Olfactory Receptor family 1 subfamily C member 1.
Sequence:
10 20 30 40 50 60 70 80 90 100 MEKRNLTVVR EFVLLGLPSS AEQQHLLSVL FLCMYLATTL GNMLIIATIG FDSHLHSPMY FFLSNLAFVD ICFTSTTVPQ MVVNILTGTK TISFAGCLTQ 110 120 130 140 150 160 170 180 190 200 LFFFVSFVNM DSLLLCVMAY DRYVAICHPL HYTARMNLCL CVQLVAGLWL VTYLHALLHT VLIAQLSFCA SNIIHHFFCD LNPLLQLSCS DVSFNVMIIF 210 220 230 240 250 260 270 280 290 300 AVGGLLALTP LVCILVSYGL IFSTVLKITS TQGKQRAVST CSCHLSVVVL FYGTAIAVYF SPSSPHMPES DTLSTIMYSM VAPMLNPFIY TLRNRDMKRG 310 320 LQKMLLKCTV FQQQ
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 Q E A S I G A F S I L F S V D S S E P M L H Q N V V T L C V T H L M V N F Y V A L T D L V S L M Q P V F F L Q L A H A F I I I A T M I T S C L F T T S S V F L Y T V G G V G Y F L M S Y A L Y M T F C I M N V F L W L L A L L V V V M P A V L T T D V F L S D G A V L L P T S L H C P N L L M N G A L N S V C L L Q V C L I C V S C T T Y I F A I I L F F Y A M L C L N Y S V S V A R L G I T Y M P S V Y R D F I L G Q K G C I A V T S Q T S T H K L UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| linalool | -7.86 1 | 10 2 | blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody | |
| coumarin | -6 1 | 2.6667 3 | coumarinic, hay, sweet, tonka | |
| pelargonic acid | - | 2.3333 3 | cheesy, dairy, dirty, waxy | |
| androstenone | - | 1 3 | animal, musky | |
| aldehyde C-10 | - | 0 3 | aldehydic, citrus, floral, orange, peel, sweet, waxy | |
| aldehyde C-9 | - | 0 3 | aldehydic, fatty, fresh, orange, orris, peel, peely, rose, waxy | |
| allyl phenylacetate | - | 0 3 | fruity, honey, rummy | |
| amyl hexanoate | - | 0 3 | apple, estery, fatty, fruity, green, pear, pineapple, sweet | |
| l-arabinose | - | 0 3 | ||
| benzene | - | 0 3 | ||
| butyl formate | - | 0 3 | brandy, fruity, plum, rummy | |
| butyric acid | - | 0 3 | acetic, buttery, cheesy, fruity, sharp | |
| (S)-(+)-carvone | - | 0 3 | bready, caraway, minty, spicy | |
| citral | - | 0 3 | citrus, lemon, sharp, sweet | |
| coffee difuran | - | 0 3 | cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty | |
| beta-damascone | - | 0 3 | berry, currant, floral, fruity, honey, plum, rose, tobacco | |
| dimethyl disulfide | - | 0 3 | cabbage, onion, sulfurous, vegetable | |
| 2,4-DNT | - | 0 3 | ||
| 2-ethyl fenchol | - | 0 3 | camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea | |
| ethyl vanillin | - | 0 3 | caramellic, creamy, sweet, vanilla | |
| eugenol | - | 0 3 | clove, spicy, sweet, woody | |
| eugenyl acetate | - | 0 3 | carnation, clove, floral, fresh, malty, spicy, sweet, woody | |
| helional | - | 0 3 | cyclamen, fresh, green, hay, ozone, watery | |
| 2-heptanone | - | 0 3 | banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody | |
| cis-3-hexen-1-ol | - | 0 3 | foliage, fresh, grassy, green, herbal, oily, vegetable | |
| isobutylamine | - | 0 3 | cheesy, fishy | |
| d-limonene | - | 0 3 | citrus, fresh, orange, sweet | |
| lyral | - | 0 3 | aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody | |
| (+)-menthol | - | 0 3 | cooling, mentholic, minty | |
| methyl eugenol | - | 0 3 | carnation, cinnamon, clove, fresh, spicy, sweet, warm | |
| methyl furfuryl disulfide | - | 0 3 | alliaceous, coffee, meaty, roasted, sulfurous | |
| methyl salicylate | - | 0 3 | minty, wintergreen | |
| octanethiol | - | 0 3 | sulfurous | |
| 1-octanol | - | 0 3 | aldehydic, green, mushroom, orange, rose, waxy | |
| octyl octanoate | - | 0 3 | coconut, fruity, oily | |
| pentanol | - | 0 3 | balsamic, fermented, fusel, oily, sweet | |
| propanal | - | 0 3 | alcoholic, cocoa, earthy, nutty, whiskey, winey | |
| propionic acid | - | 0 3 | acidic, cheesy, pungent, vinegar | |
| pyrazine | - | 0 3 | pungent, sweet, corn, roasted, hazelnut, barley | |
| quinoline | - | 0 3 | earthy, medicinal, musty, rubbery, tobacco | |
| terpinyl acetate | - | 0 3 | bergamot, citrus, herbal, lavender, lime |
1.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
2.) C. Trimmer, A. Keller, N. R. Murphy, L. L. Snyder, J. R. Willer, M. H. Nagai, N. Katsanis, L. B. Vosshall, H. Matsunami, and J. D. Mainland Genetic variation across the human olfactory receptor repertoire alters odor perception PNAS | May 7, 2019 | vol. 116 | no. 19 | 9475–9480
3.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821