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Olfactory Receptor family 10 subfamily A member 6.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MERQNQSCVV EFILLGFSNY PELQGQLFVA FLVIYLVTLI GNAIIIVIVS LDQSLHVPMY LFLLNLSVVD LSFSAVIMPE MLVVLSTEKT TISFGGCFAQ 

       110        120        130        140        150        160        170        180        190        200 
MYFILLFGGA ECFLLGAMAY DRFAAICHPL NYQMIMNKGV FMKLIIFSWA LGFMLGTVQT SWVSSFPFCG LNEINHISCE TPAVLELACA DTFLFEIYAF 

       210        220        230        240        250        260        270        280        290        300 
TGTFLIILVP FLLILLSYIR VLFAILKMPS TTGRQKAFST CAAHLTSVTL FYGTASMTYL QPKSGYSPET KKVMSLSYSL LTPLLNLLIY SLRNSEMKRA 

       310        320 
LMKLWRRRVV LHTI

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

T E P S  L Y T M  L F T D     V W   I T T K      S L  L E P Y  
 V K K    S A T    I E F   S T Q V   G F S    V V L    Q G Q   
S L S M  G Y F L  T F A Y   T G L   A F C G  M E P M  A V F L  
 L S Y    T V S    F T G   M F G L   Y M Q    I V A    V L F   
L P T L  T L H A  L I I L   A W S   L L I F  S F S L  V L Y I  
 L N L    A C T    F P V   F I I L   G G F    D V V    I L T   
S Y I L  S F A K  L I L L   K M F   F C E A  S L N L  I A N G  
          Q R G    Y S L   V G K N   G L L    L F L    V I I   
         T T S P  L V R I           Y A M A  Y M P V  L S V I  
                   I A F             F R D                 D   
                    M K L           C I A A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
(Z)-4-undecenal -5.55 1 10 1  
phenethyl acetate -5.46 2 10 2  floral, fruity, honey, rose, sweet, tropical
pelargonic acid - 8.6364 3  cheesy, dairy, dirty, waxy
(Z)-6-undecenal -5.48 1 8.3333 1  
gamma-dodecalactone -5.27 4 -  fatty, fruity, metallic, peach, sweet
gamma-undecalactone -5.27 4 -  fruity, peach, creamy, fatty, lactonic, apricot, ketonic, coconut
nectaryl -4.93 4 -  fruity, tropical, lactonic, peach, apricot, oily, waxy, custard, coconut
gamma-decalactone -4.73 4 -  fresh, oily, waxy, peach, coconut, buttery, sweet
delta-dodecalactone -4.71 4 -  fresh, sweet, metallic, peach, oily, coconut, buttery, fatty, creamy, dairy, fruity, apricot, milky
(Z)-4-nonenal -5.32 1 6.1111 1  
jasmatone -4.20 5 -  floral, fruity, jasmine
delta-decalactone -4.07 4 -  coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet
cinnamyl alcohol -6.88 6 1.9231 6  balsamic, cinnamon, cinnamyl, fermented, floral, green, hyacinth, powdery, spicy, sweet
gamma-nonalactone -3.94 4 -  buttery, coconut, creamy, oily, sweet, waxy
methyl tuberate -3.84 4 -  waxy, lactonic, metallic, tuberose, plum
(S)-(-)-citronellol -6.7 7 (agonist) 7  citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
geraniol -6.48 7 (agonist) 7  citrus, floral, fruity, rose, sweet, waxy
linalool -6.25 7 (agonist) 7  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
nerol -6.22 7 (agonist) 7  citrus, floral, fresh, green, lemon, lime, magnolia, natural, neroli, spicy, sweet, waxy
alpha-ionone -6.13 7 (agonist) 7  sweet, woody, floral, violet, orris, tropical, fruity
cyclamal -6.02 7 (agonist) 7  cyclamen, floral, fresh, green, musty, rhubarb
melafleur -5.73 7 (agonist) 7  floral, clean, muguet, ozone, marine, sandy, balsamic
benzyl acetone -5.72 7 (agonist) 7  floral, balsamic, strawberry
lyral -5.59 7 (agonist) 7  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
oranger crystals -4 8 3.2353 8  sweet, neroli, orangeflower, powdery, honey, floral, orange, naphthyl, citrus
phenylpropyl alcohol -5.31 7 (agonist) 7  sweet, spicy, cinnamyl, floral, hyacinth, balsamic, cinnamon, fruity, honey, winey
phenethyl alcohol -4.94 7 (agonist) 7  floral, rose, dried_rose, sweet, fresh, bready, honey
nonadecane -4.92 7 (agonist) 7  bland
caproic acid -4.3 3 1.9091 3  cheesy, fatty, sour, sweaty
(R)-(-)-carvone -3.8 8 2.3529 8  herbal, minty, spearmint, sweet
androstadienone -4.17 9 1.176 9  animal, musky
3-hydroxy-3-methyl hexanoic acid -4 10 1.4 10  cumin, sweaty, spicy, animalic
isoeugenol -4.04 9 1.0399 9  carnation, clove, floral, spicy, sweet, woody
3-methyl-2-hexenoic acid -3.92 10 0.76 10  cheesy, fruity
(S)-(+)-carvone -3.8 8 0.8235 8  bready, caraway, minty, spicy
butyric acid -4.1 9 0.1104 9  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
para-anisaldehyde -3.5 8 0.8824 8  sweet, powdery, mimosa, floral, hawthorn, balsamic, vanilla, anise, woody, coumarinic, creamy, spicy
3-phenyl propyl propionate -2.82 9 1.1908 9  floral, balsamic, hyacinth, mimosa, fruity
androstenone -3.06 9 0.4989 9  animal, musky
hexanol - 1.9231 6  ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
muguet propanol - 1.9231 6  floral, lily_of_the_valley, woody
amyl laurate -1.29 9 1.3654 9  fatty, oily, waxy
laitone - (agonist) 5  woody, herbal, celery, lactonic
benzyl alcohol - 0 7  floral, rose, phenolic, balsamic
alpha-damascone - 0 7  floral, rose, apple, fruity, black_currant, sweet, green, berry
gamma-heptalactone - 0 5  
(Z)-3-hexen-1-ol - 0 7  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
beta-ionone - 0 7  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
lavandulol - 0 7  floral, waxy, mimosa, herbal
gamma-octalactone - 0 5  sweet, coconut, waxy, creamy, tonka, dairy, fatty

1.) Frey, T., Kwadha, C. A., Wallin, E. A., Holgersson, E., Hedenström, E., Bohman, B., ... & Witzgall, P. (2020). The human odorant receptor OR10A6 is tuned to the pheromone of the commensal fruit fly Drosophila melanogaster. bioRxiv.

2.) Saito N, Yamano E, Ishii A, Tanaka M, Nakamura J, et al. (2018) Involvement of the olfactory system in the induction of anti-fatigue effects by odorants. PLOS ONE 13(3): e0195263. https://doi.org/10.1371/journal.pone.0195263

3.) Aya Kato, Naoko Saito, Etsuji Wakisaka (2016) Method for searching for malodor control agent, malodor control agent, and malodor control method. US9526680B2

4.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1

5.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

6.) Ashti Baghaei, K. (2015). Large scale analysis of olfactory receptors with highly genetically variations in relation with specific anosmia (Doctoral dissertation, Bochum, Ruhr-Universität Bochum, Diss., 2013).

7.) Duroux R, Mandeau A, Guiraudie-Capraz G, Quesnel Y, Loing E. A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors. Molecules. 2020 Oct 16;25(20):4743. doi: 10.3390/molecules25204743. PMID: 33081083; PMCID: PMC7587601.

8.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.

9.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

10.) Aya Kato, Naoko Saito (2018) Search method for odor control agent JP6422665B2
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