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Olfactory Receptor family 1 subfamily G member 1.

Estimated Expression: 61% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MEGKNLTSIS ECFLLGFSEQ LEEQKPLFGS FLFMYLVTVA GNLLIILVII TDTQLHTPMY FFLANLSLAD ACFVSTTVPK MLANIQIQSQ AISYSGCLLQ 

       110        120        130        140        150        160        170        180        190        200 
LYFFMLFVML EAFLLAVMAY DCYVAICHPL HYILIMSPGL CIFLVSASWI MNALHSLLHT LLMNSLSFCA NHEIPHFFCD INPLLSLSCT DPFTNELVIF 

       210        220        230        240        250        260        270        280        290        300 
ITGGLTGLIC VLCLIISYTN VFSTILKIPS AQGKRKAFST CSSHLSVVSL FFGTSFCVDF SSPSTHSAQK DTVASVMYTV VTPMLNPFIY SLRNQEIKSS 

       310        320 
LRKLIWVRKI HSP

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

K Q A S       S   T F P D     M L   I A Q S      Q I  E E L Q  
 V T D   P S S F   L E N   L T H L   S Y S    N A L    P K Q   
M V S A   D V C   I F I V   L S H   L L C G  M K P V  S G F L  
 V T Y   F S T G   G G T   L A N M   Y L Q    T T S    F L F   
M P T V   F F L   L G T L   I W S   L M F F  V F C A  V L Y M  
 P N L   S V V S   V C I   A S V L   M V F    D A L    A V T   
    I F   L H S   I L C L   F I C   F A E L  S L N A  L L N G  
         S C T S   Y S I   L G P S   A L L    L F F    L I I   
          F A K   F V N T           Y A M V  Y M P T  T I I V  
         R K G Q   I T S             Y C D                 D   
                    I K L           C I A V                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
vanillin -6.3 1 10 1  chocolate, creamy, sweet, vanilla
2-undecanone - 10 2  creamy, fatty, floral, fruity, orris, waxy
S-methyl thiobutanoate - 10 3  cabbage, cheesy, eggy, fruit, garlic, metallic, musty, sulfurous, tomato
1-nonanol - 9.8985 4  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
ethyl isobutyrate - 9.5431 2  alcoholic, ethereal, fruity, fusel, rummy, sweet
gamma-decalactone - 9.4924 3  fresh, oily, waxy, peach, coconut, buttery, sweet
2-ethyl-1-hexanol - 9.1371 3  citrus, fresh, floral, oily, sweet, fatty, fruity
benzothiazole - 7.6142 3  sulfurous, rubbery, vegetable, cooked, nutty, coffee, meaty, brown
thiazole - 7.6142 3  fishy, nutty, meaty
safrole - 7.3604 3  anise, floral, sassafrass, spicy, sweet, warm, woody
9-decen-1-ol - 7.3529 4  aldehydic, clean, dewy, floral, fresh, rose, waxy
hedione - 7.3096 3  floral, oily, jasmine, green, lactonic, tropical, natural, sweet, fruity, citrus, lemon, grapefruit, woody
acetophenone - 7.1066 3  sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
thymol - 7.1066 3  camphorous, herbal, medicinal, phenolic, thyme
manzanate -4.5 5 7 5  fresh, fruity, green, melon, apple_skin, pineapple, natural, waxy
3-nonanone - 6.802 3  floral, fresh, fruity, herbal, jasmine, leafy, spicy, sweet
camphor - 6.7647 4  camphorous
geraniol - 6.599 3  citrus, floral, fruity, rose, sweet, waxy
quinoline - 6.4467 3  earthy, medicinal, musty, rubbery, tobacco
piperonyl acetone - 6.3959 3  berry, candy, cotton, floral, fruity, heliotrope, jammy, powdery, raspberry, sweet
maltyl isobutyrate -5.7 5 3.5 5  berry, caramellic, cotton_candy, fruity, strawberry, sweet, tropical
2-nonanone - 6.2944 3  fresh, sweet, green, weedy, earthy, herbal, fruity, waxy, soapy, cheesy, coconut, dairy, dirty, buttery
(E)-anethole - 6.0914 3  sweet, anise, licorice, mimosa, medicinal, spicy
nonanal -2.49 4 7.9412 4  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
capric acid - 5.8376 3  citrus, fatty, rancid, sour
benzaldehyde - 5.5838 3  sharp, sweet, bitter, almond, cherry
(1S,2R,5S)-(+)-menthol - 5.5838 3  cooling, mentholic, minty
guaiacol - 5.3299 3  phenolic, smoky, spicy, vanilla, woody, medicinal, savory, meaty
octanal - 5.2284 3  aldehydic, citrus, fatty, green, orange, peel, waxy
lyral - 5.0761 3  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
citral - 5.0254 3  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
isoamyl acetate - 5 2  banana, fruity, solvent, sweet
1-heptanol - 4.8223 3  musty, leafy, violet, herbal, green, sweet, woody, peony, pungent, vegetable, fruity, apple, banana
2-methyl pyrazine - 4.8223 3  nutty, cocoa, roasted, chocolate, peanut, green, brown, nut_skin, musty, earthy
ethyl butyrate - 4.7716 3  cognac, fruit, fruity, juicy, pineapple
1-dodecanol - 4.5685 3  earthy, soapy, waxy, fatty, honey, coconut, clean, aldehydic, cilantro, watery, greasy
d-limonene - 4.5685 3  citrus, orange, fresh, sweet
maltol - 4.5685 3  sweet, caramellic, cotton_candy, jammy, fruity, bread, baked
pyridine - 4.5685 3  ammoniacal, fishy, sour
floralozone -3.7 5 3 5  clean, fresh, green, marine, ozone
2-octanol - 4.4162 3  fresh, spicy, green, woody, herbal, earthy, nasturtium, banana, unripe_banana, mushroom
4-octanol - 4.4162 3  
2-nonanol - 4.3147 3  waxy, green, creamy, citrus, orange, cheesy, fruity
ethyl decanoate - 4.0609 3  apple, brandy, fruity, grape, oily, sweet, waxy
pyrazine - 4.0609 3  pungent, sweet, corn, roasted, hazelnut, barley
1-decanol - 3.8071 3  aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
1-octanol - 3.8071 3  aldehydic, green, mushroom, orange, rose, waxy
methyl decanoate - 3.7563 3  oily, winey, fruity, floral, fatty
eugenyl acetate -4 5 (agonist) 5  carnation, clove, floral, fresh, malty, spicy, sweet, woody
jasmonyl -4 5 (agonist) 5  floral, herbal, oily, green, jasmine, mushroom, lactonic
acetoin - 3.5533 3  sweet, buttery, creamy, dairy, milky, fatty
benzyl alcohol - 3.5533 3  floral, rose, phenolic, balsamic
methyl caprylate - 3.5533 3  aldehydic, green, herbal, orange, sweet, vegetable, waxy
3-octanol - 3.5533 3  earthy, mushroom, herbal, melon, citrus, woody, spicy, minty, dairy, musty, creamy, waxy, fermented, green
hexanol - 3.5533 3 Y 3ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
cinnamaldehyde -4 5 0.2538 5  sweet, spicy, candy, cinnamon, warm
ethyl vanillin - 3.2995 3  sweet, creamy, vanilla, caramellic
undecanal - 3.2995 3  aldehydic, citrus, cloth, fatty, floral, green, laundered, soapy, waxy
coumarin - 3.2487 3  coumarinic, hay, sweet, tonka
ethyl caprylate - 3.198 3  fruity, winey, waxy, sweet, apricot, banana, brandy, pear, musty, pineapple, creamy, dairy
(R)-(+)-citronellal - 3.1472 3  citrus, fresh, herbal
(S)-(-)-citronellal - 3.1472 3  citrus, clean, herbal
decanal - 3.1472 3  sweet, aldehydic, waxy, orange_peel, citrus, floral
heptanal - 3.0457 6  aldehydic, cognac, fatty, fresh, green, herbal, ozone
hexanal - 3.0457 3 Y 3aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
ethyl pelargonate - 2.7919 3  fruity, natural, rose, rummy, tropical, waxy, winey
methyl pelargonate - 2.7919 3  fruity, pear, sweet, tropical, waxy, winey
pelargonic acid - 2.7919 3  cheesy, dairy, dirty, waxy
tridecanal - 2.6582 2  aldehydic, citrus, clean, fresh, grapefruit, peel, petal, soapy, waxy
galbanum pyrazine - 2.4365 3  green_pea, bell_pepper, green, galbanum
sulcatone - 2.132 3  citrus, green, musty, lemongrass, apple, ketonic, creamy, cheesy, banana, vegetable, green_bean
indole - 1.7766 3  animal, fecal, floral, naphthyl
2-decanone - 1.6244 3  cheesy, fatty, fermented, floral, orange, peach
3-octanone - 1.6244 3  fresh, herbal, lavender, mushroom, sweet
beta-ionone - 1.5228 3  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
estragole - 1.4721 3  sweet, sassafrass, anise, spicy, green, herbal, fennel, phenolic, minty
menthone - 1.3706 3  minty
lauric acid - 1.269 3  bay, coconut, fatty
oenanthic acid - 1.269 3  rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
anisole - 1.2183 3  phenolic, gasoline, ethereal, anise
eucalyptol - 1.1675 3  camphorous, eucalyptus, herbal
2-heptanone - 1.0152 3  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
lauric aldehyde - 1.0152 3  aldehydic, citrus, floral, green, soapy, waxy
citralva - 0.9645 3  aldehydic, citrus, lemon, metallic
geranyl acetate - 0.7107 3  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
butyric acid - 0.6091 7  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
cyclohexanone - 0.6091 3 Y 3acetone, minty
butyl butyrate - 0.5076 3  fruity, banana, pineapple, green, cherry, tropical_fruit, ripe_fruit, juicy_fruit, sweet, fresh, ripe
methyl oenanthate - 0.5076 3  sweet, fruity, green, orris, waxy, floral, berry, apple
propionic acid - 0.5076 3  acidic, cheesy, pungent, vinegar
ethyl oenanthate - 0.4569 3  fruity, pineapple, cognac, rummy, winey
dimethyl disulfide - 0.4061 3  sulfurous, vegetable, cabbage, onion, malty, creamy
methyl caproate - 0.4061 3  apricot, bacon, banana, ethereal, fruit, fruity, pineapple, strawberry, tropical
helional - 0.3046 3  cyclamen, fresh, green, hay, ozone, watery
methyl salicylate - 0.3046 3  minty, wintergreen
2-octanone - 0.3046 3  earthy, herbal, natural, weedy, woody
ethyl caproate - 0.2538 3  banana, fruity, green, pineapple, sweet, waxy
isobutyric acid - 0.2538 7  acidic, buttery, cheesy, dairy, rancid, sour
para-anisaldehyde - 0.1523 3  sweet, powdery, mimosa, floral, hawthorn, balsamic, vanilla, anise, woody, coumarinic, creamy, spicy
(E)-cinnamic acid - 0.1269 3  balsamic, cinnamyl, storax, sweet
caproic acid - 0.0508 3  cheesy, fatty, sour, sweaty
caprylic acid - 0.0508 3  cheesy, fatty, oily, rancid, vegetable, waxy
isovaleric acid - 0.0508 7  cheesy, sour, sweaty, tropical
(Z)-4-hexen-1-ol - 0 2  green, vegetable, tomato, turnip, brothy, gassy

1.) Sanz G, Thomas-Danguin T, Hamdani el H, Le Poupon C, Briand L, Pernollet JC, Guichard E, Tromelin A. Relationships between molecular structure and perceived odor quality of ligands for a human olfactory receptor. Chem Senses. 2008 Sep;33(7):639-53. doi: 10.1093/chemse/bjn032. Epub 2008 Jul 5. PMID: 18603653.

2.) J. Topin, C.A. de March, L. Charlier, C. Ronin, S. Antonczak, J. Golebiowski, Discrimination between Olfactory Receptor Agonists and Non-agonists, Chem. Eur. J. 20 (2014) 10227-10230.

3.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

4.) L. Charlier, J. Topin, C. Ronin, S.K. Kim, W.A. Goddard, 3rd, R. Efremov, J. Golebiowski, How broadly tuned olfactory receptors equally recognize their agonists. Human OR1G1 as a test case, Cell. Mol. Life Sci. 69 (2012) 4205-4213.

5.) D. Gonzalez-Kristeller, J.B.P. do Nascimento, P.A.F. Galante, B. Malnic, Identification of agonists for a group of human odorant receptors, Front. Pharmacol. 6 (2015)

6.) Lim J. H., J. Park, E. H. Oh, H. J. Ko, S. Hong, and Park, T. H. (2014) Nanovesicle-based bioelectronic nose for the diagnosis of lung cancer from human blood. Adv. Healthcare Mater., 3: 360–366.

7.) Huiwen Ren, Ruijing Zhang, Haibo Zhang, Che Bian. Ecnomotopic olfactory receptors in metabolic regulation. Biomedicine & Pharmacotherapy 179 (2024) 117403
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