Olfactory Receptor family 10 subfamily J member 5.
Estimated Expression: 84% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MKRKNFTEVS EFIFLGFSSF GKHQITLFVV FLTVYILTLV ANIIIVTIIC IDHHLHTPMY FFLSMLASSE TVYTLVIVPR MLLSLIFHNQ PISLAGCATQ 110 120 130 140 150 160 170 180 190 200 MFFFVILATN NCFLLTAMGY DRYVAICRPL RYTVIMSKGL CAQLVCGSFG IGLTMAVLHV TAMFNLPFCG TVVDHFFCDI YPVMKLSCID TTINEIINYG 210 220 230 240 250 260 270 280 290 300 VSSFVIFVPI GLIFISYVLV ISSILQIASA EGRKKTFATC VSHLTVVIVH CGCASIAYLK PKSESSIEKD LVLSVTYTII TPLLNPVVYS LRNKEVKDAL 310 CRVVGRNIS
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 D K E I P I T T D M A S I P Q I L H K G F L V L K L Y A I E N T V H L G A L S L L T I Q Y T V S I S A G Y N I V A M Q T A C M R P V V V F L I I T C G C H S S V T L G I F F M I V L T L F L L P T V I V F I V F G F S L I V F T Y V T L I Y V V P N V T L H I P V G C V L N T A E S S V L T S Y V S V C F I L G Q A C L F C N A L M S I I N A T A F T Y S I L G K S A T L L F F T V I K K R I V L V D Y G M Y M P T I C I I G E A S I S S V Y R D I Q L R C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
1.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.
2.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1
3.) Tong, T., Ryu, S., Min, Y. et al. Olfactory receptor 10J5 responding to α-cedrene regulates hepatic steatosis via the cAMP–PKA pathway. Sci Rep 7, 9471 (2017).
4.) C. Trimmer, A. Keller, N. R. Murphy, L. L. Snyder, J. R. Willer, M. H. Nagai, N. Katsanis, L. B. Vosshall, H. Matsunami, and J. D. Mainland Genetic variation across the human olfactory receptor repertoire alters odor perception PNAS | May 7, 2019 | vol. 116 | no. 19 | 9475–9480
5.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.
6.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR10J5 | 100 | 84% | Y | M | F | V | A | T | C | F | G | M | A | H | F | D | I | Y | N | V | S | V | I | C | A | Y | K | S | V | Y | T |
| OR10J1 | 86 | 80% | Y | M | F | V | G | I | C | F | G | V | A | Q | F | D | I | R | T | I | S | V | L | Y | A | Y | K | S | V | Y | T |
| OR10J3 | 86 | 26% | Y | L | Y | L | G | I | C | F | G | M | A | Q | F | D | V | R | N | V | S | V | L | Y | A | Y | K | S | V | Y | T |
| OR5P2 | 83 | 100% | Y | L | A | A | A | T | C | V | G | I | A | Y | F | D | F | A | L | S | S | I | I | Y | I | Y | N | S | V | Y | T |
| OR10K2 | 83 | 96% | Y | M | F | L | G | C | S | F | G | V | A | I | F | D | I | A | I | L | C | V | L | Y | A | Y | Q | S | V | Y | T |
| OR10T2 | 83 | 65% | Y | L | F | L | A | C | C | L | G | I | A | A | F | D | M | A | L | L | S | V | I | Y | A | Y | K | A | V | Y | T |
| OR11H6 | 83 | 96% | Y | F | F | F | G | T | C | F | G | C | Y | P | V | D | P | G | C | F | N | I | I | Y | L | Y | T | T | L | Y | T |
| OR11A1 | 83 | 100% | Y | F | F | G | A | T | C | L | G | V | D | V | Y | D | F | M | T | L | S | C | L | Y | L | Y | S | S | L | Y | T |
| OR11H7 | 82 | Y | F | F | F | G | T | C | F | G | G | H | S | L | D | V | D | F | V | S | F | I | Y | I | Y | T | T | L | Y | S | |
| OR10K1 | 82 | 100% | Y | M | F | L | G | S | S | F | G | V | S | T | F | D | I | S | I | L | G | A | L | Y | A | Y | K | S | V | Y | T |
| OR2A5 | 82 | 100% | Y | T | Y | M | A | H | C | L | G | L | A | H | F | E | I | L | I | A | S | I | L | F | A | Y | K | S | L | Y | S |
| OR5P3 | 82 | 100% | Y | L | V | V | G | T | C | F | G | N | A | F | F | D | Y | S | P | S | S | I | I | Y | I | Y | K | S | V | Y | T |
| OR11L1 | 81 | 100% | Y | L | F | V | G | A | C | F | G | T | G | P | F | D | L | P | I | L | S | V | L | Y | M | Y | S | S | V | Y | T |
| OR5AR1 | 81 | 53% | Y | F | F | V | V | D | C | Y | G | S | L | H | F | E | I | P | L | L | C | I | E | Y | V | Y | T | S | V | Y | T |
| OR10C1 | 81 | 61% | Y | M | F | L | G | A | C | C | G | V | G | H | F | E | I | Q | I | A | T | L | I | Y | A | Y | K | S | L | Y | A |
| OR14J1 | 81 | 88% | F | V | F | I | A | S | V | A | G | S | G | H | F | D | V | P | L | F | T | A | A | L | A | F | P | S | V | Y | T |
| OR10A2 | 80 | F | M | F | F | G | V | C | F | G | V | A | Q | F | D | S | P | A | G | T | V | V | Y | L | Y | K | S | L | Y | T | |
| OR5B21 | 80 | 100% | Y | F | F | V | A | T | C | Y | G | N | A | H | F | D | I | P | V | V | A | N | V | Y | I | Y | N | S | V | Y | T |
| OR14A16 | 80 | 100% | L | V | L | L | A | S | L | L | G | I | A | H | F | D | I | P | L | I | N | L | D | L | G | Y | A | S | V | Y | T |
| OR10A3 | 80 | 100% | F | M | I | L | G | G | C | F | G | V | A | Q | F | E | T | P | A | G | T | I | V | Y | A | Y | K | S | L | Y | T |
| OR5B2 | 80 | 100% | Y | M | F | V | A | T | N | Y | G | N | A | H | F | D | V | P | L | M | S | N | I | Y | V | Y | S | S | V | Y | A |
| OR5H2 | 80 | 65% | I | F | F | A | G | T | C | F | G | H | A | H | Y | D | I | I | V | L | S | I | Q | Y | L | Y | A | S | V | Y | T |
| OR14L1 | 80 | Y | A | F | M | A | T | V | A | G | C | G | H | F | N | I | P | V | F | G | L | V | M | G | Y | I | S | A | Y | T |