SMILES:
CC(C)CC(=O)[O-]

Aroma Description:
cheesy, sour, sweaty, tropical1

Receptor Expression log10 EC50 Adj. Top Antagonist? Correlated Perceptual Qualities
OR51E1 100 -3.68 2, -1.95 4, -2.82 5, -4.82 6, -4.82 12, -4.8 13, -4.82 14 5.6998 2, 10 4, (agonist) 5, 3.3871 6, (agonist) 12, 9.27 13, 10 14  cheesy, sour, sweaty, sharp, acidic, dairy
OR51I2 100 -4.4 14, -4.17 15 9.0909 14, 7.9 15  cheesy, sour, sweaty, sharp, dairy, milky
OR11H6 96 -3.81 2, -3.52 12 0.0679 2, 6.5 8, (agonist) 12  honey, sweaty, orangeflower, neroli, sour, sweet, tropical, naphthyl
OR11H4 100 -3.87 2, -3.52 12 0.0413 2, 6 8, (agonist) 12  honey, cinnamyl, hyacinth, sweet, sweaty, cinnamon, bready, sour
OR1G1 61 - 0.0508 3, (agonist) 17  sweet, waxy, citrus, fresh, tart, orange, aldehydic, floral, rose, fatty
OR11H7 ? -5 8 10 8  (insufficient data)
OR1A1 73 - (agonist) 17   
OR51E2 96 -4.19 2 0.1444 2  sour, vinegar, sharp, cheesy
OR1E1 80 -4.14 2 0.1063 2  (insufficient data)
OR8U8 ? -3.09 2 0.0609 2  (insufficient data)
OR52D1 100 - 2.8426 3  dairy, cheesy, anise, milky, creamy, sour, sharp, peach, lactonic, rancid
OR4Q2 ? - 2 8  (insufficient data)
OR12D2 96 - 0 8, 1.9231 11  vinegar, sour, pungent
OR7D4 96 - 0.2 7  animal, citrus, orange, peely, tart, aldehydic, blueberry
OR52E4 88 - 0 8   
OR8A1 69 - 0 8   
OR5A1 100 - 0 9   
OR5A2 100 - 0 9   
OR5AN1 100 - 0 9   
OR5I1 46 - 0 11   
OR1D5 ? - 0 16   
OR51L1 88 - 0 18   
OR2W3 100 - -0.4651 10   
 

SMILES:
CC(C)CC(=O)[O-]

Aroma Description:
cheesy, sour, sweaty, tropical

Receptor Expr.% Agonist? Dock Score Known agonist Correlated Perceptual Qualities

Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.

1.) The Good Scents Company

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3.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

4.) Pierre Chatelain, Alex Veithen, Francoise Wilkin, and Magali Philippeau Deorphanization and Characterization of Human Olfactory Receptors in Heterologous Cells Chem Biodivers. 2014 Nov;11(11):1764-81. doi: 10.1002/cbdv.201400083. PMID: 25408322.

5.) YOSHIFUMI FUJITA, TOMOKO TAKAHASHI, AKIKO SUZUKI, KAYO KAWASHIMA, FUTOSHI NARA & RYUTA KOISHI (2007) Deorphanization of Dresden G Protein-Coupled Receptor for an Odorant Receptor, Journal of Receptors and Signal Transduction, 27:4, 323-334, DOI: 10.1080/10799890701534180

6.) Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, et al. () Identification of Odorant-Receptor Interactions by Global Mapping of the Human Odorome. PLoS ONE 9(4): e93037. doi:10.1371/journal.pone.0093037

7.) Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468-72. doi: 10.1038/nature06162. Epub 2007 Sep 16. PMID: 17873857.

8.) I. Menashe, T. Abaffy, Y. Hasin, S. Goshen, V. Yahalom, C.W. Luetje, D. Lancet, Genetic Elucidation of Human Hyperosmia to Isovaleric Acid, PLoS Biol. 5 (2007) e284.

9.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]

10.) Huang, J., Lam, H., Koziol-White, C., Limjunyawong, N., Kim, D., Kim, N., ... & An, S. S. (2020). The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. Proceedings of the National Academy of Sciences, 117(45), 28485-28495.

11.) Ashti Baghaei, K. (2015). Large scale analysis of olfactory receptors with highly genetically variations in relation with specific anosmia (Doctoral dissertation, Bochum, Ruhr-Universität Bochum, Diss., 2013).

12.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

13.) Halperin Kuhns, V. L., Sanchez, J., Sarver, D. C., Khalil, Z., Rajkumar, P., Marr, K. A., & Pluznick, J. L. (2019). Characterizing novel olfactory receptors expressed in the murine renal cortex. American Journal of Physiology-Renal Physiology, 317(1), F172-F186.

14.) Aya Kato, Naoko Saito, Etsuji Wakisaka (2016) Method for searching for malodor control agent, malodor control agent, and malodor control method. US9526680B2

15.) Chatelain Pierre, Veithen Alex, Olfactory Receptors involved in the perception of sweat carboxylic acids and the use thereof. WO 2014/191047

16.) Kyung Ho Kim, Jai Eun An, Myoungjoo Riu, Jin-Soo Son, Sung Eun Seo, Hongki Kim, Gyeong-Ji Kim, Soohyun Lee, Jin Yoo, Tae Shin Park, Yong Hwan Lee, Tai Hyun Park, Choong-Min Ryu, Oh Seok Kwon. Receptonics-based real-time monitoring of bacterial volatiles for onsite fire blight diagnosis. Sensors & Actuators: B. Chemical 419 (2024) 136337

17.) Huiwen Ren, Ruijing Zhang, Haibo Zhang, Che Bian. Ecnomotopic olfactory receptors in metabolic regulation. Biomedicine & Pharmacotherapy 179 (2024) 117403

18.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

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