Olfactory Receptor family 5 subfamily K member 1.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MAEENHTMKN EFILTGFTDH PELKTLLFVV FFAIYLITVV GNISLVALIF THRRLHTPMY IFLGNLALVD SCCACAITPK MLENFFSENK RISLYECAVQ 

       110        120        130        140        150        160        170        180        190        200 
FYFLCTVETA DCFLLAAMAY DRYVAICNPL QYHIMMSKKL CIQMTTGAFI AGNLHSMIHV GLVFRLVFCG SNHINHFYCD ILPLYRLSCV DPYINELVLF 

       210        220        230        240        250        260        270        280        290        300 
IFSGSVQVFT IGSVLISYLY ILLTIFKMKS KEGRAKAFST CASHFLSVSL FYGSLFFMYV RPNLLEEGDK DIPAAILFTI VVPLLNPFIY SLRNREVISV 

       310 
LRKILMKK

    

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

L E P H        F  E Y L S       L   I Y P D     P R   K D G E  
 L T K    N E L    V A C   G V H I   L E N   V Y M F   P I D   
V V F L  M K P T  F Y F Q   M S H   I F L V   F L S   L I A A  
 A F F    I A C    T C L   L N G A   G S F   G Y F L   I T F   
I L Y I  A C C S  A T E V   I F A   V Q V S   S V S   L P V V  
 V V T    D V L    F C D   G T T M   I T F   L F H S   P N L   
S I N G  A L N G  A A L L   Q I C   L V S G   A C T   S Y I F  
 A V L    L F I    Y A M   L K K S   Y S I   S F A K       L   
  F I L  Y M P T  V Y R D           L I Y L   A R G            
                   C I A             I T L   E K S K           
                        N               K F                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
trimethylthiazoline -9 1 -  chocolate, cocoa, coffee, hazelnut, musty, nutty, vegetable
hazelnut pyrazine -6.9 2 10 3  earthy, green, hazelnut, meaty, musty, nutty, potato, roasted, toasted, vegetable
2-methoxy-3,5-dimethylpyrazine -7.7 2 8.2906 4  earthy
2-ethyl-3,5-dimethylpyrazine -5.6 2 10 4  almond, burnt, caramellic, cocoa, coffee, musty, nutty, peanut, roasted
2-ethyl-3,6-dimethylpyrazine -5.83 5 -  
earthy pyrazine -5.01 5 9.7436 4  bell_pepper, earthy, nutty, raw_potato
shoyu pyrazine -5.03 5 9.6581 4  nutty, pepper, raw
2,3,5-trimethylpyrazine -5 2 9.4017 4  nutty, nut_skin, earthy, powdery, cocoa, potato, baked_potato, peanut, roasted_peanut, hazelnut, musty
2,6-dimethylpyrazine -4.4 6 10 6  ethereal, cocoa, nutty, roasted, meaty, roasted_meaty, beefy, brown, coffee, buttermilk
almond pyrazine -5.2 2 8.4615 4  roasted, almond, hazelnut, peanut
bean pyrazine -6 4 7.094 4  beany, chocolate, earthy, green_pea, nutty
furaneol -3.9 7 10 7  sweet, cotton_candy, caramellic, strawberry, brown_sugar
2-acetyl-3,5-dimethyl pyrazine -4.3 4 8.9744 4  nutty, hazelnut, roasted_hazelnut
2-methylthio-3-methylpyrazine -5 2 7.6923 4  roasted, meaty, nutty, almond, vegetable
methyl eugenol -8.22 8 1.9333 9  carnation, cinnamon, clove, fresh, spicy, sweet, warm
2,4-lutidine -4.6 4 7.1795 4  smoky, phenolic
galbanum pyrazine -5.5 4 5.641 4  green, pea, pepper
6-methyl quinoline -4.7 4 6.4103 4  leathery, tonka, castoreum, tobacco, civet, fecal
2-acetyl-3-ethylpyrazine -4.28 5 -  corn, earthy, musty, nutty, potato
2-acetyl-3-methylpyrazine -4.27 5 -  nutty, nut_flesh, hazelnut, roasted_hazelnut, grain, toasted_grain, corn_chip, vegetable, nut_skin, caramellic
filbert pyrazine -4.27 5 6.6667 4  nutty, peanut, musty, corn, raw, earthy, bready
2,5-lutidine -4.5 4 6.2393 4  roasted, green, earthy
methyl isoeugenol -5.05 10 4.5299 4  spicy, clove, floral, carnation, woody
2,5-dimethyl pyrazine -3.9 4 5.9829 4  cocoa, nutty, roasted, beefy, woody, grassy, medicinal
2,5-dihydro-2,4,5-trimethylthiazoline -3.8 3 -  
3-ethyl pyridine -4.5 4 4.8718 4  tobacco, oakmoss, leathery, caramellic, roasted, hazelnut
2-ethyl pyridine -4.2 4 5.2991 4  green, grassy
2-sec-butyl-3-methoxypyrazine -4.8 4 3.5897 4  musty, green, pea, galbanum, bell, pepper
2,3,5-trimethylpyridine -4.1 4 3.4188 4  
2-isobutylthiazole -4.5 4 2.735 4  green, wasabi, privet, tomato, leaf, earthy, vegetable, metallic
2-isobutyl-3-methylpyrazine -3.4 4 3.4188 4  herbal, green, sugar
indole -4.7 11 0.122 11  animal, fecal, floral, naphthyl
4-vinylguaiacol -4.3 12 0.6667 12  spicy, clove, carnation, phenolic, peppery, smoky, woody, powdery
skatole -4.4 11 0.4878 11  animal, civet, fecal, naphthyl
(R)-(-)-carvone -3.6 13 0.2353 13  herbal, minty, spearmint, sweet
anisaldehyde -3.3 13 0.2941 13  anisic, balsamic, floral, hawthorn, mimosa, powdery, sweet
diacetyl -1.6 1 1.5096 1  buttery, caramellic, creamy, pungent, sweet
quinoline - 1.6667 9  earthy, medicinal, musty, rubbery, tobacco
methoxyfuraneol - 1.5 3  sweet, moldy, mushroom, vegetable, potato, burnt, sugar, nut, skin, wasabi, caramellic, fruity, brandy
d-limonene - 0.7 9  citrus, fresh, orange, sweet
citral - 0.5 9  citrus, lemon, sharp, sweet
eugenol - 0.2667 9  clove, spicy, sweet, woody
lyral - 0.2333 9  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
beta-damascone - 0.2267 9  berry, currant, floral, fruity, honey, plum, rose, tobacco
benzene - 0.2167 9  
propanal - 0.1667 9  alcoholic, cocoa, earthy, nutty, whiskey, winey
aldehyde C-9 - 0.1333 9  aldehydic, fatty, fresh, orange, orris, peel, peely, rose, waxy
2-heptanone - 0.1333 9  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
aldehyde C-10 - 0 9  aldehydic, citrus, floral, orange, peel, sweet, waxy
allyl phenylacetate - 0 9  fruity, honey, rummy
amyl hexanoate - 0 9  apple, estery, fatty, fruity, green, pear, pineapple, sweet
androstenone - 0 9  animal, musky
l-arabinose - 0 9  
butyl formate - 0 9  brandy, fruity, plum, rummy
butyric acid - 0 9  acetic, buttery, cheesy, fruity, sharp
caramel furanone - 0 9  burnt, caramellic, coffee, maple, sugar, sweet
(S)-(+)-carvone - 0 9  bready, caraway, minty, spicy
coffee difuran - 0 9  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
coumarin - 0 9  coumarinic, hay, sweet, tonka
dimethyl disulfide - 0 9  cabbage, onion, sulfurous, vegetable
2,4-DNT - 0 9  
2-ethyl fenchol - 0 9  camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl vanillin - 0 9  caramellic, creamy, sweet, vanilla
o-ethyltoluene - 0 2  
eugenyl acetate - 0 9  carnation, clove, floral, fresh, malty, spicy, sweet, woody
geranyl acetate - 0 9  floral, green, lavender, rose, waxy
helional - 0 9  cyclamen, fresh, green, hay, ozone, watery
cis-3-hexen-1-ol - 0 9  foliage, fresh, grassy, green, herbal, oily, vegetable
isobutylamine - 0 9  cheesy, fishy
linalool - 0 9  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
(+)-menthol - 0 9  cooling, mentholic, minty
methyl furfuryl disulfide - 0 9  alliaceous, coffee, meaty, roasted, sulfurous
methyl salicylate - 0 9  minty, wintergreen
1-nonanol - 0 9  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
octanethiol - 0 9  sulfurous
1-octanol - 0 9  aldehydic, green, mushroom, orange, rose, waxy
3-octen-2-one - 0 14 Yearthy, spicy, herbal, sweet, mushroom, hay, blueberry
octyl octanoate - 0 9  coconut, fruity, oily
pelargonic acid - 0 9  cheesy, dairy, dirty, waxy
pentanol - 0 9  balsamic, fermented, fusel, oily, sweet
propionic acid - 0 9  acidic, cheesy, pungent, vinegar
pyrazine - 0 9  pungent, sweet, corn, roasted, hazelnut, barley
terpinyl acetate - 0 9  bergamot, citrus, herbal, lavender, lime
1,2,4-trimethylbenzene - 0 2  
allyl cyclohexylpropionate - -0.1626 11  apple, candy, fruity, green, pineapple, sweet, tropical, waxy
alpha,alpha-dimethyl phenethyl acetate - -0.1626 11  sweet, floral, fruity, rose, green, pear, berry, jasmin, powdery
ambroxide - -0.1626 11  amber, ambergris, cedar, dry, green, musk, paper, pine, seedy, woody
citronellal natural - -0.1626 11  sweet, dry, floral, herbal, waxy, aldehydic, citrus
citronellyl acetate - -0.1626 11  floral, green, rose, fruity, citrus, woody, fruit, tropical_fruit
2-cyclohexylpropanal - -0.1626 11  natural, fresh, green, dusty, fruity
delta-damascone - -0.1626 11  fruity, sweet, rose, natural, petal, currant_bud, black_currant_bud, tobacco
geraniol - -0.1626 11  citrus, floral, fruity, rose, sweet, waxy
grapefruit pentanol - -0.1626 11  vetiver, green, citrus, grapefruit, rhubarb, floral
cis-3-hexenyl salicylate - -0.1626 11  floral, green, metallic, herbal, balsamic
lilial - -0.1626 11  cumin, floral, green, muguet, powdery, watery
melafleur - -0.1626 11  floral, clean, muguet, ozone, marine, sandy, balsamic
perillic aldehyde - -0.1626 11  fresh, green, herbal, grassy, sweet, minty, cumin, spicy, citrus
strawberry glycidate - -0.1626 11  cherry, fruity, grape, jammy, phenolic, strawberry, sweet
verdyl acetate - -0.1626 11  floral, green, soapy, cedar, pine, woody
amber butanol - -0.3143 6  woody, amber, ambrette
(5E)-3-methylcyclopenta-5-decen-1-one - -0.3571 6  
alpha-hexyl cinnamaldehyde - -0.3857 6  fresh, floral, green, jasmine, herbal, waxy
fruity carboxylate - -0.4 6  sweet, fruity, rummy, candy, floral, ripe
beta-ionone - -0.4 6  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
gamma-undecalactone - -0.4 6  apricot, coconut, creamy, fatty, fruity, ketonic, lactonic, peach
bourgeonal - -0.4065 11  cyclamen, floral, fresh, sweet, watery
civetone - -0.4065 11  animal, clean, dry, musk, sweet
ethyl linalyl ether - -0.4065 11  floral
exaltolide - -0.4065 11  musk, animal, powdery, natural, fruity
galbascone - -0.4065 11  fresh, green, galbanum, earthy, weedy, pineapple, narcissus, hyacinth, fruity
7-methoxycitronellal - -0.4065 11  fresh, melon, floral, lily, sweet
methyl ionone gamma - -0.4065 11  violet, sweet, orris, powdery, floral, woody
3-(3-propen-2-yl phenyl) butanal - -0.4065 11  ozone, cortex, green, floral, melon
spicy carbonate - -0.4065 11  spicy, woody, floral, green, herbal
tetrahydrogeraniol - -0.4065 11  leathery, musty, plastic, rose, sweet
oranger crystals - -0.4571 6  honey, neroli, orangeflower, powdery, sweet
santaliff - -0.4571 6  sandalwood, creamy, woody, milky, waxy, greasy, musk
violet decenol - -0.5286 6  green, oily, violet, lily, seedy, fruity, kiwi
alpha-isomethyl ionone - -0.5714 6  orris, woody, floral, dried, fruit, violet, jammy, powdery, tea
ebanol - -0.6504 11  
galaxolide - -0.6504 11  floral, musk, sweet
(R,S)-methyl cedryl ketone - -0.6504 11  woody, vetiver, amber, leathery, musk, cedar
patchouli hexanol - -0.6504 11  woody, musty, patchouli, camphoreous, minty, leathery
thymol - -0.6504 11  camphoraceous, herbal, medicinal, phenolic, thyme
triplal - -0.6714 6  green, aldehydic, leafy, cortex, tart, floral, peely
habanolide - -8.6957 7  animal, cloth, dry, laundered, metallic, musk, powdery, sweet, tropical, waxy
tonalide - -8.6957 7  amber, ambrette, fruity, musk, powdery, sweet
ambrettolide - -10 7  amber, berry, fruity, musk, soapy, sweet
muscone - -13.0435 7  animal, fatty, musk, natural, powdery, sweet
cedryl acetate - -15.6522 7  dry, woody, cedar, powdery

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2.) Chatelain P., Wilkin F., Veithen A., Philippeau M., Noiset O., Quesnel Y. Sensorial Chemistry: Functional characterization and structure-activity relationship understanding of OR5K1 and OR2AG1 allow to design and synthetize new selective compounds. Chem. Senses. 2017;42:e28.

3.) Marcinek, Patrick, et al. "An evolutionary conserved olfactory receptor for foodborne and semiochemical alkylpyrazines." The FASEB Journal 35.6 (2021): e21638.

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14.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147