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Olfactory Receptor family 5 subfamily P member 3.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MGTGNDTTVV EFTLLGLSED TTVCAILFLV FLGIYVVTLM GNISIIVLIR RSHHLHTPMY IFLCHLAFVD IGYSSSVTPV MLMSFLRKET SLPVAGCVAQ 

       110        120        130        140        150        160        170        180        190        200 
LCSVVTFGTA ECFLLAAMAY DRYVAICSPL LYSTCMSPGV CIILVGMSYL GGCVNAWTFI GCLLRLSFCG PNKVNHFFCD YSPLLKLACS HDFTFEIIPA 

       210        220        230        240        250        260        270        280        290        300 
ISSGSIIVAT VCVIAISYIY ILITILKMHS TKGRHKAFST CTSHLTAVTL FYGTITFIYV MPKSSYSTDQ NKVVSVFYTV VIPMLNPLIY SLRNKEIKGA 

       310        320 
LKRELRIKIF S

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

Q D T S     P M   T F D H     L C   L S T E      L F  V T T D  
 V K N   V Y I F   I E F   G I F T   A V P    S M L    I A C   
F V S V   T I T   I A P I   W A N   A V C G  M V P T  V L F L  
 V T Y   G Y F L   G S S   V C G G   C L Q    V S S    G L F   
M P I V   T V A   V I I S   L Y S   T V V S  S Y G I  V V Y I  
 P N L   T L H S   V T A   M G V L   T G F    D V F    M L T   
    I L   T C T   A I V C   I I C   F C E A  A L H C  S I N G  
         S F A K   Y S I   V G P S   A L L    L F I    V I I   
          H R G   L I Y I           Y A M A  Y M P T  R R I L  
         K T S H   I T I             Y R D                 S   
                    M K L           C I A V                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
3-octen-2-one - 10 1  earthy, spicy, herbal, sweet, mushroom, hay, blueberry
coumarin -5.44 2 9.7 2  coumarinic, hay, sweet, tonka
(R)-(-)-carvone -5.4 3 9.7 3  herbal, minty, spearmint, sweet
skatole -5.1 4 10 4  animal, civet, fecal, naphthyl
(S)-(+)-carvone -5.17 5 9.7 5  bready, caraway, minty, spicy
4-vinylguaiacol -4.46 6 10 6  spicy, clove, carnation, phenolic, peppery, smoky, woody, powdery
oranger crystals -4.2 5 10 5  sweet, neroli, orangeflower, powdery, honey, floral, orange, naphthyl, citrus
indole -4.4 4 9.3496 4  animal, fecal, floral, naphthyl
para-anisaldehyde -4.7 5 8.8235 5  sweet, powdery, mimosa, floral, hawthorn, balsamic, vanilla, anise, woody, coumarinic, creamy, spicy
acetophenone -3.9 2 9.6 2  sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
hexanol -3.76 2 9.5 2  ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
1-heptanol -2.96 2 9.3 2  musty, leafy, violet, herbal, green, sweet, woody, peony, pungent, vegetable, fruity, apple, banana
p-cresol -4.4 7 3 7  phenolic, narcissus, animal, mimosa
hexanal -3.72 8 3.3 8  aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
1-octanol -4.94 2 0.2581 2  aldehydic, green, mushroom, orange, rose, waxy
celery ketone -4.32 9 0.4032 9  celery, cumin, fresh, green
quinoline - 3 10  earthy, medicinal, musty, rubbery, tobacco
benzaldehyde - (agonist) 11  sharp, sweet, bitter, almond, cherry
heliotropin - (agonist) 11  cherry, maraschino_cherry, almond, bitter, tropical, custard, vanilla, spicy
p-cresyl acetate - 0.8 7  narcissus, phenolic, animal
allyl heptanoate - 0 2  sweet, pineapple, fruity, waxy, banana, fusel, cognac, ripe, fermented
allylbenzene - 0 2  
benzophenone - 0 2  balsamic, rose, metallic, powdery, geranium, herbal, plastic, phenolic
benzyl acetate - 0 2  sweet, floral, fruity, jasmine, fresh
butyl butyryl lactate - 0 2  creamy, buttery, buttermilk, dairy, cheesy, fatty, waxy, sweaty, green
(-)-camphor - 0 2  
camphor - 0 2  camphorous
capric acid - 0 2  citrus, fatty, rancid, sour
caproic acid - 0 2  cheesy, fatty, sour, sweaty
gamma-caprolactone - 0 2  herbal, coconut, sweet, coumarinic, tobacco, creamy, lactonic, green
caprylic acid - 0 2  cheesy, fatty, oily, rancid, vegetable, waxy
4-chromanone - 0 2  
(S)-(-)-citronellol - 0 2  citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
2-coumaranone - 0 2  
cyclohexanone - 0 2  acetone, minty
1-decanol - 0 2  aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
(+)-dihydrocarvone - 0 2  herbal, minty, mentholic
dihydrojasmone - 0 2  floral, fresh, herbal, jasmine, myrrh, outdoors, spicy, woody
ethyl isobutyrate - 0 2  alcoholic, ethereal, fruity, fusel, rummy, sweet
fenchone - 0 2  camphorous, earthy, herbal, woody
geraniol - 0 2  citrus, floral, fruity, rose, sweet, waxy
heptanal - 0 2  aldehydic, cognac, fatty, fresh, green, herbal, ozone
3-heptanone - 0 2  fatty, fruity, green
2,3-hexanedione - 0 2  buttery, sweet
3,4-hexanedione - 0 2  almond, buttery, caramellic, nutty, toasted
2-hexanone - 0 2  ethereal
hexyl acetate - 0 2  apple, banana, fruity, green, sweet
4-hydroxycoumarin - 0 2  
nonanethiol - 0 2  
1-nonanol - 0 2  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
2-nonanone - 0 2  fresh, sweet, green, weedy, earthy, herbal, fruity, waxy, soapy, cheesy, coconut, dairy, dirty, buttery
octanal - 0 2  aldehydic, citrus, fatty, green, orange, peel, waxy
2-octanone - 0 2  earthy, herbal, natural, weedy, woody
3-octanone - 0 2  fresh, herbal, lavender, mushroom, sweet
octyl octanoate - 0 10  coconut, oily, fruity
oenanthic acid - 0 2  rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
2-pentanone - 0 2  sweet, fruity, ethereal, winey, banana, woody, fermented
phenyl acetate - 0 2  phenolic, medicinal, animal, resinous, castoreum, woody, smoky, burnt
(+)-2-phenylbutyric acid - 0 2  
prenyl acetate - 0 2  sweet, fresh, banana, fruity, jasmine, ripe, heliotrope, balsamic
propionic acid - 0 10  acidic, cheesy, pungent, vinegar
valeric acid - 0 2  acidic, cheesy, fruity, milky, sharp, sour, tobacco
vanillic acid - 0 2  beany, brown, creamy, dairy, milky, phenolic, powdery, sweet, vanilla
alpha,alpha-dimethyl phenethyl acetate - -0.1626 4  sweet, floral, fruity, rose, green, pear, berry, jasmin, powdery
citronellal - -0.1626 4  sweet, dry, floral, herbal, waxy, aldehydic, citrus
2-cyclohexylpropanal - -0.1626 4  natural, fresh, green, dusty, fruity
delta-damascone - -0.1626 4  fruity, sweet, rose, natural, petal, currant_bud, black_currant_bud, tobacco
ethyl linalyl ether - -0.1626 4  floral
(-)-alpha-fenchol - -0.1626 4  camphorous, clean, cooling, eucalyptus, green, herbal, minty, piney, woody
galaxolide - -0.1626 4  floral, musk, sweet
globanone - -0.1626 4  animal, balsamic, cloth, dry, floral, laundered, musk, tobacco, waxy
hexyl salicylate - -0.1626 4  fresh, herbal, orchid, green
(Z)-jasmone - -0.1626 4  woody, herbal, floral, spicy, jasmine, celery
lilial - -0.1626 4  floral, muguet, watery, green, powdery, cumin
melafleur - -0.1626 4  floral, clean, muguet, ozone, marine, sandy, balsamic
7-methoxycitronellal - -0.1626 4  fresh, melon, floral, lily, sweet
methyl ionone gamma - -0.1626 4  violet, sweet, orris, powdery, floral, woody
muscenone - -0.1626 4  animal, musk, soapy
myraldyl acetate - -0.1626 4  fresh, lily, magnolia, sweet, citrus, freesia, green
strawberry glycidate 1 - -0.1626 4  sweet, fruity, strawberry, floral, honey, fatty
triplal - -0.1626 4  green, aldehydic, leafy, cortex, tart, floral, peely
verdyl acetate - -0.1626 4  floral, green, soapy, cedar, pine, woody
amber butanol - -0.4065 4  woody, amber, ambrette
(-)-ambroxide - -0.4065 4  dry, amber, ambergris, paper, musk, woody, cedar, pine, green, seedy
civetone - -0.4065 4  clean, musk, dry, animal, sweet
exaltolide - -0.4065 4  animal, fruity, musk, natural, powdery
galbascone - -0.4065 4  fresh, green, galbanum, earthy, weedy, pineapple, narcissus, hyacinth, fruity
(Z)-3-hexenyl salicylate - -0.4065 4  floral, green, metallic, herbal, balsamic
hydroxycitronellal - -0.4065 4  floral, green, lily, melon, sweet, tropical, waxy
methyl jasmonate - -0.4065 4  jasmin, floral, oily, green, petal, greasy, soft
3-(3-propen-2-yl phenyl) butanal - -0.4065 4  ozone, cortex, green, floral, melon
tetrahydrogeraniol - -0.4065 4  leathery, musty, plastic, rose, sweet
gamma-undecalactone - -0.4065 4  fruity, peach, creamy, fatty, lactonic, apricot, ketonic, coconut
isobutylamine - -0.5 10  cheesy, fishy
ebanol - -0.6504 4  sandalwood, woody, musk
grapefruit pentanol - -0.6504 4  vetiver, green, citrus, grapefruit, rhubarb, floral
mefrosol - -0.6504 4  floral, geranium, green, honey, lily, muguet, fresh, rose, tropical
(R,S)-methyl cedryl ketone - -0.6504 4  woody, vetiver, amber, leathery, musk, cedar
nerolidol - -0.6504 4  floral, green, waxy, citrus, woody, fruity, melon
patchouli hexanol - -0.6504 4  woody, musty, patchouli, camphorous, minty, leathery
spicy carbonate - -0.6504 4  spicy, woody, floral, green, herbal
thymol - -0.6504 4  camphorous, herbal, medicinal, phenolic, thyme
(Z)-3-hexen-1-ol - -0.6667 10  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
lyral - -1.3333 2  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
l-arabinose - -1.5667 10  
pyrazine - -1.5667 10  pungent, sweet, corn, roasted, hazelnut, barley
ethyl vanillin - -1.6333 10  sweet, creamy, vanilla, caramellic
d-limonene - -2 10  citrus, orange, fresh, sweet
methyl salicylate - -2 11  minty, wintergreen
eugenol - -2.1667 10  clove, spicy, sweet, woody
terpinyl acetate - -2.2333 10  bergamot, citrus, herbal, lavender, lime
linalool - -2.2667 10  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
2-ethyl fenchol - -2.3333 10  camphorous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
2-heptanone - -2.3333 2  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
helional - -2.3833 10  cyclamen, fresh, green, hay, ozone, watery
methyl furfuryl disulfide - -2.4 10  sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
nonanal - -2.4 2  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
citral - -2.4333 10  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
2,4-DNT - -2.4667 10  
coffee difuran - -2.5 10  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
methyl eugenol - -2.5 10  carnation, cinnamon, clove, fresh, spicy, sweet, warm
butyric acid - -2.5167 10  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
eugenyl acetate - -2.5333 10  carnation, clove, floral, fresh, malty, spicy, sweet, woody
n-amyl alcohol - -2.5467 2  fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
(1S,2R,5S)-(+)-menthol - -2.5667 10  cooling, mentholic, minty
octanethiol - -2.5833 2  sulfurous
amyl hexanoate - -2.6 2  sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
pelargonic acid - -2.6 2  cheesy, dairy, dirty, waxy
benzene - -2.6333 2  gasoline, phenolic, solvent, cinnamon
dimethyl disulfide - -2.6333 10  sulfurous, vegetable, cabbage, onion, malty, creamy
geranyl acetate - -2.6333 10  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
allyl phenylacetate - -2.6667 2  honey, fruity, rummy
androstenone - -2.6667 10  animal, musky
butyl formate - -2.6667 2  fruity, plum, rummy, brandy
beta-damascone - -2.6667 10  berry, currant, floral, fruity, honey, plum, rose, tobacco
decanal - -2.6667 2  sweet, aldehydic, waxy, orange_peel, citrus, floral
propanal - -2.6667 10  alcoholic, cocoa, earthy, nutty, whisky, winey

1.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147

2.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

3.) Saito N, Yamano E, Ishii A, Tanaka M, Nakamura J, et al. (2018) Involvement of the olfactory system in the induction of anti-fatigue effects by odorants. PLOS ONE 13(3): e0195263. https://doi.org/10.1371/journal.pone.0195263

4.) Aya Kato, Naoko Saito (2015) Odor control agent. JP5798382B2

5.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.

6.) Aya Namba, Naoko Saito, Keiichi Yoshikawa, Ichiro Mori (2015) Search method of urine odor suppressor JP2015211667A

7.) Shirai, T., Takase, D., Yokoyama, J. et al. Functions of human olfactory mucus and age-dependent changes. Sci Rep 13, 971 (2023). https://doi.org/10.1038/s41598-023-27937-1

8.) Ojiro I, Katsuyama H, Kaneko R, Ogasawara S, Murata T, Terada Y, et al. (2024) Enhancement of transcription efficiency by TAR-Tat system increases the functional expression of human olfactory receptors. PLoS ONE 19(6): e0306029. https://doi.org/10.1371/journal.pone.0306029

9.) Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, et al. () Identification of Odorant-Receptor Interactions by Global Mapping of the Human Odorome. PLoS ONE 9(4): e93037. doi:10.1371/journal.pone.0093037

10.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

11.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1
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