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Olfactory Receptor family 7 subfamily A member 17.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MEPENDTGIS EFVLLGLSEE PELQPFLFGL FLSMYLVTVL GNLLIILATI SDSHLHTPMY FFLSNLSFAD ICFISTTIPK MLINIQTQSR VITYAGCITQ 

       110        120        130        140        150        160        170        180        190        200 
MCFFVLFGGL DSLLLAVMAY DRFVAICHPL HYTVIMNPRL CGLLVLASWM IAALNSLSQS LMVLWLSFCT DLEIPHFFCE LNQVIHLACS DTFLNDMGMY 

       210        220        230        240        250        260        270        280        290        300 
FAAGLLAGGP LVGILCSYSK IVSSIRAISS AQGKYKAFST CASHLSVVSL FCCTGLGVYL TSAATHNSHT SATASVMYTV ATPMLNPFIY SLRNKDIKRA 

       310 
LKMSFRGKQ

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

T H S N    Y V G  L F T D     V M   I V R S      Q I  L E P E  
 T A S    L G T    M D N   L S Q S   A Y T    N I L    F P Q   
M V S A  C C F L  F Y M G   L S N   T I C G  M K P I  L G F L  
 V T Y    S V V    G A A   L A A I   C M Q    T T S    S L F   
M P T A  S L H S  G A L L   M W S   L V F F  I F C I  V L Y M  
 P N L    A C T    L P G   A L V L   G G F    D A F    L V T   
S Y I F  S F A K  L I G V   L G C   L S D L  S L N S  L L N G  
     L    Y K G    Y S C   L R P N   A L L    L F F    L I I   
         Q A S S  V I K S           Y A M V  Y M P T  S I T A  
                   I S S             F R D                 D   
                    I A R           C I A V                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
arborone -8.46 1 -  woody, ambery, dry
georgywood -7.63 1 -  woody, amber, floral
cedryl acetate -7.02 1 -  dry, woody, cedar, powdery
vetynal -6.61 1 -  woody, dry, earthy, amber, fruity, spicy
(-)-ambroxide -6.61 1 10 1  dry, amber, ambergris, paper, musk, woody, cedar, pine, green, seedy
nootkatone - 10 1  grapefruit_peel, citrus, gardenia, woody, grapefruit, orange, sweet, peely, bitter
ambroxan -5.89 2 -  ambergris, sweet, labdanum, dry, woody, pine, cedar, green, seedy, tea, fresh, nutty
cedramber -5.88 1 0 3  woody, dry, cedar, ambergris, earthy, vetiver
acetivenol -5.55 1 -  woody
isolongifolanone -5.21 1 -  dry, woody, patchouli, cedar, earthy, tobacco, incense
cedrol -5.04 1 -  cedarwood, woody, dry, sweet, amber, floral, ambrette, musk, powdery
delta-damascone - 8 1  fruity, sweet, rose, natural, petal, currant_bud, black_currant_bud, tobacco
rotundone - 7 1  woody, peppery, agarwood, spicy, guaiacwood
ambroxene oxide -4.056 3 7.155 3  
ambroxene -3.423 3 5.61 3  
vanillin - 5 1  chocolate, creamy, sweet, vanilla
grapefruit mercaptan - 4 1  sulfurous, aromatic, grapefruit, naphthyl, resinous, woody, alliaceous, onion, garlic, tropical
Iso-E-Super -3.926 3 0.658 3  ambergris, cedar, dry, ketonic, old_wood, phenolic, woody
patchoulol - 3 1  patchouli, earthy, camphorous, powdery
(R)-(+)-sclareolide - (agonist) 3  dry, paper, woody, ambergris, labdanum
8-drimanol - 0.5 3  
allyl hexanoate - 0 3  sweet, fruity, pineapple, tropical, ethereal, rummy, arrack, fatty, cognac
amber butanol - 0 3  woody, amber, ambrette
amberketal - 0 3  dry, amber, powdery, woody, musk
ambrinol - 0 3  amber, natural, musk, animal
ambrocenide - 0 3  woody, amber, agarwood
benzyl salicylate - 0 3  balsamic, clean, herbal, oily, sweet
citral - 0 3  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
coumarin - 0 3  coumarinic, hay, sweet, tonka
gamma-decalactone - 0 3  fresh, oily, waxy, peach, coconut, buttery, sweet
eugenol - 0 3  clove, spicy, sweet, woody
florocyclene - 0 3  fruity, herbal, woody, jasmin, oily, basil
(Z)-3-hexen-1-ol - 0 3  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
karanal - 0 3  dry, dusty, woody, mahogany, amber, resinous, earthy, floral
d-limonene - 0 3  citrus, orange, fresh, sweet
l-limonene - 0 3  terpenic, pine, herbal, peppery
linalool - 0 3  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
(1R,2S,5R)-(-)-menthol - 0 3  peppermint, cooling, mentholic, minty, camphorous, clean
octanal - 0 3  aldehydic, citrus, fatty, green, orange, peel, waxy
okoumal - 0 3  dry, amber, woody, powdery, musk
phenethyl alcohol - 0 3  floral, rose, dried_rose, sweet, fresh, bready, honey
santaliff - 0 3  sandalwood, creamy, woody, milky, waxy, greasy, musk
timberol - 0 3  dry, sawdust, woody, powdery, amber, sandalwood
ysamber K - 0 3  dry, woody, vetiver, amber, powdery, musk, fruity
chloro-ambroxide -4.395 3 -0.11 3  

1.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

2.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1

3.) Dan Takase, Tomohiro Shirai, Kensuke Misawa, Hiroaki Matsunami, Keiichi Yoshikawa, An odorant receptor for a key odor constituent of ambergris. Communications Biology | (2025)8:792. doi: 10.1038/s42003-025-08229-y
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