hexanoic acid

SMILES:
CCCCCC(=O)[O-]

Aroma Description:
cheesy, fatty, sour, sweaty1

Receptor Expression log10 EC50 Adj. Top Antagonist? Correlated Perceptual Qualities
OR51L1 88 -3.83 7, -5 10, -4.3 12 9.5 7, (agonist) 10, 2.8182 12, 3 16  sour, cheesy, honey, sweaty, civet
OR51I2 100 -4.4 12, -3.73 14 4.4545 12, 6 14  cheesy, sour, sweaty, sharp, dairy, milky
OR51E1 100 -4.52 12 -  cheesy, sour, sweaty, sharp, acidic, dairy
OR2W1 53 -2.23 3, -4.22 12 8.3333 3, 0 7, 2.6364 12, 0 15  sweet, tart, hay, fatty, coumarinic, orange, peony, cinnamon, herbal, tonka
OR5P2 100 -5.82 2 0.0427 2  (insufficient data)
OR10A6 100 -4.3 12 1.9091 12  peach, sweet, coconut, floral, lactonic, cyclamen, neroli, waxy, dairy, honey
OR52B2 100 -3.83 14 0.37 14  cheesy, rancid, dairy, sour, fatty, creamy, milky, sharp, sweaty, tart
OR1A1 73 -1.67 3 3.3333 3, 0 7  sweet, citrus, fresh, rose, herbal, waxy, orange, spearmint, floral, aldehydic
OR56A5 69 -2.83 14 0.9 14  cheesy, rancid, sweaty, buttermilk, sour, waxy
OR52D1 100 - 2.6396 4  dairy, cheesy, anise, milky, creamy, sour, sharp, peach, lactonic, rancid
OR4P4 57 - 1.9231 9  cloth, laundered, animal
OR7D4 96 - 0.2 6  animal, citrus, orange, peely, tart, aldehydic, blueberry
OR1G1 61 - 0.0508 4  sweet, waxy, citrus, fresh, tart, orange, aldehydic, floral, rose, fatty
OR10J5 84 - 0 7   
OR2C1 100 - 0 7   
OR2J2 92 - 0 7   
OR5P3 100 - 0 7   
OR5A1 100 - 0 8   
OR5A2 100 - 0 8   
OR5AN1 100 - 0 8   
OR5I1 46 - 0 9   
OR51E2 96 - 0 13   
 

hexanoic acid

SMILES:
CCCCCC(=O)[O-]

Aroma Description:
cheesy, fatty, sour, sweaty

Receptor Expr.% Agonist? Dock Score Known agonist Correlated Perceptual Qualities

Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.

1.) The Good Scents Company

2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

3.) C. Trimmer, A. Keller, N. R. Murphy, L. L. Snyder, J. R. Willer, M. H. Nagai, N. Katsanis, L. B. Vosshall, H. Matsunami, and J. D. Mainland Genetic variation across the human olfactory receptor repertoire alters odor perception PNAS | May 7, 2019 | vol. 116 | no. 19 | 9475–9480

4.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

5.) YOSHIFUMI FUJITA, TOMOKO TAKAHASHI, AKIKO SUZUKI, KAYO KAWASHIMA, FUTOSHI NARA & RYUTA KOISHI (2007) Deorphanization of Dresden G Protein-Coupled Receptor for an Odorant Receptor, Journal of Receptors and Signal Transduction, 27:4, 323-334, DOI: 10.1080/10799890701534180

6.) Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468-72. doi: 10.1038/nature06162. Epub 2007 Sep 16. PMID: 17873857.

7.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

8.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]

9.) Ashti Baghaei, K. (2015). Large scale analysis of olfactory receptors with highly genetically variations in relation with specific anosmia (Doctoral dissertation, Bochum, Ruhr-Universität Bochum, Diss., 2013).

10.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

11.) Halperin Kuhns, V. L., Sanchez, J., Sarver, D. C., Khalil, Z., Rajkumar, P., Marr, K. A., & Pluznick, J. L. (2019). Characterizing novel olfactory receptors expressed in the murine renal cortex. American Journal of Physiology-Renal Physiology, 317(1), F172-F186.

12.) Aya Kato, Naoko Saito, Etsuji Wakisaka (2016) Method for searching for malodor control agent, malodor control agent, and malodor control method. US9526680B2

13.) Christian B. Billesbølle, Claire A. de March, Wijnand J. C. van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami, Aashish Manglik. Structural basis of odorant recognition by a human odorant receptor. bioRxiv 2022.12.20.520951; doi: https://doi.org/10.1101/2022.12.20.520951

14.) Chatelain Pierre, Veithen Alex, Olfactory Receptors involved in the perception of sweat carboxylic acids and the use thereof. WO 2014/191047

15.) Franziska Haag, Antonella Di Pizio, Dietmar Krautwurst, The key food odorant receptive range of broadly tuned receptor OR2W1. Food Chemistry 375 (2022) 131680

16.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

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