octanoic acid
SMILES:
CCCCCCCC(=O)[O-]
Aroma Description:
cheesy, fatty, oily, rancid, vegetable, waxy1
| Receptor | log10 EC50 | Adj. Top | Antagonist? | Correlated Perceptual Qualities |
|---|---|---|---|---|
| OR2W1 | -4.85 5 | 8.2 5 | fatty, sweet, herbal, cucumber, orange, tart, mimosa, spicy, coumarinic, passionfruit | |
| OR56A5 | -4.1 10 | 5.7 10 | rancid, cheesy, buttermilk, sweaty, sour | |
| OR2L13 | -4.15 2 | 1.0714 2, 1 9 | cilantro, spearmint, greasy, soapy, watery | |
| OR2A7 | -4.82 2 | 1.4286 2 | pine, resinous, cumin, watery | |
| OR51E1 | - | 0 4, 0 5, 4.42 7 | cheesy, sweaty, sour, acidic | |
| OR52B2 | -3.83 10 | 0.9 10 | rancid, cheesy, sour, juicy, tart | |
| OR52D1 | - | 3.9086 3 | anise, cheesy, orange, sweet, dairy, sour, rancid, waxy, tart, sharp | |
| OR10S1 | - | 0.7143 2 | watery, cilantro, orange_peel, cumin, orris, aldehydic, greasy, muguet | |
| OR1G1 | - | 0.0508 3 | waxy, tart, orange, sweet, aldehydic, fresh, citrus, clean, medicinal, anise | |
| OR10J5 | - | 0 5 | ||
| OR1A1 | - | 0 5 | ||
| OR2C1 | - | 0 5 | ||
| OR2J2 | - | 0 5 | ||
| OR51L1 | - | 0 5 | ||
| OR5P3 | - | 0 5 | ||
| OR5A1 | - | 0 6 | ||
| OR5A2 | - | 0 6 | ||
| OR5AN1 | - | 0 6 | ||
| OR51E2 | - | 0 8 |
octanoic acid
SMILES:
CCCCCCCC(=O)[O-]
Aroma Description:
cheesy, fatty, oily, rancid, vegetable, waxy
Dock Score: This is a measure of whether the algorithm thinks the odorant is an agonist of the receptor.
Affinity: The binding affinity, in kJ/mol, of the ligand docked in the active or inactive model, whichever is greater.
A100: A measure of the degree of activation of the receptor. See
Ibrahim et al (2019).
1.) The Good Scents Company
2.) Emily A. Yasi, Sara L. Eisen, Hanfei Wang, Widianti Sugianto, Anita R. Minniefield, Kaitlyn A. Hoover, Paul J. Branham, and Pamela Peralta-Yahya Rapid Deorphanization of Human Olfactory Receptors in Yeast Biochemistry 2019, 58, 2160-2166
3.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002
4.) YOSHIFUMI FUJITA, TOMOKO TAKAHASHI, AKIKO SUZUKI, KAYO KAWASHIMA, FUTOSHI NARA & RYUTA KOISHI (2007) Deorphanization of Dresden G Protein-Coupled Receptor for an Odorant Receptor, Journal of Receptors and Signal Transduction, 27:4, 323-334, DOI: 10.1080/10799890701534180
5.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.
6.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]
7.) Halperin Kuhns, V. L., Sanchez, J., Sarver, D. C., Khalil, Z., Rajkumar, P., Marr, K. A., & Pluznick, J. L. (2019). Characterizing novel olfactory receptors expressed in the murine renal cortex. American Journal of Physiology-Renal Physiology, 317(1), F172-F186.
8.) Christian B. Billesbølle, Claire A. de March, Wijnand J. C. van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami, Aashish Manglik. Structural basis of odorant recognition by a human odorant receptor. bioRxiv 2022.12.20.520951; doi: https://doi.org/10.1101/2022.12.20.520951
9.) Morrell CN, Mix D, Aggarwal A, Bhandari R, Godwin M, Owens P 3rd, Lyden SP, Doyle A, Krauel K, Rondina MT, Mohan A, Lowenstein CJ, Shim S, Stauffer S, Josyula VP, Ture SK, Yule DI, Wagner LE 3rd, Ashton JM, Elbadawi A, Cameron SJ. Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms. J Clin Invest. 2022 May 2;132(9):e152373. doi: 10.1172/JCI152373. PMID: 35324479; PMCID: PMC9057618.
10.) Chatelain Pierre, Veithen Alex, Olfactory Receptors involved in the perception of sweat carboxylic acids and the use thereof. WO 2014/191047