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Olfactory Receptor family 51 subfamily E member 2.

Estimated Expression: 96% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MSSCNFTHAT FVLIGIPGLE KAHFWVGFPL LSMYVVAMFG NCIVVFIVRT ERSLHAPMYL FLCMLAAIDL ALSTSTMPKI LALFWFDSRE ISFEACLTQM 

       110        120        130        140        150        160        170        180        190        200 
FFIHALSAIE STILLAMAFD RYVAICHPLR HAAVLNNTVT AQIGIVAVVR GSLFFFPLPL LIKRLAFCHS NVLSHSYCVH QDVMKLAYAD TLPNVVYGLT 

       210        220        230        240        250        260        270        280        290        300 
AILLVMGVDV MFISLSYFLI IRTVLQLPSK SERAKAFGTC VSHIGVVLAF YVPLIGLSVV HRFGNSLHPI VRVVMGDIYL LLPPVINPII YGAKTKQIRT 

       310        320 
RVLAMFKISC DKDLQAVGGK

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


V I P H       G   P L T D     I L   S I E R      F W  A K E L  
 V V R   F R H V   V V N   L P L P   A E F    F L A    W F H   
I D G M   V S L   T L G Y   F F F   Q T L C  L I K P  P F G V  
 L L Y   G I L P   L I A   L S G R   F F M    M T S    S L L   
V P P L   V Y F   G M V L   V V A   L A H I  T S L A  V V Y M  
 P N I   A L V V   V D V   V I G I   I A S    L D I    F M A   
G Y I I   G I H   S I F M   Q A T   I T S E  A A L M  I C N G  
     A   S V C T   Y S L   V T N N   A L L    C L F    F V V   
          G F A   I I L F           D F A M  L Y M P  T R V I  
         K A R E   V T R             V Y R                 E   
                    L Q L             C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
propionic acid -3.96 1 10 1  acidic, cheesy, pungent, vinegar
hydroxypyruvic acid -6.38 2 11 2  sour, radish, cabbage
alpha-ionone -5.5 3 10 3  sweet, woody, floral, violet, orris, tropical, fruity
beta-ionone -7.5 3 5.9375 3  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
acetic acid -3.7 1 6.9565 1  sharp, pungent, sour, vinegar
butyric acid -4.52 1 2.6087 1  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
formic acid -4.7 4 0.8696 4  pungent, vinegar
isovaleric acid -4.19 5 0.1444 5  cheesy, sour, sweaty, tropical
delta-decalactone - 2.0833 6  coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet
valeric acid - 0.4 1  acidic, cheesy, fruity, milky, sharp, sour, tobacco
capric acid - 0 1  citrus, fatty, rancid, sour
caproic acid - 0 1  cheesy, fatty, sour, sweaty
caprylic acid - 0 1  cheesy, fatty, oily, rancid, vegetable, waxy
diacetyl - 0 6  buttery, caramellic, creamy, pungent, sweet
oenanthic acid - 0 1  rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
pelargonic acid - 0 1  cheesy, dairy, dirty, waxy

1.) Christian B. Billesbølle, Claire A. de March, Wijnand J. C. van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami, Aashish Manglik. Structural basis of odorant recognition by a human odorant receptor. bioRxiv 2022.12.20.520951; doi: https://doi.org/10.1101/2022.12.20.520951

2.) Abaffy, T.; Bain, J.R.; Muehlbauer, M.J.; Spasojevic, I.; Lodha, S.; Bruguera, E.; O’Neal, S.K.; Kim, S.Y.; Matsunami, H. A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells via an Ectopic Olfactory Receptor. Front. Oncol. 2018, 8, 162

3.) Sanz G., Leray I., Grébert D., Antoine S., Acquistapace A., Muscat A., Boukadiri A., Mir L. M. Structurally related odorant ligands of the olfactory receptor OR51E2 differentially promote metastasis emergence and tumor growth. Oncotarget. 2017; 8: 4330-4341.

4.) Aisenberg, W., Huang, J., Zhu, W. et al. Defining an olfactory receptor function in airway smooth muscle cells. Sci Rep 6, 38231 (2016). https://doi.org/10.1038/srep38231

5.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

6.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.
Prot.Sim.Expr.2.53 3.29 3.32 3.33 3.36 3.37 3.40 3.41 4.53 4.56 4.57 4.60 45.49 45.51 45.52 45.53 5.39 5.42 5.43 5.46 5.47 6.48 6.51 6.55 6.59 7.38 7.39 7.41 7.42
OR51E2100 96%L M I H S A S T G F F L Y V H Q G A I V M Y L S R G D Y L
OR51D195 65%L M I H S A S A G F F L F L H Q G I I V M Y L S R A N Y L
OR51E195 100%I M I H S G S T G L M L Y L H Q G V I A I Y F S R A N Y L
OR51Q188 100%L F L H S F S S C A V S Y L H Q G L A I I Y M S R A N Y L
OR51M188 100%L M I H S F S S G A T I F L H Q G V V T V F M S R A N Y L
OR51V187 69%M S I H S F S S S F I P F L H Q A L V I L Y I T R G N Y I
OR51G285 92%L L I H S F S S S L I L Y L H Q G V I T V Y M S R G F Y L
OR52K285 80%L M L H S I S A A L M L Y E H M G V A I V Y V S R A N Y L
OR51T185 76%L M V H S L S S P F L L F Y H P G L Q L N Y L S R A N Y L
OR51L184 88%M L I H T F S S S V V T F L H Q G V V T L F V S R A D Y L
OR51A283 84%L E I H S V S S S L V F Y L H Q G G A L M Y I A R A N L L
OR51A483 84%L E I H S V S S S L V F Y L H Q G G A L M Y I A R A N L L
OR52K182 92%L M L H S I S A A L M L Y E H M G V A I V Y V S R A I Y L
OR52P182A M I H C M S T G L M C Y E H M G A A V I Y A F R A N Y L
OR52E181L M I H T G S A P F V F Y E H M G A I L V Y A F R A N Y V
OR51B581L A I H S F S G G S V P F L H Q P L V I F Y V S R S Y Y F
OR51B681V A I H S V S G A S I I F L H Q P V L M V Y V T R S Y H F
OR51B280 100%V A I H S V S G G S I V F L H Q P L I T I Y V T R S Y Y F
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