Olfactory Receptor family 1 subfamily A member 1.
Estimated Expression: 73% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MRENNQSSTL EFILLGVTGQ QEQEDFFYIL FLFIYPITLI GNLLIVLAIC SDVRLHNPMY FLLANLSLVD IFFSSVTIPK MLANHLLGSK SISFGGCLTQ 110 120 130 140 150 160 170 180 190 200 MYFMIALGNT DSYILAAMAY DRAVAISRPL HYTTIMSPRS CIWLIAGSWV IGNANALPHT LLTASLSFCG NQEVANFYCD ITPLLKLSCS DIHFHVKMMY 210 220 230 240 250 260 270 280 290 300 LGVGIFSVPL LCIIVSYIRV FSTVFQVPST KGVLKAFSTC GSHLTVVSLY YGTVMGTYFR PLTNYSLKDA VITVMYTAVT PMLNPFIYSL RNRDMKAALR 310 KLFNKRISS
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 I V A D N H I D S T L S I S K L H Q E Q Q M V T T L P R V H F L T H P G G F N A L F D E V A T Y F Y T Y M M K L A N Q T L C M K P I L I Y F M P T G M V T V G L A N G I F Y M T V S F L F F P N L G Y Y S F I G V W S L A I M S F F I I P Y I S Y I L S V V L P V G A I L T N G D V L I L T L T L H I I C L W I C I Y S D S L N A L L N G S G C T Y S V S R P S A A L L L F L V I S F A F V R I D Y A M Y M P N S C I A K L V G V T S V A R D Q F R S I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
1.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025
2.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.
3.) Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J Struct Biol. 2007 Sep;159(3):400-12. doi: 10.1016/j.jsb.2007.04.013. Epub 2007 May 25. PMID: 17601748.
4.) Saito N, Yamano E, Ishii A, Tanaka M, Nakamura J, et al. (2018) Involvement of the olfactory system in the induction of anti-fatigue effects by odorants. PLOS ONE 13(3): e0195263. https://doi.org/10.1371/journal.pone.0195263
5.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.
6.) Jabeen A, de March CA, Matsunami H, Ranganathan S. Machine Learning Assisted Approach for Finding Novel High Activity Agonists of Human Ectopic Olfactory Receptors. International Journal of Molecular Sciences. 2021; 22(21):11546. https://doi.org/10.3390/ijms222111546
7.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821
8.) Liu, Dobson, Zhang, Sun, Lowe, Liu, Zhuang, O’Hagan (2025) Exploring Linear mono-, bis- and tris-Acetylene Containing Agonists of the Human Olfactory Receptor OR1A1. J. Med. Chem. Article ASAP 2025/06/16
9.) Keiichi Yoshikawa, Naoko Saito (2016) Method for selecting odor-controlling substance EP3305898B1
10.) Aya Kato, Naoko Saito (2018) Search method for odor control agent JP6422665B2
11.) Christiane Geithe, Franziska Noe, Johanna Kreissl, Dietmar Krautwurst, The Broadly Tuned Odorant Receptor OR1A1 is Highly Selective for 3-Methyl-2,4-nonanedione, a Key Food Odorant in Aged Wines, Tea, and Other Foods, Chemical Senses, Volume 42, Issue 3, 1 March 2017, Pages 181–193, https://doi.org/10.1093/chemse/bjw117
12.) Shirai, T., Takase, D., Yokoyama, J. et al. Functions of human olfactory mucus and age-dependent changes. Sci Rep 13, 971 (2023). https://doi.org/10.1038/s41598-023-27937-1
13.) Ahmed, Lucky et al "Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds." Proceedings of the National Academy of Sciences 115.17 (2018): E3950-E3958. Web. 29 Aug. 2021.
14.) Silva Teixeira CS, Silva Ferreira AC, Cerqueira NM. Studying Haloanisoles Interaction with Olfactory Receptors. ACS Chem Neurosci. 2016 Jul 20;7(7):870-85. doi: 10.1021/acschemneuro.5b00335. Epub 2016 May 9. PMID: 27092849.
15.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147
16.) Ojiro I, Katsuyama H, Kaneko R, Ogasawara S, Murata T, Terada Y, et al. (2024) Enhancement of transcription efficiency by TAR-Tat system increases the functional expression of human olfactory receptors. PLoS ONE 19(6): e0306029. https://doi.org/10.1371/journal.pone.0306029
17.) Ichie Ojiro, Ryusei Kaneko, Takahiro Kashiwagi, Ikuo Terada, Kunihide Hoshino, Yuko Terada, Keisuke Ito, Odorants have the potential to enhance the heterologous expression of human olfactory receptors: evidence from ethyl 3-phenylglycidate and its effects on OR1A1, OR11G2, and OR2W1, Biochemical and Biophysical Research Communications, 2025, 151459, ISSN 0006-291X,
18.) Aya Namba, Naoko Saito, Keiichi Yoshikawa, Ichiro Mori (2015) Search method of urine odor suppressor JP2015211667A
19.) Haag, Franziska et al. “Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3.” Cellular and molecular life sciences : CMLS vol. 77,11 (2020): 2157-2179. doi:10.1007/s00018-019-03279-y
20.) Ligand Specificity and Evolution of Mammalian Musk Odor Receptors: Effect of Single Receptor Deletion on Odor Detection Narumi Sato-Akuhara, Nao Horio, Aya Kato-Namba, Keiichi Yoshikawa, Yoshihito Niimura, Sayoko Ihara, Mika Shirasu, Kazushige Touhara Journal of Neuroscience 20 April 2016, 36 (16) 4482-4491; DOI: 10.1523/JNEUROSCI.3259-15.2016
21.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.
22.) Huiwen Ren, Ruijing Zhang, Haibo Zhang, Che Bian. Ecnomotopic olfactory receptors in metabolic regulation. Biomedicine & Pharmacotherapy 179 (2024) 117403
| 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR1A1 | F | M | M | I | G | N | S | Y | G | N | A | H | Y | D | I | T | M | L | G | I | F | Y | V | Y | L | T | V | Y | T |
| OR1F1 | F | M | V | F | V | D | N | F | A | N | V | H | F | D | V | T | I | E | G | V | M | Y | I | Y | L | T | V | Y | T |
| OR1A2 | F | M | M | I | A | K | S | Y | G | S | A | H | Y | D | I | M | M | L | G | V | F | Y | T | Y | L | T | V | Y | V |
| OR1F12 | L | M | C | M | A | N | N | F | A | N | P | H | F | D | I | N | V | T | V | I | F | Y | I | Y | L | S | V | F | M |
| OR1J1 | F | T | F | I | A | D | S | F | A | C | A | H | F | D | L | G | I | A | A | A | I | Y | I | Y | P | S | V | Y | T |
| OR10K1 | Y | M | F | L | G | S | S | F | G | V | S | T | F | D | I | S | I | L | G | A | L | Y | A | Y | K | S | V | Y | T |
| OR1C1 | F | L | F | V | V | N | S | L | T | H | A | H | F | D | L | N | I | V | G | L | A | Y | A | Y | S | T | I | Y | S |
| OR1N1 | L | M | F | L | G | D | S | F | T | V | A | H | F | D | I | T | V | L | G | V | L | Y | L | Y | P | A | A | Y | T |
| OR14L1 | Y | A | F | M | A | T | V | A | G | C | G | H | F | N | I | P | V | F | G | L | V | M | G | Y | I | S | A | Y | T |
| OR5B21 | Y | F | F | V | A | T | C | Y | G | N | A | H | F | D | I | P | V | V | A | N | V | Y | I | Y | N | S | V | Y | T |
| OR5H14 | L | L | F | A | V | T | C | F | G | H | A | H | Y | D | I | I | V | F | A | I | Q | Y | L | Y | A | S | L | Y | T |
| OR5H6 | L | F | L | V | V | T | C | F | G | H | A | H | Y | D | I | I | V | F | A | V | Q | Y | L | Y | A | S | L | Y | T |
| OR1L1 | Y | M | F | L | G | N | S | Y | P | H | S | H | F | D | D | Q | V | E | G | V | I | Y | I | Y | L | T | I | Y | T |
| OR5B3 | Y | M | F | V | A | T | N | Y | G | N | A | H | F | D | I | P | L | V | V | N | I | Y | I | Y | S | P | V | Y | T |
| OR5P3 | Y | L | V | V | G | T | C | F | G | N | A | F | F | D | Y | S | P | S | S | I | I | Y | I | Y | K | S | V | Y | T |
| OR1E1 | F | M | F | L | G | D | S | F | T | H | A | H | F | D | M | S | I | M | G | I | L | Y | V | Y | S | A | M | Y | T |
| OR2AG1 | F | M | A | L | G | G | D | L | A | S | A | Y | L | E | I | P | V | M | G | F | L | Y | A | Y | S | S | V | Y | T |
| OR8D4 | Y | L | F | C | V | I | C | Y | G | D | A | H | F | D | I | V | I | I | G | N | M | Y | L | Y | A | S | V | Y | T |
| OR5AR1 | Y | F | F | V | V | D | C | Y | G | S | L | H | F | E | I | P | L | L | C | I | E | Y | V | Y | T | S | V | Y | T |
| OR14J1 | F | V | F | I | A | S | V | A | G | S | G | H | F | D | V | P | L | F | T | A | A | L | A | F | P | S | V | Y | T |
| OR5C1 | Y | M | F | A | A | D | C | C | G | S | A | H | F | D | I | P | L | I | C | I | Q | Y | L | Y | S | S | V | Y | T |
| OR7E24 | F | M | F | V | A | C | D | M | S | D | S | H | F | D | P | S | I | M | G | F | G | Y | G | Y | S | S | V | Y | T |
| OR1J4 | L | M | F | I | T | D | N | F | S | N | A | H | F | D | L | V | I | V | G | V | I | Y | I | Y | S | S | V | Y | T |