Olfactory Receptor family 10 subfamily A member 6.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MERQNQSCVV EFILLGFSNY PELQGQLFVA FLVIYLVTLI GNAIIIVIVS LDQSLHVPMY LFLLNLSVVD LSFSAVIMPE MLVVLSTEKT TISFGGCFAQ 

       110        120        130        140        150        160        170        180        190        200 
MYFILLFGGA ECFLLGAMAY DRFAAICHPL NYQMIMNKGV FMKLIIFSWA LGFMLGTVQT SWVSSFPFCG LNEINHISCE TPAVLELACA DTFLFEIYAF 

       210        220        230        240        250        260        270        280        290        300 
TGTFLIILVP FLLILLSYIR VLFAILKMPS TTGRQKAFST CAAHLTSVTL FYGTASMTYL QPKSGYSPET KKVMSLSYSL LTPLLNLLIY SLRNSEMKRA 

       310        320 
LMKLWRRRVV LHTI

    

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

L E P Y   V V L   G G F S     V W   L F T D    Y T M  T E P S  
 Q G Q   M E P M   A F C   S T Q V   I E F    S A T    V K K   
A V F L   I V A   F Y M Q   T G L   T F A Y  G Y F L  S L S M  
 V L F   S F S L   L L I   M F G L   F T G    T V S    L S Y   
V L Y I   D V V   A G G F   A W S   L I I L  T L H A  L P T L  
 I L T   S L N L   F C E   F I I L   F P V    A C T    L N L   
I A N G   L F L   A G L L   K M F   L I L L  S F A K  S Y I L  
 V I I   Y M P V   Y A M   V G K N   Y S L    Q R G        L   
  S V I           A F R D           L V R I  T T S P           
                   C I A             I A F                     
                        H               K L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
(S)-(-)-citronellol -6.7 1 -  citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
geraniol -6.48 1 -  citrus, floral, fruity, rose, sweet, waxy
linalool -6.25 1 -  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
nerol -6.22 1 -  citrus, floral, fresh, green, lemon, lime, magnolia, natural, neroli, spicy, sweet, waxy
alpha-ionone -6.13 1 -  sweet, woody, floral, violet, orris, tropical, fruity
cyclamal -6.02 1 -  cyclamen, floral, fresh, green, musty, rhubarb
(Z)-4-undecenal -5.55 2 10 2  
phenethyl acetate -5.46 3 10 3  floral, fruity, honey, rose, sweet, tropical
melafleur -5.73 1 -  floral, clean, muguet, ozone, marine, sandy, balsamic
benzyl acetone -5.72 1 -  floral, balsamic, strawberry
lyral -5.59 1 -  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
pelargonic acid - 8.6364 4  cheesy, dairy, dirty, waxy
(Z)-6-undecenal -5.48 2 8.3333 2  
phenylpropyl alcohol -5.31 1 -  sweet, spicy, cinnamyl, floral, hyacinth, balsamic, cinnamon, fruity, honey, winey
phenethyl alcohol -4.94 1 -  floral, rose, dried_rose, sweet, fresh, bready, honey
nonadecane -4.92 1 -  bland
(Z)-4-nonenal -5.32 2 6.1111 2  
cinnamyl alcohol -6.88 1 1.9231 5  balsamic, cinnamon, cinnamyl, fermented, floral, green, hyacinth, powdery, spicy, sweet
oranger crystals -4 6 3.2353 6  sweet, neroli, orangeflower, powdery, honey, floral, orange, naphthyl, citrus
caproic acid -4.3 4 1.9091 4  cheesy, fatty, sour, sweaty
(R)-(-)-carvone -3.8 6 2.3529 6  herbal, minty, spearmint, sweet
androstadienone -4.17 7 1.176 7  animal, musky
3-hydroxy-3-methylhexanoic acid -4 8 1.4 8  cumin, sweaty, spicy, animalic
isoeugenol -4.04 7 1.0399 7  carnation, clove, floral, spicy, sweet, woody
3-methyl-2-hexenoic acid -3.92 8 0.76 8  cheesy, fruity
(S)-(+)-carvone -3.8 6 0.8235 6  bready, caraway, minty, spicy
butyric acid -4.1 7 0.1104 7  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
para-anisaldehyde -3.5 6 0.8824 6  sweet, powdery, mimosa, floral, hawthorn, balsamic, vanilla, anise, woody, coumarinic, creamy, spicy
3-phenyl propyl propionate -2.82 7 1.1908 7  floral, balsamic, hyacinth, mimosa, fruity
androstenone -3.06 7 0.4989 7  animal, musky
1-hexanol - 1.9231 5  ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
muguet propanol - 1.9231 5  floral, lily_of_the_valley, woody
amyl laurate -1.29 7 1.3654 7  fatty, oily, waxy
benzyl alcohol - 0 1  floral, rose, phenolic, balsamic
alpha-damascone - 0 1  floral, rose, apple, fruity, black_currant, sweet, green, berry
(Z)-3-hexen-1-ol - 0 1  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent
beta-ionone - 0 1  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
lavandulol - 0 1  floral, waxy, mimosa, herbal

1.) Duroux R, Mandeau A, Guiraudie-Capraz G, Quesnel Y, Loing E. A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors. Molecules. 2020 Oct 16;25(20):4743. doi: 10.3390/molecules25204743. PMID: 33081083; PMCID: PMC7587601.

2.) Frey, T., Kwadha, C. A., Wallin, E. A., Holgersson, E., Hedenström, E., Bohman, B., ... & Witzgall, P. (2020). The human odorant receptor OR10A6 is tuned to the pheromone of the commensal fruit fly Drosophila melanogaster. bioRxiv.

3.) Saito N, Yamano E, Ishii A, Tanaka M, Nakamura J, et al. (2018) Involvement of the olfactory system in the induction of anti-fatigue effects by odorants. PLOS ONE 13(3): e0195263. https://doi.org/10.1371/journal.pone.0195263

4.) Aya Kato, Naoko Saito, Etsuji Wakisaka (2016) Method for searching for malodor control agent, malodor control agent, and malodor control method. US9526680B2

5.) Ashti Baghaei, K. (2015). Large scale analysis of olfactory receptors with highly genetically variations in relation with specific anosmia (Doctoral dissertation, Bochum, Ruhr-Universität Bochum, Diss., 2013).

6.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.

7.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

8.) Aya Kato, Naoko Saito (2018) Search method for odor control agent JP6422665B2

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