☰

Olfactory Receptor family 2 subfamily W member 3.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MDGTNGSTQT HFILLGFSDR PHLERILFVV ILIAYLLTLV GNTTIILVSR LDPHLHTPMY FFLAHLSFLD LSFTTSSIPQ LLYNLNGCDK TISYMGCAIQ 

       110        120        130        140        150        160        170        180        190        200 
LFLFLGLGGV ECLLLAVMAY DRCVAICKPL HYMVIMNPRL CRGLVSVTWG CGVANSLAMS PVTLRLPRCG HHEVDHFLRE MPALIRMACV STVAIEGTVF 

       210        220        230        240        250        260        270        280        290        300 
VLAVGVVLSP LVFILLSYSY IVRAVLQIRS ASGRQKAFGT CGSHLTVVSL FYGNIIYMYM QPGASSSQDQ GMFLMLFYNI VTPLLNPLIY TLRNREVKGA 

       310        320 
LGRLLLGKRE LGKE

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


G Q D Q       S   A V T S     T V   S I T K      N L  L H P R  
 L F M   A G P Q   G E I   P S M A   G M Y    N Y L    I R E   
Y F L M   M Y M   V F V T   L S N   Q I A C  L Q P I  V V F L  
 V I N   Y I I N   V A L   A V G C   L F L    S S T    I L I   
L L P T   G Y F   L V V G   G W T   L G L F  T F S L  L L Y A  
 L P N   L S V V   L P S   V S V L   V G G    D L F    V L T   
    Y I   T L H   L I F V   G R C   L L C E  S L H A  T T N G  
         S G C T   Y S L   L R P N   V A L    L F F    L I I   
          G F A   V I Y S           D Y A M  Y M P T  L R S V  
         K Q R G   V A R             V C R                 D   
                    I Q L           K C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
citralva - 10 1  aldehydic, citrus, lemon, metallic
geraniol - 8.1395 1  citrus, floral, fruity, rose, sweet, waxy
ethyl vanillin - 7.907 1  sweet, creamy, vanilla, caramellic
eugenol - 7.2093 1  clove, spicy, sweet, woody
lilial - 6.2791 1  floral, muguet, watery, green, powdery, cumin
beta-ionone - 6.0465 1  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
hedione - 5.814 1  floral, oily, jasmine, green, lactonic, tropical, natural, sweet, fruity, citrus, lemon, grapefruit, woody
nerol -3.2 2 6.0465 2  citrus, floral, fresh, green, lemon, lime, magnolia, natural, neroli, spicy, sweet, waxy
lyral - 4.186 1  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
menthone - 2.7907 1  minty
maltol - 2.3256 1  sweet, caramellic, cotton_candy, jammy, fruity, bread, baked
(S)-(-)-citronellol - 1.8605 1  citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
linalool - 0.9302 1  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
allyl phenylacetate - 0 3  honey, fruity, rummy
benzyl alcohol - 0 1  floral, rose, phenolic, balsamic
eucalyptol - 0 1  camphorous, eucalyptus, herbal
pyrazine - 0 1  pungent, sweet, corn, roasted, hazelnut, barley
pyrrolidine - 0 1  ammoniacal, animal, eggy, fishy, shellfish, seaweed
tetramethylpyrazine - 0 1  nutty, musty, chocolate, coffee, cocoa, brown, lard, burnt
triethylamine - 0 1  
isovaleric acid - -0.4651 1  cheesy, sour, sweaty, tropical

1.) Huang, J., Lam, H., Koziol-White, C., Limjunyawong, N., Kim, D., Kim, N., ... & An, S. S. (2020). The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. Proceedings of the National Academy of Sciences, 117(45), 28485-28495.

2.) Flegel C, Vogel F, Hofreuter A, Schreiner BS, Osthold S, Veitinger S, Becker C, Brockmeyer NH, Muschol M, Wennemuth G, Altmüller J, Hatt H, Gisselmann G. Characterization of the Olfactory Receptors Expressed in Human Spermatozoa. Front Mol Biosci. 2016 Jan 7;2:73. doi: 10.3389/fmolb.2015.00073. PMID: 26779489; PMCID: PMC4703994.

3.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821
Prot.Sim.Expr.2.53 3.29 3.32 3.33 3.36 3.37 3.40 3.41 4.53 4.56 4.57 4.60 45.49 45.51 45.52 45.53 5.39 5.42 5.43 5.46 5.47 6.48 6.51 6.55 6.59 7.38 7.39 7.41 7.42
OR2W3100 100%F L F L G G C L G N S M L E M P V L A V V Y I Y G M L Y N
OR2W188 53%F L Y M G S C L S N S L L E L P V L G I V Y I Y G T L Y T
OR2Y186 73%F L Y L G S C V G N S Q F E M P M A R V V Y A Y I A L Y T
OR5V186 96%Y L F V V G C L G N S H F D I P L T G I G Y A Y I S V Y S
OR2C185 100%F L F L G A C I G N S Q L E V P L V C F T Y A Y A S L Y S
OR2C384 92%F F S H G A C V G T S G F E M P M A S F V Y I Y A A L Y T
OR2J183Y L V L G T C V G T S H F E V P L M S F V F V Y P A L Y T
OR10AC183Y M F V G G C F G V S L F D I T L A C L L Y A Y R A L Y T
OR10G883 57%F L F H G G C F G H S Q L D A P I T V V A F G Y G A V Y T
OR2B1182 100%Y Y F H G C C I G N S Q F E V P L L V F V Y A Y P S L Y S
OR2J282 92%H L V L G I C V G I S H F E V P L M S F V F V Y P A L Y T
OR2M482 96%L I Y V L G C F G D G V F D V A L C C M L Y A Y A S A Y T
OR2AG182 100%F M A L G G D L A S A Y L E I P V M G F L Y A Y S S V Y T
OR2B382 42%Y L F L G A C L G N S Q F E V P L F S I L Y A Y P S L Y G
OR2B681Y L F L G A Y L G N S L L E V P L V S F H Y A Y P S L Y G
OR13G181 100%C L F T L G M V A N S H F E I P V A D L A Y V Y A A A Y T
OR10AD181 100%F M V F G V C I G N G L F E A P I D A V I Y A Y H S L Y T
OR11L181 100%Y L F V G A C F G T G P F D L P I L S V L Y M Y S S V Y T
OR2D381 100%F I F L G C C A G V S D F E P P I M G I L Y G Y N S V Y T
OR2G681 100%F L A M G S C I G T S Q F E V P L A S F L Y I Y A S L Y T
OR5A181 100%Y F F V G L C L G S S Q F D L P N V V V G F A Y S S V Y S
OR10Q181 100%Y M F V G S C F A P S L L D V P L V S V L Y C Y R A L Y T
OR10T281 65%Y L F L A C C L G I A A F D M A L L S V I Y A Y K A V Y T
OR2B880Y L S L G S C V G N S Q L E V P L V S I L Y A Y G S L Y T
OR2J380 100%Y L V L G T C V G N S H F E V P L T S F V F A Y P A L Y T
OR3A380 38%C L F H A G C F A N A H Y D L P L A A M A Y G Y G G V M T
OR10R280 57%Y M F L A I C L G A S V F D I S I C G V L Y A Y T T V Y T
OR2H280 88%F I F L G T C I G E S Q V E V P V A S I L Y V Y K G L Y A
OR2AJ180H V S L L G C L G N S H F E V P V S A F L Y F Y K A I Y T
OR10W180 100%Y M F I G S C F G L S L F D V P V A A A I Y C Y S S L Y T
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