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Olfactory Receptor family 2 subfamily C member 1.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MDGVNDSSLQ GFVLMGISDH PQLEMIFFIA ILFSYLLTLL GNSTIILLSR LEARLHTPMY FFLSNLSSLD LAFATSSVPQ MLINLWGPGK TISYGGCITQ 

       110        120        130        140        150        160        170        180        190        200 
LYVFLWLGAT ECILLVVMAF DRYVAVCRPL RYTAIMNPQL CWLLAVIACL GGLGNSVIQS TFTLQLPLCG HRRVEGFLCE VPAMIKLACG DTSLNQAVLN 

       210        220        230        240        250        260        270        280        290        300 
GVCTFFTAVP LSIIVISYCL IAQAVLKIRS AEGRRKAFNT CLSHLLVVFL FYGSASYGYL LPAKNSKQDQ GKFISLFYSL VTPMVNPLIY TLRNMEVKGA 

       310        320 
LRRLLGKGRE VG

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

Q D Q K       K   L S T D     T F   I T K G      W L  L Q P H  
 F K G   A P L L   A Q N   T S Q I   G Y S    N I L    I M E   
F L S I   Y G Y   G N L V   V S N   T I C G  M Q P V  A I F F  
 L S Y   S A S G   T C V   G L G G   Y L Q    S S T    F L I   
M P T V   Y F L   A T F F   L C A   W L F V  A F A L  L L Y S  
 P N V   F V V L   L P V   I V A L   A G L    D L S    L L T   
    I L   L H S   V I I S   L W C   I C E T  S L N S  T S N G  
         L C T N   Y S I   L Q P N   V L L    L F F    L I I   
          F A K   A I L C           F A M V  Y M P T  L R S L  
         R R G E   V A Q             Y R D                 E   
                    I K L           C V A V                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
octanethiol -8.36 1 9.5 1  sulfurous
nonanethiol -5.3 1 9.8 1  
pentanethiol -4.7 2 10 2  sulfurous, fatty, roasted, meaty, vegetable
heptanethiol -4.9 2 9.5 2  onion, skunk, sulfurous
ethyl 3-mercaptopropionate -5.36 3 -  animal, fruity, grape, skunk, meaty
allyl mercaptan -4.66 4 -  alliaceous, sulfurous, garlic, onion, roasted, cooked_onion, grilled, charred, meaty
hexanethiol -4.8 2 6.5 2  burnt, fatty, sulfurous, meaty, garlic, roasted, alliaceous, nutty, rubbery, vegetable
diallyl disulfide - 6 4  alliaceous, garlic, metallic, onion
cinnamaldehyde -4 5 1.4653 5  sweet, spicy, candy, cinnamon, warm
acetophenone - 0 6  sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
allyl heptanoate - 0 6  sweet, pineapple, fruity, waxy, banana, fusel, cognac, ripe, fermented
allyl phenylacetate - 0 6  honey, fruity, rummy
allylbenzene - 0 6  
n-amyl alcohol - 0 6  fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
amyl hexanoate - 0 6  sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
benzene - 0 6  gasoline, phenolic, solvent, cinnamon
benzophenone - 0 6  balsamic, rose, metallic, powdery, geranium, herbal, plastic, phenolic
benzyl acetate - 0 6  sweet, floral, fruity, jasmine, fresh
butyl butyryl lactate - 0 6  creamy, buttery, buttermilk, dairy, cheesy, fatty, waxy, sweaty, green
butyl formate - 0 6  fruity, plum, rummy, brandy
(-)-camphor - 0 6  
camphor - 0 6  camphorous
capric acid - 0 6  citrus, fatty, rancid, sour
caproic acid - 0 6  cheesy, fatty, sour, sweaty
gamma-caprolactone - 0 6  herbal, coconut, sweet, coumarinic, tobacco, creamy, lactonic, green
caprylic acid - 0 6  cheesy, fatty, oily, rancid, vegetable, waxy
(R)-(-)-carvone - 0 6  herbal, minty, spearmint, sweet
(S)-(+)-carvone - 0 6  bready, caraway, minty, spicy
4-chromanone - 0 6  
(S)-(-)-citronellol - 0 6  citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
2-coumaranone - 0 6  
coumarin - 0 6  coumarinic, hay, sweet, tonka
cyclohexanone - 0 6  acetone, minty
decanal - 0 6  sweet, aldehydic, waxy, orange_peel, citrus, floral
1-decanol - 0 6  aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
di-tert-butyl disulfide - 0 4  garlic, green_onion, sulfurous
diallyl sulfide - 0 4  sulfurous, onion, garlic, horseradish, metallic, pungent
(+)-dihydrocarvone - 0 6  herbal, minty, mentholic
dihydrojasmone - 0 6  floral, fresh, herbal, jasmine, myrrh, outdoors, spicy, woody
ethyl isobutyrate - 0 6  alcoholic, ethereal, fruity, fusel, rummy, sweet
fenchone - 0 6  camphorous, earthy, herbal, woody
geraniol - 0 6  citrus, floral, fruity, rose, sweet, waxy
heptanal - 0 6  aldehydic, cognac, fatty, fresh, green, herbal, ozone
1-heptanol - 0 6  musty, leafy, violet, herbal, green, sweet, woody, peony, pungent, vegetable, fruity, apple, banana
2-heptanone - 0 6  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
3-heptanone - 0 6  fatty, fruity, green
hexanal - 0 6  aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
2,3-hexanedione - 0 6  buttery, sweet
3,4-hexanedione - 0 6  almond, buttery, caramellic, nutty, toasted
hexanol - 0 6  ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
2-hexanone - 0 6  ethereal
hexyl acetate - 0 6  apple, banana, fruity, green, sweet
4-hydroxycoumarin - 0 6  
lyral - 0 6  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
nonanal - 0 6  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
1-nonanol - 0 6  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
2-nonanone - 0 6  fresh, sweet, green, weedy, earthy, herbal, fruity, waxy, soapy, cheesy, coconut, dairy, dirty, buttery
octanal - 0 6  aldehydic, citrus, fatty, green, orange, peel, waxy
1-octanol - 0 6  aldehydic, green, mushroom, orange, rose, waxy
2-octanone - 0 6  earthy, herbal, natural, weedy, woody
3-octanone - 0 6  fresh, herbal, lavender, mushroom, sweet
oenanthic acid - 0 6  rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
pelargonic acid - 0 6  cheesy, dairy, dirty, waxy
2-pentanone - 0 6  sweet, fruity, ethereal, winey, banana, woody, fermented
phenyl acetate - 0 6  phenolic, medicinal, animal, resinous, castoreum, woody, smoky, burnt
(+)-2-phenylbutyric acid - 0 6  
prenyl acetate - 0 6  sweet, fresh, banana, fruity, jasmine, ripe, heliotrope, balsamic
propionic acid - 0 6  acidic, cheesy, pungent, vinegar
valeric acid - 0 6  acidic, cheesy, fruity, milky, sharp, sour, tobacco
vanillic acid - 0 6  beany, brown, creamy, dairy, milky, phenolic, powdery, sweet, vanilla

1.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

2.) Block, Batista, Matsunami, Zhuang, Ahmed The role of metals in mammalian olfaction of low molecular weight organosulfur compound Nat. Prod. Rep., 2017,34, 529-557

3.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1

4.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

5.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

6.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.
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