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SMILES:
CC(=CCCC(=CCO)C)C

Aroma Description:
citrus, floral, fruity, rose, sweet, waxy1

Receptor Expression log10 EC50 Adj. Top Antagonist? Correlated Perceptual Qualities
OR2W1 53 -8.46 2, -4.74 5, -3.796 16 3.5042 2, 9.5 5  sweet, tart, hay, fatty, coumarinic, orange, peony, cinnamon, herbal, tonka
OR1A1 73 -3.47 5, -8 6 9.7 5, (agonist) 6, 4.5 7  sweet, citrus, fresh, rose, herbal, waxy, orange, spearmint, floral, aldehydic
OR1A2 19 -8 6 -  citrus, waxy, aldehydic, orange, fresh, orange_peel, tart, rose, sweet, floral
OR10A6 100 -6.48 11 -  peach, sweet, coconut, floral, lactonic, cyclamen, neroli, waxy, dairy, honey
OR2AG2 100 -5.74 11 -  cinnamyl, sweet, cinnamon, floral, rose, balsamic, hyacinth, honey, magnolia, citrus
OR2A25 100 -4.85 17 -  rose, peony, floral, geranium, citrus
OR2M7 34 -3 2, -3.2 5 0.5427 2, 8 5  alliaceous, eggy, cabbage, garlic
OR2W3 100 - 8.1395 10  sweet, lemon, citrus, clove
OR1G1 61 - 6.599 4  sweet, waxy, citrus, fresh, tart, orange, aldehydic, floral, rose, fatty
OR1D2 100 -4 8 -  rose, citrus, fresh, sweet, floral, waxy, fatty, bois_de_rose, peach, blueberry
OR4C3 34 -2.7 2 1.1127 2  currant, plum, rose, honey, berry
OR4X2 53 -2.46 2 1.2152 2  grape, sweet, animal
OR4E2 96 - 1.9231 12  sweet, cork_taint, cortex, foliage, solvent, floral, ethereal, pear
OR10S1 92 - 1.5 3  watery, peely, orange_peel, cilantro, waxy, floral
OR52D1 100 - 0.7614 4  dairy, cheesy, anise, milky, creamy, sour, sharp, peach, lactonic, rancid
OR10J5 84 - 0 5   
OR2C1 100 - 0 5   
OR2J2 92 - 0 5   
OR51E1 100 - 0 5   
OR51L1 88 - 0 5   
OR5A1 100 - 0 9   
OR5A2 100 - 0 9   
OR5AN1 100 - 0 9   
OR11H4 100 - 0 11   
OR5I1 46 - 0 12   
OR2L13 88 - 0 15   
OR5P3 100 - 0 5, -0.4065 13   
OR8H1 88 - -0.4065 13   
OR5K1 100 - -0.1626 13, -0.5714 14   
 

SMILES:
CC(=CCCC(=CCO)C)C

Aroma Description:
citrus, floral, fruity, rose, sweet, waxy

Receptor Expr.% Agonist? Dock Score Known agonist Correlated Perceptual Qualities

Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.

1.) The Good Scents Company

2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

3.) Emily A. Yasi, Sara L. Eisen, Hanfei Wang, Widianti Sugianto, Anita R. Minniefield, Kaitlyn A. Hoover, Paul J. Branham, and Pamela Peralta-Yahya Rapid Deorphanization of Human Olfactory Receptors in Yeast Biochemistry 2019, 58, 2160-2166

4.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

5.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

6.) Silva Teixeira CS, Silva Ferreira AC, Cerqueira NM. Studying Haloanisoles Interaction with Olfactory Receptors. ACS Chem Neurosci. 2016 Jul 20;7(7):870-85. doi: 10.1021/acschemneuro.5b00335. Epub 2016 May 9. PMID: 27092849.

7.) Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J Struct Biol. 2007 Sep;159(3):400-12. doi: 10.1016/j.jsb.2007.04.013. Epub 2007 May 25. PMID: 17601748.

8.) Veithen, A.; Wilin, F.; Philippeau, M.; Chatelain, P. OR1D2 is a broadly tuned human olfactory receptor. Chem. Senses 2015, 40, 262–263.

9.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]

10.) Huang, J., Lam, H., Koziol-White, C., Limjunyawong, N., Kim, D., Kim, N., ... & An, S. S. (2020). The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. Proceedings of the National Academy of Sciences, 117(45), 28485-28495.

11.) Duroux R, Mandeau A, Guiraudie-Capraz G, Quesnel Y, Loing E. A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors. Molecules. 2020 Oct 16;25(20):4743. doi: 10.3390/molecules25204743. PMID: 33081083; PMCID: PMC7587601.

12.) Ashti Baghaei, K. (2015). Large scale analysis of olfactory receptors with highly genetically variations in relation with specific anosmia (Doctoral dissertation, Bochum, Ruhr-Universität Bochum, Diss., 2013).

13.) Aya Kato, Naoko Saito (2015) Odor control agent. JP5798382B2

14.) Aya Kato, Naoko Saito, Michiaki Inoue, Kayoko Nomizu (2015) Method of identifying an agent for inhibiting odor of pyrazine derivatives US9057090B2

15.) Morrell CN, Mix D, Aggarwal A, Bhandari R, Godwin M, Owens P 3rd, Lyden SP, Doyle A, Krauel K, Rondina MT, Mohan A, Lowenstein CJ, Shim S, Stauffer S, Josyula VP, Ture SK, Yule DI, Wagner LE 3rd, Ashton JM, Elbadawi A, Cameron SJ. Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms. J Clin Invest. 2022 May 2;132(9):e152373. doi: 10.1172/JCI152373. PMID: 35324479; PMCID: PMC9057618.

16.) Franziska Haag, Antonella Di Pizio, Dietmar Krautwurst, The key food odorant receptive range of broadly tuned receptor OR2W1. Food Chemistry 375 (2022) 131680

17.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025
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