Olfactory Receptor family 52 subfamily A member 1.
Estimated Expression: 88% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MSISNITVYM PSVLTLVGIP GLESVQCWIG IPFCAIYLIA MIGNSLLLSI IKSERSLHEP LYIFLGMLGA TDIALASSIM PKMLGIFWFN VPEIYFDSCL 110 120 130 140 150 160 170 180 190 200 LQMWFIHTLQ GIESGILVAM ALDRYVAICY PLRHANIFTH QLVIQIGTMV VLRAAILVAP CLVLIKCRFQ FYHTTVISHS YCEHMAIVKL AAANVQVNKI 210 220 230 240 250 260 270 280 290 300 YGLFVAFTVA GFDLTFITLS YIQIFITVFR LPQKEARFKA FNTCIAHICV FLQFYLLAFF SFFTHRFGSH ISPYIHILFS SIYLLVPPFL NPLVYGAKTT 310 320 QIRIHVVKMF CS
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 I Y P S G V Q V N I L Y I E P F W V S E L L I H F R H T I K N V L C P S D F F I G W C Q I S S F F F S F L G Y A V L Q L L C L M K P P I G I L L Y F F A L F A V I A A R F W M M I S A C F F P P V L Y F G A V T L V V L T H I S A L A I L Y I P N L Q L F V L D F M T G I I G Q I D T I M A G Y V L C I H T I F T Q I V I G S E A G L M L S N G A A I C T Y S L L Q H T A V L G L F S L L N F A F I Q I D L A M I Y L P S K I I K F R A V T I V Y R E L R F C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| nonanal | -3.2 1 | (agonist) 1 | waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely | |
| delta-decalactone | - | 2.5 2 | coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet | |
| butyric acid | - | 2.0833 2 | sharp, acetic, cheesy, buttery, fruity, dairy, creamy | |
| diacetyl | - | 0 2 | buttery, caramellic, creamy, pungent, sweet |
1.) Cong X, Ren W, Pacalon J, Xu R, Xu L, Li X, de March CA, Matsunami H, Yu H, Yu Y, Golebiowski J. Large-Scale G Protein-Coupled Olfactory Receptor-Ligand Pairing. ACS Cent Sci. 2022 Mar 23;8(3):379-387. doi: 10.1021/acscentsci.1c01495. Epub 2022 Feb 18. PMID: 35350604; PMCID: PMC8949627.
2.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR52A1 | 100 | 88% | L | M | I | H | Q | G | S | G | A | L | V | C | Y | E | H | M | G | V | A | V | A | Y | A | F | R | S | S | Y | L |
| OR52E2 | 91 | 42% | L | M | I | H | T | L | S | A | A | F | V | S | Y | E | H | M | G | A | I | L | V | Y | A | F | R | A | N | Y | V |
| OR52P1 | 89 | A | M | I | H | C | M | S | T | G | L | M | C | Y | E | H | M | G | A | A | V | I | Y | A | F | R | A | N | Y | L | |
| OR52E1 | 89 | L | M | I | H | T | G | S | A | P | F | V | F | Y | E | H | M | G | A | I | L | V | Y | A | F | R | A | N | Y | V | |
| OR52N1 | 89 | 92% | M | M | V | H | T | G | S | G | G | L | V | S | Y | D | H | M | G | V | A | I | G | Y | A | F | H | A | N | Y | L |
| OR52K2 | 89 | 80% | L | M | L | H | S | I | S | A | A | L | M | L | Y | E | H | M | G | V | A | I | V | Y | V | S | R | A | N | Y | L |
| OR52A5 | 88 | 92% | L | M | I | H | Q | A | S | G | A | L | I | S | Y | E | H | M | G | V | A | I | L | Y | A | F | R | L | L | N | L |
| OR52L1 | 88 | 96% | L | M | I | H | S | S | S | G | G | L | L | F | Y | E | H | M | G | M | A | V | I | Y | G | F | R | A | T | Y | L |
| OR52N2 | 88 | 100% | L | M | V | H | T | G | S | G | N | L | I | F | Y | D | H | M | G | V | A | I | G | Y | A | F | R | A | N | Y | L |
| OR52N5 | 87 | 92% | T | M | V | H | T | G | S | G | G | L | M | F | Y | D | H | M | G | V | A | I | G | Y | A | F | R | A | N | Y | L |
| OR52R1 | 87 | 73% | L | V | I | H | S | S | S | G | G | W | V | F | Y | E | H | M | G | V | A | V | A | Y | A | F | R | A | N | Y | L |
| OR52N4 | 87 | 100% | M | M | T | H | T | G | S | G | G | L | I | F | Y | D | H | M | G | V | A | I | W | Y | A | F | R | A | N | Y | L |
| OR52K1 | 86 | 92% | L | M | L | H | S | I | S | A | A | L | M | L | Y | E | H | M | G | V | A | I | V | Y | V | S | R | A | I | Y | L |
| OR52E8 | 85 | 84% | L | M | I | H | T | A | S | I | S | M | V | L | Y | E | H | M | G | N | I | L | L | F | A | F | R | A | N | Y | V |
| OR52E4 | 84 | 88% | L | M | I | H | T | G | T | V | N | L | V | F | Y | E | H | R | G | V | I | I | I | Y | A | F | R | A | N | Y | V |
| OR52W1 | 84 | 100% | L | M | V | H | T | A | S | G | A | I | V | F | Y | A | H | M | G | L | S | I | S | Y | G | Y | R | S | N | Y | L |
| OR52D1 | 83 | 100% | L | M | V | H | Y | A | S | S | S | I | V | F | Y | E | H | M | G | V | A | A | M | Y | A | F | R | A | N | Y | V |
| OR52A4 | 81 | 46% | L | M | I | H | Q | G | S | G | P | L | V | C | Y | E | R | V | G | G | A | V | G | Y | A | I | Q | H | L | Q | S |
| OR52H1 | 81 | 100% | L | M | L | H | F | V | S | A | S | I | I | D | Y | E | H | I | G | V | P | T | V | Y | A | I | R | A | N | Y | I |
| OR52I2 | 80 | 100% | M | M | V | H | T | A | T | G | A | A | I | L | Y | E | H | I | S | G | S | M | V | Y | G | I | W | A | D | Y | V |
| OR51D1 | 80 | 65% | L | M | I | H | S | A | S | A | G | F | F | L | F | L | H | Q | G | I | I | V | M | Y | L | S | R | A | N | Y | L |