OR4S2

Olfactory Receptor family 4 subfamily S member 2.

Estimated Expression: 57% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MEKINNVTEF IFWGLSQSPE IEKVCFVVFS FFYIIILLGN LLIMLTVCLS NLFKSPMYFF LSFLSFVDIC YSSVTAPKMI VDLLAKDKTI SYVGCMLQLF 

       110        120        130        140        150        160        170        180        190        200 
GVHFFGCTEI FILTVMAYDR YVAICKPLHY MTIMNRETCN KMLLGTWVGG FLHSIIQVAL VVQLPFCGPN EIDHYFCDVH PVLKLACTET YIVGVVVTAN 

       210        220        230        240        250        260        270        280        290        300 
SGTIALGSFV ILLISYSIIL VSLRKQSAEG RRKALSTCGS HIAMVVIFFG PCTFMYMRPD TTFSEDKMVA VFYTIITPML NPLIYTLRNA EVKNAMKKLW 

       310        320 
GRNVFLEAKG K

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


V M K D       T   I Y T E     V L   S I T K      L L  I E P S  
 F V A   T D P R   V G V   A V Q I   G V Y    D V I    V K E   
I I T Y   M Y M   A T V V   I S H   Q L M C  M K P A  V V F C  
 M P T   F T C P   G S N   L F G G   G F L    T V S    F S F   
L P N L   G F F   L A I T   V W T   F F H V  S Y C I  I I Y F  
 T Y I   I V V M   F S G   G L L M   T C G    D V F    L L I   
          A I H   L L I V   K N C   I F I E  S L F S  L L N G  
         S G C T   Y S I   T E R N   V T L    L F F    L M I   
          S L A   L I I S           D Y A M  Y M P S  L C V T  
         K R R G   L S V             V Y R                 S   
                      K R           K C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards

Odorant	EC₅₀	Adjusted Top	Aroma Notes
benzothiazole	-3.983 ¹	-	sulfurous, rubbery, vegetable, cooked, nutty, coffee, meaty, brown
p-cresol	-4.4 ²	1.8 ²	phenolic, narcissus, animal, mimosa
(Z)-3-hexen-1-ol	-3.2 ³	0.1529 ³	fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce

1.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1

2.) Shirai, T., Takase, D., Yokoyama, J. et al. Functions of human olfactory mucus and age-dependent changes. Sci Rep 13, 971 (2023). https://doi.org/10.1038/s41598-023-27937-1

3.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.

Prot.	Sim.	Expr.	2.53	3.29	3.32	3.33	3.36	3.37	3.40	3.41	4.53	4.56	4.57	4.60	45.49	45.51	45.52	45.53	5.39	5.42	5.43	5.46	5.47	6.48	6.51	6.55	6.59	7.38	7.39	7.41	7.42
OR4S2	100	57%	Y	L	V	H	G	C	I	F	G	H	S	Q	F	D	V	H	V	N	S	I	A	F	C	Y	D	A	V	Y	T
OR4X1	88	23%	Y	M	L	H	G	G	A	F	G	H	S	Q	F	D	V	H	I	N	G	I	S	F	C	Y	C	A	V	Y	T
OR4P4	88	57%	Y	L	T	H	G	G	I	F	G	H	S	Q	F	D	V	Y	V	N	S	I	A	F	A	Y	V	A	L	Y	T
OR4C3	85	34%	Y	L	A	H	G	G	I	I	G	H	S	Q	A	D	L	Y	V	N	S	I	C	F	C	Y	P	A	L	Y	G
OR4D1	85	100%	Y	I	F	H	G	G	V	F	G	H	S	Q	Y	D	V	P	M	N	S	L	V	F	C	Y	P	S	I	Y	T
OR4C12	85	23%	Y	A	E	H	G	A	I	I	G	H	A	Q	M	D	L	Y	V	N	S	I	C	F	C	Y	S	A	V	Y	T
OR4K17	85	84%	L	I	L	H	G	G	M	V	G	H	S	Q	F	D	L	P	I	N	S	I	S	F	C	Y	P	A	V	Y	T
OR4D10	84	96%	F	M	F	H	G	G	V	F	G	H	S	Q	Y	D	V	H	M	N	N	L	T	F	C	Y	P	S	V	F	T
OR4X2	84	53%	Y	L	L	H	G	G	I	F	G	H	S	Q	F	D	L	V	I	N	G	L	S	F	C	S	S	A	V	Y	T
OR4F4	84	92%	L	I	L	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	L	T	F	C	Y	P	A	V	Y	S
OR4F5	84	92%	L	I	L	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	L	T	F	C	Y	P	A	V	Y	S
OR4F17	84	92%	L	I	L	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	L	T	F	C	Y	P	A	V	Y	S
OR4E2	84	96%	H	L	L	H	A	C	I	F	G	H	S	Q	F	D	V	P	I	N	S	I	S	F	C	Y	P	S	V	Y	T
OR4S1	83	42%	Y	L	A	H	G	G	I	F	G	H	S	Q	F	D	V	H	V	N	S	I	S	L	P	Y	S	I	L	N	I
OR4Q2	83		Y	L	L	H	G	A	M	F	G	H	S	Q	F	D	V	P	M	N	S	I	S	F	C	Y	F	S	V	Y	N
OR4C11	83	69%	F	V	L	H	G	C	I	F	S	H	S	Q	C	D	L	Q	L	N	S	I	C	F	C	Y	P	A	V	Y	T
OR10G4	83	88%	F	L	F	H	G	S	C	F	G	H	S	Q	F	D	A	P	I	D	I	V	A	F	C	Y	G	A	I	Y	T
OR4M1	83		Y	L	L	H	G	A	M	F	G	H	S	Q	F	D	I	T	M	S	S	I	S	F	S	Y	P	S	V	H	T
OR4C16	82	19%	L	V	S	H	G	C	I	F	S	H	S	Q	F	D	L	Q	L	N	S	I	C	F	C	Y	L	A	V	Y	T
OR4B1	82	69%	Y	I	F	H	G	V	I	L	G	H	S	Q	F	D	L	Q	V	N	S	F	S	F	A	Y	P	A	V	Y	T
OR4M2	82	92%	Y	L	L	H	G	A	M	F	G	H	S	Q	F	D	I	T	M	S	S	I	S	F	S	Y	P	S	V	N	T
OR10G6	82		I	L	F	H	G	C	C	F	G	H	S	Q	F	D	I	P	T	D	I	L	A	Y	C	Y	C	A	V	Y	T
OR10G7	82	80%	F	L	F	H	G	S	C	F	G	H	S	Q	F	D	A	P	I	N	I	V	A	F	G	Y	G	A	V	Y	T
OR4A5	82	15%	Y	L	D	H	G	G	V	F	G	H	S	Q	S	D	M	H	V	N	S	I	C	F	C	Y	P	T	V	Y	T
OR4D5	82	80%	Y	L	F	H	G	G	I	F	G	H	S	Q	Y	D	V	P	M	N	N	V	T	F	C	Y	P	S	V	Y	T
OR10G9	82	46%	F	L	F	H	G	S	C	F	G	H	S	Q	L	D	A	P	I	D	I	V	A	F	C	Y	G	A	I	Y	T
OR4Q3	82	92%	L	I	L	H	G	A	M	F	G	H	S	Q	Y	D	V	P	V	N	S	L	S	F	C	Y	F	S	L	Y	T
OR4L1	81	11%	L	M	M	H	G	G	M	T	G	H	S	Q	F	D	L	P	V	D	S	L	S	F	C	Y	P	A	V	Y	T
OR4C15	81	69%	F	L	E	H	A	G	V	I	G	H	S	Q	M	D	L	Y	V	N	S	I	C	F	C	Y	P	A	I	Y	I
OR4D11	81	34%	F	I	F	H	G	G	I	F	G	H	S	Q	Y	D	V	P	M	N	N	V	T	F	C	Y	P	S	V	F	T
OR4K2	81	100%	L	I	L	H	T	G	I	I	G	H	S	Q	F	D	L	P	M	T	S	I	A	F	C	Y	P	S	V	Y	T
OR4K3	81		L	M	L	H	G	G	I	V	G	H	A	Q	F	D	L	P	M	T	S	I	A	F	C	Y	P	S	V	Y	T
OR4D9	81	100%	F	M	F	H	G	G	V	F	G	H	S	Q	Y	D	V	P	M	N	N	V	S	F	C	Y	P	S	V	F	T
OR10G8	81	57%	F	L	F	H	G	G	C	F	G	H	S	Q	L	D	A	P	I	T	V	V	A	F	G	Y	G	A	V	Y	T
OR4A47	80		Y	L	E	H	G	G	V	F	G	H	S	Q	F	D	M	Y	V	N	G	A	C	F	C	Y	P	S	V	Y	T
OR4K13	80	96%	L	M	M	H	G	G	M	M	G	H	S	Q	F	D	L	P	V	D	S	L	S	F	C	Y	P	S	V	Y	T
OR4K14	80	80%	L	I	L	H	G	G	M	V	G	H	S	Q	F	D	L	P	M	D	S	L	S	F	C	Y	P	S	V	Y	T
OR4K15	80	42%	V	I	V	H	T	G	M	V	G	H	T	Q	F	D	L	P	I	D	S	L	S	F	C	Y	P	A	V	Y	T
OR4N5	80	96%	Y	L	L	H	G	A	M	F	G	H	S	Q	F	D	V	P	M	N	S	L	S	F	A	Y	F	S	L	H	T
OR4C6	80	69%	F	L	E	H	G	G	I	I	G	H	A	Q	I	D	L	F	V	N	S	M	C	F	C	Y	P	A	V	D	S

Active model:	text	3D	download
Inactive model:	text	3D	download
Active dock:	text	3D	download
Inactive dock:	text	3D	download
JSON entry:	text		download

primaryodors.org

Olfactory Receptor family 4 subfamily S member 2.

Estimated Expression: 57% of the population.

Sequence:

Transmembrane Helices: