Olfactory Receptor family 2 subfamily B member 3.
Estimated Expression: 42% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MNWENESSPK EFILLGFSDR AWLQMPLFVV LLISYTITIF GNVSIMMVCI LDPKLHTPMY FFLTNLSILD LCYTTTTVPH MLVNIGCNKK TISYAGCVAH 110 120 130 140 150 160 170 180 190 200 LIIFLALGAT ECLLLAVMSF DRYVAVCRPL HYVVIMNYWF CLRMAAFSWL IGFGNSVLQS SLTLNMPRCG HQEVDHFFCE VPALLKLSCA DTKPIEAELF 210 220 230 240 250 260 270 280 290 300 FFSVLILLIP VTLILISYGF IAQAVLKIRS AEGRQKAFGT CGSHMIVVSL FYGTAIYMYL QPPSSTSKDW GKMVSLFYGI ITSMLNSLIY SLRNKDMKEA 310 320 FKRLMPRIFF CKK
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 G W D K S P K T D T L S I T K G I L W A R V M K S P P Q A E I S S Q L G A Y N V L P M Q Y F L S L Y M F F L E V S N H A V C M H P V V V F L I I G Y I A T V S F G F G I I I L T T T I L L L M S T G Y F L L I L L W S L A L F T Y C L I T Y S L S N L S V V V P I F A A M T A G D L I F I T Y I I M H L I L T R L C L L C E S L N T S V N G S G C T Y S I F W Y N V A L L F F M M I G F A A I F G D F S M Y M P T L I C V K Q R G V A Q V Y R D I K L R C V A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB 2
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| pyrazine | -8.61 1 | 0.0638 1 | pungent, sweet, corn, roasted, hazelnut, barley | |
| eugenyl acetate | -4 2 | (agonist) 2 | carnation, clove, floral, fresh, malty, spicy, sweet, woody | |
| nerolidol | -4 2 | (agonist) 2 | floral, green, waxy, citrus, woody, fruity, melon | |
| beta-ionone | -3 2 | (agonist) 2 | beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent | |
| hexanal | - | 0.5 3 | aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty |
1.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
2.) D. Gonzalez-Kristeller, J.B.P. do Nascimento, P.A.F. Galante, B. Malnic, Identification of agonists for a group of human odorant receptors, Front. Pharmacol. 6 (2015)
3.) Ojiro I, Katsuyama H, Kaneko R, Ogasawara S, Murata T, Terada Y, et al. (2024) Enhancement of transcription efficiency by TAR-Tat system increases the functional expression of human olfactory receptors. PLoS ONE 19(6): e0306029. https://doi.org/10.1371/journal.pone.0306029
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR2B3 | 100 | 42% | Y | L | F | L | G | A | C | L | G | N | S | Q | F | E | V | P | L | F | S | I | L | Y | A | Y | P | S | L | Y | G |
| OR2B2 | 92 | Y | L | F | L | G | S | C | L | G | N | S | Q | F | E | V | P | L | I | S | F | L | Y | A | Y | P | S | L | C | G | |
| OR2G6 | 88 | 100% | F | L | A | M | G | S | C | I | G | T | S | Q | F | E | V | P | L | A | S | F | L | Y | I | Y | A | S | L | Y | T |
| OR2B6 | 88 | Y | L | F | L | G | A | Y | L | G | N | S | L | L | E | V | P | L | V | S | F | H | Y | A | Y | P | S | L | Y | G | |
| OR2C1 | 87 | 100% | F | L | F | L | G | A | C | I | G | N | S | Q | L | E | V | P | L | V | C | F | T | Y | A | Y | A | S | L | Y | S |
| OR2B8 | 87 | Y | L | S | L | G | S | C | V | G | N | S | Q | L | E | V | P | L | V | S | I | L | Y | A | Y | G | S | L | Y | T | |
| OR5A2 | 85 | 100% | Y | Y | F | C | G | L | C | F | G | S | S | E | F | D | L | P | T | V | S | V | G | Y | G | Y | S | S | I | Y | A |
| OR2H2 | 85 | 88% | F | I | F | L | G | T | C | I | G | E | S | Q | V | E | V | P | V | A | S | I | L | Y | V | Y | K | G | L | Y | A |
| OR2Y1 | 85 | 73% | F | L | Y | L | G | S | C | V | G | N | S | Q | F | E | M | P | M | A | R | V | V | Y | A | Y | I | A | L | Y | T |
| OR13C8 | 85 | 69% | Y | M | S | F | G | A | C | M | G | D | S | Q | V | E | I | L | M | S | N | V | L | Y | I | Y | E | S | L | Y | G |
| OR2D2 | 85 | 100% | F | L | F | L | G | C | C | A | G | V | S | D | F | E | A | P | I | M | G | I | L | Y | A | Y | K | S | V | Y | A |
| OR13C2 | 84 | 100% | Y | M | G | L | G | T | C | V | G | N | S | Q | T | E | I | L | M | A | T | F | I | Y | I | Y | K | S | M | Y | G |
| OR5V1 | 84 | 96% | Y | L | F | V | V | G | C | L | G | N | S | H | F | D | I | P | L | T | G | I | G | Y | A | Y | I | S | V | Y | S |
| OR2B11 | 84 | 100% | Y | Y | F | H | G | C | C | I | G | N | S | Q | F | E | V | P | L | L | V | F | V | Y | A | Y | P | S | L | Y | S |
| OR13C3 | 84 | 92% | Y | M | G | F | G | S | C | L | G | N | S | Q | A | E | I | L | M | S | N | F | L | Y | I | Y | K | S | L | Y | G |
| OR13C4 | 83 | 88% | Y | M | G | F | G | S | C | F | G | N | S | Q | L | E | I | L | L | S | N | F | L | Y | I | Y | K | S | M | Y | G |
| OR11L1 | 82 | 100% | Y | L | F | V | G | A | C | F | G | T | G | P | F | D | L | P | I | L | S | V | L | Y | M | Y | S | S | V | Y | T |
| OR2W3 | 82 | 100% | F | L | F | L | G | G | C | L | G | N | S | M | L | E | M | P | V | L | A | V | V | Y | I | Y | G | M | L | Y | N |
| OR5A1 | 82 | 100% | Y | F | F | V | G | L | C | L | G | S | S | Q | F | D | L | P | N | V | V | V | G | F | A | Y | S | S | V | Y | S |
| OR2J1 | 81 | Y | L | V | L | G | T | C | V | G | T | S | H | F | E | V | P | L | M | S | F | V | F | V | Y | P | A | L | Y | T | |
| OR7D4 | 81 | 96% | F | V | L | M | A | G | T | F | I | F | S | H | F | E | P | A | L | A | T | L | G | Y | G | Y | S | S | V | Y | A |
| OR13C9 | 81 | 96% | Y | M | G | L | G | T | C | V | G | N | S | Q | S | E | I | L | M | A | T | F | T | Y | I | Y | K | S | M | Y | G |
| OR2G2 | 81 | 38% | F | L | S | H | G | S | C | V | G | T | T | Q | I | E | V | P | L | A | S | F | L | Y | I | Y | A | S | L | Y | T |
| OR2D3 | 81 | 100% | F | I | F | L | G | C | C | A | G | V | S | D | F | E | P | P | I | M | G | I | L | Y | G | Y | N | S | V | Y | T |
| OR2F1 | 80 | 100% | Y | L | S | L | G | G | F | V | G | S | S | Q | S | E | L | L | I | S | S | L | L | Y | A | Y | H | S | V | Y | A |
| OR14J1 | 80 | 88% | F | V | F | I | A | S | V | A | G | S | G | H | F | D | V | P | L | F | T | A | A | L | A | F | P | S | V | Y | T |
| OR9K2 | 80 | 96% | Y | L | F | A | I | V | G | F | G | S | S | Q | Y | D | S | R | S | L | S | I | I | Y | V | Y | P | S | L | Y | S |
| OR2J2 | 80 | 92% | H | L | V | L | G | I | C | V | G | I | S | H | F | E | V | P | L | M | S | F | V | F | V | Y | P | A | L | Y | T |