SMILES:
C[C@@H]1CCCCCCCCCCCCC(=O)C1
Aroma Description:
musk, animal, powdery1
| Receptor | log10 EC50 | Adj. Top | Antagonist? | Correlated Perceptual Qualities |
|---|---|---|---|---|
| OR5AN1 | -5.49 3, -6.54 6 | 9.1045 2, 10 3, 3.6 4, 4.7 5, 9.2857 6 | musk, animal, powdery | |
| OR4K2 | - | 1.3462 7 | storax, animal, clove, cortex, malty, musk, natural, foliage, almond, powdery | |
| OR5A2 | - | 1.1 5 | musk, animal | |
| OR10Q1 | - | 0.1923 7 | natural, orangeflower, powdery, neroli, animal, musk, naphthyl | |
| OR1A1 | - | 0 4 | ||
| OR2J3 | - | 0 4 | ||
| OR5A1 | - | 0 5 | ||
| OR4P4 | - | 0 7 | ||
| OR5I1 | - | 0 7 | ||
| OR10G4 | - | 0 9 | ||
| OR9Q2 | - | 0 9 | ||
| OR8D1 | - | -0.2538 8 | ||
| OR5K1 | - | -13.0435 10 |
SMILES:
C[C@@H]1CCCCCCCCCCCCC(=O)C1
Aroma Description:
musk, animal, powdery
| Receptor | Dock Score | Affinity | A100 | Correlated Perceptual Qualities |
|---|
Dock Score: This is a measure of whether the algorithm thinks the odorant is an agonist of the receptor.
Affinity: The binding affinity, in kJ/mol, of the ligand docked in the active or inactive model, whichever is greater.
A100: A measure of the degree of activation of the receptor. See
Ibrahim et al (2019).
1.) The Good Scents Company
2.) Ahmed, Lucky et al "Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds." Proceedings of the National Academy of Sciences 115.17 (2018): E3950-E3958. Web. 29 Aug. 2021.
3.) M. Shirasu, K. Yoshikawa, Y. Takai, A. Nakashima, H. Takeuchi, H. Sakano, K. Touhara, Olfactory receptor and neural pathway responsible for highly selective sensing of musk odors, Neuron 81 (2014) 165-178.
4.) Ligand Specificity and Evolution of Mammalian Musk Odor Receptors: Effect of Single Receptor Deletion on Odor Detection Narumi Sato-Akuhara, Nao Horio, Aya Kato-Namba, Keiichi Yoshikawa, Yoshihito Niimura, Sayoko Ihara, Mika Shirasu, Kazushige Touhara Journal of Neuroscience 20 April 2016, 36 (16) 4482-4491; DOI: 10.1523/JNEUROSCI.3259-15.2016
5.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]
6.) Omura M, Takabatake Y, Lempert E, Benjamin-Hong S, D'Hulst C, Feinstein P. A genetic platform for functionally profiling odorant receptors in olfactory cilia ex vivo. Sci Signal. 2022 Aug 9;15(746):eabm6112. doi: 10.1126/scisignal.abm6112. Epub 2022 Aug 9. PMID: 35944068.
7.) Ashti Baghaei, K. (2015). Large scale analysis of olfactory receptors with highly genetically variations in relation with specific anosmia (Doctoral dissertation, Bochum, Ruhr-Universität Bochum, Diss., 2013).
8.) Aya NAMBA, Naoko Saito, Michiaki Inoue, Tsuyoshi TOYABE (2016) Inhibitor of odor caused by sotolone US9254248B2
9.) Keiichi Yoshikawa, Naoko Saito (2016) Method for selecting odor-controlling substance EP3305898B1
10.) Aya Namba, Naoko Saito, Michiaki Inoue, Go Toriyabe (2018) Search method of odor control agent by furaneol JP6276555B2