Olfactory Receptor family 52 subfamily B member 2.
Sequence:
10 20 30 40 50 60 70 80 90 100 MSHTNVTIFH PAVFVLPGIP GLEAYHIWLS IPLCLIYITA VLGNSILIVV IVMERNLHVP MYFFLSMLAV MDILLSTTTV PKALAIFWLQ AHNIAFDACV 110 120 130 140 150 160 170 180 190 200 TQGFFVHMMF VGESAILLAM AFDRFVAICA PLRYTTVLTW PVVGRIALAV ITRSFCIIFP VIFLLKRLPF CLTNIVPHSY CEHIGVARLA CADITVNIWY 210 220 230 240 250 260 270 280 290 300 GFSVPIVMVI LDVILIAVSY SLILRAVFRL PSQDARHKAL STCGSHLCVI LMFYVPSFFT LLTHHFGRNI PQHVHILLAN LYVAVPPMLN PIVYGVKTKQ 310 320 330 IREGVAHRFF DIKTWCCTSP LGS
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 A E L G I A L A D F A L V T I D T V H Q P I H Y A K P V T V C F I V P W I N L L T F L I H I S L W T T T F F G Q F I I S F G Y F S P L N A L C L P S L L I M H V C F S R I P V V Y F M A V Y I Y I L D M V G V F M T I V I V M V L I V M P P V V A T A L M S A S E A L A I V D L C L H S P N L S N G L L F F A L L I R G V A I L I G C T G Y V I I L I Y M P V F A M V P W T Y S V S L A K K V V I V V V F R D L I L S H R A C I A V A R D Q S P A R F UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| citral | -3.3 1 | - | sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal | |
| undecanoic acid | -4.47 2 | 2.2 2 | waxy, creamy, cheesy, fatty, coconut | |
| capric acid | -4.28 2 | 1.2 2 | citrus, fatty, rancid, sour | |
| pelargonic acid | -4.08 2 | 1.2 2 | cheesy, dairy, dirty, waxy | |
| oenanthic acid | -4.56 2 | 0.3 2 | rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity | |
| caprylic acid | -3.83 2 | 0.9 2 | cheesy, fatty, oily, rancid, vegetable, waxy | |
| caproic acid | -3.83 2 | 0.37 2 | cheesy, fatty, sour, sweaty | |
| delta-decalactone | - | 2.0833 3 | coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet | |
| butyric acid | - | 0 3 | sharp, acetic, cheesy, buttery, fruity, dairy, creamy | |
| diacetyl | - | 0 3 | buttery, caramellic, creamy, pungent, sweet |
1.) Cong X, Ren W, Pacalon J, Xu R, Xu L, Li X, de March CA, Matsunami H, Yu H, Yu Y, Golebiowski J. Large-Scale G Protein-Coupled Olfactory Receptor-Ligand Pairing. ACS Cent Sci. 2022 Mar 23;8(3):379-387. doi: 10.1021/acscentsci.1c01495. Epub 2022 Feb 18. PMID: 35350604; PMCID: PMC8949627.
2.) Chatelain Pierre, Veithen Alex, Olfactory Receptors involved in the perception of sweat carboxylic acids and the use thereof. WO 2014/191047
3.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.