OR10G9

Olfactory Receptor family 10 subfamily G member 9.

Estimated Expression: 46% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MSKTSLVTAF ILTGLPHAPG LDAPLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL 

       110        120        130        140        150        160        170        180        190        200 
YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTSMMSGSRC ALLATSTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYLCDA PPILKLACAD TSANEMVIFV 

       210        220        230        240        250        260        270        280        290        300 
DIGLVASGCF LLIVLSYVSI VCSILRIHTS EGRHRAFQTC ASHCIVVLCF FVPCVFIYLR PGSRDVVDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK 

       310        320 
LRDKVAHSQG E

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


D V V D  R L Y I  A S T D     T L   S I A R      V L  L G P A  
 V V G    F V C    M E N   I T Q V   S H F    T M L    P A D   
Y F I A  P V F F  V F I V   A S H   Q A V C  M K P V  I G F L  
 L V T    C L V    G I D   L S G S   F Y L    T V T    V L F   
L L P T  V I C H  S A V L   L W T   L F H F  S F W M  L V Y V  
 V P N    S A C    F C G   S T A L   T S G    D I F    L V T   
    Y V  T Q F A  V I L L   L A C   L F C E  S L N T  L L N G  
          R H R    Y S L   R S G S   V T Y    L F Y    L L I   
         G E S T  V I S V           D Y S M  Y M P T  V R I V  
                   I S C             L Y R                 D   
                    I R L           Y S I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards

Odorant	EC₅₀	Adjusted Top	Antagonist?	Aroma Notes
vanilla cresol	-4.72 ¹	-		vanilla, woody, spicy, guaiacol
guaiacol	-2.49 ²	3.75 ²		phenolic, smoky, spicy, vanilla, woody, medicinal, savory, meaty, balsamic, sweet, burnt

1.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

2.) C. Trimmer, A. Keller, N. R. Murphy, L. L. Snyder, J. R. Willer, M. H. Nagai, N. Katsanis, L. B. Vosshall, H. Matsunami, and J. D. Mainland Genetic variation across the human olfactory receptor repertoire alters odor perception PNAS | May 7, 2019 | vol. 116 | no. 19 | 9475–9480

Prot.	Sim.	Expr.	2.53	3.29	3.32	3.33	3.36	3.37	3.40	3.41	4.53	4.56	4.57	4.60	45.49	45.51	45.52	45.53	5.39	5.42	5.43	5.46	5.47	6.48	6.51	6.55	6.59	7.38	7.39	7.41	7.42
OR10G9	100	46%	F	L	F	H	G	S	C	F	G	H	S	Q	L	D	A	P	I	D	I	V	A	F	C	Y	G	A	I	Y	T
OR10G4	98	88%	F	L	F	H	G	S	C	F	G	H	S	Q	F	D	A	P	I	D	I	V	A	F	C	Y	G	A	I	Y	T
OR10G7	96	80%	F	L	F	H	G	S	C	F	G	H	S	Q	F	D	A	P	I	N	I	V	A	F	G	Y	G	A	V	Y	T
OR10G8	93	57%	F	L	F	H	G	G	C	F	G	H	S	Q	L	D	A	P	I	T	V	V	A	F	G	Y	G	A	V	Y	T
OR10G6	90		I	L	F	H	G	C	C	F	G	H	S	Q	F	D	I	P	T	D	I	L	A	Y	C	Y	C	A	V	Y	T
OR10G2	87	80%	L	L	F	H	G	S	C	F	G	H	G	Q	I	D	I	R	T	D	V	V	A	Y	C	Y	A	A	V	Y	T
OR10G3	85	96%	I	L	Y	H	G	S	C	F	G	H	G	Q	F	D	I	P	T	D	I	V	V	Y	C	Y	E	A	L	P	T
OR4D1	84	100%	Y	I	F	H	G	G	V	F	G	H	S	Q	Y	D	V	P	M	N	S	L	V	F	C	Y	P	S	I	Y	T
OR4A16	82		Y	L	E	H	G	G	V	F	G	H	S	Q	V	D	M	Y	V	N	G	I	C	F	C	Y	P	T	V	Y	S
OR4K17	82	84%	L	I	L	H	G	G	M	V	G	H	S	Q	F	D	L	P	I	N	S	I	S	F	C	Y	P	A	V	Y	T
OR4S2	82	57%	Y	L	V	H	G	C	I	F	G	H	S	Q	F	D	V	H	V	N	S	I	A	F	C	Y	D	A	V	Y	T
OR10S1	82	92%	L	L	F	H	A	S	C	F	G	H	A	H	F	D	I	P	M	S	I	V	A	Y	P	Y	R	A	V	Y	T
OR4X1	82	23%	Y	M	L	H	G	G	A	F	G	H	S	Q	F	D	V	H	I	N	G	I	S	F	C	Y	C	A	V	Y	T
OR4P4	82	57%	Y	L	T	H	G	G	I	F	G	H	S	Q	F	D	V	Y	V	N	S	I	A	F	A	Y	V	A	L	Y	T
OR4X2	82	53%	Y	L	L	H	G	G	I	F	G	H	S	Q	F	D	L	V	I	N	G	L	S	F	C	S	S	A	V	Y	T
OR4F4	82	92%	L	I	L	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	L	T	F	C	Y	P	A	V	Y	S
OR4F5	82	92%	L	I	L	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	L	T	F	C	Y	P	A	V	Y	S
OR4F17	82	92%	L	I	L	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	L	T	F	C	Y	P	A	V	Y	S
OR4A47	81		Y	L	E	H	G	G	V	F	G	H	S	Q	F	D	M	Y	V	N	G	A	C	F	C	Y	P	S	V	Y	T
OR4D5	81	80%	Y	L	F	H	G	G	I	F	G	H	S	Q	Y	D	V	P	M	N	N	V	T	F	C	Y	P	S	V	Y	T
OR4D9	81	100%	F	M	F	H	G	G	V	F	G	H	S	Q	Y	D	V	P	M	N	N	V	S	F	C	Y	P	S	V	F	T
OR4D11	81	34%	F	I	F	H	G	G	I	F	G	H	S	Q	Y	D	V	P	M	N	N	V	T	F	C	Y	P	S	V	F	T
OR4E2	81	96%	H	L	L	H	A	C	I	F	G	H	S	Q	F	D	V	P	I	N	S	I	S	F	C	Y	P	S	V	Y	T
OR4C3	80	34%	Y	L	A	H	G	G	I	I	G	H	S	Q	A	D	L	Y	V	N	S	I	C	F	C	Y	P	A	L	Y	G
OR2Y1	80	73%	F	L	Y	L	G	S	C	V	G	N	S	Q	F	E	M	P	M	A	R	V	V	Y	A	Y	I	A	L	Y	T
OR4A15	80	15%	Y	L	D	H	A	G	V	I	G	H	S	Q	L	D	L	Y	M	N	G	I	C	F	C	Y	P	T	V	L	T
OR4L1	80	11%	L	M	M	H	G	G	M	T	G	H	S	Q	F	D	L	P	V	D	S	L	S	F	C	Y	P	A	V	Y	T

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