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Olfactory Receptor family 2 subfamily J member 3.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MNDDGKVNAS SEGYFILVGF SNWPHLEVVI FVVVLIFYLM TLIGNLFIII LSYLDSHLHT PMYFFLSNLS FLDLCYTTSS IPQLLVNLWG PEKTISYAGC 

       110        120        130        140        150        160        170        180        190        200 
MIQLYFVLAL GTTECVLLVV MSYDRYAAVC RPLHYTVLMH PRFCHLLAVA SWVSGFTNSA LHSSFTFWVP LCGHRQVDHF FCEVPALLRL SCVDTHVNEL 

       210        220        230        240        250        260        270        280        290        300 
TLMITSSIFV LIPLILILTS YGAIVRAVLR MQSTTGLQKV FGTCGAHLMA VSLFFIPAMC IYLQPPSGNS QDQGKFIALF YTVVTPSLNP LIYTLRNKVV 

       310        320 
RGAVKRLMGW E

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

L H P W   N V L   G A Y S       F   V H T D       Q   Q D Q S  
 V V E   L Q P I   I M C   S S H L   L E N   L Y I C   F K G   
V V F I   S S T   F Y L Q   A S N   I M L T   M A P   F L A I  
 I L V   T Y C L   A L V   T F G S   S S T   I F F L   V T Y   
M L Y F   D L F   T T G L   V W S   L V F I   S V A   S P T V  
 I L T   S L N S   V C E   A V A L   L P I   M L H A   P N L   
F L N G   L F F   V V L L   L H C   L I L I   G C T   T Y I L  
 I I I   Y M P T   Y S M   F R P H   Y S T   G F V K       L   
  Y S L           A Y R D           V I A G   Q L G            
                   C V A             V A R   T T S Q           
                        R               R L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB 2
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
(Z)-3-hexen-1-ol -5.61 1 10 2  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
geranyl acetate -4.71 1 -  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
cinnamaldehyde -6 3 2 4  sweet, spicy, candy, cinnamon, warm
musk xylene - 5.4 5  dry, fatty, musk, soapy, sweet
citral - 4.8667 6  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
(S)-3-mercapto-3-methylhexan-1-ol -4.82 7 1.5 7  passionfruit, currant, blackcurrant, green, fruity
n-amyl acetate -5.44 3 0.3362 3  banana, fruity, solvent, sweet, apple, ethereal, pear
(R)-3-mercapto-3-methylhexan-1-ol -5.22 7 0.4 7  passionfruit, currant, blackcurrant, green, fruity
oranger crystals -4.7 8 0.1889 8  sweet, neroli, orangeflower, powdery, honey, floral, orange, naphthyl, citrus
para-anisaldehyde -3.3 9 0.8824 9  sweet, powdery, mimosa, floral, hawthorn, balsamic, vanilla, anise, woody, coumarinic, creamy, spicy
3-octen-2-one - 3 10  earthy, spicy, herbal, sweet, mushroom, hay, blueberry
1-octanol - 2.5667 6  aldehydic, green, mushroom, orange, rose, waxy
methyl eugenol - 1.9 6  carnation, cinnamon, clove, fresh, spicy, sweet, warm
coumarin - 1.8333 6  coumarinic, hay, sweet, tonka
2,4-DNT - 1.6333 6  
helional - 1.3333 6  cyclamen, fresh, green, hay, ozone, watery
velvione - 1.2 5  dry, powdery, musk, amber, civet
cyclopentadecanol - 1 5  musk
celestolide - 0.4 5  ambergris, animal, cedar, musk, woody
ethylene brassylate - 0.4 5  ambrette, floral, musk, powdery, sweet, woody
exaltolide - 0.4 5  animal, fruity, musk, natural, powdery
allyl phenylacetate - 0 6  honey, fruity, rummy
ambrettolide - 0 5  sweet, soapy, musk, amber, fruity, berry
amyl hexanoate - 0 6  sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
androstenone - 0 6  animal, musky
l-arabinose - 0 6  
benzene - 0 6  
butyl formate - 0 6  fruity, plum, rummy, brandy
butyric acid - 0 6  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
(S)-(+)-carvone - 0 6  bready, caraway, minty, spicy
cashmeran - 0 5  spicy, musk, woody, clean
coffee difuran - 0 6  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
cosmone - 0 5  ambergris, animal, anisic, cloth, fatty, laundered, musk, powdery, woody
cyclodecanone - 0 5  
cyclohexanone - 0 5  acetone, minty
cyclopentadecane - 0 5  
cyclopentadecanone - 0 5  animal, greasy, musk, natural, powdery
cycloundecanone - 0 5  
beta-damascone - 0 6  berry, currant, floral, fruity, honey, plum, rose, tobacco
decanal - 0 6  sweet, aldehydic, waxy, orange_peel, citrus, floral
dimethyl disulfide - 0 6  sulfurous, vegetable, cabbage, onion, malty, creamy
2-ethyl fenchol - 0 6  camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl vanillin - 0 6  sweet, creamy, vanilla, caramellic
eugenol - 0 6  clove, spicy, sweet, woody
eugenyl acetate - 0 6  carnation, clove, floral, fresh, malty, spicy, sweet, woody
galaxolide - 0 5  floral, musk, sweet
globanone - 0 5  animal, balsamic, cloth, dry, floral, laundered, musk, tobacco, waxy
habanolide - 0 5  animal, cloth, dry, laundered, metallic, musk, powdery, sweet, tropical, waxy
helvetolide - 0 5  musk, ambrette, fruity, pear, woody, floral
2-heptanone - 0 6  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
isobutylamine - 0 6  cheesy, fishy
d-limonene - 0 6  citrus, orange, fresh, sweet
linalool - 0 6  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
lyral - 0 6  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
(1S,2R,5S)-(+)-menthol - 0 6  cooling, mentholic, minty
methyl furfuryl disulfide - 0 6  sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
methyl salicylate - 0 6  minty, wintergreen
3-methylcyclotetradecanone - 0 5  
muscenone - 0 5  animal, musk, soapy
muscone - 0 5  musk, animal, powdery
musk ketone - 0 5  dry, fatty, floral, musk, powdery, soapy
nonanal - 0 6  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
1-nonanol - 0 6  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
octanethiol - 0 6  sulfurous
octyl octanoate - 0 6  coconut, oily, fruity
oxacyclohexan-2-one - 0 5  
pelargonic acid - 0 6  cheesy, dairy, dirty, waxy
2-pentadecanone - 0 5  burnt, celery, fatty, fresh, jasmine, oily, waxy
8-pentadecanone - 0 5  
pentanol - 0 6  fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
propanal - 0 6  alcoholic, cocoa, earthy, nutty, whiskey, winey
propionic acid - 0 6  acidic, cheesy, pungent, vinegar
pyrazine - 0 6  pungent, sweet, corn, roasted, hazelnut, barley
quinoline - 0 6  earthy, medicinal, musty, rubbery, tobacco
sotolone - 0 6  sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
terpinyl acetate - 0 6  bergamot, citrus, herbal, lavender, lime
tonalide - 0 5  amber, ambrette, fruity, musk, powdery, sweet

1.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

2.) Jeremy F. McRae, Joel D. Mainland, Sara R. Jaeger, Kaylin A. Adipietro, Hiroaki Matsunami, and Richard D. Newcomb Genetic Variation in the Odorant Receptor OR2J3 Is Associated with the Ability to Detect the "Grassy" Smelling Odor, cis-3-hexen-1-ol Chem. Senses 37: 585–593, 2012 doi:10.1093/chemse/bjs049

3.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

4.) Fukutani, Y., Koshizawa, T., & Yohda, M. (2021). Application of Vapor Phase Stimulation Method for Screening of Human Odorant Receptors Responding to Cinnamaldehyde. Sensors and Materials, 33(12), 4203-4210.

5.) Ligand Specificity and Evolution of Mammalian Musk Odor Receptors: Effect of Single Receptor Deletion on Odor Detection Narumi Sato-Akuhara, Nao Horio, Aya Kato-Namba, Keiichi Yoshikawa, Yoshihito Niimura, Sayoko Ihara, Mika Shirasu, Kazushige Touhara Journal of Neuroscience 20 April 2016, 36 (16) 4482-4491; DOI: 10.1523/JNEUROSCI.3259-15.2016

6.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

7.) Aya Kato, Naoko Saito (2018) Search method for odor control agent JP6422665B2

8.) Saito N, Yamano E, Ishii A, Tanaka M, Nakamura J, et al. (2018) Involvement of the olfactory system in the induction of anti-fatigue effects by odorants. PLOS ONE 13(3): e0195263. https://doi.org/10.1371/journal.pone.0195263

9.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.

10.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147
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