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Olfactory Receptor family 2 subfamily B member 11.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MKSDNHSFLG DSPKAFILLG VSDRPWLELP LFVVLLLSYV LAMLGNVAII LASRVDPQLH SPMYIFLSHL SFLDLCYTTT TVPQMLVNMG SSQKTISYGG 

       110        120        130        140        150        160        170        180        190        200 
CTVQYAVFHW LGCTECIVLA AMALDRYVAI CKPLHYAVLM HRALCQQLVA LAWLSGFGNS FVQVVLTVQL PFCGRQVLNN FFCEVPAVIK LSCADTAVND 

       210        220        230        240        250        260        270        280        290        300 
TILAVLVAFF VLVPLALILL SYGFIARAVL RIQSSKGRHK AFGTCSSHLM IVSLFYLPAI YMYLQPPSSY SQEQGKFISL FYSIITPTLN PFTYTLRNKD 

       310        320 
MKGALRRLLA RIWRLCG

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

Q E Q S       S   V A T D     T L   I T K Q      G M  L W P R  
 F K G   P P Q L   T D N   V V Q V   G Y S    N V L    P L E   
F L S I   Y M Y   V A L I   F S N   V T C G  M Q P V  V V F L  
 I S Y   I A P L   A V L   G F G S   A Y Q    T T T    L L L   
T P T I   Y F L   L V F F   L W A   W H F V  T Y C L  L V Y S  
 P N L   S V I M   L P V   L A V L   C G L    D L F    L M A   
    T F   L H S   L I L A   Q Q C   I C E T  S L H S  A V N G  
         S C T G   Y S L   L A R H   A L V    L F I    L I I   
          F A K   A I F G           L A M A  Y M P S  V R S A  
         H R G K   V A R             Y R D                 D   
                    I R L           C I A V                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Docks Aroma Notes
quinoline -5.4 1 10 1   earthy, medicinal, musty, rubbery, tobacco
coumarin -3.5 1 9.3333 2   coumarinic, hay, sweet, tonka
coffee difuran -6.8 3 0.442 3   cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
cinnamaldehyde -6 3 0.5195 3   sweet, spicy, candy, cinnamon, warm
d-limonene - 4.1667 2   citrus, orange, fresh, sweet
dicyclohexyl disulfide -3.82 3 0.9179 3   alliaceous, eggy, nut_skin, coffee, clam, seafood
allyl phenylacetate - 0 2   honey, fruity, rummy
n-amyl alcohol - 0 2   fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
amyl hexanoate - 0 2   sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
androstenone - 0 2   animal, musky
benzene - 0 2   gasoline, phenolic, solvent, cinnamon
butyl formate - 0 2   fruity, plum, rummy, brandy
(S)-(+)-carvone - 0 2   bready, caraway, minty, spicy
citral - 0 2   sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
beta-damascone - 0 2   berry, currant, floral, fruity, honey, plum, rose, tobacco
decanal - 0 2   sweet, aldehydic, waxy, orange_peel, citrus, floral
dimethyl disulfide - 0 2   sulfurous, vegetable, cabbage, onion, malty, creamy
2,4-DNT - 0 2   
2-ethyl fenchol - 0 2   camphorous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
eugenol - 0 2   clove, spicy, sweet, woody
eugenyl acetate - 0 2   carnation, clove, floral, fresh, malty, spicy, sweet, woody
geranyl acetate - 0 2   floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
helional - 0 2   cyclamen, fresh, green, hay, ozone, watery
2-heptanone - 0 2   banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
(Z)-3-hexen-1-ol - 0 2   fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
isobutylamine - 0 2   cheesy, fishy
linalool - 0 2   blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
lyral - 0 2   aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
(1S,2R,5S)-(+)-menthol - 0 2   cooling, mentholic, minty
methyl eugenol - 0 2   carnation, cinnamon, clove, fresh, spicy, sweet, warm
methyl furfuryl disulfide - 0 2   sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
methyl salicylate - 0 2   minty, wintergreen
nonanal - 0 2   waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
1-nonanol - 0 2   aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
octanethiol - 0 2   sulfurous
1-octanol - 0 2   aldehydic, green, mushroom, orange, rose, waxy
pelargonic acid - 0 2   cheesy, dairy, dirty, waxy
propanal - 0 2   alcoholic, cocoa, earthy, nutty, whisky, winey
propionic acid - 0 2   acidic, cheesy, pungent, vinegar
sotolone - 0 2   sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
butyric acid - -0.3333 2   sharp, acetic, cheesy, buttery, fruity, dairy, creamy
ethyl vanillin - -0.5 2   sweet, creamy, vanilla, caramellic
l-arabinose - -0.6667 2   
octyl octanoate - -0.6667 2   coconut, oily, fruity
pyrazine - -0.6667 2   pungent, sweet, corn, roasted, hazelnut, barley
terpinyl acetate - -0.6667 2   bergamot, citrus, herbal, lavender, lime

1.) J.D. Mainland, A. Keller, Y.R. Li, T. Zhou, C. Trimmer, L.L. Snyder, A.H. Moberly, K.A. Adipietro, W.L.L. Liu, H. Zhuang et al, The missense of smell: functional variability in the human odorant receptor repertoire, Nat. Neurosci. 17 (2014) 114-120

2.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

3.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
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