OR1A1

Olfactory Receptor family 1 subfamily A member 1.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MRENNQSSTL EFILLGVTGQ QEQEDFFYIL FLFIYPITLI GNLLIVLAIC SDVRLHNPMY FLLANLSLVD IFFSSVTIPK MLANHLLGSK SISFGGCLTQ 

       110        120        130        140        150        160        170        180        190        200 
MYFMIALGNT DSYILAAMAY DRAVAISRPL HYTTIMSPRS CIWLIAGSWV IGNANALPHT LLTASLSFCG NQEVANFYCD ITPLLKLSCS DIHFHVKMMY 

       210        220        230        240        250        260        270        280        290        300 
LGVGIFSVPL LCIIVSYIRV FSTVFQVPST KGVLKAFSTC GSHLTVVSLY YGTVMGTYFR PLTNYSLKDA VITVMYTAVT PMLNPFIYSL RNRDMKAALR 

       310 
KLFNKRISS

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

Q E Q Q     A L   G G F S     T L   H I D S       R   K L S Y  
 F D E   M K P I   T L C   L T H P   V H F   F Y T G   V A D   
L I Y F   T V S   F Y M Q   L A N   Y M M K   M V T   M V T I  
 F L F   S F F I   A I M   A N G I   V G L   G Y Y L   A T Y   
I P Y I   D V L   T N G L   V W S   S F I G   S V V   M P T V  
 I L T   S L N A   Y S D   G A I L   L P V   T L H S   P N L   
L L N G   L L F   A A L I   W I C   I I C L   G C T   S Y I F  
 L V I   Y M P N   Y A M   S R P S   Y S V   S F A K           
  C I A           V A R D           F V R I   L V G            
                   S I A             V T S   K T S P           
                        R                 F                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB

Odorant	EC₅₀	Adjusted Top	Aroma Notes
(S)-(+)-carvone	-8.54 ¹	9.6 ²	bready, caraway, minty, spicy
geraniol	-8 ³	9.7 ²	citrus, floral, fruity, rose, sweet, waxy
dihydrojasmone	-7.24 ²	9.8 ²	floral, fresh, herbal, jasmine, myrrh, outdoors, spicy, woody
(S)-(-)-citronellal	-6.66 ³	-	citrus, clean, herbal
hydroxycitronellal	-6.25 ³	-	floral, green, lily, melon, sweet, tropical, waxy
(R)-(-)-carvone	-6.15 ⁴	10 ⁵	herbal, minty, spearmint, sweet
(-)-carveol	-5.79 ⁶	-	minty, spearmint, cooling, green, herbal, caraway, spicy, weedy, plastic, earthy, mahogany
3-octanone	-5.4 ²	9.7 ²	fresh, herbal, lavender, mushroom, sweet
3-methyl-2,4-nonanedione	-5.16 ⁷	10 ⁸	burnt, caramellic, fruity, hay
3-heptanone	-5.29 ²	9.5 ²	fatty, fruity, green
allyl phenylacetate	-5.12 ²	9.7 ²	honey, fruity, rummy
benzophenone	-5 ⁹	9.6 ²	balsamic, rose, metallic, powdery, geranium, herbal, plastic, phenolic
1-octanol	-5.42 ³	-	aldehydic, green, mushroom, orange, rose, waxy
(S)-(-)-citronellol	-5.03 ³	9 ²	citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
2-heptanone	-4.4 ²	9.8 ²	banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
benzyl acetate	-5 ¹	8.7 ²	sweet, floral, fruity, jasmine, fresh
(+)-dihydrocarvone	-4.99 ²	8.7 ²	herbal, minty, mentholic
(Z)-3-hexen-1-ol	-4.05 ¹¹	10 ¹¹	fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
(R)-(+)-citronellol	-5.08 ⁶	-	citronella, floral, leafy, oily, petal, rose
(R)-3-mercapto-3-methylhexan-1-ol	-4.96 ¹²	8 ¹²	passionfruit, currant, blackcurrant, green, fruity
2-octanone	-4.37 ²	8.9 ²	earthy, herbal, natural, weedy, woody
helional	-6.59 ³	5 ⁶	cyclamen, fresh, green, hay, ozone, watery
heptanal	-6.49 ³	5 ⁶	aldehydic, cognac, fatty, fresh, green, herbal, ozone
4-chromanone	-3.34 ²	9.8 ²
allyl heptanoate	-3.32 ²	9.8 ²	sweet, pineapple, fruity, waxy, banana, fusel, cognac, ripe, fermented
2-phenylethanethiol	-4.72 ⁷	-	rubbery, sulfurous
(E)-anethole	-4.7 ⁷	-	sweet, anise, licorice, mimosa, medicinal, spicy
2-pentylpyridine	-4.67 ⁷	-	fatty, tallow, green, bell_pepper, mushroom, herbal
2-nonanone	-4.33 ⁷	8 ²	fresh, sweet, green, weedy, earthy, herbal, fruity, waxy, soapy, cheesy, coconut, dairy, dirty, buttery
estragole	-4.62 ⁷	-	sweet, sassafrass, anise, spicy, green, herbal, fennel, phenolic, minty
phenethyl acetate	-4.56 ⁷	-	floral, fruity, honey, rose, sweet, tropical
ethylphenyl acetate	-4.54 ⁷	-	anisic, balsamic, black, chocolate, cocoa, dark, floral, honey, licorice, rose, sweet
nonanethiol	-3.24 ²	9.3 ²
p-cresyl acetate	-3.4 ¹³	9 ¹³	narcissus, phenolic, animal
nonanal	-5.26 ³	6 ⁶	waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
gamma-nonalactone	-4.46 ⁷	-	buttery, coconut, creamy, oily, sweet, waxy
octanal	-6.41 ³	4 ⁶	aldehydic, citrus, fatty, green, orange, peel, waxy
ethyl caproate	-4.45 ⁷	-	banana, fruity, green, pineapple, sweet, waxy
octanethiol	-3.23 ²	9 ²	sulfurous
3-mercaptohexyl acetate	-4.42 ⁷	-	floral, fruity, pear, tropical, passionfruit, blackberry, raspberry, blackcurrant_bud
nerolidol	-	7 ⁶	floral, green, waxy, citrus, woody, fruity, melon
1-heptanol	-3.01 ²	9 ²	musty, leafy, violet, herbal, green, sweet, woody, peony, pungent, vegetable, fruity, apple, banana
1-octen-3-ol	-4.24 ⁷	-	mushroom
phenethyl alcohol	-4.3 ¹¹	6.6667 ¹¹	floral, rose, dried_rose, sweet, fresh, bready, honey
ethyl cyclohexanecarboxylate	-4.22 ⁷	-	cheesy, fruity, winey
4-decenal	-5.6 ³	4.5 ⁶	aldehydic, citrus, fatty, fresh, green, mandarin, orange, tangerine
1-decanol	-3.08 ²	8.5 ²	aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
musk ambrette	-2.71 ¹⁴	9.0299 ¹⁴	ambrette, musty, seedy, sweet
d-limonene	-4.73 ⁷	5.3333 ¹⁰	citrus, orange, fresh, sweet
ethyl 2-(3-bromophenyl)acetate	-4.8 ⁹	5 ⁹
methyl (2-methylphenyl)acetate	-4.8 ⁹	4.5833 ⁹
(E),(E)-2,4-decadienal	-	6 ⁶	oily, cucumber, melon, citrus, pumpkin, nutty, fatty, chicken, fried, chicken_fat, coriander, brothy
3-octen-2-one	-	6 ¹⁵	earthy, spicy, herbal, sweet, mushroom, hay, blueberry
l-limonene	-4.61 ⁷	4 ⁶	terpenic, pine, herbal, peppery
hexanal	-3.00 ¹⁶	6.5 ¹⁶	aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
3-methyl-2-hexenoic acid	-3.92 ¹²	4.6 ¹²	cheesy, fruity
citral	-5.79 ³	1 ¹⁰	sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
nerol	-	5 ⁶	citrus, floral, fresh, green, lemon, lime, magnolia, natural, neroli, spicy, sweet, waxy
strawberry glycidate 2	-5.0 ¹⁷	-	sweet, strawberry, berry, floral, tropical, honey, rose
(S)-3-mercapto-3-methylhexan-1-ol	-4.96 ¹²	1 ¹²	passionfruit, currant, blackcurrant, green, fruity
4-vinylguaiacol	-4.3 ¹⁸	2 ¹⁸	spicy, clove, carnation, phenolic, peppery, smoky, woody, powdery
(R)-(+)-citronellal	-	4 ⁶	citrus, fresh, herbal
decanal	-	4 ⁶	sweet, aldehydic, waxy, orange_peel, citrus, floral
quinoline	-	3.6667 ¹⁰	earthy, medicinal, musty, rubbery, tobacco
celestolide	-	3.2 ¹⁹	ambergris, animal, cedar, musk, woody
linalool	-3.4 ²⁰	0.7059 ²⁰	blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
para-anisaldehyde	-3.3 ²⁰	0.8235 ²⁰	sweet, powdery, mimosa, floral, hawthorn, balsamic, vanilla, anise, woody, coumarinic, creamy, spicy
oranger crystals	-3.3 ²⁰	0.8235 ²⁰	sweet, neroli, orangeflower, powdery, honey, floral, orange, naphthyl, citrus
caproic acid	-1.67 ²¹	3.3333 ²¹	cheesy, fatty, sour, sweaty
1-octen-3-one	-	3 ⁶	earthy, metallic, mushroom
musk tibetene	-2.45 ¹⁴	1.9403 ¹⁴	fatty, musk, powdery, sweet
musk xylene	-	2.6119 ¹⁴	dry, fatty, musk, soapy, sweet
cosmone	-	2 ¹⁹	ambergris, animal, anisic, cloth, fatty, laundered, musk, powdery, woody
isobutyric acid	-	(agonist) ²²	acidic, buttery, cheesy, dairy, rancid, sour
isovaleric acid	-	(agonist) ²²	cheesy, sour, sweaty, tropical
muscenone	-	0.8 ¹⁹	animal, musk, soapy
musk ketone	-	0.4 ¹⁹	dry, fatty, floral, musk, powdery, soapy
acetophenone	-	0 ²	sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
allylbenzene	-	0 ²
ambrettolide	-	0 ¹⁹	sweet, soapy, musk, amber, fruity, berry
butyl butyryl lactate	-	0 ²	creamy, buttery, buttermilk, dairy, cheesy, fatty, waxy, sweaty, green
(-)-camphor	-	0 ²
camphor	-	0 ²	camphoraceous
capric acid	-	0 ²	citrus, fatty, rancid, sour
gamma-caprolactone	-	0 ²	herbal, coconut, sweet, coumarinic, tobacco, creamy, lactonic, green
caprylic acid	-	0 ²	cheesy, fatty, oily, rancid, vegetable, waxy
cashmeran	-	0 ¹⁹	spicy, musk, woody, clean
cinnamyl acetate	-	0 ⁷	sweet, floral, spicy, balsamic, cinnamon
citralva	-	0 ⁶	aldehydic, citrus, lemon, metallic
citronellic acid	-	0 ⁶	green, grassy, smoky, fatty, floral, waxy, citronella, vegetable, tobacco
coffee difuran	-	0 ¹⁰	cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
2-coumaranone	-	0 ²
coumarin	-	0 ¹⁰	coumarinic, hay, sweet, tonka
p-cresol	-	0 ¹³	phenolic, narcissus, animal, mimosa
cyclodecanone	-	0 ¹⁹
cyclohexanone	-	0 ²	acetone, minty
cyclopentadecane	-	0 ¹⁹
cyclopentadecanol	-	0 ¹⁹	musk
cyclopentadecanone	-	0 ¹⁹	animal, greasy, musk, natural, powdery
cycloundecanone	-	0 ¹⁹
ethyl isobutyrate	-	0 ²	alcoholic, ethereal, fruity, fusel, rummy, sweet
ethylene brassylate	-	0 ¹⁹	ambrette, floral, musk, powdery, sweet, woody
eugenol	-	0 ¹⁰	clove, spicy, sweet, woody
eugenyl acetate	-	0 ¹⁰	carnation, clove, floral, fresh, malty, spicy, sweet, woody
fenchone	-	0 ²	camphoraceous, earthy, herbal, woody
galaxolide	-	0 ¹⁹	floral, musk, sweet
globanone	-	0 ¹⁹	animal, balsamic, cloth, dry, floral, laundered, musk, tobacco, waxy
habanolide	-	0 ¹⁹	animal, cloth, dry, laundered, metallic, musk, powdery, sweet, tropical, waxy
helvetolide	-	0 ¹⁹	musk, ambrette, fruity, pear, woody, floral
2-heptanol	-	0 ⁷	floral, fresh, fruity, green, herbal, lemongrass, sweet, coconut, dill
(E)-2-heptenal	-	0 ⁷	pungent, green, vegetable, fresh, fatty
2,3-hexanedione	-	0 ²	buttery, sweet
3,4-hexanedione	-	0 ²	almond, buttery, caramellic, nutty, toasted
hexanol	-	0 ²	ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
2-hexanone	-	0 ²	ethereal
hexyl acetate	-	0 ²	apple, banana, fruity, green, sweet
4-hydroxycoumarin	-	0 ²
alpha-ionone	-	0 ⁶	sweet, woody, floral, violet, orris, tropical, fruity
isoamyl acetate	-	0 ⁷	banana, fruity, solvent, sweet
(1S,2R,5S)-(+)-menthol	-	0 ¹⁰	cooling, mentholic, minty
4-methyl acetophenone	-	0 ⁷	hawthorn, sweet, mimosa, coumarinic, cherry, acacia
methyl cinnamate	-	0 ⁷	balsamic, cherry, strawberry, sweet
methyl eugenol	-	0 ¹⁰	carnation, cinnamon, clove, fresh, spicy, sweet, warm
methyl furfuryl disulfide	-	0 ¹⁰	sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
3-methylcyclotetradecanone	-	0 ¹⁹
muscone	-	0 ¹⁹	musk, animal, powdery
1-nonanol	-	0 ¹⁰	aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
gamma-octalactone	-	0 ⁷	sweet, coconut, waxy, creamy, tonka, dairy, fatty
oenanthic acid	-	0 ²	rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
oxacyclohexan-2-one	-	0 ¹⁹
p,alpha-dimethylstyrene	-	0 ⁷	clove, guaiacol, phenolic, spicy, styrene
2-pentadecanone	-	0 ¹⁹	burnt, celery, fatty, fresh, jasmine, oily, waxy
8-pentadecanone	-	0 ¹⁹
2-pentanone	-	0 ²	sweet, fruity, ethereal, winey, banana, woody, fermented
phenyl acetate	-	0 ²	phenolic, medicinal, animal, resinous, castoreum, woody, smoky, burnt
(+)-2-phenylbutyric acid	-	0 ²
prenyl acetate	-	0 ²	sweet, fresh, banana, fruity, jasmine, ripe, heliotrope, balsamic
sotolone	-	0 ¹⁰	sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
tonalide	-	0 ¹⁹	amber, ambrette, fruity, musk, powdery, sweet
trimethylamine	-	0 ⁶	ammonia, fishy, prawn
valeric acid	-	0 ²	acidic, cheesy, fruity, milky, sharp, sour, tobacco
vanillic acid	-	0 ²	beany, brown, creamy, dairy, milky, phenolic, powdery, sweet, vanilla
velvione	-	0 ¹⁹	dry, powdery, musk, amber, civet
lyral	-	-0.5 ¹⁰	aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
pelargonic acid	-	-1 ¹⁰	cheesy, dairy, dirty, waxy
amyl hexanoate	-	-1.1667 ¹⁰	sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
dimethyl disulfide	-	-1.1667 ¹⁰	sulfurous, vegetable, cabbage, onion, malty, creamy
geranyl acetate	-	-1.1667 ¹⁰	floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
terpinyl acetate	-	-1.2 ¹⁰	bergamot, citrus, herbal, lavender, lime
propionic acid	-	-1.2333 ¹⁰	acidic, cheesy, pungent, vinegar
butyric acid	-	-1.2667 ¹⁰	sharp, acetic, cheesy, buttery, fruity, dairy, creamy
2,4-DNT	-	-1.2667 ¹⁰
butyl formate	-	-1.3 ¹⁰	fruity, plum, rummy, brandy
beta-damascone	-	-1.3333 ¹⁰	berry, currant, floral, fruity, honey, plum, rose, tobacco
methyl salicylate	-	-1.3333 ¹⁰	minty, wintergreen
octyl octanoate	-	-1.3333 ¹⁰	coconut, oily, fruity
androstenone	-	-1.4333 ¹⁰	animal, musky
isobutylamine	-	-1.5 ¹⁰	cheesy, fishy
l-arabinose	-	-1.5667 ¹⁰
ethyl vanillin	-	-1.5667 ¹⁰	sweet, creamy, vanilla, caramellic
propanal	-	-1.5667 ¹⁰	alcoholic, cocoa, earthy, nutty, whiskey, winey
pyrazine	-	-1.5667 ¹⁰	pungent, sweet, corn, roasted, hazelnut, barley
1,10-phenanthroline	-3.9 ⁹	-1.6667 ⁹
n-amyl alcohol	-	-1.6667 ¹⁰	fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
benzene	-	-1.6667 ¹⁰	gasoline, phenolic, solvent, cinnamon
2-ethyl fenchol	-	-1.6667 ¹⁰	camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea

1.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

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5.) Geithe C, Protze J, Kreuchwig F, Krause G, Krautwurst D. Structural determinants of a conserved enantiomer-selective carvone binding pocket in the human odorant receptor OR1A1. Cell Mol Life Sci. 2017 Nov;74(22):4209-4229. doi: 10.1007/s00018-017-2576-z. Epub 2017 Jun 27. PMID: 28656349.

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15.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147

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18.) Aya Namba, Naoko Saito, Keiichi Yoshikawa, Ichiro Mori (2015) Search method of urine odor suppressor JP2015211667A

19.) Ligand Specificity and Evolution of Mammalian Musk Odor Receptors: Effect of Single Receptor Deletion on Odor Detection Narumi Sato-Akuhara, Nao Horio, Aya Kato-Namba, Keiichi Yoshikawa, Yoshihito Niimura, Sayoko Ihara, Mika Shirasu, Kazushige Touhara Journal of Neuroscience 20 April 2016, 36 (16) 4482-4491; DOI: 10.1523/JNEUROSCI.3259-15.2016

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21.) C. Trimmer, A. Keller, N. R. Murphy, L. L. Snyder, J. R. Willer, M. H. Nagai, N. Katsanis, L. B. Vosshall, H. Matsunami, and J. D. Mainland Genetic variation across the human olfactory receptor repertoire alters odor perception PNAS | May 7, 2019 | vol. 116 | no. 19 | 9475–9480

22.) Huiwen Ren, Ruijing Zhang, Haibo Zhang, Che Bian. Ecnomotopic olfactory receptors in metabolic regulation. Biomedicine & Pharmacotherapy 179 (2024) 117403

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primaryodors.org

Olfactory Receptor family 1 subfamily A member 1.

Sequence:

Transmembrane Helices: