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Olfactory Receptor family 10 subfamily G member 3.

Estimated Expression: 96% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MERINSTLLT AFILTGIPYP LRLRTLFFVF FFLIYILTQL GNLLILITVW ADPRLHARPM YIFLGVLSVI DMSISSIIVP RLMMNFTLGV KPIPFGGCVA 

       110        120        130        140        150        160        170        180        190        200 
QLYFYHFLGS TQCFLYTLMA YDRYLAICQP LRYPVLMTAK LSALLVAGAW MAGSIHGALQ AILTFRLPYC GPNQVDYFFC DIPAVLRLAC ADTTVNELVT 

       210        220        230        240        250        260        270        280        290        300 
FVDIGVVVAS CFSLILLSYI QIIQAILRIH TADGRRRAFS TCGAHVTVVT VYYVPCAFIY LRPETNSPLD GAAALVPTAI TPFLNPLIYT LRNQEVKLAL 

       310        320 
KRMLRSPRTP SEV

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

L P S N  L Y I F  V T T D     T L   I P K V      T F  L R L P  
 A G D    A C P    L E N   I A Q L   G F P    N M M    L T R   
V L A A  V Y Y V  V F T V   A G H   A V C G  L R P V  F V F F  
 A T P    T V V    G I D   I S G A   Y L Q    I I S    L F F   
F P T I  T V H A  A V V V   M W A   F H Y F  S I S M  L I Y I  
 P N L    G C T    F C S   G A V L   S G L    D I V    L Q T   
    I L  S F A R  L I L S   L A S   F C Q T  S L V G  L L N G  
          R R G    Y S L   L K A T   T Y L    L F I    I L I   
         D A T H  I I Q I           Y A M L  Y M P R  A W V T  
                   I A Q             Y R D                 D   
                    I R L           C I A L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
vanillin -5.02 1 10 1  chocolate, creamy, sweet, vanilla
propenyl guaethol -5.25 1 -  sweet, vanilla, woody, tobacco, spicy, phenolic, powdery, anisic, creamy, floral
vanillyl isobutyrate -5.06 1 -  sweet, vanilla, creamy, fruity, caramellic, chocolate, powdery, buttery, cheesy
vanilla cresol -4.36 1 -  vanilla, woody, spicy, guaiacol
ethyl vanillin -5.44 1 0.6667 1  sweet, creamy, vanilla, caramellic
isoeugenol -3.88 1 2 1  carnation, clove, floral, spicy, sweet, woody
eugenyl acetate -4 2 0.0667 2  carnation, clove, floral, fresh, malty, spicy, sweet, woody
n-amyl acetate -1.4 3 0.2041 3  banana, fruity, solvent, sweet, apple, ethereal, pear
eugenol - 0.1 2  clove, spicy, sweet, woody
citral - 0.0667 2  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
2-heptanone - 0.0333 2  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
decanal - 0.0167 2  sweet, aldehydic, waxy, orange_peel, citrus, floral
1-nonanol - 0.01 2  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
amyl hexanoate - 0 2  sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
androstenone - 0 2  animal, musky
l-arabinose - 0 2  
benzene - 0 2  gasoline, phenolic, solvent, cinnamon
butyl formate - 0 2  fruity, plum, rummy, brandy
butyric acid - 0 2  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
coffee difuran - 0 2  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
coumarin - 0 2  coumarinic, hay, sweet, tonka
p-cresol - 0 1  phenolic, narcissus, animal, mimosa
beta-damascone - 0 2  berry, currant, floral, fruity, honey, plum, rose, tobacco
dimethyl disulfide - 0 2  sulfurous, vegetable, cabbage, onion, malty, creamy
2,4-DNT - 0 2  
2-ethyl fenchol - 0 2  camphorous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
geranyl acetate - 0 2  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
helional - 0 2  cyclamen, fresh, green, hay, ozone, watery
(Z)-3-hexen-1-ol - 0 2  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
isobutylamine - 0 2  cheesy, fishy
d-limonene - 0 2  citrus, orange, fresh, sweet
linalool - 0 2  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
lyral - 0 2  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
(1S,2R,5S)-(+)-menthol - 0 2  cooling, mentholic, minty
methyl eugenol - 0 2  carnation, cinnamon, clove, fresh, spicy, sweet, warm
methyl furfuryl disulfide - 0 2  sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
methyl salicylate - 0 2  minty, wintergreen
nonanal - 0 2  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
octanethiol - 0 2  sulfurous
1-octanol - 0 2  aldehydic, green, mushroom, orange, rose, waxy
octyl octanoate - 0 2  coconut, oily, fruity
pelargonic acid - 0 2  cheesy, dairy, dirty, waxy
propanal - 0 2  alcoholic, cocoa, earthy, nutty, whisky, winey
propionic acid - 0 2  acidic, cheesy, pungent, vinegar
pyrazine - 0 2  pungent, sweet, corn, roasted, hazelnut, barley
quinoline - 0 2  earthy, medicinal, musty, rubbery, tobacco
sotolone - 0 2  sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
terpinyl acetate - 0 2  bergamot, citrus, herbal, lavender, lime
allyl phenylacetate - -0.0167 2  honey, fruity, rummy
n-amyl alcohol - -0.0167 2  fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent

1.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

2.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

3.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
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