☰

Olfactory Receptor family 1 subfamily G member 1.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MEGKNLTSIS ECFLLGFSEQ LEEQKPLFGS FLFMYLVTVA GNLLIILVII TDTQLHTPMY FFLANLSLAD ACFVSTTVPK MLANIQIQSQ AISYSGCLLQ 

       110        120        130        140        150        160        170        180        190        200 
LYFFMLFVML EAFLLAVMAY DCYVAICHPL HYILIMSPGL CIFLVSASWI MNALHSLLHT LLMNSLSFCA NHEIPHFFCD INPLLSLSCT DPFTNELVIF 

       210        220        230        240        250        260        270        280        290        300 
ITGGLTGLIC VLCLIISYTN VFSTILKIPS AQGKRKAFST CSSHLSVVSL FFGTSFCVDF SSPSTHSAQK DTVASVMYTV VTPMLNPFIY SLRNQEIKSS 

       310        320 
LRKLIWVRKI HSP

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

E E L Q   N A L   G S Y S     M L   T F P D       S   K Q A S  
 P K Q   M K P V   L L C   L T H L   L E N   F D V C   V T D   
S G F L   T T S   F Y L Q   L S H   I F I V   F S T   M V S A  
 F L F   V F C A   L M F   L A N M   G G T   G F F L   V T Y   
V L Y M   D A L   L M V F   I W S   L G T L   S V V   M P T V  
 A V T   S L N A   F A E   A S V L   V C I   S L H S   P N L   
L L N G   L F F   V A L L   F I C   I L C L   S C T   S Y I F  
 L I I   Y M P T   Y A M   L G P S   Y S I   S F A K       L   
T I I V           V Y C D           F V N T   R K G            
                   C I A             I T S   Q A S P           
                        H               K L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
vanillin -6.3 1 10 1  chocolate, creamy, sweet, vanilla
2-undecanone - 10 2  creamy, fatty, floral, fruity, orris, waxy
(S)-methylthiobutanoate - 10 3  cabbage, cheesy, eggy, fruit, garlic, metallic, musty, sulfurous, tomato
1-nonanol - 9.8985 3  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
ethyl isobutyrate - 9.5431 3  alcoholic, ethereal, fruity, fusel, rummy, sweet
gamma-decalactone - 9.4924 3  fresh, oily, waxy, peach, coconut, buttery, sweet
2-ethyl-1-hexanol - 9.1371 3  citrus, fresh, floral, oily, sweet, fatty, fruity
benzothiazole - 7.6142 3  sulfurous, rubbery, vegetable, cooked, nutty, coffee, meaty, brown
thiazole - 7.6142 3  fishy, nutty, meaty
safrole - 7.3604 3  anise, floral, sassafrass, spicy, sweet, warm, woody
9-decen-1-ol - 7.3529 4  aldehydic, clean, dewy, floral, fresh, rose, waxy
hedione - 7.3096 3  floral, oily, jasmine, green, lactonic, tropical, natural, sweet, fruity, citrus, lemon, grapefruit, woody
acetophenone - 7.1066 3  sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
thymol - 7.1066 3  camphoraceous, herbal, medicinal, phenolic, thyme
manzanate -4.5 5 7 5  fresh, fruity, green, melon, apple_skin, pineapple, natural, waxy
3-nonanone - 6.802 3  floral, fresh, fruity, herbal, jasmine, leafy, spicy, sweet
camphor - 6.7647 4  camphoraceous
geraniol - 6.599 3  citrus, floral, fruity, rose, sweet, waxy
quinoline - 6.4467 3  earthy, medicinal, musty, rubbery, tobacco
eugenyl acetate -4 5 -  carnation, clove, floral, fresh, malty, spicy, sweet, woody
jasmonyl -4 5 -  floral, herbal, oily, green, jasmine, mushroom, lactonic
piperonyl acetone - 6.3959 3  berry, candy, cotton, floral, fruity, heliotrope, jammy, powdery, raspberry, sweet
maltyl isobutyrate -5.7 5 3.5 5  berry, caramellic, cotton_candy, fruity, strawberry, sweet, tropical
2-nonanone - 6.2944 3  fresh, sweet, green, weedy, earthy, herbal, fruity, waxy, soapy, cheesy, coconut, dairy, dirty, buttery
(E)-anethole - 6.0914 3  sweet, anise, licorice, mimosa, medicinal, spicy
nonanal -2.49 6 7.9412 4  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
capric acid - 5.8376 3  citrus, fatty, rancid, sour
benzaldehyde - 5.5838 3  sharp, sweet, bitter, almond, cherry
(1S,2R,5S)-(+)-menthol - 5.5838 3  cooling, mentholic, minty
guaiacol - 5.3299 3  phenolic, smoky, spicy, vanilla, woody, medicinal, savory, meaty
octanal - 5.2284 3  aldehydic, citrus, fatty, green, orange, peel, waxy
lyral - 5.0761 3  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
citral - 5.0254 3  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
isoamyl acetate - 5 7  banana, fruity, solvent, sweet
1-heptanol - 4.8223 3  musty, leafy, violet, herbal, green, sweet, woody, peony, pungent, vegetable, fruity, apple, banana
2-methyl pyrazine - 4.8223 3  nutty, cocoa, roasted, chocolate, peanut, green, brown, nut_skin, musty, earthy
ethyl butyrate - 4.7716 3  cognac, fruit, fruity, juicy, pineapple
1-dodecanol - 4.5685 3  earthy, soapy, waxy, fatty, honey, coconut, clean, aldehydic, cilantro, watery, greasy
d-limonene - 4.5685 3  citrus, orange, fresh, sweet
maltol - 4.5685 3  sweet, caramellic, cotton_candy, jammy, fruity, bread, baked
pyridine - 4.5685 3  ammoniacal, fishy, sour
floralozone -3.7 5 3 5  clean, fresh, green, marine, ozone
2-octanol - 4.4162 3  fresh, spicy, green, woody, herbal, earthy, nasturtium, banana, unripe_banana, mushroom
4-octanol - 4.4162 3  
2-nonanol - 4.3147 3  waxy, green, creamy, citrus, orange, cheesy, fruity
ethyl decanoate - 4.0609 3  apple, brandy, fruity, grape, oily, sweet, waxy
pyrazine - 4.0609 3  pungent, sweet, corn, roasted, hazelnut, barley
1-decanol - 3.8071 3  aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
1-octanol - 3.8071 3  aldehydic, green, mushroom, orange, rose, waxy
methyl decanoate - 3.7563 3  oily, winey, fruity, floral, fatty
benzyl alcohol - 3.5533 3  floral, rose, phenolic, balsamic
1-hexanol - 3.5533 3 Yethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
3-hydroxybutan-2-one - 3.5533 3  buttery, creamy, dairy, fatty, milky, sweet
methyl caprylate - 3.5533 3  aldehydic, green, herbal, orange, sweet, vegetable, waxy
3-octanol - 3.5533 3  earthy, mushroom, herbal, melon, citrus, woody, spicy, minty, dairy, musty, creamy, waxy, fermented, green
cinnamaldehyde -4 5 0.2538 3  sweet, spicy, candy, cinnamon, warm
ethyl vanillin - 3.2995 3  sweet, creamy, vanilla, caramellic
undecanal - 3.2995 3  aldehydic, citrus, cloth, fatty, floral, green, laundered, soapy, waxy
coumarin - 3.2487 3  coumarinic, hay, sweet, tonka
ethyl caprylate - 3.198 3  fruity, winey, waxy, sweet, apricot, banana, brandy, pear, musty, pineapple, creamy, dairy
(R)-(+)-citronellal - 3.1472 3  citrus, fresh, herbal
(S)-(-)-citronellal - 3.1472 3  citrus, clean, herbal
decanal - 3.1472 3  sweet, aldehydic, waxy, orange_peel, citrus, floral
heptanal - 3.0457 3  aldehydic, cognac, fatty, fresh, green, herbal, ozone
hexanal - 3.0457 3 Yaldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
ethyl pelargonate - 2.7919 3  fruity, natural, rose, rummy, tropical, waxy, winey
methyl pelargonate - 2.7919 3  fruity, pear, sweet, tropical, waxy, winey
pelargonic acid - 2.7919 3  cheesy, dairy, dirty, waxy
tridecanal - 2.6582 2  aldehydic, citrus, clean, fresh, grapefruit, peel, petal, soapy, waxy
galbanum pyrazine - 2.4365 3  green_pea, bell_pepper, green, galbanum
6-methyl-5-hepten-2-one - 2.132 3  apple, citrus, green, lemongrass, musty
indole - 1.7766 3  animal, fecal, floral, naphthyl
2-decanone - 1.6244 3  cheesy, fatty, fermented, floral, orange, peach
3-octanone - 1.6244 3  fresh, herbal, lavender, mushroom, sweet
beta-ionone - 1.5228 3  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
estragole - 1.4721 3  sweet, sassafrass, anise, spicy, green, herbal, fennel, phenolic, minty
menthone - 1.3706 3  minty
lauric acid - 1.269 3  bay, coconut, fatty
oenanthic acid - 1.269 3  rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
anisole - 1.2183 3  phenolic, gasoline, ethereal, anise
eucalyptol - 1.1675 3  camphoraceous, eucalyptus, herbal
2-heptanone - 1.0152 3  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
lauric aldehyde - 1.0152 3  aldehydic, citrus, floral, green, soapy, waxy
citralva - 0.9645 3  aldehydic, citrus, lemon, metallic
geranyl acetate - 0.7107 3  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
butyric acid - 0.6091 3  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
cyclohexanone - 0.6091 3 Yacetone, minty
butyl butyrate - 0.5076 3  fruity, banana, pineapple, green, cherry, tropical_fruit, ripe_fruit, juicy_fruit, sweet, fresh, ripe
methyl oenanthate - 0.5076 3  sweet, fruity, green, orris, waxy, floral, berry, apple
propionic acid - 0.5076 3  acidic, cheesy, pungent, vinegar
ethyl oenanthate - 0.4569 3  fruity, pineapple, cognac, rummy, winey
dimethyl disulfide - 0.4061 3  sulfurous, vegetable, cabbage, onion, malty, creamy
methyl caproate - 0.4061 3  apricot, bacon, banana, ethereal, fruit, fruity, pineapple, strawberry, tropical
helional - 0.3046 3  cyclamen, fresh, green, hay, ozone, watery
methyl salicylate - 0.3046 3  minty, wintergreen
2-octanone - 0.3046 3  earthy, herbal, natural, weedy, woody
ethyl caproate - 0.2538 3  banana, fruity, green, pineapple, sweet, waxy
isobutyric acid - 0.2538 3  acidic, buttery, cheesy, dairy, rancid, sour
para-anisaldehyde - 0.1523 3  sweet, powdery, mimosa, floral, hawthorn, balsamic, vanilla, anise, woody, coumarinic, creamy, spicy
(E)-cinnamic acid - 0.1269 3  balsamic, cinnamyl, storax, sweet
caproic acid - 0.0508 3  cheesy, fatty, sour, sweaty
caprylic acid - 0.0508 3  cheesy, fatty, oily, rancid, vegetable, waxy
isovaleric acid - 0.0508 3  cheesy, sour, sweaty, tropical
(Z)-4-hexen-1-ol - 0 2  green, vegetable, tomato, turnip, brothy, gassy

1.) Sanz G, Thomas-Danguin T, Hamdani el H, Le Poupon C, Briand L, Pernollet JC, Guichard E, Tromelin A. Relationships between molecular structure and perceived odor quality of ligands for a human olfactory receptor. Chem Senses. 2008 Sep;33(7):639-53. doi: 10.1093/chemse/bjn032. Epub 2008 Jul 5. PMID: 18603653.

2.) J. Topin, C.A. de March, L. Charlier, C. Ronin, S. Antonczak, J. Golebiowski, Discrimination between Olfactory Receptor Agonists and Non-agonists, Chem. Eur. J. 20 (2014) 10227-10230.

3.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

4.) L. Charlier, J. Topin, C. Ronin, S.K. Kim, W.A. Goddard, 3rd, R. Efremov, J. Golebiowski, How broadly tuned olfactory receptors equally recognize their agonists. Human OR1G1 as a test case, Cell. Mol. Life Sci. 69 (2012) 4205-4213.

5.) D. Gonzalez-Kristeller, J.B.P. do Nascimento, P.A.F. Galante, B. Malnic, Identification of agonists for a group of human odorant receptors, Front. Pharmacol. 6 (2015)

6.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

7.) V. Matarazzo, O. Clot-Faybesse, B. Marcet, G. Guiraudie-Capraz, B. Atanasova, G. Devauchelle, M. Cerutti, P. Etiévant, C. Ronin, Functional Characterization of Two Human Olfactory Receptors Expressed in the Baculovirus Sf9 Insect Cell System, Chem. Sens. 30 (2005) 195-207.
×
 
 

Code version:
 

Docker used:
 

Files:
Active model: text 3D download
Inactive model: text 3D download
Active dock: text 3D download
Inactive dock: text 3D download
JSON entry: text   download