☰

Olfactory Receptor family 10 subfamily G member 4.

Estimated Expression: 88% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MSNASLVTAF ILTGLPHAPG LDALLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL 

       110        120        130        140        150        160        170        180        190        200 
YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTSMMSGSRC ALLATGTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA PPILKLACAD TSANVMVIFV 

       210        220        230        240        250        260        270        280        290        300 
DIGIVASGCF VLIVLSYVSI VCSILRIRTS DGRRRAFQTC ASHCIVVLCF FVPCVVIYLR PGSMDAMDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK 

       310        320 
LRDKVAHPQR K

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


D M A D  R L Y I  A S T D     T L   S I A R      V L  L G P A  
 V V G    V V C    M V N   I T Q V   S H F    T M L    L A D   
Y F I A  P V F F  V F I V   A S H   Q A V C  M K P V  I G F L  
 L V T    C L V    G I D   L S G S   F Y L    T V T    V L F   
L L P T  V I C H  S A V I   L W T   L F H F  S F W M  L V Y V  
 V P N    S A C    F C G   G T A L   T S G    D I F    L V T   
    Y V  T Q F A  V I L V   L A C   L F C E  S L N T  L L N G  
          R R R    Y S L   R S G S   V T Y    L F Y    L L I   
         G D S T  V I S V           D Y S M  Y M P T  V R I V  
                   I S C             L Y R                 D   
                    I R L           Y S I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
guaiacol -7.7 1 10 1  phenolic, smoky, spicy, vanilla, woody, medicinal, savory, meaty, balsamic, sweet, burnt
ethyl vanillin -4.9 1 9.5 1  sweet, creamy, vanilla, caramellic
vanillin -5 2 9 2  chocolate, creamy, sweet, vanilla
isoeugenol -2.71 2 7.9167 2  carnation, clove, floral, spicy, sweet, woody
4-vinylguaiacol -4.52 3 2.2667 3  spicy, clove, carnation, phenolic, peppery, smoky, woody, powdery
para-anisaldehyde -3.3 4 1.7647 4  sweet, powdery, mimosa, floral, hawthorn, balsamic, vanilla, anise, woody, coumarinic, creamy, spicy
muscone - 0 5  musk, animal, powdery
3-octen-2-one - 0 6  earthy, spicy, herbal, sweet, mushroom, hay, blueberry

1.) J.D. Mainland, A. Keller, Y.R. Li, T. Zhou, C. Trimmer, L.L. Snyder, A.H. Moberly, K.A. Adipietro, W.L.L. Liu, H. Zhuang et al, The missense of smell: functional variability in the human odorant receptor repertoire, Nat. Neurosci. 17 (2014) 114-120

2.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

3.) Aya Namba, Naoko Saito, Keiichi Yoshikawa, Ichiro Mori (2015) Search method of urine odor suppressor JP2015211667A

4.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.

5.) Keiichi Yoshikawa, Naoko Saito (2016) Method for selecting odor-controlling substance EP3305898B1

6.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147
Prot.Sim.Expr.2.53 3.29 3.32 3.33 3.36 3.37 3.40 3.41 4.53 4.56 4.57 4.60 45.49 45.51 45.52 45.53 5.39 5.42 5.43 5.46 5.47 6.48 6.51 6.55 6.59 7.38 7.39 7.41 7.42
OR10G4100 88%F L F H G S C F G H S Q F D A P I D I V A F C Y G A I Y T
OR10G998 46%F L F H G S C F G H S Q L D A P I D I V A F C Y G A I Y T
OR10G797 80%F L F H G S C F G H S Q F D A P I N I V A F G Y G A V Y T
OR10G892 57%F L F H G G C F G H S Q L D A P I T V V A F G Y G A V Y T
OR10G691I L F H G C C F G H S Q F D I P T D I L A Y C Y C A V Y T
OR10G286 80%L L F H G S C F G H G Q I D I R T D V V A Y C Y A A V Y T
OR10G386 96%I L Y H G S C F G H G Q F D I P T D I V V Y C Y E A L P T
OR4D185 100%Y I F H G G V F G H S Q Y D V P M N S L V F C Y P S I Y T
OR4S283 57%Y L V H G C I F G H S Q F D V H V N S I A F C Y D A V Y T
OR10S183 92%L L F H A S C F G H A H F D I P M S I V A Y P Y R A V Y T
OR4K1783 84%L I L H G G M V G H S Q F D L P I N S I S F C Y P A V Y T
OR4P483 57%Y L T H G G I F G H S Q F D V Y V N S I A F A Y V A L Y T
OR4X183 23%Y M L H G G A F G H S Q F D V H I N G I S F C Y C A V Y T
OR4X283 53%Y L L H G G I F G H S Q F D L V I N G L S F C S S A V Y T
OR4A4782Y L E H G G V F G H S Q F D M Y V N G A C F C Y P S V Y T
OR4F482 92%L I L H G G M V G H S Q Y D L P V N S L T F C Y P A V Y S
OR4F582 92%L I L H G G M V G H S Q Y D L P V N S L T F C Y P A V Y S
OR4F1782 92%L I L H G G M V G H S Q Y D L P V N S L T F C Y P A V Y S
OR4D582 80%Y L F H G G I F G H S Q Y D V P M N N V T F C Y P S V Y T
OR4E282 96%H L L H A C I F G H S Q F D V P I N S I S F C Y P S V Y T
OR4D982 100%F M F H G G V F G H S Q Y D V P M N N V S F C Y P S V F T
OR4D1182 34%F I F H G G I F G H S Q Y D V P M N N V T F C Y P S V F T
OR2Y181 73%F L Y L G S C V G N S Q F E M P M A R V V Y A Y I A L Y T
OR4A1681Y L E H G G V F G H S Q V D M Y V N G I C F C Y P T V Y S
OR4L181 11%L M M H G G M T G H S Q F D L P V D S L S F C Y P A V Y T
OR2B1180 100%Y Y F H G C C I G N S Q F E V P L L V F V Y A Y P S L Y S
OR4Q280Y L L H G A M F G H S Q F D V P M N S I S F C Y F S V Y N
OR4K1580 42%V I V H T G M V G H T Q F D L P I D S L S F C Y P A V Y T
OR4K1380 96%L M M H G G M M G H S Q F D L P V D S L S F C Y P S V Y T
OR4K1480 80%L I L H G G M V G H S Q F D L P M D S L S F C Y P S V Y T
OR10A780 15%F M F F G S C F G V S Q F D G P A S T F I Y A Y K S L Y T
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