☰

Olfactory Receptor family 52 subfamily N member 5.

Estimated Expression: 92% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MPLFNSLCWF PTIHVTPPSF ILNGIPGLER VHVWISLPLC TMYIIFLVGN LGLVYLIYYE ESLHHPMYFF FGHALSLIDL LTCTTTLPNA LCIFWFSLKE 

       110        120        130        140        150        160        170        180        190        200 
INFNACLAQM FFVHGFTGVE SGVLMLMALD RYVAICYPLR YATTLTNPII AKAELATFLR GVLLMIPFPF LVKRLPFCQS NIISHTYCDH MSVVKLSCAS 

       210        220        230        240        250        260        270        280        290        300 
IKVNVIYGLM VALLIGVFDI CCISLSYTLI LKAAISLSSS DARQKAFSTC TAHISAIIIT YVPAFFTFFA HRFGGHTIPP SLHIIVANLY LLLPPTLNPI 

       310        320        330 
VYGVKTKQIR KSVIKFFQGD KGAG

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


S P P I       G   V K I S     V L   N I E K    F W F  V R E L  
 I H L   F R H A   I V N   F P F P   A N F    I C L    W V H   
N A V I   F F T   M L G Y   I M L   Q A L C  A N P L  P L S I  
 L Y L   F F A P   L A V   L V G R   F F M    T T T    T C L   
P P L L   V Y T   V G I L   L F T   F G H V  C T L L  I I Y M  
 N L T   I I I A   I D F   A L E A   V G T    D I L    V L F   
Y V I P   S I H   S I C C   K A I   V G S E  S L A H  G L N G  
   V G   A T C T   Y S L   I P N T   L M L    G F F    Y V L   
          S F A   L I L T           D L A M  F Y M P  Y Y I L  
         K Q R A   A A K             V Y R                 E   
                    L S I             C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
delta-decalactone - 8.75 1  coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet
butyric acid - 1.25 1  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
diacetyl - 0 1  buttery, caramellic, creamy, pungent, sweet

1.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.
Prot.Sim.Expr.2.53 3.29 3.32 3.33 3.36 3.37 3.40 3.41 4.53 4.56 4.57 4.60 45.49 45.51 45.52 45.53 5.39 5.42 5.43 5.46 5.47 6.48 6.51 6.55 6.59 7.38 7.39 7.41 7.42
OR52N5100 92%T M V H T G S G G L M F Y D H M G V A I G Y A F R A N Y L
OR52E193L M I H T G S A P F V F Y E H M G A I L V Y A F R A N Y V
OR52N292 100%L M V H T G S G N L I F Y D H M G V A I G Y A F R A N Y L
OR52N491 100%M M T H T G S G G L I F Y D H M G V A I W Y A F R A N Y L
OR52L191 96%L M I H S S S G G L L F Y E H M G M A V I Y G F R A T Y L
OR52R190 73%L V I H S S S G G W V F Y E H M G V A V A Y A F R A N Y L
OR52K290 80%L M L H S I S A A L M L Y E H M G V A I V Y V S R A N Y L
OR52E290 42%L M I H T L S A A F V S Y E H M G A I L V Y A F R A N Y V
OR52N189 92%M M V H T G S G G L V S Y D H M G V A I G Y A F H A N Y L
OR52E488 88%L M I H T G T V N L V F Y E H R G V I I I Y A F R A N Y V
OR52A187 88%L M I H Q G S G A L V C Y E H M G V A V A Y A F R S S Y L
OR52K187 92%L M L H S I S A A L M L Y E H M G V A I V Y V S R A I Y L
OR52P186A M I H C M S T G L M C Y E H M G A A V I Y A F R A N Y L
OR52D186 100%L M V H Y A S S S I V F Y E H M G V A A M Y A F R A N Y V
OR52E886 84%L M I H T A S I S M V L Y E H M G N I L L F A F R A N Y V
OR52A586 92%L M I H Q A S G A L I S Y E H M G V A I L Y A F R L L N L
OR52W181 100%L M V H T A S G A I V F Y A H M G L S I S Y G Y R S N Y L
OR52I281 100%M M V H T A T G A A I L Y E H I S G S M V Y G I W A D Y V
OR51D181 65%L M I H S A S A G F F L F L H Q G I I V M Y L S R A N Y L
OR52E680 88%L M I H T V S I S M V L Y E H M F G S L L S A F C A N Y V
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