Olfactory Receptor family 52 subfamily K member 1.
Estimated Expression: 92% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MLPSNITSTH PAVFLLVGIP GLEHLHAWIS IPFCFAYTLA LLGNCTLLFI IQADAALHEP MYLFLAMLAT IDLVLSSTTL PKMLAIFWFR DQEINFFACL 110 120 130 140 150 160 170 180 190 200 VQMFFLHSFS IMESAVLLAM AFDRYVAICK PLHYTTVLTG SLITKIGMAA VARAVTLMTP LPFLLRRFHY CRGPVIAHCY CEHMAVVRLA CGDTSFNNIY 210 220 230 240 250 260 270 280 290 300 GIAVAMFIVV LDLLFVILSY VFILQAVLQL ASQEARYKAF GTCVSHIGAI LSTYTPVVIS SVMHRVARHA APRVHILLAI FYLLFPPMVN PIIYGVKTKQ 310 320 IREYVLSLFQ RKNM
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 V R P A A F S T D L L N I E Q F W L H E L L I H V R H M I N N F P L P A F F F I A W A H F I A L V S S A I G Y T M L Q V L C L M K P P I S I L L Y I V V P M A V T V A R F F M L T T F C F M P P F T Y T V V I F A V A F S H L S S L V L T Y A P N V S L I A L D L A M G I M I S L D I L L A G Y I I G I H I V F L K T I V A S E T A L M T C N G V S V C T Y S L L S G T A L L A L F F L L G F A L I F V D F A M L Y M P A Q I I K Y R A V A Q V Y R D L Q L C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| delta-decalactone | - | 8.3333 1 | coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet | |
| 4-ethyloctanoic acid | - | 3 2 | goaty, lamb, mutton, fatty | |
| butyric acid | - | 2.5 1 | sharp, acetic, cheesy, buttery, fruity, dairy, creamy | |
| caprylic acid | - | (agonist) 3 | cheesy, fatty, oily, rancid, vegetable, waxy | |
| citronellic acid | - | (agonist) 3 | green, grassy, smoky, fatty, floral, waxy, citronella, vegetable, tobacco | |
| 3-methyl-2-hexenoic acid | - | (agonist) 3 | cheesy, fruity | |
| diacetyl | - | 0 1 | buttery, caramellic, creamy, pungent, sweet |
1.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.
2.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025
3.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR52K1 | 100 | 92% | L | M | L | H | S | I | S | A | A | L | M | L | Y | E | H | M | G | V | A | I | V | Y | V | S | R | A | I | Y | L |
| OR52K2 | 96 | 80% | L | M | L | H | S | I | S | A | A | L | M | L | Y | E | H | M | G | V | A | I | V | Y | V | S | R | A | N | Y | L |
| OR52A5 | 89 | 92% | L | M | I | H | Q | A | S | G | A | L | I | S | Y | E | H | M | G | V | A | I | L | Y | A | F | R | L | L | N | L |
| OR52E1 | 89 | L | M | I | H | T | G | S | A | P | F | V | F | Y | E | H | M | G | A | I | L | V | Y | A | F | R | A | N | Y | V | |
| OR52L1 | 87 | 96% | L | M | I | H | S | S | S | G | G | L | L | F | Y | E | H | M | G | M | A | V | I | Y | G | F | R | A | T | Y | L |
| OR52N2 | 87 | 100% | L | M | V | H | T | G | S | G | N | L | I | F | Y | D | H | M | G | V | A | I | G | Y | A | F | R | A | N | Y | L |
| OR52N5 | 87 | 92% | T | M | V | H | T | G | S | G | G | L | M | F | Y | D | H | M | G | V | A | I | G | Y | A | F | R | A | N | Y | L |
| OR52E2 | 87 | 42% | L | M | I | H | T | L | S | A | A | F | V | S | Y | E | H | M | G | A | I | L | V | Y | A | F | R | A | N | Y | V |
| OR52A1 | 86 | 88% | L | M | I | H | Q | G | S | G | A | L | V | C | Y | E | H | M | G | V | A | V | A | Y | A | F | R | S | S | Y | L |
| OR52N4 | 86 | 100% | M | M | T | H | T | G | S | G | G | L | I | F | Y | D | H | M | G | V | A | I | W | Y | A | F | R | A | N | Y | L |
| OR52R1 | 86 | 73% | L | V | I | H | S | S | S | G | G | W | V | F | Y | E | H | M | G | V | A | V | A | Y | A | F | R | A | N | Y | L |
| OR51D1 | 85 | 65% | L | M | I | H | S | A | S | A | G | F | F | L | F | L | H | Q | G | I | I | V | M | Y | L | S | R | A | N | Y | L |
| OR52P1 | 84 | A | M | I | H | C | M | S | T | G | L | M | C | Y | E | H | M | G | A | A | V | I | Y | A | F | R | A | N | Y | L | |
| OR52N1 | 84 | 92% | M | M | V | H | T | G | S | G | G | L | V | S | Y | D | H | M | G | V | A | I | G | Y | A | F | H | A | N | Y | L |
| OR51E1 | 83 | 100% | I | M | I | H | S | G | S | T | G | L | M | L | Y | L | H | Q | G | V | I | A | I | Y | F | S | R | A | N | Y | L |
| OR52E8 | 83 | 84% | L | M | I | H | T | A | S | I | S | M | V | L | Y | E | H | M | G | N | I | L | L | F | A | F | R | A | N | Y | V |
| OR52E4 | 83 | 88% | L | M | I | H | T | G | T | V | N | L | V | F | Y | E | H | R | G | V | I | I | I | Y | A | F | R | A | N | Y | V |
| OR51E2 | 82 | 96% | L | M | I | H | S | A | S | T | G | F | F | L | Y | V | H | Q | G | A | I | V | M | Y | L | S | R | G | D | Y | L |
| OR51F1 | 82 | 34% | L | M | L | H | T | F | S | G | A | L | I | L | Y | Y | H | P | G | D | L | T | T | Y | M | S | R | A | N | Y | L |
| OR52D1 | 82 | 100% | L | M | V | H | Y | A | S | S | S | I | V | F | Y | E | H | M | G | V | A | A | M | Y | A | F | R | A | N | Y | V |
| OR51F2 | 81 | 84% | L | M | L | H | T | F | S | G | N | V | M | V | Y | Y | H | V | G | A | L | T | T | Y | L | S | R | A | N | F | L |
| OR51T1 | 81 | 76% | L | M | V | H | S | L | S | S | P | F | L | L | F | Y | H | P | G | L | Q | L | N | Y | L | S | R | A | N | Y | L |
| OR52I2 | 80 | 100% | M | M | V | H | T | A | T | G | A | A | I | L | Y | E | H | I | S | G | S | M | V | Y | G | I | W | A | D | Y | V |
| OR51B6 | 80 | V | A | I | H | S | V | S | G | A | S | I | I | F | L | H | Q | P | V | L | M | V | Y | V | T | R | S | Y | H | F |