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Olfactory Receptor family 56 subfamily A member 4.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MASPSNDSTA PVSEFLLICF PNFQSWQHWL SLPLSLLFLL AMGANTTLLI TIQLEASLHQ PLYYLLSLLS LLDIVLCLTV IPKVLAIFWF DLRSISFPAC 

       110        120        130        140        150        160        170        180        190        200 
FLQMFIMNSF LTMESCTFMV MAYDRYVAIC HPLRYPSIIT DQFVARAVVF VIARNAFVSL PVPMLSARLR YCAGNIIKNC ICSNLSVSKL SCDDITFNQL 

       210        220        230        240        250        260        270        280        290        300 
YQFVAGWTLL GSDLILIVIS YSFILKVVLR IKAEGAVAKA LSTCGSHFIL ILFFSTVLLV LVITNLARKR IPPDVPILLN ILHHLIPPAL NPIVYGVRTK 

       310        320 
EIKQGIQNLL KRL

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

S Q F N   I A L   A P F S       L   F T I D  I V L V  V D P P  
 H Q W   V K P I   L F C   M P V P   L Q N    L L V    L I P   
L S L W   V T L   I F M Q   L S V   V F Q Y  T S F F  L I N L  
 S L P   C L V I   S N M   F A N R   W G A    L I L    L H H   
L F L L   D L L   M T L F   A I V   G L L T  I F H S  A P P I  
 M A L   S L L S   C S E   F V V A   L D S    G C T    P N L   
T N A G   L L Y   V M F T   R A V   V I L I  S L A K  G Y V I  
 L L T   Y L P Q   Y A M   F Q D T   Y S I    A V A        V   
Q I T I           V Y R D           L I F S  G E A K           
                   C I A             V V K                     
                        H               R L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
undecanal -7 1 -  aldehydic, citrus, cloth, fatty, floral, green, laundered, soapy, waxy
decanal -4.41 2 3.1751 1  sweet, aldehydic, waxy, orange_peel, citrus, floral
butyric acid - 2.0833 3  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
delta-decalactone - 1.25 3  coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet
allyl phenylacetate - 0 4  honey, fruity, rummy
amyl hexanoate - 0 4  sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
androstenone - 0 4  animal, musky
l-arabinose - 0 4  
benzene - 0 4  
(S)-(+)-carvone - 0 4  bready, caraway, minty, spicy
citral - 0 4  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
coffee difuran - 0 4  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
coumarin - 0 4  coumarinic, hay, sweet, tonka
beta-damascone - 0 4  berry, currant, floral, fruity, honey, plum, rose, tobacco
diacetyl - 0 3  buttery, caramellic, creamy, pungent, sweet
dimethyl disulfide - 0 4  sulfurous, vegetable, cabbage, onion, malty, creamy
2,4-DNT - 0 4  
2-ethyl fenchol - 0 4  camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl vanillin - 0 4  sweet, creamy, vanilla, caramellic
eugenol - 0 4  clove, spicy, sweet, woody
eugenyl acetate - 0 4  carnation, clove, floral, fresh, malty, spicy, sweet, woody
geranyl acetate - 0 4  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
helional - 0 4  cyclamen, fresh, green, hay, ozone, watery
2-heptanone - 0 4  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
(Z)-3-hexen-1-ol - 0 4  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
isobutylamine - 0 4  cheesy, fishy
d-limonene - 0 4  citrus, orange, fresh, sweet
linalool - 0 4  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
lyral - 0 4  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
(1S,2R,5S)-(+)-menthol - 0 4  cooling, mentholic, minty
methyl eugenol - 0 4  carnation, cinnamon, clove, fresh, spicy, sweet, warm
methyl furfuryl disulfide - 0 4  sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
methyl salicylate - 0 4  minty, wintergreen
nonanal - 0 4  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
1-nonanol - 0 4  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
1-octanol - 0 4  aldehydic, green, mushroom, orange, rose, waxy
octyl octanoate - 0 4  coconut, oily, fruity
pelargonic acid - 0 4  cheesy, dairy, dirty, waxy
pentanol - 0 4  fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
propanal - 0 4  alcoholic, cocoa, earthy, nutty, whiskey, winey
propionic acid - 0 4  acidic, cheesy, pungent, vinegar
pyrazine - 0 4  pungent, sweet, corn, roasted, hazelnut, barley
quinoline - 0 4  earthy, medicinal, musty, rubbery, tobacco
sotolone - 0 4  sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
terpinyl acetate - 0 4  bergamot, citrus, herbal, lavender, lime
butyl formate - -0.1667 4  fruity, plum, rummy, brandy
octanethiol - -0.2667 4  sulfurous

1.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

2.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

3.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.

4.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821
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