Olfactory Receptor family 5 subfamily P member 3.
Sequence:
10 20 30 40 50 60 70 80 90 100 MGTGNDTTVV EFTLLGLSED TTVCAILFLV FLGIYVVTLM GNISIIVLIR RSHHLHTPMY IFLCHLAFVD IGYSSSVTPV MLMSFLRKET SLPVAGCVAQ 110 120 130 140 150 160 170 180 190 200 LCSVVTFGTA ECFLLAAMAY DRYVAICSPL LYSTCMSPGV CIILVGMSYL GGCVNAWTFI GCLLRLSFCG PNKVNHFFCD YSPLLKLACS HDFTFEIIPA 210 220 230 240 250 260 270 280 290 300 ISSGSIIVAT VCVIAISYIY ILITILKMHS TKGRHKAFST CTSHLTAVTL FYGTITFIYV MPKSSYSTDQ NKVVSVFYTV VIPMLNPLIY SLRNKEIKGA 310 320 LKRELRIKIF S
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 V T T D F G A V P L C T F D H M Q D T S I A C S M L A V C G I F T I E F V Y I F V K N V L F L M V P T S C L Q W A N I A P I T I T F V S V G L F V S S T V V V C G G G S S G Y F L V T Y V V Y I S Y G I A T G F L Y S V I I S T V A M P I V M L T D V F F C E M G V L V T A T L H S P N L S I N G A L H C A A L L I I C A I V C T C T S Y I L V I I L F I Y A M V G P S Y S I S F A K L R I L Y M P T V Y R D L I Y I H R G C I A I T I K T S H S K L UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| 3-octen-2-one | - | 10 1 | earthy, spicy, herbal, sweet, mushroom, hay, blueberry | |
| coumarin | -5.44 2 | 9.7 3 | coumarinic, hay, sweet, tonka | |
| (R)-(-)-carvone | -5.4 4 | 9.7 3 | herbal, minty, spearmint, sweet | |
| skatole | -5.1 5 | 10 5 | animal, civet, fecal, naphthyl | |
| (S)-(+)-carvone | -5.17 3 | 9.7 3 | bready, caraway, minty, spicy | |
| 4-vinylguaiacol | -4.46 6 | 10 6 | spicy, clove, carnation, phenolic, peppery, smoky, woody, powdery | |
| oranger crystals | -4.2 7 | 10 7 | honey, neroli, orangeflower, powdery, sweet | |
| indole | -4.4 5 | 9.3496 5 | animal, fecal, floral, naphthyl | |
| anisaldehyde | -4.7 7 | 8.8235 7 | anisic, balsamic, floral, hawthorn, mimosa, powdery, sweet | |
| acetophenone | -3.9 3 | 9.6 3 | sweet, pungent, hawthorn, mimosa, almond, acacia, chemical | |
| 1-hexanol | -3.76 3 | 9.5 3 | alcoholic, ethereal, fruity, fusel, green, herbal, oily, pungent, sweet | |
| 1-heptanol | -2.96 3 | 9.3 3 | apple, banana, fruity, green, herbal, leafy, musty, peony, pungent, sweet, vegetable, violet, woody | |
| p-cresol | -4.4 6 | 3 8 | phenolic, narcissus, animal, mimosa | |
| 1-octanol | -4.94 9 | 0.2581 9 | aldehydic, green, mushroom, orange, rose, waxy | |
| celery ketone | -4.32 9 | 0.4032 9 | celery, cumin, fresh, green | |
| quinoline | - | 3 10 | earthy, medicinal, musty, rubbery, tobacco | |
| p-cresyl acetate | - | 0.8 8 | narcissus, phenolic, animal | |
| aldehyde C-8 | - | 0 3 | aldehydic, citrus, fatty, green, orange, peel, waxy | |
| allyl heptanoate | - | 0 3 | banana, cognac, fruity, fusel, pineapple, sweet, waxy | |
| allylbenzene | - | 0 3 | ||
| benzophenone | - | 0 3 | balsamic, geranium, herbal, metallic, powdery, rose | |
| benzyl acetate | - | 0 3 | floral, fresh, fruity, jasmine, sweet | |
| butyl butyryl lactate | - | 0 3 | buttermilk, buttery, cheesy, creamy, dairy | |
| (-)-camphor | - | 0 3 | ||
| camphor | - | 0 3 | camphoraceous | |
| capric acid | - | 0 3 | citrus, fatty, rancid, sour | |
| caproic acid | - | 0 3 | cheesy, fatty, sour, sweaty | |
| gamma-caprolactone | - | 0 3 | coconut, coumarinic, herbal, sweet, tobacco | |
| caprylic acid | - | 0 3 | cheesy, fatty, oily, rancid, vegetable, waxy | |
| 4-chromanone | - | 0 3 | ||
| (S)-(-)-citronellol | - | 0 3 | citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy | |
| 2-coumaranone | - | 0 3 | ||
| cyclohexanone | - | 0 3 | acetone, minty | |
| 1-decanol | - | 0 3 | aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy | |
| (+)-dihydrocarvone | - | 0 3 | herbal, mentholic, minty | |
| dihydrojasmone | - | 0 3 | floral, fresh, herbal, jasmine, myrrh, outdoors, spicy, woody | |
| ethyl isobutyrate | - | 0 3 | alcoholic, ethereal, fruity, fusel, rummy, sweet | |
| fenchone | - | 0 3 | camphoraceous, earthy, herbal, woody | |
| geraniol | - | 0 3 | citrus, floral, fruity, rose, sweet, waxy | |
| heptanal | - | 0 3 | aldehydic, cognac, fatty, fresh, green, herbal, ozone | |
| 3-heptanone | - | 0 3 | fatty, fruity, green | |
| hexanal | - | 0 3 | aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty | |
| 2,3-hexanedione | - | 0 3 | buttery, sweet | |
| 3,4-hexanedione | - | 0 3 | almond, buttery, caramellic, nutty, toasted | |
| 2-hexanone | - | 0 3 | ethereal | |
| hexyl acetate | - | 0 3 | apple, banana, fruity, green, sweet | |
| 4-hydroxycoumarin | - | 0 3 | ||
| nonanethiol | - | 0 3 | ||
| 1-nonanol | - | 0 3 | aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet | |
| 2-nonanone | - | 0 3 | earthy, fresh, fruity, green, herbal, sweet, weedy | |
| 2-octanone | - | 0 3 | earthy, herbal, natural, weedy, woody | |
| 3-octanone | - | 0 3 | fresh, herbal, lavender, mushroom, sweet | |
| octyl octanoate | - | 0 10 | coconut, fruity, oily | |
| oenanthic acid | - | 0 3 | rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity | |
| 2-pentanone | - | 0 3 | banana, ethereal, fruity, sweet, winey, woody | |
| phenyl acetate | - | 0 3 | animal, burnt, castoreum, medicinal, phenolic, resinous, smoky, woody | |
| (+)-2-phenylbutyric acid | - | 0 3 | ||
| prenyl acetate | - | 0 3 | balsamic, banana, fresh, fruity, heliotrope, jasmine, ripe, sweet | |
| propionic acid | - | 0 10 | acidic, cheesy, pungent, vinegar | |
| valeric acid | - | 0 3 | acidic, cheesy, fruity, milky, sharp, sour, tobacco | |
| vanillic acid | - | 0 3 | beany, brown, creamy, dairy, milky, phenolic, powdery, sweet, vanilla | |
| alpha,alpha-dimethyl phenethyl acetate | - | -0.1626 5 | sweet, floral, fruity, rose, green, pear, berry, jasmin, powdery | |
| citronellal natural | - | -0.1626 5 | sweet, dry, floral, herbal, waxy, aldehydic, citrus | |
| 2-cyclohexylpropanal | - | -0.1626 5 | natural, fresh, green, dusty, fruity | |
| delta-damascone | - | -0.1626 5 | fruity, sweet, rose, natural, petal, currant_bud, black_currant_bud, tobacco | |
| ethyl linalyl ether | - | -0.1626 5 | floral | |
| (-)-alpha-fenchol | - | -0.1626 5 | camphoraceous, clean, cooling, eucalyptus, green, herbal, minty, piney, woody | |
| galaxolide | - | -0.1626 5 | floral, musk, sweet | |
| globanone | - | -0.1626 5 | animal, balsamic, cloth, dry, floral, laundered, musk, tobacco, waxy | |
| hexyl salicylate | - | -0.1626 5 | ||
| ivy carbaldehyde | - | -0.1626 5 | green, aldehydic, weedy, herbal, cortex, privet, soapy | |
| cis-jasmone | - | -0.1626 5 | woody, herbal, floral, spicy, jasmine, celery | |
| lilial | - | -0.1626 5 | cumin, floral, green, muguet, powdery, watery | |
| melafleur | - | -0.1626 5 | floral, clean, muguet, ozone, marine, sandy, balsamic | |
| 7-methoxycitronellal | - | -0.1626 5 | fresh, melon, floral, lily, sweet | |
| methyl ionone gamma | - | -0.1626 5 | violet, sweet, orris, powdery, floral, woody | |
| muscenone | - | -0.1626 5 | animal, musk, soapy | |
| myraldyl acetate | - | -0.1626 5 | fresh, lily, magnolia, sweet, citrus, freesia, green | |
| strawberry glycidate | - | -0.1626 5 | cherry, fruity, grape, jammy, phenolic, strawberry, sweet | |
| verdyl acetate | - | -0.1626 5 | floral, green, soapy, cedar, pine, woody | |
| amber butanol | - | -0.4065 5 | woody, amber, ambrette | |
| ambroxide | - | -0.4065 5 | amber, ambergris, cedar, dry, green, musk, paper, pine, seedy, woody | |
| civetone | - | -0.4065 5 | animal, clean, dry, musk, sweet | |
| exaltolide | - | -0.4065 5 | musk, animal, powdery, natural, fruity | |
| galbascone | - | -0.4065 5 | fresh, green, galbanum, earthy, weedy, pineapple, narcissus, hyacinth, fruity | |
| cis-3-hexenyl salicylate | - | -0.4065 5 | floral, green, metallic, herbal, balsamic | |
| hydroxycitronellal | - | -0.4065 5 | floral, green, lily, melon, sweet, tropical, waxy | |
| methyl jasmonate | - | -0.4065 5 | jasmin, floral, oily, green, petal, greasy, soft | |
| 3-(3-propen-2-yl phenyl) butanal | - | -0.4065 5 | ozone, cortex, green, floral, melon | |
| tetrahydrogeraniol | - | -0.4065 5 | leathery, musty, plastic, rose, sweet | |
| gamma-undecalactone | - | -0.4065 5 | apricot, coconut, creamy, fatty, fruity, ketonic, lactonic, peach | |
| isobutylamine | - | -0.5 10 | cheesy, fishy | |
| ebanol | - | -0.6504 5 | ||
| grapefruit pentanol | - | -0.6504 5 | vetiver, green, citrus, grapefruit, rhubarb, floral | |
| mefrosol | - | -0.6504 5 | floral, geranium, green, honey, lily, muguet, resh, rose, tropical | |
| (R,S)-methyl cedryl ketone | - | -0.6504 5 | woody, vetiver, amber, leathery, musk, cedar | |
| nerolidol | - | -0.6504 5 | citrus, floral, green, waxy, woody | |
| patchouli hexanol | - | -0.6504 5 | woody, musty, patchouli, camphoreous, minty, leathery | |
| spicy carbonate | - | -0.6504 5 | spicy, woody, floral, green, herbal | |
| thymol | - | -0.6504 5 | camphoraceous, herbal, medicinal, phenolic, thyme | |
| cis-3-hexen-1-ol | - | -0.6667 10 | foliage, fresh, grassy, green, herbal, oily, vegetable | |
| lyral | - | -1.3333 10 | aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody | |
| l-arabinose | - | -1.5667 10 | ||
| pyrazine | - | -1.5667 10 | pungent, sweet, corn, roasted, hazelnut, barley | |
| ethyl vanillin | - | -1.6333 10 | caramellic, creamy, sweet, vanilla | |
| d-limonene | - | -2 10 | citrus, fresh, orange, sweet | |
| methyl salicylate | - | -2 10 | minty, wintergreen | |
| eugenol | - | -2.1667 10 | clove, spicy, sweet, woody | |
| terpinyl acetate | - | -2.2333 10 | bergamot, citrus, herbal, lavender, lime | |
| linalool | - | -2.2667 10 | blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody | |
| 2-ethyl fenchol | - | -2.3333 10 | camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea | |
| 2-heptanone | - | -2.3333 10 | banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody | |
| helional | - | -2.3833 10 | cyclamen, fresh, green, hay, ozone, watery | |
| aldehyde C-9 | - | -2.4 10 | aldehydic, fatty, fresh, orange, orris, peel, peely, rose, waxy | |
| methyl furfuryl disulfide | - | -2.4 10 | alliaceous, coffee, meaty, roasted, sulfurous | |
| citral | - | -2.4333 10 | citrus, lemon, sharp, sweet | |
| 2,4-DNT | - | -2.4667 10 | ||
| coffee difuran | - | -2.5 10 | cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty | |
| methyl eugenol | - | -2.5 10 | carnation, cinnamon, clove, fresh, spicy, sweet, warm | |
| butyric acid | - | -2.5167 10 | acetic, buttery, cheesy, fruity, sharp | |
| eugenyl acetate | - | -2.5333 10 | carnation, clove, floral, fresh, malty, spicy, sweet, woody | |
| pentanol | - | -2.5467 10 | balsamic, fermented, fusel, oily, sweet | |
| (+)-menthol | - | -2.5667 10 | cooling, mentholic, minty | |
| octanethiol | - | -2.5833 10 | sulfurous | |
| amyl hexanoate | - | -2.6 10 | apple, estery, fatty, fruity, green, pear, pineapple, sweet | |
| pelargonic acid | - | -2.6 10 | cheesy, dairy, dirty, waxy | |
| benzene | - | -2.6333 10 | ||
| dimethyl disulfide | - | -2.6333 10 | cabbage, onion, sulfurous, vegetable | |
| geranyl acetate | - | -2.6333 10 | floral, green, lavender, rose, waxy | |
| aldehyde C-10 | - | -2.6667 10 | aldehydic, citrus, floral, orange, peel, sweet, waxy | |
| allyl phenylacetate | - | -2.6667 10 | fruity, honey, rummy | |
| androstenone | - | -2.6667 10 | animal, musky | |
| butyl formate | - | -2.6667 10 | brandy, fruity, plum, rummy | |
| beta-damascone | - | -2.6667 10 | berry, currant, floral, fruity, honey, plum, rose, tobacco | |
| propanal | - | -2.6667 10 | alcoholic, cocoa, earthy, nutty, whiskey, winey |
1.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147
2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
3.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.
4.) Saito N, Yamano E, Ishii A, Tanaka M, Nakamura J, et al. (2018) Involvement of the olfactory system in the induction of anti-fatigue effects by odorants. PLOS ONE 13(3): e0195263. https://doi.org/10.1371/journal.pone.0195263
5.) Aya Kato, Naoko Saito (2015) Odor control agent. JP5798382B2
6.) Aya Namba, Naoko Saito, Keiichi Yoshikawa, Ichiro Mori (2015) Search method of urine odor suppressor JP2015211667A
7.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.
8.) Shirai, T., Takase, D., Yokoyama, J. et al. Functions of human olfactory mucus and age-dependent changes. Sci Rep 13, 971 (2023). https://doi.org/10.1038/s41598-023-27937-1
9.) Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, et al. () Identification of Odorant-Receptor Interactions by Global Mapping of the Human Odorome. PLoS ONE 9(4): e93037. doi:10.1371/journal.pone.0093037
10.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821