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Olfactory Receptor family 5 subfamily K member 1.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MAEENHTMKN EFILTGFTDH PELKTLLFVV FFAIYLITVV GNISLVALIF THRRLHTPMY IFLGNLALVD SCCACAITPK MLENFFSENK RISLYECAVQ 

       110        120        130        140        150        160        170        180        190        200 
FYFLCTVETA DCFLLAAMAY DRYVAICNPL QYHIMMSKKL CIQMTTGAFI AGNLHSMIHV GLVFRLVFCG SNHINHFYCD ILPLYRLSCV DPYINELVLF 

       210        220        230        240        250        260        270        280        290        300 
IFSGSVQVFT IGSVLISYLY ILLTIFKMKS KEGRAKAFST CASHFLSVSL FYGSLFFMYV RPNLLEEGDK DIPAAILFTI VVPLLNPFIY SLRNREVISV 

       310 
LRKILMKK

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

K D G E     P R   I Y P D     V L   I R K N      F F  L E P H  
 P I D   V Y M F   L E N   G V H I   Y L S    N E L    L T K   
L I A A   F L S   I F L V   M S H   V A C E  M K P T  V V F L  
 I T F   G Y F L   G S F   L N G A   Y F Q    I A C    A F F   
L P V V   S V S   V Q V S   I F A   T C L F  A C C S  I L Y I  
 P N L   L F H S   I T F   G T T M   T E V    D V L    V V T   
    I F   A C T   L V S G   Q I C   F C D A  A L N G  S I N G  
         S F A K   Y S I   L K K S   A L L    L F I    A V L   
          A R G   L I Y L           Y A M A  Y M P T  T F I L  
         E K S K   I T L             Y R D                 H   
                    M K F           C I A V                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
hazelnut pyrazine -6.9 1 10 1  earthy, green, hazelnut, meaty, musty, nutty, potato, roasted, toasted, vegetable
2-methoxy-3,5-dimethylpyrazine -7.7 1 8.2906 1  earthy
2-ethyl-3,5-dimethylpyrazine -5.6 1 10 1  almond, burnt, caramellic, cocoa, coffee, musty, nutty, peanut, roasted
earthy pyrazine -5.01 1 9.7436 1  raw_potato, earthy, green, bell_pepper, nutty
shoyu pyrazine -5.03 1 9.6581 1  nutty, pepper, raw
2,3,5-trimethylpyrazine -5 1 9.4017 1  nutty, nut_skin, earthy, powdery, cocoa, potato, baked_potato, peanut, roasted_peanut, hazelnut, musty
2,6-dimethylpyrazine -4.4 2 10 2  ethereal, cocoa, nutty, roasted, meaty, roasted_meaty, beefy, brown, coffee, buttermilk
almond pyrazine -5.2 1 8.4615 1  roasted, almond, hazelnut, peanut
bean pyrazine -6 1 7.094 1  green_pea, earthy, beany, chocolate, nutty
furaneol -3.9 3 10 3  sweet, cotton_candy, caramellic, strawberry, brown_sugar
2-acetyl-3,5-dimethyl pyrazine -4.3 1 8.9744 1  nutty, hazelnut, roasted_hazelnut
2-methylthio-3-methylpyrazine -5 1 7.6923 1  roasted, meaty, nutty, almond, vegetable
trimethylthiazoline -9 4 (agonist) 4  chocolate, cocoa, coffee, hazelnut, musty, nutty, vegetable
methyl eugenol -8.22 5 1.9333 5  carnation, cinnamon, clove, fresh, spicy, sweet, warm
2,4-lutidine -4.6 1 7.1795 1  smoky, phenolic
galbanum pyrazine -5.5 1 5.641 1  green_pea, bell_pepper, green, galbanum
6-methyl quinoline -4.7 1 6.4103 1  leathery, tonka, castoreum, tobacco, civet, fecal
filbert pyrazine -4.27 1 6.6667 1  nutty, peanut, musty, corn, raw, earthy, bready
2,5-lutidine -4.5 1 6.2393 1  roasted, green, earthy
methyl isoeugenol -5.05 1 4.5299 1  spicy, clove, floral, carnation, woody
2,5-dimethyl pyrazine -3.9 1 5.9829 1  cocoa, nutty, roasted, beefy, woody, grassy, medicinal
3-ethyl pyridine -4.5 1 4.8718 1  tobacco, oakmoss, leathery, caramellic, roasted, hazelnut
2-ethyl pyridine -4.2 1 5.2991 1  green, grassy
2-sec-butyl-3-methoxypyrazine -4.8 1 3.5897 1  musty, green, pea, galbanum, bell, pepper
2-ethyl-3,6-dimethylpyrazine -5.83 6 (agonist) 6  
2,3,5-trimethylpyridine -4.1 1 3.4188 1  
2-isobutylthiazole -4.5 1 2.735 1  green, wasabi, privet, tomato, leaf, earthy, vegetable, metallic
2-isobutyl-3-methylpyrazine -3.4 1 3.4188 1  herbal, green, sugar
hexanal -5.0 7 0.7 7  aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
2-acetyl-3-ethylpyrazine -4.28 6 (agonist) 6  earthy, potato_chip, nutty, popcorn, corn
2-acetyl-3-methylpyrazine -4.27 6 (agonist) 6  nutty, nut_flesh, hazelnut, roasted_hazelnut, grain, toasted_grain, corn_chip, vegetable, nut_skin, caramellic
indole -4.7 8 0.122 8  animal, fecal, floral, naphthyl
4-vinylguaiacol -4.3 9 0.6667 9  spicy, clove, carnation, phenolic, peppery, smoky, woody, powdery
skatole -4.4 8 0.4878 8  animal, civet, fecal, naphthyl
2,5-dihydro-2,4,5-trimethylthiazoline -3.8 10 (agonist) 10  
(R)-(-)-carvone -3.6 11 0.2353 11  herbal, minty, spearmint, sweet
para-anisaldehyde -3.3 11 0.2941 11  sweet, powdery, mimosa, floral, hawthorn, balsamic, vanilla, anise, woody, coumarinic, creamy, spicy
diacetyl -1.6 4 1.5096 4  buttery, caramellic, creamy, pungent, sweet
quinoline - 1.6667 12  earthy, medicinal, musty, rubbery, tobacco
methoxyfuraneol - 1.5 10  sweet, moldy, mushroom, vegetable, potato, burnt, sugar, nut, skin, wasabi, caramellic, fruity, brandy
d-limonene - 0.7 12  citrus, orange, fresh, sweet
citral - 0.5 3  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
eugenol - 0.2667 12  clove, spicy, sweet, woody
lyral - 0.2333 12  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
beta-damascone - 0.2267 2  berry, currant, floral, fruity, honey, plum, rose, tobacco
benzene - 0.2167 12  gasoline, phenolic, solvent, cinnamon
propanal - 0.1667 12  alcoholic, cocoa, earthy, nutty, whisky, winey
2-heptanone - 0.1333 12  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
nonanal - 0.1333 12  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
allyl phenylacetate - 0 12  honey, fruity, rummy
n-amyl alcohol - 0 12  fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
amyl hexanoate - 0 12  sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
androstenone - 0 12  animal, musky
l-arabinose - 0 12  
butyl formate - 0 12  fruity, plum, rummy, brandy
butyric acid - 0 12  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
(S)-(+)-carvone - 0 12  bready, caraway, minty, spicy
coffee difuran - 0 12  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
coumarin - 0 12  coumarinic, hay, sweet, tonka
decanal - 0 12  sweet, aldehydic, waxy, orange_peel, citrus, floral
dimethyl disulfide - 0 12  sulfurous, vegetable, cabbage, onion, malty, creamy
2,4-DNT - 0 12  
2-ethyl fenchol - 0 12  camphorous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl vanillin - 0 12  sweet, creamy, vanilla, caramellic
o-ethyltoluene - 0 13  
eugenyl acetate - 0 12  carnation, clove, floral, fresh, malty, spicy, sweet, woody
geranyl acetate - 0 12  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
helional - 0 12  cyclamen, fresh, green, hay, ozone, watery
(Z)-3-hexen-1-ol - 0 12  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
isobutylamine - 0 12  cheesy, fishy
linalool - 0 12  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
(1S,2R,5S)-(+)-menthol - 0 12  cooling, mentholic, minty
methyl furfuryl disulfide - 0 12  sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
methyl salicylate - 0 12  minty, wintergreen
1-nonanol - 0 12  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
octanethiol - 0 12  sulfurous
1-octanol - 0 12  aldehydic, green, mushroom, orange, rose, waxy
octyl octanoate - 0 12  coconut, oily, fruity
pelargonic acid - 0 12  cheesy, dairy, dirty, waxy
propionic acid - 0 12  acidic, cheesy, pungent, vinegar
pyrazine - 0 12  pungent, sweet, corn, roasted, hazelnut, barley
sotolone - 0 12  sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
terpinyl acetate - 0 12  bergamot, citrus, herbal, lavender, lime
1,2,4-trimethylbenzene - 0 13  
3-octen-2-one - 0 14 Y 14earthy, spicy, herbal, sweet, mushroom, hay, blueberry
allyl cyclohexylpropionate - -0.1626 8  sweet, pineapple, tropical, fruity, candy, waxy, apple, green
alpha,alpha-dimethyl phenethyl acetate - -0.1626 8  sweet, floral, fruity, rose, green, pear, berry, jasmin, powdery
(-)-ambroxide - -0.1626 8  dry, amber, ambergris, paper, musk, woody, cedar, pine, green, seedy
citronellal - -0.1626 8  sweet, dry, floral, herbal, waxy, aldehydic, citrus
citronellyl acetate - -0.1626 8  floral, green, rose, fruity, citrus, woody, fruit, tropical_fruit
2-cyclohexylpropanal - -0.1626 8  natural, fresh, green, dusty, fruity
delta-damascone - -0.1626 8  fruity, sweet, rose, natural, petal, currant_bud, black_currant_bud, tobacco
geraniol - -0.1626 2  citrus, floral, fruity, rose, sweet, waxy
grapefruit pentanol - -0.1626 8  vetiver, green, citrus, grapefruit, rhubarb, floral
(Z)-3-hexenyl salicylate - -0.1626 8  floral, green, metallic, herbal, balsamic
lilial - -0.1626 2  floral, muguet, watery, green, powdery, cumin
melafleur - -0.1626 8  floral, clean, muguet, ozone, marine, sandy, balsamic
perillic aldehyde - -0.1626 8  fresh, green, herbal, grassy, sweet, minty, cumin, spicy, citrus
strawberry glycidate 1 - -0.1626 8  sweet, fruity, strawberry, floral, honey, fatty
verdyl acetate - -0.1626 8  floral, green, soapy, cedar, pine, woody
amber butanol - -0.3143 2  woody, amber, ambrette
(5E)-3-methylcyclopenta-5-decen-1-one - -0.3571 3  
alpha-hexyl cinnamaldehyde - -0.3857 2  fresh, floral, green, jasmine, herbal, waxy
fruity carboxylate - -0.4 2  sweet, fruity, rummy, candy, floral, ripe
beta-ionone - -0.4 2  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
gamma-undecalactone - -0.4 2  fruity, peach, creamy, fatty, lactonic, apricot, ketonic, coconut
bourgeonal - -0.4065 3  fresh, watery, floral, cyclamen, sweet
civetone - -0.4065 8  clean, musk, dry, animal, sweet
ethyl linalyl ether - -0.4065 8  floral
exaltolide - -0.4065 8  animal, fruity, musk, natural, powdery
galbascone - -0.4065 2  fresh, green, galbanum, earthy, weedy, pineapple, narcissus, hyacinth, fruity
7-methoxycitronellal - -0.4065 8  fresh, melon, floral, lily, sweet
methyl ionone gamma - -0.4065 8  violet, sweet, orris, powdery, floral, woody
3-(3-propen-2-yl phenyl) butanal - -0.4065 8  ozone, cortex, green, floral, melon
spicy carbonate - -0.4065 8  spicy, woody, floral, green, herbal
tetrahydrogeraniol - -0.4065 8  leathery, musty, plastic, rose, sweet
oranger crystals - -0.4571 2  sweet, neroli, orangeflower, powdery, honey, floral, orange, naphthyl, citrus
santaliff - -0.4571 2  sandalwood, creamy, woody, milky, waxy, greasy, musk
violet decenol - -0.5286 2  green, oily, violet, lily, seedy, fruity, kiwi
alpha-isomethyl ionone - -0.5714 3  orris, woody, floral, dried, fruit, violet, jammy, powdery, tea
ebanol - -0.6504 8  sandalwood, woody, musk
galaxolide - -0.6504 8  floral, musk, sweet
(R,S)-methyl cedryl ketone - -0.6504 8  woody, vetiver, amber, leathery, musk, cedar
patchouli hexanol - -0.6504 8  woody, musty, patchouli, camphorous, minty, leathery
thymol - -0.6504 3  camphorous, herbal, medicinal, phenolic, thyme
triplal - -0.6714 2  green, aldehydic, leafy, cortex, tart, floral, peely
habanolide - -8.6957 3  animal, cloth, dry, laundered, metallic, musk, powdery, sweet, tropical, waxy
tonalide - -8.6957 3  amber, ambrette, fruity, musk, powdery, sweet
ambrettolide - -10 3  sweet, soapy, musk, amber, fruity, berry
muscone - -13.0435 3  musk, animal, powdery
cedryl acetate - -15.6522 3  dry, woody, cedar, powdery

1.) Françoise, W., Philippeau, M., Veithen, A., Chatelain, P., & Quesnel, Y. (2016, May). Functional characterization of human olfactory receptors responding to pyrazine odorants. In CHEMICAL SENSES (Vol. 41, No. 4, pp. 433-434). GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND: OXFORD UNIV PRESS.

2.) Aya Kato, Naoko Saito, Michiaki Inoue, Kayoko Nomizu (2015) Method of identifying an agent for inhibiting odor of pyrazine derivatives US9057090B2

3.) Aya Namba, Naoko Saito, Michiaki Inoue, Go Toriyabe (2018) Search method of odor control agent by furaneol JP6276555B2

4.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

5.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

6.) Alessandro Nicoli, Franziska Haag, Patrick Marcinek, Ruiming He, Johanna Kreißl, Jörg Stein, Alessandro Marchetto, Andreas Dunkel, Thomas Hofmann, Dietmar Krautwurst, Antonella Di Pizio Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1. bioRxiv 2022.06.01.494157; doi: https://doi.org/10.1101/2022.06.01.494157

7.) Ojiro I, Katsuyama H, Kaneko R, Ogasawara S, Murata T, Terada Y, et al. (2024) Enhancement of transcription efficiency by TAR-Tat system increases the functional expression of human olfactory receptors. PLoS ONE 19(6): e0306029. https://doi.org/10.1371/journal.pone.0306029

8.) Aya Kato, Naoko Saito (2015) Odor control agent. JP5798382B2

9.) Aya Namba, Naoko Saito, Keiichi Yoshikawa, Ichiro Mori (2015) Search method of urine odor suppressor JP2015211667A

10.) Marcinek, Patrick, et al. "An evolutionary conserved olfactory receptor for foodborne and semiochemical alkylpyrazines." The FASEB Journal 35.6 (2021): e21638.

11.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.

12.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

13.) Chatelain P., Wilkin F., Veithen A., Philippeau M., Noiset O., Quesnel Y. Sensorial Chemistry: Functional characterization and structure-activity relationship understanding of OR5K1 and OR2AG1 allow to design and synthetize new selective compounds. Chem. Senses. 2017;42:e28.

14.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147
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