Olfactory Receptor family 56 subfamily A member 5.
Estimated Expression: 69% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MTLPSNNSTS PVFEFFLICF PSFQSWQHWL SLPLSLLFLL AMGANATLLI TIYLEASLHQ PLYYLLSLLS LLDIVLCLTV IPKVLAIFWF DLRSISFPAC 110 120 130 140 150 160 170 180 190 200 FLQVFIMNSF LTMESCTFMI MAYDRYVAIC KPLQYSSIIT DQFVARAAIF VVARNGLLTM PIPILSSRLR YCAGHIIKNC ICTNVSVSKL SCDDITLNQS 210 220 230 240 250 260 270 280 290 300 YQFVIGWTLL GSDLILIVLS YFFILKTVLR IKGEGDMAKA LGTCGSHFIL ILFFTTVLLV LVITNLARKR IPPDVPILLN ILHHLIPPAL NPIVYGVRTK 310 320 EIKQGIQNLL RRL
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 V D P P T L T I D S L S I S R W F W S Q F L I P I V L V S Q N I P I P A P F I A L W H Q L I N L L L V V F Q Y M T L Q L F C V K P I P L S L L H H T T F F W G I L G N R I F V V T L L S L A P P I L I L G L L T A V V F S N M C L V I L L F L P N L I F H S L D S F I A A M T L D L L G M A G Y V I G C T V I L I R A V T C S E S L L S T A N A V G L A K Y S L F Q D T I M F L L Y I L L A M D L I F F D Y A M Y L P Q L Y I T G E G K V T K V Y R E I R L C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| undecanoic acid | -3.97 1 | 10 1 | waxy, creamy, cheesy, fatty, coconut | |
| 2-methylheptanoic acid | -3.12 1 | 10 1 | waxy, green, cheesy, sweaty, buttermilk | |
| pelargonic acid | -4.42 1 | 7.7 1 | cheesy, dairy, dirty, waxy | |
| capric acid | -4.4 1 | 5.3 1 | citrus, fatty, rancid, sour | |
| caprylic acid | -4.1 1 | 5.7 1 | cheesy, fatty, oily, rancid, vegetable, waxy | |
| oenanthic acid | -3.24 1 | 5 1 | rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity | |
| caproic acid | -2.83 1 | 0.9 1 | cheesy, fatty, sour, sweaty | |
| phenylacetic acid | - | 2 2 | sweet, honey, floral, honeysuckle, sour, waxy, civet | |
| butyric acid | - | 0 3 | sharp, acetic, cheesy, buttery, fruity, dairy, creamy | |
| delta-decalactone | - | 0 3 | coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet | |
| diacetyl | - | 0 3 | buttery, caramellic, creamy, pungent, sweet |
1.) Chatelain Pierre, Veithen Alex, Olfactory Receptors involved in the perception of sweat carboxylic acids and the use thereof. WO 2014/191047
2.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025
3.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.