Olfactory Receptor family 5 subfamily V member 1.
Estimated Expression: 96% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MERKNQTAIT EFIILGFSNL NELQFLLFTI FFLTYFCTLG GNILIILTTV TDPHLHTPMY YFLGNLAFID ICYTTSNVPQ MMVHLLSKKK SISYVGCVVQ 110 120 130 140 150 160 170 180 190 200 LFAFVFFVGS ECLLLAAMAY DRYIAICNPL RYSVILSKVL CNQLAASCWA AGFLNSVVHT VLTFCLPFCG NNQINYFFCD IPPLLILSCG NTSVNELALL 210 220 230 240 250 260 270 280 290 300 STGVFIGWTP FLCIVLSYIC IISTILRIQS SEGRRKAFST CASHLAIVFL FYGSAIFTYV RPISTYSLKK DRLVSVLYSV VTPMLNPIIY TLRNKDIKEA 310 320 330 VKTIGSKWQP PISSLDSKLT Y
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 D K K L I P V S T N T L S I S K L L L E N L V L R R V Y T L E N V T H V G V Y H V M L F Q Y L V S F I A S L L A V S N Q V V C M Q P V I T F L V V S S G Y F V G T L F G A A F L N S T L F F L M P T L F V W G I F A W C F F V F T Y C I C F Y T I P N I A L H F P T S A A L S G V D I F G L T Y I S A C V I C L Q N C L L C E A L N G L I N G T S F A Y S L L V K S A A L L F Y L I I K R R I I C I D Y A M Y M P T T V T T G E S S I T S I Y R D I R L N C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| 2,4,6-tribromoanisole | -8.32 1 | - | cork_taint | |
| 2,4,6-trichloroanisole | -7.51 1 | - | cork_taint | |
| 2,4,6-trichlorophenol | -4.17 1 | - | cork_taint | |
| 2,4-dibromoanisole | -3.54 1 | - | ||
| methyl salicylate | -2.12 2 | 1.4861 2 | minty, wintergreen | |
| 2-methoxy-3,5-dimethylpyrazine | - | 0 1 | earthy |
1.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025
2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR5V1 | 100 | 96% | Y | L | F | V | V | G | C | L | G | N | S | H | F | D | I | P | L | T | G | I | G | Y | A | Y | I | S | V | Y | S |
| OR14C36 | 86 | 84% | Y | V | V | V | V | Y | L | L | G | Y | A | H | F | D | I | P | I | S | A | V | G | L | C | Y | P | S | G | Y | S |
| OR2W3 | 86 | 100% | F | L | F | L | G | G | C | L | G | N | S | M | L | E | M | P | V | L | A | V | V | Y | I | Y | G | M | L | Y | N |
| OR2J3 | 85 | 100% | Y | L | V | L | G | T | C | V | G | N | S | H | F | E | V | P | L | T | S | F | V | F | A | Y | P | A | L | Y | T |
| OR2M4 | 84 | 96% | L | I | Y | V | L | G | C | F | G | D | G | V | F | D | V | A | L | C | C | M | L | Y | A | Y | A | S | A | Y | T |
| OR8D4 | 84 | 96% | Y | L | F | C | V | I | C | Y | G | D | A | H | F | D | I | V | I | I | G | N | M | Y | L | Y | A | S | V | Y | T |
| OR2B3 | 84 | 42% | Y | L | F | L | G | A | C | L | G | N | S | Q | F | E | V | P | L | F | S | I | L | Y | A | Y | P | S | L | Y | G |
| OR10AD1 | 84 | 100% | F | M | V | F | G | V | C | I | G | N | G | L | F | E | A | P | I | D | A | V | I | Y | A | Y | H | S | L | Y | T |
| OR2B11 | 84 | 100% | Y | Y | F | H | G | C | C | I | G | N | S | Q | F | E | V | P | L | L | V | F | V | Y | A | Y | P | S | L | Y | S |
| OR2AJ1 | 84 | H | V | S | L | L | G | C | L | G | N | S | H | F | E | V | P | V | S | A | F | L | Y | F | Y | K | A | I | Y | T | |
| OR2A2 | 84 | Y | T | Y | L | A | V | C | L | G | L | S | H | F | E | I | L | I | T | C | V | L | F | A | Y | D | S | L | H | S | |
| OR2C1 | 84 | 100% | F | L | F | L | G | A | C | I | G | N | S | Q | L | E | V | P | L | V | C | F | T | Y | A | Y | A | S | L | Y | S |
| OR5G3 | 83 | S | M | F | G | E | A | C | F | A | S | T | H | F | D | I | F | L | L | A | I | G | Y | L | Y | S | S | L | Y | T | |
| OR5A1 | 83 | 100% | Y | F | F | V | G | L | C | L | G | S | S | Q | F | D | L | P | N | V | V | V | G | F | A | Y | S | S | V | Y | S |
| OR8A1 | 83 | 69% | Y | L | F | L | V | I | C | Y | G | G | S | E | F | D | I | L | V | S | A | N | I | Y | T | Y | P | S | V | Y | T |
| OR10R2 | 82 | 57% | Y | M | F | L | A | I | C | L | G | A | S | V | F | D | I | S | I | C | G | V | L | Y | A | Y | T | T | V | Y | T |
| OR14L1 | 82 | Y | A | F | M | A | T | V | A | G | C | G | H | F | N | I | P | V | F | G | L | V | M | G | Y | I | S | A | Y | T | |
| OR2W1 | 82 | 53% | F | L | Y | M | G | S | C | L | S | N | S | L | L | E | L | P | V | L | G | I | V | Y | I | Y | G | T | L | Y | T |
| OR2D3 | 82 | 100% | F | I | F | L | G | C | C | A | G | V | S | D | F | E | P | P | I | M | G | I | L | Y | G | Y | N | S | V | Y | T |
| OR1F1 | 82 | 30% | F | M | V | F | V | D | N | F | A | N | V | H | F | D | V | T | I | E | G | V | M | Y | I | Y | L | T | V | Y | T |
| OR2Z1 | 81 | 84% | C | I | L | T | G | V | G | V | G | N | A | Q | F | E | V | P | L | S | G | I | L | Y | A | Y | C | S | L | Y | S |
| OR10G8 | 81 | 57% | F | L | F | H | G | G | C | F | G | H | S | Q | L | D | A | P | I | T | V | V | A | F | G | Y | G | A | V | Y | T |
| OR1D2 | 81 | 100% | F | L | L | V | V | A | N | L | S | Y | G | H | F | E | M | Y | L | T | G | I | F | Y | L | Y | L | T | V | Y | A |
| OR2G6 | 81 | 100% | F | L | A | M | G | S | C | I | G | T | S | Q | F | E | V | P | L | A | S | F | L | Y | I | Y | A | S | L | Y | T |
| OR2J1 | 81 | Y | L | V | L | G | T | C | V | G | T | S | H | F | E | V | P | L | M | S | F | V | F | V | Y | P | A | L | Y | T | |
| OR2T4 | 81 | 80% | Y | M | Y | V | A | G | F | F | G | D | G | F | F | E | V | P | M | C | C | M | L | Y | A | Y | S | S | V | Y | T |
| OR2AG1 | 81 | 100% | F | M | A | L | G | G | D | L | A | S | A | Y | L | E | I | P | V | M | G | F | L | Y | A | Y | S | S | V | Y | T |
| OR8B2 | 81 | 88% | Y | L | F | L | V | I | C | Y | G | G | A | H | L | D | I | L | V | V | V | N | I | F | A | Y | Y | S | V | Y | T |
| OR8B3 | 81 | 88% | Y | L | F | L | V | I | C | Y | G | G | A | H | L | D | I | L | V | V | V | N | I | F | A | Y | Y | S | V | Y | T |
| OR2L5 | 81 | Y | S | F | M | A | G | A | L | G | N | S | H | F | D | V | P | V | S | S | F | L | Y | F | Y | R | A | V | Y | T | |
| OR8D1 | 81 | 96% | Y | L | F | V | V | V | G | Y | G | S | A | H | F | D | V | L | L | I | A | N | T | F | I | Y | P | S | V | Y | T |
| OR13G1 | 81 | 100% | C | L | F | T | L | G | M | V | A | N | S | H | F | E | I | P | V | A | D | L | A | Y | V | Y | A | A | A | Y | T |
| OR2L8 | 81 | 100% | Y | S | F | L | G | G | A | L | G | N | A | H | F | D | V | P | V | S | A | F | L | Y | F | Y | R | A | V | Y | T |
| OR2M5 | 81 | 34% | L | I | Y | V | L | G | C | F | G | D | A | D | F | D | F | P | L | C | C | M | I | Y | G | Y | T | S | V | Y | T |
| OR2V2 | 81 | 96% | L | I | F | V | V | G | G | L | G | D | G | Q | F | E | M | L | I | C | C | M | L | Y | A | Y | R | S | I | Y | T |
| OR2T6 | 80 | 92% | Y | C | Y | M | M | G | F | F | G | D | S | L | F | E | A | P | M | C | C | M | L | Y | A | Y | Q | S | A | Y | T |
| OR2T10 | 80 | 92% | Y | M | Y | L | G | G | C | C | G | D | G | L | F | E | V | P | M | C | C | M | L | Y | A | Y | S | S | F | Y | T |
| OR14J1 | 80 | 88% | F | V | F | I | A | S | V | A | G | S | G | H | F | D | V | P | L | F | T | A | A | L | A | F | P | S | V | Y | T |
| OR1L1 | 80 | 100% | Y | M | F | L | G | N | S | Y | P | H | S | H | F | D | D | Q | V | E | G | V | I | Y | I | Y | L | T | I | Y | T |
| OR3A3 | 80 | 38% | C | L | F | H | A | G | C | F | A | N | A | H | Y | D | L | P | L | A | A | M | A | Y | G | Y | G | G | V | M | T |
| OR7A17 | 80 | 100% | F | M | F | V | G | G | S | L | A | N | S | Q | F | E | L | N | M | A | A | L | A | C | G | Y | S | S | V | Y | T |
| OR2Y1 | 80 | 73% | F | L | Y | L | G | S | C | V | G | N | S | Q | F | E | M | P | M | A | R | V | V | Y | A | Y | I | A | L | Y | T |
| OR2J2 | 80 | 92% | H | L | V | L | G | I | C | V | G | I | S | H | F | E | V | P | L | M | S | F | V | F | V | Y | P | A | L | Y | T |
| OR2T12 | 80 | 69% | L | I | L | P | G | G | C | F | G | D | G | Q | F | E | A | P | M | C | C | M | L | Y | G | Y | K | S | A | Y | T |
| OR2B8 | 80 | Y | L | S | L | G | S | C | V | G | N | S | Q | L | E | V | P | L | V | S | I | L | Y | A | Y | G | S | L | Y | T |