Olfactory Receptor family 8 subfamily D member 1.
Sequence:
10 20 30 40 50 60 70 80 90 100 MTMENYSMAA QFVLDGLTQQ AELQLPLFLL FLGIYVVTVV GNLGMILLIA VSPLLHTPMY YFLSSLSFVD FCYSSVITPK MLVNFLGKKN TILYSECMVQ 110 120 130 140 150 160 170 180 190 200 LFFFVVFVVA EGYLLTAMAY DRYVAICSPL LYNAIMSSWV CSLLVLAAFF LGFLSALTHT SAMMKLSFCK SHIINHYFCD VLPLLNLSCS NTHLNELLLF 210 220 230 240 250 260 270 280 290 300 IIAGFNTLVP TLAVAVSYAF ILYSILHIRS SEGRSKAFGT CSSHLMAVVI FFGSITFMYF KPPSSNSLDQ EKVSSVFYTT VIPMLNPLIY SLRNKDVKKA 310 LRKVLVGK
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 L E A Q L F E S Y L M A L H T N F Y M F Q D L S P L Q N V L V M C S T H T L E N T I S V K E L L F L M K P T F F L Q L A S I F L L G F F I F V S S G L F I V S V V F L F G L G A I V V A T T Y V V Y I S Y C F A V V F F F A L T N F M L H S M P I V V V T D V F Y G E A L V L T P V S C T P N L G L N G S L S S A T L L L S C A V A L G F A K S Y I L L I M L F Y Y A M V W S S Y S V S R G L A I L Y M P T V Y R D L I F A E S S R C I A I S Y S H L UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| caramel furanone | -6.4 1 | 10 1 | burnt, caramellic, coffee, maple, sugar, sweet | |
| abhexone | -5.5 2 | 5 2 | sweet, fruity, caramellic, maple, fenugreek, brown, sugar, nutty, chicory, praline, butterscotch | |
| oenanthic acid | -3.58 3 | 0.0803 3 | rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity | |
| p-cymene | -2.27 3 | 1.1909 3 | citrus, fresh, spicy, terpenic, woody | |
| androstadienone | -1.45 3 | 0.0683 3 | animal, musky | |
| aldehyde C-9 | - | 0 4 | aldehydic, fatty, fresh, orange, orris, peel, peely, rose, waxy | |
| allyl phenylacetate | - | 0 4 | fruity, honey, rummy | |
| amyl hexanoate | - | 0 4 | apple, estery, fatty, fruity, green, pear, pineapple, sweet | |
| androstenone | - | 0 4 | animal, musky | |
| l-arabinose | - | 0 4 | ||
| benzene | - | 0 4 | ||
| butyl formate | - | 0 4 | brandy, fruity, plum, rummy | |
| butyric acid | - | 0 4 | acetic, buttery, cheesy, fruity, sharp | |
| (S)-(+)-carvone | - | 0 4 | bready, caraway, minty, spicy | |
| citral | - | 0 4 | citrus, lemon, sharp, sweet | |
| coumarin | - | 0 4 | coumarinic, hay, sweet, tonka | |
| beta-damascone | - | 0 4 | berry, currant, floral, fruity, honey, plum, rose, tobacco | |
| 2,4-DNT | - | 0 4 | ||
| eugenol | - | 0 4 | clove, spicy, sweet, woody | |
| eugenyl acetate | - | 0 4 | carnation, clove, floral, fresh, malty, spicy, sweet, woody | |
| geranyl acetate | - | 0 4 | floral, green, lavender, rose, waxy | |
| cis-3-hexen-1-ol | - | 0 4 | foliage, fresh, grassy, green, herbal, oily, vegetable | |
| d-limonene | - | 0 4 | citrus, fresh, orange, sweet | |
| linalool | - | 0 4 | blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody | |
| lyral | - | 0 4 | aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody | |
| methyl eugenol | - | 0 4 | carnation, cinnamon, clove, fresh, spicy, sweet, warm | |
| 1-nonanol | - | 0 4 | aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet | |
| octanethiol | - | 0 4 | sulfurous | |
| 1-octanol | - | 0 4 | aldehydic, green, mushroom, orange, rose, waxy | |
| pelargonic acid | - | 0 4 | cheesy, dairy, dirty, waxy | |
| propionic acid | - | 0 4 | acidic, cheesy, pungent, vinegar | |
| ethyl vanillin | - | -0.0167 4 | caramellic, creamy, sweet, vanilla | |
| dimethyl disulfide | - | -0.02 4 | cabbage, onion, sulfurous, vegetable | |
| isobutylamine | - | -0.0217 4 | cheesy, fishy | |
| octyl octanoate | - | -0.0233 4 | coconut, fruity, oily | |
| helional | - | -0.025 4 | cyclamen, fresh, green, hay, ozone, watery | |
| 2-heptanone | - | -0.025 4 | banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody | |
| methyl salicylate | - | -0.0267 4 | minty, wintergreen | |
| terpinyl acetate | - | -0.0283 4 | bergamot, citrus, herbal, lavender, lime | |
| coffee difuran | - | -0.03 4 | cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty | |
| methyl furfuryl disulfide | - | -0.03 4 | alliaceous, coffee, meaty, roasted, sulfurous | |
| propanal | - | -0.0317 4 | alcoholic, cocoa, earthy, nutty, whiskey, winey | |
| quinoline | - | -0.0317 4 | earthy, medicinal, musty, rubbery, tobacco | |
| pentanol | - | -0.0333 4 | balsamic, fermented, fusel, oily, sweet | |
| pyrazine | - | -0.0333 4 | pungent, sweet, corn, roasted, hazelnut, barley | |
| (+)-menthol | - | -0.0367 4 | cooling, mentholic, minty | |
| aldehyde C-10 | - | -0.04 4 | aldehydic, citrus, floral, orange, peel, sweet, waxy | |
| 2-ethyl fenchol | - | -0.0433 4 | camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea | |
| vernolide | - | -0.1538 1 | ||
| jasminaldehyde | - | -0.1692 1 | ||
| habanolide | - | -0.1769 1 | animal, cloth, dry, laundered, metallic, musk, powdery, sweet, tropical, waxy | |
| ambrettolide | - | -0.2 1 | amber, berry, fruity, musk, soapy, sweet | |
| (R,S)-methyl cedryl ketone | - | -0.2462 1 | woody, vetiver, amber, leathery, musk, cedar | |
| (5E)-3-methylcyclopenta-5-decen-1-one | - | -0.2538 1 | ||
| muscone | - | -0.2538 1 | animal, fatty, musk, natural, powdery, sweet | |
| bourgeonal | - | -0.2769 1 | cyclamen, floral, fresh, sweet, watery |
1.) Aya NAMBA, Naoko Saito, Michiaki Inoue, Tsuyoshi TOYABE (2016) Inhibitor of odor caused by sotolone US9254248B2
2.) HAAG, Franziska, HOFFMANN, Sandra, et KRAUTWURST, Dietmar. Key Food Furanones Furaneol and Sotolone Specifically Activate Distinct Odorant Receptors. Journal of Agricultural and Food Chemistry, 2021, vol. 69, no 37, p. 10999-11005.
3.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
4.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821