nonanoic acid

SMILES:
CCCCCCCCC(=O)[O-]

Aroma Description:
cheesy, dairy, dirty, waxy1

Receptor Expression log10 EC50 Adj. Top Antagonist? Correlated Perceptual Qualities
OR51E1 100 -4.71 4, -3.61 5, -5.3 6 -  cheesy, sour, sweaty, sharp, acidic, dairy
OR2W1 53 -3.72 5 4.6667 3, 9.5 5, 9.0909 8  sweet, tart, hay, fatty, coumarinic, orange, peony, cinnamon, herbal, tonka
OR10A6 100 - 8.6364 8  peach, sweet, coconut, lactonic, floral, cyclamen, waxy, neroli, dairy, honey
OR56A5 69 -4.42 10 7.7 10  cheesy, rancid, sweaty, buttermilk, sour, waxy
OR52A5 92 -3.68 11 -  dairy, fatty, cheesy, rancid
OR52B2 100 -4.08 10 1.2 10  cheesy, rancid, dairy, sour, fatty, creamy, milky, sharp, sweaty, tart
OR52D1 100 - 2.8934 2  dairy, cheesy, anise, milky, creamy, sour, sharp, peach, rancid, lactonic
OR1G1 61 - 2.7919 2  sweet, waxy, citrus, tart, orange, fresh, aldehydic, rose, floral, fatty
OR1C1 100 - 2.3333 3  blueberry, bois_de_rose, rose, sweet, citrus
OR10G3 96 - 0 3   
OR10G7 80 - 0 3   
OR10J5 84 - 0 3, 0 5   
OR11A1 100 - 0 3   
OR2A25 100 - 0 3   
OR2B11 100 - 0 3   
OR2J2 92 - 0 3, 0 5   
OR2J3 100 - 0 3   
OR51L1 88 - 0 3, 0 5, 0 11   
OR56A4 100 - 0 3   
OR5K1 100 - 0 3   
OR8D1 96 - 0 3   
OR8K3 92 - 0 3   
OR2C1 100 - 0 5   
OR51E2 96 - 0 9   
OR1A1 73 - -1 3, 0 5   
OR5P3 100 - -2.6 3, 0 5   
 

nonanoic acid

SMILES:
CCCCCCCCC(=O)[O-]

Aroma Description:
cheesy, dairy, dirty, waxy

Receptor Expr.% Agonist? Dock Score Known agonist Correlated Perceptual Qualities

Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.

1.) The Good Scents Company

2.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

3.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

4.) Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, et al. () Identification of Odorant-Receptor Interactions by Global Mapping of the Human Odorome. PLoS ONE 9(4): e93037. doi:10.1371/journal.pone.0093037

5.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

6.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

7.) Halperin Kuhns, V. L., Sanchez, J., Sarver, D. C., Khalil, Z., Rajkumar, P., Marr, K. A., & Pluznick, J. L. (2019). Characterizing novel olfactory receptors expressed in the murine renal cortex. American Journal of Physiology-Renal Physiology, 317(1), F172-F186.

8.) Aya Kato, Naoko Saito, Etsuji Wakisaka (2016) Method for searching for malodor control agent, malodor control agent, and malodor control method. US9526680B2

9.) Christian B. Billesbølle, Claire A. de March, Wijnand J. C. van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami, Aashish Manglik. Structural basis of odorant recognition by a human odorant receptor. bioRxiv 2022.12.20.520951; doi: https://doi.org/10.1101/2022.12.20.520951

10.) Chatelain Pierre, Veithen Alex, Olfactory Receptors involved in the perception of sweat carboxylic acids and the use thereof. WO 2014/191047

11.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

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