQFWLA FPLCSLYLIA VLGNLTIIYI VRTEHSLHEP MYIFLCMLSG IDILISTSSM PKMLAIFWFN STTIQFDACL 

       110        120        130        140        150        160        170        180        190        200 
LQMFAIHSLS GMESTVLLAM AFDRYVAICH PLRHATVLTL PRVTKIGVAA VVRGAALMAP LPVFIKQLPF CRSNILSHSY CLHQDVMKLA CDDIRVNVVY 

       210        220        230        240        250        260        270        280        290        300 
GLIVIISAIG LDSLLISFSY LLILKTVLGL TREAQAKAFG TCVSHVCAVF IFYVPFIGLS MVHRFSKRRD SPLPVILANI YLLVPPVLNP IVYGVKTKEI 

       310        320 
RQRILRLFHV ATHASEP

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

E E L G   I A L   A D F Q       F   V R I D    S L G  L P S D  
 F Q A   M K P M   L L C   V P L P   V V N    I F P    I V P   
F A L W   S S T   A F M Q   A M L   I L G Y  V Y F I  I N A L  
 C L P   S I L I   S H I   A A G R   I I V    F V A    L L Y   
L Y L S   D I G   M G S L   V V A   G I A S  C V H S  V P P V  
 V A I   S L M C   T S E   A V G I   S D L    V C T    P N L   
L N G L   L F I   A L L V   K T V   S I L L  G F A K  G Y V I  
 I I T   Y M P E   F A M   R P L T   Y S F    A Q A      K V   
R V I Y           V Y R D           L I L L  E R T L           
                   C I A             V T K                     
                        H               G L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB

This page features beta versions of predictions, including links to viewable 3D models. The numbers and models are not yet guaranteed to be accurate, and we welcome collaboration on our codebase. The repository is accepting pull requests at https://github.com/primaryodors/primarydock.

Odorant	EC₅₀	Adjusted Top	Dock Score	Dock Energy	Aroma Notes
butyric acid	-5.47 ¹	10 ²	15.3512	-60.5968	sharp, acetic, cheesy, buttery, fruity, dairy, creamy
3-methylvaleric acid	-5.47 ²	10 ³	6.2693	-14.1475	animal, sharp, acidic, cheesy, green, fruity, sweaty
isovaleric acid	-4.82 ⁴	10 ⁵	12.488	-16.4353	cheesy, sour, sweaty, tropical
pelargonic acid	-5.3 ¹	8 ⁶	3.3339	-17.549	cheesy, dairy, dirty, waxy
valeric acid	-4.74 ²	8.07 ²	8.9739	-17.7264	acidic, cheesy, fruity, milky, sharp, sour, tobacco
4-methylvaleric acid	-5.21 ²	6.86 ²	24.8439	-26.1516	cheesy, pungent
cyclobutane carboxylic acid	-4.6 ²	7.78 ²	15.1908	-24.0102
caproic acid	-4.52 ⁷	6.49 ²	21.8494	-28.7532	cheesy, fatty, sour, sweaty
5-norbornene-2-carboxylic acid	-	6.85 ²	4.9083	-19.4106	fruity, green
butyl butyryl lactate	-3.47 ⁶	7 ⁶	0	0	creamy, buttery, buttermilk, dairy, cheesy, fatty, waxy, sweaty, green
propionic acid	-4.97 ⁴	3.52 ²	22.642	-25.5363	acidic, cheesy, pungent, vinegar
2-methylvaleric acid	-3.3 ³	5.63 ²	5.4014	-21.322	cheesy, sour
oenanthic acid	-	4.85 ²	9.0201	-20.347	rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
2-decenoic acid	-	4.52 ²	0.4553	-7.2324	fatty
2-methylbutanoic acid	-1.78 ⁵	6.17 ²	10.8932	-21.5001	pungent, acidic, cheesy, roquefort, fruity, dirty, fermented
caprylic acid	-	4.42 ²	10.8686	-34.3219	cheesy, fatty, oily, rancid, vegetable, waxy
norbornane-2-carboxylic acid	-2.3 ⁵	4.2353 ⁵	7.8316	-22.0755
3-methyl-2-hexenoic acid	-4.22 ⁸	0.48 ⁸	9.9575	-19.6559	cheesy, fruity
cyclohexanecarboxylic acid	-1.87 ⁵	4.1176 ⁵	1.6299	-8.66	fruity, acidic, metallic, cheesy, tropical
capric acid	-	3.51 ²	0	0	citrus, fatty, rancid, sour
2-nonenoic acid	-	3.43 ²	0.3921	-1.6061	fatty, oily
4-methyl nonanoic acid	-	3.4 ²	1.2024	-9.5168	meaty, pork, lamb, chicken, fatty, goaty
cyclopropanecarboxylic acid	-1.3 ⁵	1.1765 ⁵	0	0
methyl eugenol	-	1.1667 ⁹	0	0	carnation, cinnamon, clove, fresh, spicy, sweet, warm
(1S,2R,5S)-(+)-menthol	-	0.7 ⁹	0	3.579	cooling, mentholic, minty
methyl salicylate	-	0.7 ⁹	0	0	minty, wintergreen
eugenyl acetate	-	0.6 ⁹	0	0	carnation, clove, floral, fresh, malty, spicy, sweet, woody
2,4-DNT	-	0.5 ⁹	0	3.8274
pyrazine	-	0.5 ⁹	0	0	pungent, sweet, corn, roasted, hazelnut, barley
dimethyl disulfide	-	0.4333 ⁹	0.1621	-1.3606	sulfurous, vegetable, cabbage, onion, malty, creamy
delta-decalactone	-	0.4167 ¹⁰	0	0	coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet
methyl furfuryl disulfide	-	0.4 ⁹	0.0809	-1.3392	sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
n-amyl alcohol	-	0.3333 ⁹			fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
propanal	-	0.3333 ⁹	1.2199	-6.5228	alcoholic, cocoa, earthy, nutty, whiskey, winey
acetophenone	-	0 ⁶	0.177	-2.8683	sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
allyl heptanoate	-	0 ⁶			sweet, pineapple, fruity, waxy, banana, fusel, cognac, ripe, fermented
allyl phenylacetate	-	0 ⁹			honey, fruity, rummy
allylbenzene	-	0 ⁶
amyl hexanoate	-	0 ⁹			sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
androstenone	-	0 ⁹			animal, musky
l-arabinose	-	0 ⁹
benzene	-	0 ⁹			gasoline, phenolic, solvent, cinnamon
benzoic acid	-	0 ³			balsamic, urine
benzophenone	-	0 ⁶			balsamic, rose, metallic, powdery, geranium, herbal, plastic, phenolic
benzyl acetate	-	0 ⁶			sweet, floral, fruity, jasmine, fresh
bornane-2-carboxylic acid	-	0 ⁵	0	0
butyl formate	-	0 ⁹	0.2101	-3.392	fruity, plum, rummy, brandy
(-)-camphor	-	0 ⁶	0	0
camphor	-	0 ⁶			camphoraceous
gamma-caprolactone	-	0 ⁶	0	13.5929	herbal, coconut, sweet, coumarinic, tobacco, creamy, lactonic, green
(R)-(-)-carvone	-	0 ⁶	0	3.0625	herbal, minty, spearmint, sweet
(S)-(+)-carvone	-	0 ⁹	0	0	bready, caraway, minty, spicy
4-chromanone	-	0 ⁶	1.0669	-8.4548
citral	-	0 ⁹	0	0	sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
citric acid	-	0 ³	0.6374	-10.0857
(S)-(-)-citronellol	-	0 ⁶	0	17.9445	citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
coffee difuran	-	0 ⁹	0	0.8237	cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
2-coumaranone	-	0 ⁶	0	0
coumarin	-	0 ⁹			coumarinic, hay, sweet, tonka
cyclohexanone	-	0 ⁶			acetone, minty
beta-damascone	-	0 ⁹			berry, currant, floral, fruity, honey, plum, rose, tobacco
decanal	-	0 ⁹			sweet, aldehydic, waxy, orange_peel, citrus, floral
1-decanol	-	0 ³			aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
diacetyl	-	0 ¹⁰			buttery, caramellic, creamy, pungent, sweet
(+)-dihydrocarvone	-	0 ⁶			herbal, minty, mentholic
dihydrojasmone	-	0 ⁶			floral, fresh, herbal, jasmine, myrrh, outdoors, spicy, woody
2-ethyl fenchol	-	0 ⁹			camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl isobutyrate	-	0 ⁶			alcoholic, ethereal, fruity, fusel, rummy, sweet
ethyl vanillin	-	0 ⁹			sweet, creamy, vanilla, caramellic
eugenol	-	0 ⁹			clove, spicy, sweet, woody
fenchone	-	0 ⁶			camphoraceous, earthy, herbal, woody
geraniol	-	0 ⁶			citrus, floral, fruity, rose, sweet, waxy
geranyl acetate	-	0 ⁹			floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
helional	-	0 ⁹			cyclamen, fresh, green, hay, ozone, watery
heptanal	-	0 ⁶			aldehydic, cognac, fatty, fresh, green, herbal, ozone
1-heptanol	-	0 ⁶	0	8.1673	musty, leafy, violet, herbal, green, sweet, woody, peony, pungent, vegetable, fruity, apple, banana
2-heptanone	-	0 ⁹			banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
3-heptanone	-	0 ⁶			fatty, fruity, green
hexanal	-	0 ⁶			aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
2,3-hexanedione	-	0 ⁶			buttery, sweet
3,4-hexanedione	-	0 ⁶	0	0	almond, buttery, caramellic, nutty, toasted
hexanol	-	0 ³	1.9057	-10.0406	ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
2-hexanone	-	0 ⁶	0.3876	-6.153	ethereal
(Z)-3-hexen-1-ol	-	0 ⁹	0	0	fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
hexyl acetate	-	0 ⁶	0	0	apple, banana, fruity, green, sweet
4-hydroxycoumarin	-	0 ⁶	0	0
isobutylamine	-	0 ⁹	0	0	cheesy, fishy
lauric acid	-	0 ³	0	0	bay, coconut, fatty
d-limonene	-	0 ⁹	0.6356	-5.0828	citrus, orange, fresh, sweet
linalool	-	0 ⁹	0.7006	-11.0779	blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
lyral	-	0 ⁹	0	3.3214	aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
myristic acid	-	0 ³	0	0	citrus, coconut, fatty, peel, pineapple, soapy, waxy
nonanal	-	0 ⁹	0.3464	-2.8089	waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
nonanethiol	-	0 ⁶	0	7.9876
1-nonanol	-	0 ⁹	0	0.0839	aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
2-nonanone	-	0 ⁶	0	0	fresh, sweet, green, weedy, earthy, herbal, fruity, waxy, soapy, cheesy, coconut, dairy, dirty, buttery
octanal	-	0 ⁶	0	0	aldehydic, citrus, fatty, green, orange, peel, waxy
octanethiol	-	0 ⁹	0	5.276	sulfurous
1-octanol	-	0 ³	0	9.6679	aldehydic, green, mushroom, orange, rose, waxy
2-octanone	-	0 ⁶	0	0	earthy, herbal, natural, weedy, woody
3-octanone	-	0 ⁶	0	0	fresh, herbal, lavender, mushroom, sweet
octyl octanoate	-	0 ⁹	0	0	coconut, oily, fruity
palmitic acid	-	0 ³	0	0	creamy, fatty, waxy
2-pentanone	-	0 ⁶	1.4778	-7.8426	sweet, fruity, ethereal, winey, banana, woody, fermented
phenyl acetate	-	0 ⁶	0	0	phenolic, medicinal, animal, resinous, castoreum, woody, smoky, burnt
(+)-2-phenylbutyric acid	-	0 ⁶	0	0
prenyl acetate	-	0 ⁶	0	0	sweet, fresh, banana, fruity, jasmine, ripe, heliotrope, balsamic
quinoline	-	0 ⁹	0	0	earthy, medicinal, musty, rubbery, tobacco
sotolone	-	0 ⁹	0	0	sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
terpinyl acetate	-	0 ⁹	0	0	bergamot, citrus, herbal, lavender, lime
vanillic acid	-	0 ⁶			beany, brown, creamy, dairy, milky, phenolic, powdery, sweet, vanilla
citronellal	-	-0.9091 ⁷			sweet, dry, floral, herbal, waxy, aldehydic, citrus
2-cyclohexylpropanal	-	-0.9091 ⁷			natural, fresh, green, dusty, fruity
hydroxycitronellal	-	-0.9091 ⁷			floral, green, lily, melon, sweet, tropical, waxy
bourgeonal	-	-1.8182 ⁷			fresh, watery, floral, cyclamen, sweet
florhydral	-	-1.8182 ⁷			floral, green, muguet, linden_flower, lily_of_the_valley, fresh
7-methoxycitronellal	-	-1.8182 ⁷			fresh, melon, floral, lily, sweet
			0.5264	-1.7009

1.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

2.) Halperin Kuhns, V. L., Sanchez, J., Sarver, D. C., Khalil, Z., Rajkumar, P., Marr, K. A., & Pluznick, J. L. (2019). Characterizing novel olfactory receptors expressed in the murine renal cortex. American Journal of Physiology-Renal Physiology, 317(1), F172-F186.

3.) YOSHIFUMI FUJITA, TOMOKO TAKAHASHI, AKIKO SUZUKI, KAYO KAWASHIMA, FUTOSHI NARA & RYUTA KOISHI (2007) Deorphanization of Dresden G Protein-Coupled Receptor for an Odorant Receptor, Journal of Receptors and Signal Transduction, 27:4, 323-334, DOI: 10.1080/10799890701534180

4.) Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, et al. () Identification of Odorant-Receptor Interactions by Global Mapping of the Human Odorome. PLoS ONE 9(4): e93037. doi:10.1371/journal.pone.0093037

5.) Pierre Chatelain, Alex Veithen, Francoise Wilkin, and Magali Philippeau Deorphanization and Characterization of Human Olfactory Receptors in Heterologous Cells Chem Biodivers. 2014 Nov;11(11):1764-81. doi: 10.1002/cbdv.201400083. PMID: 25408322.

6.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

7.) Aya Kato, Naoko Saito, Etsuji Wakisaka (2016) Method for searching for malodor control agent, malodor control agent, and malodor control method. US9526680B2

8.) Aya Kato, Naoko Saito (2018) Search method for odor control agent JP6422665B2

9.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

10.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.

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primaryodors.org

Olfactory Receptor family 51 subfamily E member 1.

Sequence:

Transmembrane Helices: