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Olfactory Receptor family 10 subfamily J member 5.

Estimated Expression: 84% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MKRKNFTEVS EFIFLGFSSF GKHQITLFVV FLTVYILTLV ANIIIVTIIC IDHHLHTPMY FFLSMLASSE TVYTLVIVPR MLLSLIFHNQ PISLAGCATQ 

       110        120        130        140        150        160        170        180        190        200 
MFFFVILATN NCFLLTAMGY DRYVAICRPL RYTVIMSKGL CAQLVCGSFG IGLTMAVLHV TAMFNLPFCG TVVDHFFCDI YPVMKLSCID TTINEIINYG 

       210        220        230        240        250        260        270        280        290        300 
VSSFVIFVPI GLIFISYVLV ISSILQIASA EGRKKTFATC VSHLTVVIVH CGCASIAYLK PKSESSIEKD LVLSVTYTII TPLLNPVVYS LRNKEVKDAL 

       310 
CRVVGRNIS

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

K E I S       K   I T T D     M A   I P Q N      I L  H K G F  
 V L D   L Y A I   I E N   T V H L   A L S    S L L    T I Q   
T V S L   S A C   G Y N I   V A M   T A C G  M R P V  V V F L  
 I T Y   G C H V   S S V   T L G I   F M Q    I V L    T L F   
L P T I   I V V   F I V F   G F S   I V F F  T Y V T  L I Y V  
 P N L   T L H S   I P V   G C V L   T A L    E S S    V L T   
  Y V V   V C T   F I L G   Q A C   F C N N  A L M S  I I N A  
         A F T K   Y S I   L G K S   T L L    L F F    T V I   
          K R G   I V L V           Y G M A  Y M P T  I C I I  
         E A S A   I S S             Y R D                 D   
                    I Q L           C I A V                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Docks Aroma Notes
lyral -5.14 1 10 2   aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
alpha-cedrene - 8.125 2   woody, cedar, sweet, fresh
bourgeonal -3.05 3 7.5 3   fresh, watery, floral, cyclamen, sweet
acetophenone - 0 4   sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
allyl heptanoate - 0 4   sweet, pineapple, fruity, waxy, banana, fusel, cognac, ripe, fermented
allyl phenylacetate - 0 5   honey, fruity, rummy
allylbenzene - 0 4   
n-amyl alcohol - 0 5   fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
amyl hexanoate - 0 5   sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
androstenone - 0 5   animal, musky
l-arabinose - 0 5   
benzene - 0 5   gasoline, phenolic, solvent, cinnamon
benzophenone - 0 4   balsamic, rose, metallic, powdery, geranium, herbal, plastic, phenolic
benzyl acetate - 0 4   sweet, floral, fruity, jasmine, fresh
butyl butyryl lactate - 0 4   creamy, buttery, buttermilk, dairy, cheesy, fatty, waxy, sweaty, green
butyl formate - 0 5   fruity, plum, rummy, brandy
butyric acid - 0 5   sharp, acetic, cheesy, buttery, fruity, dairy, creamy
(-)-camphor - 0 4   
camphor - 0 4   camphorous
capric acid - 0 4   citrus, fatty, rancid, sour
caproic acid - 0 4   cheesy, fatty, sour, sweaty
gamma-caprolactone - 0 4   herbal, coconut, sweet, coumarinic, tobacco, creamy, lactonic, green
caprylic acid - 0 4   cheesy, fatty, oily, rancid, vegetable, waxy
(R)-(-)-carvone - 0 4   herbal, minty, spearmint, sweet
(S)-(+)-carvone - 0 5   bready, caraway, minty, spicy
4-chromanone - 0 4   
citral - 0 5   sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
(S)-(-)-citronellol - 0 4   citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
coffee difuran - 0 5   cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
2-coumaranone - 0 4   
coumarin - 0 5   coumarinic, hay, sweet, tonka
cyclohexanone - 0 4   acetone, minty
beta-damascone - 0 5   berry, currant, floral, fruity, honey, plum, rose, tobacco
decanal - 0 5   sweet, aldehydic, waxy, orange_peel, citrus, floral
1-decanol - 0 4   aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
(+)-dihydrocarvone - 0 4   herbal, minty, mentholic
dihydrojasmone - 0 4   floral, fresh, herbal, jasmine, myrrh, outdoors, spicy, woody
dimethyl disulfide - 0 5   sulfurous, vegetable, cabbage, onion, malty, creamy
2,4-DNT - 0 5   
2-ethyl fenchol - 0 5   camphorous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl isobutyrate - 0 4   alcoholic, ethereal, fruity, fusel, rummy, sweet
ethyl vanillin - 0 5   sweet, creamy, vanilla, caramellic
eugenol - 0 5   clove, spicy, sweet, woody
eugenyl acetate - 0 5   carnation, clove, floral, fresh, malty, spicy, sweet, woody
fenchone - 0 4   camphorous, earthy, herbal, woody
geraniol - 0 4   citrus, floral, fruity, rose, sweet, waxy
geranyl acetate - 0 5   floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
helional - 0 5   cyclamen, fresh, green, hay, ozone, watery
heptanal - 0 4   aldehydic, cognac, fatty, fresh, green, herbal, ozone
1-heptanol - 0 4   musty, leafy, violet, herbal, green, sweet, woody, peony, pungent, vegetable, fruity, apple, banana
2-heptanone - 0 5   banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
3-heptanone - 0 4   fatty, fruity, green
hexanal - 0 4   aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
2,3-hexanedione - 0 4   buttery, sweet
3,4-hexanedione - 0 4   almond, buttery, caramellic, nutty, toasted
hexanol - 0 4   ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
2-hexanone - 0 4   ethereal
(Z)-3-hexen-1-ol - 0 5   fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
hexyl acetate - 0 4   apple, banana, fruity, green, sweet
4-hydroxycoumarin - 0 4   
isobutylamine - 0 5   cheesy, fishy
d-limonene - 0 5   citrus, orange, fresh, sweet
linalool - 0 5   blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
(1S,2R,5S)-(+)-menthol - 0 5   cooling, mentholic, minty
methyl eugenol - 0 5   carnation, cinnamon, clove, fresh, spicy, sweet, warm
methyl furfuryl disulfide - 0 5   sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
methyl salicylate - 0 5   minty, wintergreen
nonanal - 0 5   waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
nonanethiol - 0 4   
1-nonanol - 0 4   aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
2-nonanone - 0 4   fresh, sweet, green, weedy, earthy, herbal, fruity, waxy, soapy, cheesy, coconut, dairy, dirty, buttery
octanal - 0 4   aldehydic, citrus, fatty, green, orange, peel, waxy
octanethiol - 0 5   sulfurous
1-octanol - 0 5   aldehydic, green, mushroom, orange, rose, waxy
2-octanone - 0 4   earthy, herbal, natural, weedy, woody
3-octanone - 0 4   fresh, herbal, lavender, mushroom, sweet
octyl octanoate - 0 5   coconut, oily, fruity
oenanthic acid - 0 4   rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
pelargonic acid - 0 5   cheesy, dairy, dirty, waxy
2-pentanone - 0 4   sweet, fruity, ethereal, winey, banana, woody, fermented
phenyl acetate - 0 4   phenolic, medicinal, animal, resinous, castoreum, woody, smoky, burnt
(+)-2-phenylbutyric acid - 0 4   
prenyl acetate - 0 4   sweet, fresh, banana, fruity, jasmine, ripe, heliotrope, balsamic
propanal - 0 5   alcoholic, cocoa, earthy, nutty, whisky, winey
propionic acid - 0 5   acidic, cheesy, pungent, vinegar
pyrazine - 0 5   pungent, sweet, corn, roasted, hazelnut, barley
quinoline - 0 5   earthy, medicinal, musty, rubbery, tobacco
sotolone - 0 5   sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
terpinyl acetate - 0 5   bergamot, citrus, herbal, lavender, lime
valeric acid - 0 4   acidic, cheesy, fruity, milky, sharp, sour, tobacco
vanillic acid - 0 4   beany, brown, creamy, dairy, milky, phenolic, powdery, sweet, vanilla

1.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

2.) Tong, T., Ryu, S., Min, Y. et al. Olfactory receptor 10J5 responding to α-cedrene regulates hepatic steatosis via the cAMP–PKA pathway. Sci Rep 7, 9471 (2017).

3.) C. Trimmer, A. Keller, N. R. Murphy, L. L. Snyder, J. R. Willer, M. H. Nagai, N. Katsanis, L. B. Vosshall, H. Matsunami, and J. D. Mainland Genetic variation across the human olfactory receptor repertoire alters odor perception PNAS | May 7, 2019 | vol. 116 | no. 19 | 9475–9480

4.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

5.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821
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