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Olfactory Receptor family 5 subfamily K member 1.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MAEENHTMKN EFILTGFTDH PELKTLLFVV FFAIYLITVV GNISLVALIF THRRLHTPMY IFLGNLALVD SCCACAITPK MLENFFSENK RISLYECAVQ 

       110        120        130        140        150        160        170        180        190        200 
FYFLCTVETA DCFLLAAMAY DRYVAICNPL QYHIMMSKKL CIQMTTGAFI AGNLHSMIHV GLVFRLVFCG SNHINHFYCD ILPLYRLSCV DPYINELVLF 

       210        220        230        240        250        260        270        280        290        300 
IFSGSVQVFT IGSVLISYLY ILLTIFKMKS KEGRAKAFST CASHFLSVSL FYGSLFFMYV RPNLLEEGDK DIPAAILFTI VVPLLNPFIY SLRNREVISV 

       310 
LRKILMKK

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

L E P H        F  E Y L S       L   I Y P D     P R   K D G E  
 L T K    N E L    V A C   G V H I   L E N   V Y M F   P I D   
V V F L  M K P T  F Y F Q   M S H   I F L V   F L S   L I A A  
 A F F    I A C    T C L   L N G A   G S F   G Y F L   I T F   
I L Y I  A C C S  A T E V   I F A   V Q V S   S V S   L P V V  
 V V T    D V L    F C D   G T T M   I T F   L F H S   P N L   
S I N G  A L N G  A A L L   Q I C   L V S G   A C T   S Y I F  
 A V L    L F I    Y A M   L K K S   Y S I   S F A K       L   
  F I L  Y M P T  V Y R D           L I Y L   A R G            
                   C I A             I T L   E K S K           
                        N               K F                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
trimethylthiazoline -9 1 -  chocolate, cocoa, coffee, hazelnut, musty, nutty, vegetable
hazelnut pyrazine -6.9 2 10 3  earthy, green, hazelnut, meaty, musty, nutty, potato, roasted, toasted, vegetable
2-methoxy-3,5-dimethylpyrazine -7.7 2 8.2906 4  earthy
2-ethyl-3,5-dimethylpyrazine -5.6 2 10 4  almond, burnt, caramellic, cocoa, coffee, musty, nutty, peanut, roasted
2-ethyl-3,6-dimethylpyrazine -5.83 5 -  
earthy pyrazine -5.01 5 9.7436 4  raw_potato, earthy, green, bell_pepper, nutty
shoyu pyrazine -5.03 5 9.6581 4  nutty, pepper, raw
2,3,5-trimethylpyrazine -5 2 9.4017 4  nutty, nut_skin, earthy, powdery, cocoa, potato, baked_potato, peanut, roasted_peanut, hazelnut, musty
2,6-dimethylpyrazine -4.4 6 10 6  ethereal, cocoa, nutty, roasted, meaty, roasted_meaty, beefy, brown, coffee, buttermilk
almond pyrazine -5.2 2 8.4615 4  roasted, almond, hazelnut, peanut
bean pyrazine -6 4 7.094 4  green_pea, earthy, beany, chocolate, nutty
furaneol -3.9 7 10 7  sweet, cotton_candy, caramellic, strawberry, brown_sugar
2-acetyl-3,5-dimethyl pyrazine -4.3 4 8.9744 4  nutty, hazelnut, roasted_hazelnut
2-methylthio-3-methylpyrazine -5 2 7.6923 4  roasted, meaty, nutty, almond, vegetable
methyl eugenol -8.22 8 1.9333 9  carnation, cinnamon, clove, fresh, spicy, sweet, warm
2,4-lutidine -4.6 4 7.1795 4  smoky, phenolic
galbanum pyrazine -5.5 4 5.641 4  green_pea, bell_pepper, green, galbanum
6-methyl quinoline -4.7 4 6.4103 4  leathery, tonka, castoreum, tobacco, civet, fecal
2-acetyl-3-ethylpyrazine -4.28 5 -  earthy, potato_chip, nutty, popcorn, corn
2-acetyl-3-methylpyrazine -4.27 5 -  nutty, nut_flesh, hazelnut, roasted_hazelnut, grain, toasted_grain, corn_chip, vegetable, nut_skin, caramellic
filbert pyrazine -4.27 5 6.6667 4  nutty, peanut, musty, corn, raw, earthy, bready
2,5-lutidine -4.5 4 6.2393 4  roasted, green, earthy
methyl isoeugenol -5.05 10 4.5299 4  spicy, clove, floral, carnation, woody
2,5-dimethyl pyrazine -3.9 4 5.9829 4  cocoa, nutty, roasted, beefy, woody, grassy, medicinal
2,5-dihydro-2,4,5-trimethylthiazoline -3.8 3 -  
3-ethyl pyridine -4.5 4 4.8718 4  tobacco, oakmoss, leathery, caramellic, roasted, hazelnut
2-ethyl pyridine -4.2 4 5.2991 4  green, grassy
2-sec-butyl-3-methoxypyrazine -4.8 4 3.5897 4  musty, green, pea, galbanum, bell, pepper
2,3,5-trimethylpyridine -4.1 4 3.4188 4  
2-isobutylthiazole -4.5 4 2.735 4  green, wasabi, privet, tomato, leaf, earthy, vegetable, metallic
2-isobutyl-3-methylpyrazine -3.4 4 3.4188 4  herbal, green, sugar
indole -4.7 11 0.122 11  animal, fecal, floral, naphthyl
4-vinylguaiacol -4.3 12 0.6667 12  spicy, clove, carnation, phenolic, peppery, smoky, woody, powdery
skatole -4.4 11 0.4878 11  animal, civet, fecal, naphthyl
(R)-(-)-carvone -3.6 13 0.2353 13  herbal, minty, spearmint, sweet
para-anisaldehyde -3.3 13 0.2941 13  sweet, powdery, mimosa, floral, hawthorn, balsamic, vanilla, anise, woody, coumarinic, creamy, spicy
diacetyl -1.6 1 1.5096 1  buttery, caramellic, creamy, pungent, sweet
quinoline - 1.6667 9  earthy, medicinal, musty, rubbery, tobacco
methoxyfuraneol - 1.5 3  sweet, moldy, mushroom, vegetable, potato, burnt, sugar, nut, skin, wasabi, caramellic, fruity, brandy
d-limonene - 0.7 9  citrus, orange, fresh, sweet
citral - 0.5 9  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
eugenol - 0.2667 9  clove, spicy, sweet, woody
lyral - 0.2333 9  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
beta-damascone - 0.2267 9  berry, currant, floral, fruity, honey, plum, rose, tobacco
benzene - 0.2167 9  
propanal - 0.1667 9  alcoholic, cocoa, earthy, nutty, whiskey, winey
2-heptanone - 0.1333 9  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
nonanal - 0.1333 9  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
allyl phenylacetate - 0 9  honey, fruity, rummy
amyl hexanoate - 0 9  sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
androstenone - 0 9  animal, musky
l-arabinose - 0 9  
butyl formate - 0 9  fruity, plum, rummy, brandy
butyric acid - 0 9  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
(S)-(+)-carvone - 0 9  bready, caraway, minty, spicy
coffee difuran - 0 9  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
coumarin - 0 9  coumarinic, hay, sweet, tonka
decanal - 0 9  sweet, aldehydic, waxy, orange_peel, citrus, floral
dimethyl disulfide - 0 9  sulfurous, vegetable, cabbage, onion, malty, creamy
2,4-DNT - 0 9  
2-ethyl fenchol - 0 9  camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl vanillin - 0 9  sweet, creamy, vanilla, caramellic
o-ethyltoluene - 0 2  
eugenyl acetate - 0 9  carnation, clove, floral, fresh, malty, spicy, sweet, woody
geranyl acetate - 0 9  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
helional - 0 9  cyclamen, fresh, green, hay, ozone, watery
(Z)-3-hexen-1-ol - 0 9  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
isobutylamine - 0 9  cheesy, fishy
linalool - 0 9  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
(1S,2R,5S)-(+)-menthol - 0 9  cooling, mentholic, minty
methyl furfuryl disulfide - 0 9  sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
methyl salicylate - 0 9  minty, wintergreen
1-nonanol - 0 9  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
octanethiol - 0 9  sulfurous
1-octanol - 0 9  aldehydic, green, mushroom, orange, rose, waxy
3-octen-2-one - 0 14 Yearthy, spicy, herbal, sweet, mushroom, hay, blueberry
octyl octanoate - 0 9  coconut, oily, fruity
pelargonic acid - 0 9  cheesy, dairy, dirty, waxy
pentanol - 0 9  fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
propionic acid - 0 9  acidic, cheesy, pungent, vinegar
pyrazine - 0 9  pungent, sweet, corn, roasted, hazelnut, barley
sotolone - 0 9  sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
terpinyl acetate - 0 9  bergamot, citrus, herbal, lavender, lime
1,2,4-trimethylbenzene - 0 2  
allyl cyclohexylpropionate - -0.1626 11  sweet, pineapple, tropical, fruity, candy, waxy, apple, green
alpha,alpha-dimethyl phenethyl acetate - -0.1626 11  sweet, floral, fruity, rose, green, pear, berry, jasmin, powdery
ambroxide - -0.1626 11  dry, amber, ambergris, paper, musk, woody, cedar, pine, green, seedy
citronellal - -0.1626 11  sweet, dry, floral, herbal, waxy, aldehydic, citrus
citronellyl acetate - -0.1626 11  floral, green, rose, fruity, citrus, woody, fruit, tropical_fruit
2-cyclohexylpropanal - -0.1626 11  natural, fresh, green, dusty, fruity
delta-damascone - -0.1626 11  fruity, sweet, rose, natural, petal, currant_bud, black_currant_bud, tobacco
geraniol - -0.1626 11  citrus, floral, fruity, rose, sweet, waxy
grapefruit pentanol - -0.1626 11  vetiver, green, citrus, grapefruit, rhubarb, floral
(Z)-3-hexenyl salicylate - -0.1626 11  floral, green, metallic, herbal, balsamic
lilial - -0.1626 11  floral, muguet, watery, green, powdery, cumin
melafleur - -0.1626 11  floral, clean, muguet, ozone, marine, sandy, balsamic
perillic aldehyde - -0.1626 11  fresh, green, herbal, grassy, sweet, minty, cumin, spicy, citrus
strawberry glycidate - -0.1626 11  cherry, fruity, grape, jammy, phenolic, strawberry, sweet
verdyl acetate - -0.1626 11  floral, green, soapy, cedar, pine, woody
amber butanol - -0.3143 6  woody, amber, ambrette
(5E)-3-methylcyclopenta-5-decen-1-one - -0.3571 6  
alpha-hexyl cinnamaldehyde - -0.3857 6  fresh, floral, green, jasmine, herbal, waxy
fruity carboxylate - -0.4 6  sweet, fruity, rummy, candy, floral, ripe
beta-ionone - -0.4 6  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
gamma-undecalactone - -0.4 6  fruity, peach, creamy, fatty, lactonic, apricot, ketonic, coconut
bourgeonal - -0.4065 11  fresh, watery, floral, cyclamen, sweet
civetone - -0.4065 11  clean, musk, dry, animal, sweet
ethyl linalyl ether - -0.4065 11  floral
exaltolide - -0.4065 11  animal, fruity, musk, natural, powdery
galbascone - -0.4065 11  fresh, green, galbanum, earthy, weedy, pineapple, narcissus, hyacinth, fruity
7-methoxycitronellal - -0.4065 11  fresh, melon, floral, lily, sweet
methyl ionone gamma - -0.4065 11  violet, sweet, orris, powdery, floral, woody
3-(3-propen-2-yl phenyl) butanal - -0.4065 11  ozone, cortex, green, floral, melon
spicy carbonate - -0.4065 11  spicy, woody, floral, green, herbal
tetrahydrogeraniol - -0.4065 11  leathery, musty, plastic, rose, sweet
oranger crystals - -0.4571 6  sweet, neroli, orangeflower, powdery, honey, floral, orange, naphthyl, citrus
santaliff - -0.4571 6  sandalwood, creamy, woody, milky, waxy, greasy, musk
violet decenol - -0.5286 6  green, oily, violet, lily, seedy, fruity, kiwi
alpha-isomethyl ionone - -0.5714 6  orris, woody, floral, dried, fruit, violet, jammy, powdery, tea
ebanol - -0.6504 11  sandalwood, woody, musk
galaxolide - -0.6504 11  floral, musk, sweet
(R,S)-methyl cedryl ketone - -0.6504 11  woody, vetiver, amber, leathery, musk, cedar
patchouli hexanol - -0.6504 11  woody, musty, patchouli, camphoreous, minty, leathery
thymol - -0.6504 11  camphoraceous, herbal, medicinal, phenolic, thyme
triplal - -0.6714 6  green, aldehydic, leafy, cortex, tart, floral, peely
habanolide - -8.6957 7  animal, cloth, dry, laundered, metallic, musk, powdery, sweet, tropical, waxy
tonalide - -8.6957 7  amber, ambrette, fruity, musk, powdery, sweet
ambrettolide - -10 7  sweet, soapy, musk, amber, fruity, berry
muscone - -13.0435 7  musk, animal, powdery
cedryl acetate - -15.6522 7  dry, woody, cedar, powdery

1.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

2.) Chatelain P., Wilkin F., Veithen A., Philippeau M., Noiset O., Quesnel Y. Sensorial Chemistry: Functional characterization and structure-activity relationship understanding of OR5K1 and OR2AG1 allow to design and synthetize new selective compounds. Chem. Senses. 2017;42:e28.

3.) Marcinek, Patrick, et al. "An evolutionary conserved olfactory receptor for foodborne and semiochemical alkylpyrazines." The FASEB Journal 35.6 (2021): e21638.

4.) Françoise, W., Philippeau, M., Veithen, A., Chatelain, P., & Quesnel, Y. (2016, May). Functional characterization of human olfactory receptors responding to pyrazine odorants. In CHEMICAL SENSES (Vol. 41, No. 4, pp. 433-434). GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND: OXFORD UNIV PRESS.

5.) Alessandro Nicoli, Franziska Haag, Patrick Marcinek, Ruiming He, Johanna Kreißl, Jörg Stein, Alessandro Marchetto, Andreas Dunkel, Thomas Hofmann, Dietmar Krautwurst, Antonella Di Pizio Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1. bioRxiv 2022.06.01.494157; doi: https://doi.org/10.1101/2022.06.01.494157

6.) Aya Kato, Naoko Saito, Michiaki Inoue, Kayoko Nomizu (2015) Method of identifying an agent for inhibiting odor of pyrazine derivatives US9057090B2

7.) Aya Namba, Naoko Saito, Michiaki Inoue, Go Toriyabe (2018) Search method of odor control agent by furaneol JP6276555B2

8.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

9.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

10.) Saito N, Yamano E, Ishii A, Tanaka M, Nakamura J, et al. (2018) Involvement of the olfactory system in the induction of anti-fatigue effects by odorants. PLOS ONE 13(3): e0195263. https://doi.org/10.1371/journal.pone.0195263

11.) Aya Kato, Naoko Saito (2015) Odor control agent. JP5798382B2

12.) Aya Namba, Naoko Saito, Keiichi Yoshikawa, Ichiro Mori (2015) Search method of urine odor suppressor JP2015211667A

13.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.

14.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147
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