Olfactory Receptor family 10 subfamily G member 4.
Sequence:
10 20 30 40 50 60 70 80 90 100 MSNASLVTAF ILTGLPHAPG LDALLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL 110 120 130 140 150 160 170 180 190 200 YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTSMMSGSRC ALLATGTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA PPILKLACAD TSANVMVIFV 210 220 230 240 250 260 270 280 290 300 DIGIVASGCF VLIVLSYVSI VCSILRIRTS DGRRRAFQTC ASHCIVVLCF FVPCVVIYLR PGSMDAMDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK 310 320 LRDKVAHPQR K
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 L G P A L S H F S L A S T D L Y I V M A D M L A D T M L A V C I T Q V M V N V C P V G D I G F L M K P V F Y L Q A S H V F I V V F F C F I A V V L F T V T F H F L S G S G I D L V V V T Y L V Y V S F W M T S G L L W T S A V I I C H S L P T L L V T D I F F C E G T A L F C G A C T P N L L L N G S L N T V T Y L L A C V I L V Q F A R T Y V V L L I L F Y Y S M R S G S Y S L R R G L R I V Y M P T L Y R D V I S V D S T R S I A I S C Y R L UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| guaiacol | -7.7 1 | 10 1 | phenolic, smoky, spicy, vanilla, woody, medicinal, savory, meaty | |
| ethyl vanillin | -4.9 1 | 9.5 1 | sweet, creamy, vanilla, caramellic | |
| vanillin | -5 2 | 9 1 | chocolate, creamy, sweet, vanilla | |
| isoeugenol | -2.71 3 | 7.9167 3 | carnation, clove, floral, spicy, sweet, woody | |
| 4-vinylguaiacol | -4.52 4 | 2.2667 4 | spicy, clove, carnation, phenolic, peppery, smoky, woody, powdery | |
| para-anisaldehyde | -3.3 5 | 1.7647 5 | sweet, powdery, mimosa, floral, hawthorn, balsamic, vanilla, anise, woody, coumarinic, creamy, spicy | |
| muscone | - | 0 6 | musk, animal, powdery | |
| 3-octen-2-one | - | 0 7 | earthy, spicy, herbal, sweet, mushroom, hay, blueberry |
1.) J.D. Mainland, A. Keller, Y.R. Li, T. Zhou, C. Trimmer, L.L. Snyder, A.H. Moberly, K.A. Adipietro, W.L.L. Liu, H. Zhuang et al, The missense of smell: functional variability in the human odorant receptor repertoire, Nat. Neurosci. 17 (2014) 114-120
2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
3.) C. Trimmer, A. Keller, N. R. Murphy, L. L. Snyder, J. R. Willer, M. H. Nagai, N. Katsanis, L. B. Vosshall, H. Matsunami, and J. D. Mainland Genetic variation across the human olfactory receptor repertoire alters odor perception PNAS | May 7, 2019 | vol. 116 | no. 19 | 9475–9480
4.) Aya Namba, Naoko Saito, Keiichi Yoshikawa, Ichiro Mori (2015) Search method of urine odor suppressor JP2015211667A
5.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.
6.) Keiichi Yoshikawa, Naoko Saito (2016) Method for selecting odor-controlling substance EP3305898B1
7.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147