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Olfactory Receptor family 10 subfamily G member 7.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MSNATLLTAF ILTGLPHAPG LDAPLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF LTNLSFIDMW FSTVTVPKML MTLVSPSGRT ISFHSCVAQL 

       110        120        130        140        150        160        170        180        190        200 
YFFHFLGSTE CFLYTVMSYD RYLAISYPLR YTNMMTGRSC ALLATGTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA PPILKLACAD TSANEMVIFV 

       210        220        230        240        250        260        270        280        290        300 
NIGLVASGCF VLIVLSYVSI VCSILRIRTS EGRHRAFQTC ASHCIVVLCF FGPGLFIYLR PGSRDALHGV VAVFYTTLTP LFNPVVYTLR NKEVKKALLK 

       310        320 
LKNGSVFAQG E

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

L G P A        L  S H F S       L   A S T D  L Y I F  L A D R  
 P A D    T M L    A V C   I T Q V   M E N    L G P    V G H   
I G F L  M K P V  F Y L Q   A S H   V F I V  G F F C  F V A V  
 V L F    T V T    F H F   L S G S   G I N    L V V    T T Y   
L V Y V  S F W M  T S G L   L W T   S A V L  I C H S  L P T L  
 L V T    D I F    F C E   G T A L   F C G    A C T    P N F   
L L N G  S L N T  V T Y L   L A C   V I L V  Q F A R  T Y V V  
 L L I    L F Y    Y S M   S R G T   Y S L    H R G        L   
  R I V  Y M P T  L Y R D           V I S V  E S T R           
                   S I A             I S C                     
                        Y               R L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
eugenol -9 1 5.654 2  clove, spicy, sweet, woody
creosol -6 2 10 2  burnt, clove, leathery, medicinal, phenolic, smoky, spicy, vanilla, woody
guaiacol -6 2 8.1972 2  phenolic, smoky, spicy, vanilla, woody, medicinal, savory, meaty
methyl eugenol -6 2 2.3333 3  carnation, cinnamon, clove, fresh, spicy, sweet, warm
isoeugenol -3.23 4 5.4167 4  carnation, clove, floral, spicy, sweet, woody
4-vinylguaiacol -4.7 5 1.3333 5  spicy, clove, carnation, phenolic, peppery, smoky, woody, powdery
eugenyl acetate - 3 3  carnation, clove, floral, fresh, malty, spicy, sweet, woody
ethyl vanillin - 0.2333 3  sweet, creamy, vanilla, caramellic
coumarin - 0.1667 3  coumarinic, hay, sweet, tonka
octyl octanoate - 0.1667 3  coconut, oily, fruity
methyl furfuryl disulfide - 0.1333 3  sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
1-octanol - 0.1333 3  aldehydic, green, mushroom, orange, rose, waxy
quinoline - 0.0667 3  earthy, medicinal, musty, rubbery, tobacco
allyl phenylacetate - 0 3  honey, fruity, rummy
androstenone - 0 3  animal, musky
l-arabinose - 0 3  
butyric acid - 0 3  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
(S)-(+)-carvone - 0 3  bready, caraway, minty, spicy
citral - 0 3  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
coffee difuran - 0 3  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
dimethyl disulfide - 0 3  sulfurous, vegetable, cabbage, onion, malty, creamy
2,4-DNT - 0 3  
2-ethyl fenchol - 0 3  camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
geranyl acetate - 0 3  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
helional - 0 3  cyclamen, fresh, green, hay, ozone, watery
heptanal - 0 6  aldehydic, cognac, fatty, fresh, green, herbal, ozone
2-heptanone - 0 3  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
(Z)-3-hexen-1-ol - 0 3  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
isobutylamine - 0 3  cheesy, fishy
d-limonene - 0 3  citrus, orange, fresh, sweet
linalool - 0 3  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
lyral - 0 3  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
methyl salicylate - 0 3  minty, wintergreen
nonanal - 0 3  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
1-nonanol - 0 3  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
octanethiol - 0 3  sulfurous
3-octen-2-one - 0 7  earthy, spicy, herbal, sweet, mushroom, hay, blueberry
pelargonic acid - 0 3  cheesy, dairy, dirty, waxy
propionic acid - 0 3  acidic, cheesy, pungent, vinegar
pyrazine - 0 3  pungent, sweet, corn, roasted, hazelnut, barley
sotolone - 0 3  sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
terpinyl acetate - 0 3  bergamot, citrus, herbal, lavender, lime
amyl hexanoate - -0.0667 3  sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
benzene - -0.0667 3  
butyl formate - -0.0667 3  fruity, plum, rummy, brandy
beta-damascone - -0.0667 3  berry, currant, floral, fruity, honey, plum, rose, tobacco
decanal - -0.0667 3  sweet, aldehydic, waxy, orange_peel, citrus, floral
(1S,2R,5S)-(+)-menthol - -0.0667 3  cooling, mentholic, minty
pentanol - -0.0667 3  fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
propanal - -0.0667 3  alcoholic, cocoa, earthy, nutty, whiskey, winey

1.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

3.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

4.) C. Trimmer, A. Keller, N. R. Murphy, L. L. Snyder, J. R. Willer, M. H. Nagai, N. Katsanis, L. B. Vosshall, H. Matsunami, and J. D. Mainland Genetic variation across the human olfactory receptor repertoire alters odor perception PNAS | May 7, 2019 | vol. 116 | no. 19 | 9475–9480

5.) Aya Namba, Naoko Saito, Keiichi Yoshikawa, Ichiro Mori (2015) Search method of urine odor suppressor JP2015211667A

6.) Lim J. H., J. Park, E. H. Oh, H. J. Ko, S. Hong, and Park, T. H. (2014) Nanovesicle-based bioelectronic nose for the diagnosis of lung cancer from human blood. Adv. Healthcare Mater., 3: 360–366.

7.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147
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